PMC:7228307 / 56615-57300 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7228307","sourcedb":"PMC","sourceid":"7228307","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7228307","text":"One cautionary note is that the arginine 131 (R131) of the IgG‐binding site in FcγRIIb is critical for the enhanced affinity binding of “SELF”‐mutated Fcs but it is also present in the activating‐type “high responder” FcγRIIa‐R131. Thus, antibodies modified with “SELF” have very‐high‐affinity binding to FcγRIIa‐R131 115 with a potentially increased risk of FcγRIIa‐dependent complications in patients expressing this allelic form, although, so far, none have been reported in clinical trials. However, an alternative set of six Fc mutations, termed “V12” (P238D, E233D, G237D, H268D, P271G and A330R), potently enhanced FcγRIIb binding without increasing FcγRIIa–R131 interaction.115","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"1162","span":{"begin":79,"end":86},"obj":"Gene"},{"id":"1163","span":{"begin":622,"end":629},"obj":"Gene"},{"id":"1164","span":{"begin":359,"end":366},"obj":"Gene"},{"id":"1165","span":{"begin":394,"end":402},"obj":"Species"},{"id":"1166","span":{"begin":32,"end":40},"obj":"Chemical"},{"id":"1167","span":{"begin":558,"end":563},"obj":"Mutation"},{"id":"1168","span":{"begin":565,"end":570},"obj":"Mutation"},{"id":"1169","span":{"begin":572,"end":577},"obj":"Mutation"},{"id":"1170","span":{"begin":586,"end":591},"obj":"Mutation"},{"id":"1171","span":{"begin":596,"end":601},"obj":"Mutation"}],"attributes":[{"id":"A1162","pred":"tao:has_database_id","subj":"1162","obj":"Gene:2213"},{"id":"A1163","pred":"tao:has_database_id","subj":"1163","obj":"Gene:2213"},{"id":"A1164","pred":"tao:has_database_id","subj":"1164","obj":"Gene:2212"},{"id":"A1165","pred":"tao:has_database_id","subj":"1165","obj":"Tax:9606"},{"id":"A1166","pred":"tao:has_database_id","subj":"1166","obj":"MESH:D001120"},{"id":"A1167","pred":"tao:has_standard_notation","subj":"1167","obj":"p.P238D"},{"id":"A1168","pred":"tao:has_standard_notation","subj":"1168","obj":"p.E233D"},{"id":"A1169","pred":"tao:has_standard_notation","subj":"1169","obj":"p.G237D"},{"id":"A1170","pred":"tao:has_standard_notation","subj":"1170","obj":"p.P271G"},{"id":"A1171","pred":"tao:has_standard_notation","subj":"1171","obj":"p.A330R"},{"subj":"1162","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1163","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1164","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1165","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1166","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1167","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1168","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1169","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1170","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1171","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T440","span":{"begin":32,"end":40},"obj":"Body_part"},{"id":"T441","span":{"begin":59,"end":62},"obj":"Body_part"}],"attributes":[{"id":"A440","pred":"fma_id","subj":"T440","obj":"http://purl.org/sig/ont/fma/fma82763"},{"id":"A441","pred":"fma_id","subj":"T441","obj":"http://purl.org/sig/ont/fma/fma62872"},{"subj":"T440","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T441","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T954","span":{"begin":79,"end":81},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T955","span":{"begin":185,"end":195},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T956","span":{"begin":218,"end":220},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T957","span":{"begin":305,"end":307},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T958","span":{"begin":327,"end":328},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T959","span":{"begin":359,"end":361},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T960","span":{"begin":530,"end":532},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T961","span":{"begin":622,"end":624},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T962","span":{"begin":657,"end":659},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"}],"attributes":[{"subj":"T954","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T955","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T956","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T957","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T958","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T959","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T960","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T961","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T962","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