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PMC:7228307 / 57302-58032 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1176 67-74 Gene denotes FcγRIIb Gene:2213
1177 208-215 Gene denotes FcγRIIb Gene:2213
1178 666-673 Gene denotes FcγRIIb Gene:2213
1179 607-615 Species denotes patients Tax:9606

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T442 243-253 Body_part denotes Antibodies http://purl.org/sig/ont/fma/fma62871
T443 267-275 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T444 346-349 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875
T445 353-362 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T446 579-582 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875
T447 638-641 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T110 291-294 Disease denotes MOA http://purl.obolibrary.org/obo/MONDO_0016702

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T963 67-69 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T964 153-156 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T965 208-210 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T966 257-259 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T967 457-460 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T968 502-504 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T969 525-526 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T970 666-668 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T32821 193-204 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T86511 267-275 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T45 328-337 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367

LitCovid-sample-Enju

Id Subject Object Predicate Lexical cue
T20 164-166 RP denotes up
T21 167-170 JJ denotes new
T22 171-184 NNS denotes possibilities
T23 185-188 IN denotes for
T24 189-192 DT denotes the
T25 193-204 NN denotes application
T26 205-207 IN denotes of
T27 208-225 VBG denotes FcγRIIb‐enhancing
T28 226-242 NN denotes modifications.17
T29 243-253 NNS denotes Antibodies
T30 254-256 CC denotes or
T31 257-259 NN denotes Fc
T32 260-266 NN denotes fusion
T33 267-275 NNS denotes proteins
T34 275-276 -COMMA- denotes ,
T35 277-282 WP-DOLLAR- denotes whose
T36 283-290 JJ denotes primary
T37 291-294 NN denotes MOA
T38 295-297 VBZ denotes is
T39 298-301 DT denotes the
T40 302-316 NN denotes neutralization
T41 317-319 IN denotes of
T42 320-327 JJ denotes soluble
T43 328-337 NNS denotes molecules
T44 338-342 JJ denotes such
T45 343-345 IN denotes as
T46 346-349 NN denotes IgE
T47 350-352 CC denotes or
T48 353-362 NNS denotes cytokines
T49 362-363 -COMMA- denotes ,
T50 364-367 VBP denotes are
T51 368-380 RB denotes particularly
T52 381-391 JJ denotes attractive
T53 392-402 NNS denotes candidates
T54 403-406 IN denotes for
T55 407-411 DT denotes this
T56 412-420 NN denotes approach
T57 422-438 NN denotes Proof‐of‐concept
T58 439-442 IN denotes for
T59 443-447 DT denotes this
T60 448-456 NN denotes strategy
T61 457-460 VBZ denotes has
T62 461-465 VBN denotes been
T63 466-478 VBN denotes demonstrated
T64 479-481 IN denotes in
T65 482-494 JJ denotes experimental
T66 495-504 NN denotes models.48
T67 505-511 RB denotes Indeed
T68 511-512 -COMMA- denotes ,
T69 513-517 DT denotes this
T70 518-521 MD denotes may
T71 522-524 VB denotes be
T72 525-526 DT denotes a
T73 527-538 JJ denotes significant
T74 539-548 NN denotes component
T75 549-551 IN denotes of
T76 552-555 DT denotes the
T77 556-561 JJ denotes rapid
T78 562-575 NN denotes disappearance
T79 576-578 IN denotes of
T80 579-582 NN denotes IgE
T81 583-587 IN denotes from
T82 588-591 DT denotes the
T83 592-603 NN denotes circulation
T84 604-606 IN denotes of
T85 607-615 NNS denotes patients
T86 616-623 VBN denotes treated
T87 624-628 IN denotes with
T88 629-632 DT denotes the
T89 633-641 NN denotes anti‐IgE
T90 642-650 NN denotes XmAb7195
T91 651-661 VBG denotes containing
T92 662-665 DT denotes the
T93 666-673 NN denotes FcγRIIb
T94 674-683 VBG denotes enhancing
T95 684-690 NNP denotes “SELF”
T96 691-704 NNS denotes modifications
T97 704-705 -COMMA- denotes ,
T98 706-708 IN denotes as
