PMC:7228307 / 50368-50602 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1003","span":{"begin":54,"end":60},"obj":"Gene"},{"id":"1004","span":{"begin":68,"end":73},"obj":"Gene"},{"id":"1005","span":{"begin":74,"end":78},"obj":"Gene"},{"id":"1015","span":{"begin":176,"end":181},"obj":"Disease"}],"attributes":[{"id":"A1003","pred":"tao:has_database_id","subj":"1003","obj":"Gene:1493"},{"id":"A1004","pred":"tao:has_database_id","subj":"1004","obj":"Gene:29126"},{"id":"A1005","pred":"tao:has_database_id","subj":"1005","obj":"Gene:5133"},{"id":"A1015","pred":"tao:has_database_id","subj":"1015","obj":"MESH:D009369"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Indeed, checkpoint inhibitors, such as mAbs targeting CTLA‐4 or the PD‐L1/PD‐1 interaction for the suppression of inhibitory signals that contribute to immune tolerance in the tumor microenvironment, are formatted on an IgG4 backbone."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T399","span":{"begin":225,"end":233},"obj":"Body_part"}],"attributes":[{"id":"A399","pred":"fma_id","subj":"T399","obj":"http://purl.org/sig/ont/fma/fma13478"}],"text":"Indeed, checkpoint inhibitors, such as mAbs targeting CTLA‐4 or the PD‐L1/PD‐1 interaction for the suppression of inhibitory signals that contribute to immune tolerance in the tumor microenvironment, are formatted on an IgG4 backbone."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T101","span":{"begin":176,"end":181},"obj":"Disease"}],"attributes":[{"id":"A101","pred":"mondo_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"}],"text":"Indeed, checkpoint inhibitors, such as mAbs targeting CTLA‐4 or the PD‐L1/PD‐1 interaction for the suppression of inhibitory signals that contribute to immune tolerance in the tumor microenvironment, are formatted on an IgG4 backbone."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T858","span":{"begin":54,"end":60},"obj":"http://purl.obolibrary.org/obo/PR_000001852"},{"id":"T859","span":{"begin":68,"end":73},"obj":"http://purl.obolibrary.org/obo/CLO_0008407"},{"id":"T860","span":{"begin":125,"end":132},"obj":"http://purl.obolibrary.org/obo/SO_0000418"}],"text":"Indeed, checkpoint inhibitors, such as mAbs targeting CTLA‐4 or the PD‐L1/PD‐1 interaction for the suppression of inhibitory signals that contribute to immune tolerance in the tumor microenvironment, are formatted on an IgG4 backbone."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T3637","span":{"begin":19,"end":29},"obj":"Chemical"},{"id":"T24725","span":{"begin":68,"end":70},"obj":"Chemical"},{"id":"T35015","span":{"begin":74,"end":76},"obj":"Chemical"}],"attributes":[{"id":"A60839","pred":"chebi_id","subj":"T3637","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A72999","pred":"chebi_id","subj":"T24725","obj":"http://purl.obolibrary.org/obo/CHEBI_74756"},{"id":"A81437","pred":"chebi_id","subj":"T35015","obj":"http://purl.obolibrary.org/obo/CHEBI_74756"}],"text":"Indeed, checkpoint inhibitors, such as mAbs targeting CTLA‐4 or the PD‐L1/PD‐1 interaction for the suppression of inhibitory signals that contribute to immune tolerance in the tumor microenvironment, are formatted on an IgG4 backbone."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1003","span":{"begin":54,"end":60},"obj":"Gene"},{"id":"1004","span":{"begin":68,"end":73},"obj":"Gene"},{"id":"1005","span":{"begin":74,"end":78},"obj":"Gene"},{"id":"1015","span":{"begin":176,"end":181},"obj":"Disease"}],"attributes":[{"id":"A1003","pred":"pubann:denotes","subj":"1003","obj":"Gene:1493"},{"id":"A1004","pred":"pubann:denotes","subj":"1004","obj":"Gene:29126"},{"id":"A1005","pred":"pubann:denotes","subj":"1005","obj":"Gene:5133"},{"id":"A1015","pred":"pubann:denotes","subj":"1015","obj":"MESH:D009369"}],"text":"Indeed, checkpoint inhibitors, such as mAbs targeting CTLA‐4 or the PD‐L1/PD‐1 interaction for the suppression of inhibitory signals that contribute to immune tolerance in the tumor microenvironment, are formatted on an IgG4 backbone."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T289","span":{"begin":0,"end":234},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Indeed, checkpoint inhibitors, such as mAbs targeting CTLA‐4 or the PD‐L1/PD‐1 interaction for the suppression of inhibitory signals that contribute to immune tolerance in the tumor microenvironment, are formatted on an IgG4 backbone."