PMC:7228307 / 58074-58419
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1188 | 250-254 | Gene | denotes | OX40 | Gene:7293 |
1189 | 327-330 | Gene | denotes | DR4 | Gene:3126 |
1190 | 332-335 | Gene | denotes | DR5 | Gene:8795 |
1191 | 243-248 | Gene | denotes | 4‐1BB | Gene:3604 |
1192 | 289-294 | Disease | denotes | death | MESH:D003643 |
1193 | 308-314 | Disease | denotes | cancer | MESH:D009369 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T448 | 42-47 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T449 | 195-219 | Body_part | denotes | antigen‐presenting cells | http://purl.org/sig/ont/fma/fma273565 |
T450 | 214-219 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T451 | 225-230 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T452 | 315-320 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T111 | 308-314 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T972 | 42-47 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T973 | 63-72 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
T974 | 214-219 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T975 | 223-230 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
T976 | 315-320 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T977 | 342-345 | http://purl.obolibrary.org/obo/CLO_0001046 | denotes | 116 |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T38447 | 182-191 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T65735 | 195-202 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
LitCovid-sample-PD-IDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T247 | 42-47 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T248 | 214-219 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T249 | 225-230 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T250 | 315-320 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
LitCovid-sample-Enju
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T106 | 0-9 | JJ | denotes | Agonistic |
T107 | 10-14 | NNS | denotes | mAbs |
T108 | 15-21 | VBP | denotes | induce |
T109 | 22-31 | NNS | denotes | responses |
T110 | 32-34 | IN | denotes | in |
T111 | 35-41 | NN | denotes | target |
T112 | 42-47 | NNS | denotes | cells |
T113 | 48-50 | IN | denotes | by |
T114 | 51-62 | VBG | denotes | stimulating |
T115 | 63-72 | NN | denotes | signaling |
T116 | 73-75 | IN | denotes | of |
T117 | 76-81 | PRP-DOLLAR- | denotes | their |
T118 | 82-91 | JJ | denotes | molecular |
T119 | 92-98 | NN | denotes | target |
T120 | 100-109 | RB | denotes | Typically |
T121 | 109-110 | -COMMA- | denotes | , |
T122 | 111-115 | DT | denotes | this |
T123 | 116-118 | VBZ | denotes | is |
T124 | 119-121 | TO | denotes | to |
T125 | 122-128 | CC | denotes | either |
T126 | 129-136 | VB | denotes | enhance |
T127 | 137-146 | NN | denotes | antitumor |
T128 | 147-155 | NN | denotes | immunity |
T129 | 156-158 | IN | denotes | by |
T130 | 159-167 | VBG | denotes | engaging |
T131 | 168-181 | JJ | denotes | costimulatory |
T132 | 182-191 | NNS | denotes | molecules |
T133 | 192-194 | IN | denotes | on |
T134 | 195-213 | JJ | denotes | antigen‐presenting |
T135 | 214-219 | NNS | denotes | cells |
T136 | 220-222 | CC | denotes | or |
T137 | 223-224 | NN | denotes | T |
T138 | 225-230 | NNS | denotes | cells |
T139 | 231-232 | -LRB- | denotes | ( |
T140 | 232-236 | FW | denotes | i.e. |
T141 | 237-241 | NN | denotes | CD40 |
T142 | 241-242 | -COMMA- | denotes | , |
T143 | 243-248 | NN | denotes | 4‐1BB |
T144 | 248-249 | -COMMA- | denotes | , |
T145 | 250-254 | NN | denotes | OX40 |
T146 | 254-255 | -RRB- | denotes | ) |
T147 | 256-258 | CC | denotes | or |
T148 | 259-266 | VB | denotes | promote |
T149 | 267-276 | NN | denotes | apoptosis |
T150 | 277-279 | IN | denotes | by |
T151 | 280-288 | VBG | denotes | engaging |