T40","span":{"begin":32,"end":40},"obj":"Chemical"}],"attributes":[{"id":"A34095","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_16467"},{"id":"A45431","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_29016"},{"id":"A73563","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_32696"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T246","span":{"begin":71,"end":75},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"}],"attributes":[{"subj":"T246","pred":"source","obj":"LitCovid-sample-PD-IDO"}]},{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T62","span":{"begin":32,"end":40},"obj":"Chemical"}],"attributes":[{"id":"A62","pred":"chebi_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/CHEBI_32696"},{"id":"A63","pred":"chebi_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/CHEBI_16467"},{"id":"A64","pred":"chebi_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/CHEBI_29016"},{"subj":"T62","pred":"source","obj":"LitCovid-sample-CHEBI"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1162","span":{"begin":79,"end":86},"obj":"Gene"},{"id":"1163","span":{"begin":622,"end":629},"obj":"Gene"},{"id":"1164","span":{"begin":359,"end":366},"obj":"Gene"},{"id":"1165","span":{"begin":394,"end":402},"obj":"Species"},{"id":"1166","span":{"begin":32,"end":40},"obj":"Chemical"},{"id":"1167","span":{"begin":558,"end":563},"obj":"Mutation"},{"id":"1168","span":{"begin":565,"end":570},"obj":"Mutation"},{"id":"1169","span":{"begin":572,"end":577},"obj":"Mutation"},{"id":"1170","span":{"begin":586,"end":591},"obj":"Mutation"},{"id":"1171","span":{"begin":596,"end":601},"obj":"Mutation"}],"attributes":[{"id":"A1163","pred":"pubann:denotes","subj":"1163","obj":"Gene:2213"},{"id":"A1171","pred":"pubann:has_HGVS_notation","subj":"1171","obj":"p.A330R"},{"id":"A1166","pred":"pubann:denotes","subj":"1166","obj":"MESH:D001120"},{"id":"A1167","pred":"pubann:has_HGVS_notation","subj":"1167","obj":"p.P238D"},{"id":"A1169","pred":"pubann:has_HGVS_notation","subj":"1169","obj":"p.G237D"},{"id":"A1164","pred":"pubann:denotes","subj":"1164","obj":"Gene:2212"},{"id":"A1162","pred":"pubann:denotes","subj":"1162","obj":"Gene:2213"},{"id":"A1168","pred":"pubann:has_HGVS_notation","subj":"1168","obj":"p.E233D"},{"id":"A1170","pred":"pubann:has_HGVS_notation","subj":"1170","obj":"p.P271G"},{"id":"A1165","pred":"pubann:denotes","subj":"1165","obj":"Tax:9606"},{"subj":"1162","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1163","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1164","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1165","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1166","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1167","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1168","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1169","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1170","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1171","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T315","span":{"begin":0,"end":231},"obj":"Sentence"},{"id":"T316","span":{"begin":232,"end":494},"obj":"Sentence"},{"id":"T317","span":{"begin":495,"end":685},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T315","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T316","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T317","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T439","span":{"begin":32,"end":40},"obj":"Body_part"},{"id":"T440","span":{"begin":59,"end":62},"obj":"Body_part"}],"attributes":[{"id":"A440","pred":"fma_id","subj":"T440","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A439","pred":"fma_id","subj":"T439","obj":"http://purl.org/sig/ont/fma/fma82763"},{"subj":"T439","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T440","pred":"source","obj":"LitCovid-sample-PD-FMA"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T315","span":{"begin":0,"end":231},"obj":"Sentence"},{"id":"T316","span":{"begin":232,"end":494},"obj":"Sentence"},{"id":"T317","span":{"begin":495,"end":685},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T315","pred":"source","obj":"LitCovid-sentences"},{"subj":"T316","pred":"source","obj":"LitCovid-sentences"},{"subj":"T317","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#bb93ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93eca1"},{"id":"LitCovid-PD-CLO","color":"#ec939e"},{"id":"LitCovid-PD-CHEBI","color":"#93b8ec"},{"id":"LitCovid-sample-PD-IDO","color":"#d2ec93"},{"id":"LitCovid-sample-CHEBI","color":"#eb93ec"},{"id":"LitCovid-sample-Pubtator","color":"#93ecd1"},{"id":"LitCovid-sample-sentences","color":"#ecb793"},{"id":"LitCovid-sample-PD-FMA","color":"#9d93ec"},{"id":"LitCovid-sentences","color":"#a2ec93"}]}]}}