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T612","span":{"begin":54,"end":60},"obj":"Protein"},{"id":"T629","span":{"begin":68,"end":73},"obj":"Protein"},{"id":"T638","span":{"begin":74,"end":78},"obj":"Protein"}],"attributes":[{"id":"A612","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/Q9XSI1"},{"id":"A613","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/Q9UKN9"},{"id":"A614","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/Q9TT02"},{"id":"A615","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/Q9QZZ7"},{"id":"A616","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/Q9MYX7"},{"id":"A617","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/Q96P43"},{"id":"A618","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/Q8WXJ1"},{"id":"A619","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/Q5S005"},{"id":"A620","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/Q53TD5"},{"id":"A621","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/Q52MC1"},{"id":"A622","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/Q0PP65"},{"id":"A623","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/P42072"},{"id":"A624","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/P16410"},{"id":"A625","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/P09793"},{"id":"A626","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/O95653"},{"id":"A627","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/E9PDH0"},{"id":"A628","pred":"uniprot_id","subj":"T612","obj":"https://www.uniprot.org/uniprot/A0N1S0"},{"id":"A629","pred":"uniprot_id","subj":"T629","obj":"https://www.uniprot.org/uniprot/Q9NZQ7"},{"id":"A630","pred":"uniprot_id","subj":"T629","obj":"https://www.uniprot.org/uniprot/Q9NUZ5"},{"id":"A631","pred":"uniprot_id","subj":"T629","obj":"https://www.uniprot.org/uniprot/Q9EP73"},{"id":"A632","pred":"uniprot_id","subj":"T629","obj":"https://www.uniprot.org/uniprot/Q6WEX4"},{"id":"A633","pred":"uniprot_id","subj":"T629","obj":"https://www.uniprot.org/uniprot/Q66RK1"},{"id":"A634","pred":"uniprot_id","subj":"T629","obj":"https://www.uniprot.org/uniprot/Q2V8D5"},{"id":"A635","pred":"uniprot_id","subj":"T629","obj":"https://www.uniprot.org/uniprot/Q14CJ2"},{"id":"A636","pred":"uniprot_id","subj":"T629","obj":"https://www.uniprot.org/uniprot/B4DU27"},{"id":"A637","pred":"uniprot_id","subj":"T629","obj":"https://www.uniprot.org/uniprot/B2RBA2"},{"id":"A638","pred":"uniprot_id","subj":"T638","obj":"https://www.uniprot.org/uniprot/Q7M4M5"},{"id":"A639","pred":"uniprot_id","subj":"T638","obj":"https://www.uniprot.org/uniprot/Q6NZ54"},{"id":"A640","pred":"uniprot_id","subj":"T638","obj":"https://www.uniprot.org/uniprot/Q3KQW2"},{"id":"A641","pred":"uniprot_id","subj":"T638","obj":"https://www.uniprot.org/uniprot/P18621"},{"id":"A642","pred":"uniprot_id","subj":"T638","obj":"https://www.uniprot.org/uniprot/J3QL51"},{"id":"A643","pred":"uniprot_id","subj":"T638","obj":"https://www.uniprot.org/uniprot/B5ME31"},{"id":"A644","pred":"uniprot_id","subj":"T638","obj":"https://www.uniprot.org/uniprot/B4E3C2"},{"id":"A645","pred":"uniprot_id","subj":"T638","obj":"https://www.uniprot.org/uniprot/B2R4H3"}],"text":"Indeed, checkpoint inhibitors, such as mAbs targeting CTLA‐4 or the PD‐L1/PD‐1 interaction for the suppression of inhibitory signals that contribute to immune tolerance in the tumor microenvironment, are formatted on an IgG4 backbone."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T398","span":{"begin":225,"end":233},"obj":"Body_part"}],"attributes":[{"id":"A398","pred":"fma_id","subj":"T398","obj":"http://purl.org/sig/ont/fma/fma13478"}],"text":"Indeed, checkpoint inhibitors, such as mAbs targeting CTLA‐4 or the PD‐L1/PD‐1 interaction for the suppression of inhibitory signals that contribute to immune tolerance in the tumor microenvironment, are formatted on an IgG4 backbone."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T42","span":{"begin":176,"end":181},"obj":"Disease"}],"attributes":[{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"}],"text":"Indeed, checkpoint inhibitors, such as mAbs targeting CTLA‐4 or the PD‐L1/PD‐1 interaction for the suppression of inhibitory signals that contribute to immune tolerance in the tumor microenvironment, are formatted on an IgG4 backbone."}

{"project":"LitCovid-sample-PD-HP","denotations":[{"id":"T38","span":{"begin":176,"end":181},"obj":"Phenotype"}],"attributes":[{"id":"A38","pred":"hp_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/HP_0002664"}],"text":"Indeed, checkpoint inhibitors, such as mAbs targeting CTLA‐4 or the PD‐L1/PD‐1 interaction for the suppression of inhibitory signals that contribute to immune tolerance in the tumor microenvironment, are formatted on an IgG4 backbone."}

{"project":"LitCovid-sentences","denotations":[{"id":"T289","span":{"begin":0,"end":234},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Indeed, checkpoint inhibitors, such as mAbs targeting CTLA‐4 or the PD‐L1/PD‐1 interaction for the suppression of inhibitory signals that contribute to immune tolerance in the tumor microenvironment, are formatted on an IgG4 backbone."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T38","span":{"begin":176,"end":181},"obj":"Phenotype"}],"attributes":[{"id":"A38","pred":"hp_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/HP_0002664"}],"text":"Indeed, checkpoint inhibitors, such as mAbs targeting CTLA‐4 or the PD‐L1/PD‐1 interaction for the suppression of inhibitory signals that contribute to immune tolerance in the tumor microenvironment, are formatted on an IgG4 backbone."}