T152 | 289-294 | NN | denotes | death |
T153 | 295-304 | NNS | denotes | receptors |
T154 | 305-307 | IN | denotes | on |
T155 | 308-314 | NN | denotes | cancer |
T156 | 315-320 | NNS | denotes | cells |
T157 | 321-322 | -LRB- | denotes | ( |
T158 | 322-326 | FW | denotes | i.e. |
T159 | 327-330 | NN | denotes | DR4 |
T160 | 330-331 | -COMMA- | denotes | , |
T161 | 332-335 | NN | denotes | DR5 |
T162 | 335-336 | -COMMA- | denotes | , |
T163 | 337-340 | NN | denotes | Fas |
T164 | 340-341 | -RRB- | denotes | ) |
R108 | T107 | T106 | arg1Of | mAbs,Agonistic |
R109 | T107 | T108 | arg1Of | mAbs,induce |
R110 | T109 | T108 | arg2Of | responses,induce |
R111 | T109 | T110 | arg1Of | responses,in |
R112 | T112 | T110 | arg2Of | cells,in |
R113 | T112 | T111 | arg1Of | cells,target |
R114 | T108 | T113 | arg1Of | induce,by |
R115 | T114 | T113 | arg2Of | stimulating,by |
R116 | T107 | T114 | arg1Of | mAbs,stimulating |
R117 | T115 | T114 | arg2Of | signaling,stimulating |
R118 | T115 | T116 | arg1Of | signaling,of |
R119 | T119 | T116 | arg2Of | target,of |
R120 | T119 | T117 | arg1Of | target,their |
R121 | T119 | T118 | arg1Of | target,molecular |
R122 | T123 | T120 | arg1Of | is,Typically |
R123 | T123 | T121 | arg1Of | is,"," |
R124 | T122 | T123 | arg1Of | this,is |
R125 | T147 | T123 | arg2Of | or,is |
R126 | T147 | T124 | arg1Of | or,to |
R127 | T147 | T125 | arg1Of | or,either |
R128 | T128 | T126 | arg2Of | immunity,enhance |
R129 | T128 | T127 | arg1Of | immunity,antitumor |
R130 | T126 | T129 | arg1Of | enhance,by |
R131 | T130 | T129 | arg2Of | engaging,by |
R132 | T132 | T130 | arg2Of | molecules,engaging |
R133 | T132 | T131 | arg1Of | molecules,costimulatory |
R134 | T132 | T133 | arg1Of | molecules,on |
R135 | T136 | T133 | arg2Of | or,on |
R136 | T135 | T134 | arg1Of | cells,antigen‐presenting |
R137 | T135 | T136 | arg1Of | cells,or |
R138 | T138 | T136 | arg2Of | cells,or |
R139 | T138 | T137 | arg1Of | cells,T |
R140 | T136 | T139 | arg1Of | or,( |
R141 | T142 | T139 | arg2Of | ",",( |
R142 | T146 | T139 | arg3Of | ),( |
R143 | T142 | T140 | arg1Of | ",",i.e. |
R144 | T141 | T142 | arg1Of | CD40,"," |
R145 | T143 | T142 | arg2Of | 4‐1BB,"," |
R146 | T142 | T144 | arg1Of | ",","," |
R147 | T145 | T144 | arg2Of | OX40,"," |
R148 | T126 | T147 | arg1Of | enhance,or |
R149 | T148 | T147 | arg2Of | promote,or |
R150 | T149 | T148 | arg2Of | apoptosis,promote |
R151 | T148 | T150 | arg1Of | promote,by |
R152 | T151 | T150 | arg2Of | engaging,by |
R153 | T153 | T151 | arg2Of | receptors,engaging |
R154 | T153 | T152 | arg1Of | receptors,death |
R155 | T153 | T154 | arg1Of | receptors,on |
R156 | T156 | T154 | arg2Of | cells,on |
R157 | T156 | T155 | arg1Of | cells,cancer |
R158 | T156 | T157 | arg1Of | cells,( |
R159 | T159 | T157 | arg2Of | DR4,( |
R160 | T164 | T157 | arg3Of | ),( |
R161 | T159 | T158 | arg1Of | DR4,i.e. |
R162 | T159 | T160 | arg1Of | DR4,"," |
R163 | T161 | T160 | arg2Of | DR5,"," |
R164 | T159 | T162 | arg1Of | DR4,"," |
R165 | T163 | T162 | arg2Of | Fas,"," |
LitCovid-sample-Pubtator
Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
---|---|---|---|---|---|
1188 | 250-254 | Gene | denotes | OX40 | Gene:7293 |
1189 | 327-330 | Gene | denotes | DR4 | Gene:3126 |
1190 | 332-335 | Gene | denotes | DR5 | Gene:8795 |
1191 | 243-248 | Gene | denotes | 4‐1BB | Gene:3604 |
1192 | 289-294 | Disease | denotes | death | MESH:D003643 |
1193 | 308-314 | Disease | denotes | cancer | MESH:D009369 |
LitCovid-sample-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T322 | 0-99 | Sentence | denotes | Agonistic mAbs induce responses in target cells by stimulating signaling of their molecular target. |