T99 709-718 VBN denotes described
T100 719-729 RB denotes previously
T0 49-52 DT denotes The
T1 53-63 NN denotes expression
T2 64-66 IN denotes of
T3 67-74 NN denotes FcγRIIb
T4 75-77 IN denotes on
T5 78-82 NNP denotes LSEC
T6 83-86 CC denotes and
T7 87-90 PRP-DOLLAR- denotes its
T8 91-97 NN denotes action
T9 98-100 IN denotes in
T10 101-104 DT denotes the
T11 105-115 NN denotes “sweeping”
T12 116-118 CC denotes or
T13 119-126 NN denotes removal
T14 127-129 IN denotes of
T15 130-135 JJ denotes small
T16 136-142 JJ denotes immune
T17 143-152 NNS denotes complexes
T18 153-156 VBZ denotes has
T19 157-163 VBN denotes opened
R0 T1 T0 arg1Of expression,The
R1 T1 T2 arg1Of expression,of
R2 T3 T2 arg2Of FcγRIIb,of
R3 T1 T4 arg1Of expression,on
R4 T5 T4 arg2Of LSEC,on
R5 T1 T6 arg1Of expression,and
R6 T8 T6 arg2Of action,and
R7 T8 T7 arg1Of action,its
R8 T8 T9 arg1Of action,in
R9 T12 T9 arg2Of or,in
R10 T12 T10 arg1Of or,the
R11 T11 T12 arg1Of “sweeping”,or
R12 T13 T12 arg2Of removal,or
R13 T12 T14 arg1Of or,of
R14 T17 T14 arg2Of complexes,of
R15 T17 T15 arg1Of complexes,small
R16 T17 T16 arg1Of complexes,immune
R17 T6 T18 arg1Of and,has
R18 T19 T18 arg2Of opened,has
R19 T6 T19 arg1Of and,opened
R20 T22 T19 arg2Of possibilities,opened
R21 T19 T20 arg1Of opened,up
R22 T22 T21 arg1Of possibilities,new
R23 T22 T23 arg1Of possibilities,for
R24 T25 T23 arg2Of application,for
R25 T25 T24 arg1Of application,the
R26 T25 T26 arg1Of application,of
R27 T30 T26 arg2Of or,of
R28 T29 T27 arg1Of Antibodies,FcγRIIb‐enhancing
R29 T29 T28 arg1Of Antibodies,modifications.17
R30 T29 T30 arg1Of Antibodies,or
R31 T33 T30 arg2Of proteins,or
R32 T33 T31 arg1Of proteins,Fc
R33 T33 T32 arg1Of proteins,fusion
R34 T22 T34 arg1Of possibilities,","
R35 T37 T35 arg1Of MOA,whose
R36 T22 T35 arg2Of possibilities,whose
R37 T37 T36 arg1Of MOA,primary
R38 T37 T38 arg1Of MOA,is
R39 T40 T38 arg2Of neutralization,is
R40 T40 T39 arg1Of neutralization,the
R41 T40 T41 arg1Of neutralization,of
R42 T43 T41 arg2Of molecules,of
R43 T43 T42 arg1Of molecules,soluble
R44 T45 T44 arg1Of as,such
R45 T43 T45 arg1Of molecules,as
R46 T47 T45 arg2Of or,as
R47 T46 T47 arg1Of IgE,or
R48 T48 T47 arg2Of cytokines,or
R49 T38 T49 arg1Of is,","
R50 T50 T49 arg2Of are,","
R51 T37 T50 arg1Of MOA,are
R52 T53 T50 arg2Of candidates,are
R53 T52 T51 arg1Of attractive,particularly
R54 T53 T52 arg1Of candidates,attractive
R55 T53 T54 arg1Of candidates,for
R56 T56 T54 arg2Of approach,for
R57 T56 T55 arg1Of approach,this
R58 T57 T58 arg1Of Proof‐of‐concept,for
R59 T60 T58 arg2Of strategy,for
R60 T60 T59 arg1Of strategy,this
R61 T57 T61 arg1Of Proof‐of‐concept,has
R62 T63 T61 arg2Of demonstrated,has
R63 T57 T62 arg1Of Proof‐of‐concept,been
R64 T63 T62 arg2Of demonstrated,been
R65 T57 T63 arg2Of Proof‐of‐concept,demonstrated
R66 T63 T64 arg1Of demonstrated,in
R67 T66 T64 arg2Of models.48,in
R68 T66 T65 arg1Of models.48,experimental
R69 T66 T67 arg1Of models.48,Indeed
R70 T63 T68 arg1Of demonstrated,","
R71 T71 T68 arg2Of be,","
R72 T69 T70 arg1Of this,may
R73 T71 T70 arg2Of be,may
R74 T69 T71 arg1Of this,be
R75 T74 T71 arg2Of component,be
R76 T74 T72 arg1Of component,a
R77 T74 T73 arg1Of component,significant
R78 T74 T75 arg1Of component,of
R79 T78 T75 arg2Of disappearance,of
R80 T78 T76 arg1Of disappearance,the
R81 T78 T77 arg1Of disappearance,rapid
R82 T78 T79 arg1Of disappearance,of
R83 T80 T79 arg2Of IgE,of
R84 T80 T81 arg1Of IgE,from
R85 T83 T81 arg2Of circulation,from
R86 T83 T82 arg1Of circulation,the
R87 T83 T84 arg1Of circulation,of
R88 T85 T84 arg2Of patients,of
R89 T85 T86 arg2Of patients,treated
R90 T86 T87 arg1Of treated,with
R91 T90 T87 arg2Of XmAb7195,with
R92 T90 T88 arg1Of XmAb7195,the
R93 T90 T89 arg1Of XmAb7195,anti‐IgE
R94 T90 T91 arg1Of XmAb7195,containing
R95 T93 T91 arg2Of FcγRIIb,containing
R96 T93 T92 arg1Of FcγRIIb,the
R97 T93 T94 arg1Of FcγRIIb,enhancing
R98 T96 T94 arg2Of modifications,enhancing
R99 T96 T95 arg1Of modifications,“SELF”
R100 T94 T97 arg1Of enhancing,","
R101 T94 T98 arg1Of enhancing,as
R102 T99 T98 arg2Of described,as
R103 T99 T100 arg1Of described,previously

