> top > docs > PMC:7228307 > spans > 52503-53104 > annotations

PMC:7228307 / 52503-53104 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
1063 267-272 Gene denotes PD‐L1 Gene:29126
1064 584-587 Gene denotes C1q Gene:712
1065 531-535 Gene denotes FcγR Gene:2213
1066 135-139 Gene denotes FcγR Gene:2213
1067 494-498 Gene denotes FcγR Gene:2213
1068 74-78 Gene denotes FcγR Gene:2213
1069 250-260 Chemical denotes durvalumab MESH:C000613593
1070 278-289 Chemical denotes anifrolumab MESH:C582345
1071 376-381 Mutation denotes L234F p.L234F
1072 415-420 Mutation denotes L235E p.L235E
1073 444-449 Mutation denotes P331S p.P331S

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T407 45-55 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T408 221-232 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T886 0-1 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T887 20-23 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T888 45-64 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residues
T889 45-64 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residues
T890 74-76 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T891 135-137 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T892 267-272 http://purl.obolibrary.org/obo/CLO_0008407 denotes PD‐L1
T893 494-496 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T894 531-533 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T895 588-598 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T5000 45-55 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T20266 45-50 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T44260 51-55 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T10443 221-232 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T57589 221-226 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T8912 227-232 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T75315 267-269 Chemical denotes PD http://purl.obolibrary.org/obo/CHEBI_74756
T36188 296-306 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T57 45-55 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T58 221-232 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes pubann:has_HGVS_notation
1063 267-272 Gene denotes PD‐L1 Gene:29126
1064 584-587 Gene denotes C1q Gene:712
1065 531-535 Gene denotes FcγR Gene:2213
1066 135-139 Gene denotes FcγR Gene:2213
1067 494-498 Gene denotes FcγR Gene:2213
1068 74-78 Gene denotes FcγR Gene:2213
1069 250-260 Chemical denotes durvalumab MESH:C000613593
1070 278-289 Chemical denotes anifrolumab MESH:C582345
1071 376-381 Mutation denotes L234F p.L234F
1072 415-420 Mutation denotes L235E p.L235E
1073 444-449 Mutation denotes P331S p.P331S

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T299 0-204 Sentence denotes A separate strategy has used combinations of amino acid residues from the FcγR‐binding regions of IgG2 and IgG4, which have restricted FcγR specificity, together with other binding‐inactivating mutations.
T300 205-383 Sentence denotes The lower hinge amino acids of the IgG1 mAbs durvalumab (anti‐PD‐L1) and anifrolumab (anti‐interferon‐α receptor; Table 4) were modified to mimic the lower hinge of IgG4 (L234F).
T301 384-601 Sentence denotes They additionally incorporated L235E in the lower hinge and P331S in the F/G loop of the CH2 domain to ablate FcγR binding by disrupting two major FcγR contact sites7 and also coincidently decreasing C1q activation.16

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T704 267-272 Protein denotes PD‐L1 https://www.uniprot.org/uniprot/Q9NZQ7|https://www.uniprot.org/uniprot/Q9NUZ5|https://www.uniprot.org/uniprot/Q9EP73|https://www.uniprot.org/uniprot/Q6WEX4|https://www.uniprot.org/uniprot/Q66RK1|https://www.uniprot.org/uniprot/Q2V8D5|https://www.uniprot.org/uniprot/Q14CJ2|https://www.uniprot.org/uniprot/B4DU27|https://www.uniprot.org/uniprot/B2RBA2
T713 296-306 Protein denotes interferon https://www.uniprot.org/uniprot/P51527|https://www.uniprot.org/uniprot/P51526

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T406 45-55 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T407 221-232 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T299 0-204 Sentence denotes A separate strategy has used combinations of amino acid residues from the FcγR‐binding regions of IgG2 and IgG4, which have restricted FcγR specificity, together with other binding‐inactivating mutations.
T300 205-383 Sentence denotes The lower hinge amino acids of the IgG1 mAbs durvalumab (anti‐PD‐L1) and anifrolumab (anti‐interferon‐α receptor; Table 4) were modified to mimic the lower hinge of IgG4 (L234F).
T301 384-601 Sentence denotes They additionally incorporated L235E in the lower hinge and P331S in the F/G loop of the CH2 domain to ablate FcγR binding by disrupting two major FcγR contact sites7 and also coincidently decreasing C1q activation.16