PMC:7228307 / 53476-53693 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1093","span":{"begin":103,"end":113},"obj":"Chemical"},{"id":"1099","span":{"begin":44,"end":49},"obj":"Mutation"},{"id":"1100","span":{"begin":62,"end":67},"obj":"Mutation"},{"id":"1101","span":{"begin":72,"end":77},"obj":"Mutation"}],"attributes":[{"id":"A1093","pred":"tao:has_database_id","subj":"1093","obj":"MESH:D004220"},{"id":"A1099","pred":"tao:has_standard_notation","subj":"1099","obj":"rs1469294455"},{"id":"A1100","pred":"tao:has_standard_notation","subj":"1100","obj":"p.L309V"},{"id":"A1101","pred":"tao:has_standard_notation","subj":"1101","obj":"p.R409K"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"It also has substitutions in the core hinge S228P and the CH3 L309V and R409K to stabilize the H‐chain disulfides and CH3 interactions, respectively, thereby preventing half‐Ig exchange characteristic of natural IgG4."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T410","span":{"begin":174,"end":176},"obj":"Body_part"}],"attributes":[{"id":"A410","pred":"fma_id","subj":"T410","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"It also has substitutions in the core hinge S228P and the CH3 L309V and R409K to stabilize the H‐chain disulfides and CH3 interactions, respectively, thereby preventing half‐Ig exchange characteristic of natural IgG4."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T904","span":{"begin":8,"end":11},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"text":"It also has substitutions in the core hinge S228P and the CH3 L309V and R409K to stabilize the H‐chain disulfides and CH3 interactions, respectively, thereby preventing half‐Ig exchange characteristic of natural IgG4."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T2607","span":{"begin":103,"end":113},"obj":"Chemical"}],"attributes":[{"id":"A58404","pred":"chebi_id","subj":"T2607","obj":"http://purl.obolibrary.org/obo/CHEBI_35489"},{"id":"A67524","pred":"chebi_id","subj":"T2607","obj":"http://purl.obolibrary.org/obo/CHEBI_48343"}],"text":"It also has substitutions in the core hinge S228P and the CH3 L309V and R409K to stabilize the H‐chain disulfides and CH3 interactions, respectively, thereby preventing half‐Ig exchange characteristic of natural IgG4."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T59","span":{"begin":103,"end":113},"obj":"Chemical"}],"attributes":[{"id":"A59","pred":"chebi_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/CHEBI_35489"},{"id":"A60","pred":"chebi_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/CHEBI_48343"}],"text":"It also has substitutions in the core hinge S228P and the CH3 L309V and R409K to stabilize the H‐chain disulfides and CH3 interactions, respectively, thereby preventing half‐Ig exchange characteristic of natural IgG4."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1093","span":{"begin":103,"end":113},"obj":"Chemical"},{"id":"1099","span":{"begin":44,"end":49},"obj":"Mutation"},{"id":"1100","span":{"begin":62,"end":67},"obj":"Mutation"},{"id":"1101","span":{"begin":72,"end":77},"obj":"Mutation"}],"attributes":[{"id":"A1093","pred":"pubann:denotes","subj":"1093","obj":"MESH:D004220"},{"id":"A1099","pred":"pubann:has_HGVS_notation","subj":"1099","obj":"rs1469294455"},{"id":"A1100","pred":"pubann:has_HGVS_notation","subj":"1100","obj":"p.L309V"},{"id":"A1101","pred":"pubann:has_HGVS_notation","subj":"1101","obj":"p.R409K"}],"text":"It also has substitutions in the core hinge S228P and the CH3 L309V and R409K to stabilize the H‐chain disulfides and CH3 interactions, respectively, thereby preventing half‐Ig exchange characteristic of natural IgG4."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T304","span":{"begin":0,"end":217},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"It also has substitutions in the core hinge S228P and the CH3 L309V and R409K to stabilize the H‐chain disulfides and CH3 interactions, respectively, thereby preventing half‐Ig exchange characteristic of natural IgG4."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T409","span":{"begin":174,"end":176},"obj":"Body_part"}],"attributes":[{"id":"A409","pred":"fma_id","subj":"T409","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"It also has substitutions in the core hinge S228P and the CH3 L309V and R409K to stabilize the H‐chain disulfides and CH3 interactions, respectively, thereby preventing half‐Ig exchange characteristic of natural IgG4."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T122","span":{"begin":177,"end":185},"obj":"http://purl.obolibrary.org/obo/GO_0015297"}],"text":"It also has substitutions in the core hinge S228P and the CH3 L309V and R409K to stabilize the H‐chain disulfides and CH3 interactions, respectively, thereby preventing half‐Ig exchange characteristic of natural IgG4."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T122","span":{"begin":177,"end":185},"obj":"http://purl.obolibrary.org/obo/GO_0015297"}],"text":"It also has substitutions in the core hinge S228P and the CH3 L309V and R409K to stabilize the H‐chain disulfides and CH3 interactions, respectively, thereby preventing half‐Ig exchange characteristic of natural IgG4."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T122","span":{"begin":177,"end":185},"obj":"http://purl.obolibrary.org/obo/GO_0015297"}],"text":"It also has substitutions in the core hinge S228P and the CH3 L309V and R409K to stabilize the H‐chain disulfides and CH3 interactions, respectively, thereby preventing half‐Ig exchange characteristic of natural IgG4."}

{"project":"LitCovid-sentences","denotations":[{"id":"T304","span":{"begin":0,"end":217},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"It also has substitutions in the core hinge S228P and the CH3 L309V and R409K to stabilize the H‐chain disulfides and CH3 interactions, respectively, thereby preventing half‐Ig exchange characteristic of natural IgG4."}