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T65 267-275 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
1176 67-74 Gene denotes FcγRIIb Gene:2213
1177 208-215 Gene denotes FcγRIIb Gene:2213
1178 666-673 Gene denotes FcγRIIb Gene:2213
1179 607-615 Species denotes patients Tax:9606

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T318 0-48 Sentence denotes Enhancing the sweeping of small immune complexes
T319 49-421 Sentence denotes The expression of FcγRIIb on LSEC and its action in the “sweeping” or removal of small immune complexes has opened up new possibilities for the application of FcγRIIb‐enhancing modifications.17 Antibodies or Fc fusion proteins, whose primary MOA is the neutralization of soluble molecules such as IgE or cytokines, are particularly attractive candidates for this approach.
T320 422-730 Sentence denotes Proof‐of‐concept for this strategy has been demonstrated in experimental models.48 Indeed, this may be a significant component of the rapid disappearance of IgE from the circulation of patients treated with the anti‐IgE XmAb7195 containing the FcγRIIb enhancing “SELF” modifications, as described previously.

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T441 243-253 Body_part denotes Antibodies http://purl.org/sig/ont/fma/fma62871
T442 267-275 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T443 346-349 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875
T444 353-362 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T445 579-582 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875
T446 638-641 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T318 0-48 Sentence denotes Enhancing the sweeping of small immune complexes
T319 49-421 Sentence denotes The expression of FcγRIIb on LSEC and its action in the “sweeping” or removal of small immune complexes has opened up new possibilities for the application of FcγRIIb‐enhancing modifications.17 Antibodies or Fc fusion proteins, whose primary MOA is the neutralization of soluble molecules such as IgE or cytokines, are particularly attractive candidates for this approach.
T320 422-730 Sentence denotes Proof‐of‐concept for this strategy has been demonstrated in experimental models.48 Indeed, this may be a significant component of the rapid disappearance of IgE from the circulation of patients treated with the anti‐IgE XmAb7195 containing the FcγRIIb enhancing “SELF” modifications, as described previously.