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PMC:7228307 / 50985-51770 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1022 127-132 Gene denotes FcγRI Gene:2214
1023 336-341 Gene denotes FcγRI Gene:2214
1024 419-426 Gene denotes FcγRIIb Gene:2213
1025 313-317 Gene denotes PD‐1 Gene:5133

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T403 198-208 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T864 89-99 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T865 110-112 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T866 127-129 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T867 209-219 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T868 336-338 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T869 355-363 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T870 419-421 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T871 756-758 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T872 762-763 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T60873 130-132 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T66616 171-179 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T93768 313-315 Chemical denotes PD http://purl.obolibrary.org/obo/CHEBI_74756
T92385 339-341 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T227 180-189 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
1022 127-132 Gene denotes FcγRI Gene:2214
1023 336-341 Gene denotes FcγRI Gene:2214
1024 419-426 Gene denotes FcγRIIb Gene:2213
1025 313-317 Gene denotes PD‐1 Gene:5133

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T292 0-71 Sentence denotes However, the use of IgG2 and IgG4 as “inert” subclasses is problematic.
T293 72-467 Sentence denotes Both bind to the activating receptors FcγRIIa‐H131 and FcγRI, respectively (Table 2), and initiate effector functions such as neutrophil activation and apoptosis induction.75, 99 Interestingly, in experimental systems, cross‐linking of anti‐PD‐1 IgG4‐based mAb by FcγRI switched its activity from blocking to activatory.10 Moreover, IgG4 binds to FcγRIIb, which may scaffold the therapeutic mAb.
T294 468-785 Sentence denotes Although scaffolding may be beneficial in some contexts, for example, in immune agonism,43 it can be disastrous and unexpected in others as it was for the anti‐CD28 TGN1412 mAb.59 Thus, the IgG2 and IgG4 subclasses are not the optimum choice for “FcR‐inactive” mAbs, and so modifying the Fc is a more direct approach.

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T671 313-317 Protein denotes PD‐1 https://www.uniprot.org/uniprot/Q7M4M5|https://www.uniprot.org/uniprot/Q6NZ54|https://www.uniprot.org/uniprot/Q3KQW2|https://www.uniprot.org/uniprot/P18621|https://www.uniprot.org/uniprot/J3QL51|https://www.uniprot.org/uniprot/B5ME31|https://www.uniprot.org/uniprot/B4E3C2|https://www.uniprot.org/uniprot/B2R4H3
T679 628-632 Protein denotes CD28 https://www.uniprot.org/uniprot/Q9BYV0|https://www.uniprot.org/uniprot/Q8WXJ2|https://www.uniprot.org/uniprot/Q8NI56|https://www.uniprot.org/uniprot/Q8NI55|https://www.uniprot.org/uniprot/Q8NI54|https://www.uniprot.org/uniprot/Q70WG0|https://www.uniprot.org/uniprot/Q6GSH7|https://www.uniprot.org/uniprot/Q52M23|https://www.uniprot.org/uniprot/Q28071|https://www.uniprot.org/uniprot/Q13964|https://www.uniprot.org/uniprot/P42069|https://www.uniprot.org/uniprot/P31042|https://www.uniprot.org/uniprot/P31041|https://www.uniprot.org/uniprot/P10747|https://www.uniprot.org/uniprot/O02757|https://www.uniprot.org/uniprot/A8KAC1

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T402 198-208 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T118 198-219 http://purl.obolibrary.org/obo/GO_0042119 denotes neutrophil activation
T119 224-233 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T120 224-233 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T118 198-219 http://purl.obolibrary.org/obo/GO_0042119 denotes neutrophil activation
T119 224-233 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T120 224-233 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T118 198-219 http://purl.obolibrary.org/obo/GO_0042119 denotes neutrophil activation
T119 224-233 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T120 224-233 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T292 0-71 Sentence denotes However, the use of IgG2 and IgG4 as “inert” subclasses is problematic.
T293 72-467 Sentence denotes Both bind to the activating receptors FcγRIIa‐H131 and FcγRI, respectively (Table 2), and initiate effector functions such as neutrophil activation and apoptosis induction.75, 99 Interestingly, in experimental systems, cross‐linking of anti‐PD‐1 IgG4‐based mAb by FcγRI switched its activity from blocking to activatory.10 Moreover, IgG4 binds to FcγRIIb, which may scaffold the therapeutic mAb.
T294 468-785 Sentence denotes Although scaffolding may be beneficial in some contexts, for example, in immune agonism,43 it can be disastrous and unexpected in others as it was for the anti‐CD28 TGN1412 mAb.59 Thus, the IgG2 and IgG4 subclasses are not the optimum choice for “FcR‐inactive” mAbs, and so modifying the Fc is a more direct approach.