T323 | 100-345 | Sentence | denotes | Typically, this is to either enhance antitumor immunity by engaging costimulatory molecules on antigen‐presenting cells or T cells (i.e. CD40, 4‐1BB, OX40) or promote apoptosis by engaging death receptors on cancer cells (i.e. DR4, DR5, Fas).116 |
LitCovid-sample-UniProt
Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
---|---|---|---|---|---|
T738 | 168-191 | Protein | denotes | costimulatory molecules | https://www.uniprot.org/uniprot/Q9BXR1|https://www.uniprot.org/uniprot/Q8VE98|https://www.uniprot.org/uniprot/Q8NCB6|https://www.uniprot.org/uniprot/Q8NC34|https://www.uniprot.org/uniprot/Q8NBI8|https://www.uniprot.org/uniprot/Q7TPB4|https://www.uniprot.org/uniprot/Q6UXI2|https://www.uniprot.org/uniprot/Q6P5Y4|https://www.uniprot.org/uniprot/Q5ZPR3 |
T747 | 237-241 | Protein | denotes | CD40 | https://www.uniprot.org/uniprot/Q9BYU0|https://www.uniprot.org/uniprot/Q99NE3|https://www.uniprot.org/uniprot/Q99NE2|https://www.uniprot.org/uniprot/Q99NE1|https://www.uniprot.org/uniprot/Q99NE0|https://www.uniprot.org/uniprot/Q8SQ34|https://www.uniprot.org/uniprot/Q8K2X6|https://www.uniprot.org/uniprot/Q86YK5|https://www.uniprot.org/uniprot/Q7YRL5|https://www.uniprot.org/uniprot/Q7M4Q8|https://www.uniprot.org/uniprot/Q5U007|https://www.uniprot.org/uniprot/Q5JY15|https://www.uniprot.org/uniprot/Q542B1|https://www.uniprot.org/uniprot/Q53GN5|https://www.uniprot.org/uniprot/Q3ZTK5|https://www.uniprot.org/uniprot/Q3UBH3|https://www.uniprot.org/uniprot/Q3U7C9|https://www.uniprot.org/uniprot/Q3U799|https://www.uniprot.org/uniprot/Q3TSL2|https://www.uniprot.org/uniprot/Q3TS33|https://www.uniprot.org/uniprot/Q3LRP1|https://www.uniprot.org/uniprot/Q28203|https://www.uniprot.org/uniprot/P27512|https://www.uniprot.org/uniprot/P25942|https://www.uniprot.org/uniprot/E1P5S9|https://www.uniprot.org/uniprot/A7YWS9 |
LitCovid-sample-PD-FMA
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T447 | 42-47 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T448 | 195-219 | Body_part | denotes | antigen‐presenting cells | http://purl.org/sig/ont/fma/fma273565 |
T449 | 214-219 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T450 | 225-230 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T451 | 315-320 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-sample-PD-GO-BP-0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T132 | 63-72 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T133 | 267-276 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T134 | 267-276 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T135 | 289-294 | http://purl.obolibrary.org/obo/GO_0016265 | denotes | death |
LitCovid-sample-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T48 | 308-314 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
LitCovid-sample-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T43 | 308-314 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-sample-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T132 | 63-72 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T133 | 267-276 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T134 | 267-276 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T132 | 63-72 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T133 | 267-276 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T134 | 267-276 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T322 | 0-99 | Sentence | denotes | Agonistic mAbs induce responses in target cells by stimulating signaling of their molecular target. |
T323 | 100-345 | Sentence | denotes | Typically, this is to either enhance antitumor immunity by engaging costimulatory molecules on antigen‐presenting cells or T cells (i.e. CD40, 4‐1BB, OX40) or promote apoptosis by engaging death receptors on cancer cells (i.e. DR4, DR5, Fas).116 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T43 | 308-314 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |