PMC:7228307 / 47519-48030
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id | tao:has_standard_notation |
|---|---|---|---|---|---|---|
| 914 | 328-336 | Gene | denotes | FcγRIIIa | Gene:2214 | |
| 915 | 372-380 | Gene | denotes | FcγRIIIa | Gene:2214 | |
| 916 | 418-425 | Gene | denotes | FcγRIII | Gene:14131 | |
| 917 | 498-503 | Species | denotes | mouse | Tax:10090 | |
| 918 | 209-237 | Disease | denotes | chronic lymphocytic leukemia | MESH:D015451 | |
| 919 | 471-494 | Disease | denotes | reduced lymphoma growth | MESH:D006130 | |
| 920 | 283-288 | Mutation | denotes | S329D | p.S329D | |
| 921 | 293-298 | Mutation | denotes | I332E | p.I332E |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T386 | 18-29 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T387 | 62-65 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
| T388 | 127-135 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T389 | 217-228 | Body_part | denotes | lymphocytic | http://purl.org/sig/ont/fma/fma62863 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T84 | 209-237 | Disease | denotes | chronic lymphocytic leukemia | http://purl.obolibrary.org/obo/MONDO_0004948 |
| T85 | 217-237 | Disease | denotes | lymphocytic leukemia | http://purl.obolibrary.org/obo/MONDO_0005402 |
| T86 | 229-237 | Disease | denotes | leukemia | http://purl.obolibrary.org/obo/MONDO_0005059 |
| T87 | 435-439 | Disease | denotes | ADCC | http://purl.obolibrary.org/obo/MONDO_0008734 |
| T88 | 479-487 | Disease | denotes | lymphoma | http://purl.obolibrary.org/obo/MONDO_0005062 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T817 | 49-51 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T818 | 95-105 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activating |
| T819 | 106-108 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T820 | 109-111 | http://purl.obolibrary.org/obo/CLO_0008882 | denotes | Rs |
| T821 | 122-126 | http://purl.obolibrary.org/obo/CLO_0053432 | denotes | CD19 |
| T822 | 279-281 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T823 | 328-330 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T824 | 372-374 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T825 | 418-420 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T826 | 498-503 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T243 | 18-29 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T244 | 18-23 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T245 | 24-29 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
LitCovid-sample-PD-IDO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T223 | 488-494 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
LitCovid-sample-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T52 | 18-29 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
LitCovid-sample-Pubtator
| Id | Subject | Object | Predicate | Lexical cue | pubann:denotes | pubann:has_HGVS_notation |
|---|---|---|---|---|---|---|
| 914 | 328-336 | Gene | denotes | FcγRIIIa | Gene:2214 | |
| 915 | 372-380 | Gene | denotes | FcγRIIIa | Gene:2214 | |
| 916 | 418-425 | Gene | denotes | FcγRIII | Gene:14131 | |
| 917 | 498-503 | Species | denotes | mouse | Tax:10090 | |
| 918 | 209-237 | Disease | denotes | chronic lymphocytic leukemia | MESH:D015451 | |
| 919 | 471-494 | Disease | denotes | reduced lymphoma growth | MESH:D006130 | |
| 920 | 283-288 | Mutation | denotes | S329D | p.S329D | |
| 921 | 293-298 | Mutation | denotes | I332E | p.I332E |
LitCovid-sample-PD-NCBITaxon
| Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
|---|---|---|---|---|---|
| T44 | 498-503 | Species | denotes | mouse | NCBItxid:10090|NCBItxid:10088 |
LitCovid-sample-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T275 | 0-112 | Sentence | denotes | Alteration of the amino acids in the heavy‐chain Fc can alter IgG specificity and affinity for activating FcγRs. |
| T276 | 113-393 | Sentence | denotes | The anti‐CD19 antibody MOR208 (XmAb 5574) is currently in phase III trials for the treatment of chronic lymphocytic leukemia.92 It contains two mutations in its IgG1 Fc, S329D and I332E, which increases affinity to FcγRIIIa, particularly the “lower‐affinity” FcγRIIIa F158 allele. |
| T277 | 394-511 | Sentence | denotes | The mAb shows increased FcγRIII‐mediated ADCC and phagocytosis in vitro, and reduced lymphoma growth in mouse models. |
LitCovid-sample-UniProt
| Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
|---|---|---|---|---|---|
| T596 | 122-126 | Protein | denotes | CD19 | https://www.uniprot.org/uniprot/Q9BRD6|https://www.uniprot.org/uniprot/Q96S68|https://www.uniprot.org/uniprot/Q542B2|https://www.uniprot.org/uniprot/Q3LRP3|https://www.uniprot.org/uniprot/P25918|https://www.uniprot.org/uniprot/P25917|https://www.uniprot.org/uniprot/P15391|https://www.uniprot.org/uniprot/F5H635|https://www.uniprot.org/uniprot/A0N0P9 |
LitCovid-sample-PD-FMA
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T385 | 18-29 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T386 | 62-65 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
| T387 | 127-135 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T388 | 217-228 | Body_part | denotes | lymphocytic | http://purl.org/sig/ont/fma/fma62863 |
LitCovid-sample-PD-GO-BP-0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T110 | 435-439 | http://purl.obolibrary.org/obo/GO_0001788 | denotes | ADCC |
| T111 | 444-456 | http://purl.obolibrary.org/obo/GO_0006909 | denotes | phagocytosis |
| T112 | 488-494 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
LitCovid-sample-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T37 | 209-237 | Disease | denotes | chronic lymphocytic leukemia | http://purl.obolibrary.org/obo/MONDO_0004948 |
| T38 | 479-487 | Disease | denotes | lymphoma | http://purl.obolibrary.org/obo/MONDO_0005062 |
LitCovid-sample-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T33 | 209-237 | Phenotype | denotes | chronic lymphocytic leukemia | http://purl.obolibrary.org/obo/HP_0005550 |
| T34 | 479-487 | Phenotype | denotes | lymphoma | http://purl.obolibrary.org/obo/HP_0002665 |
LitCovid-sample-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T110 | 435-439 | http://purl.obolibrary.org/obo/GO_0001788 | denotes | ADCC |
| T111 | 444-456 | http://purl.obolibrary.org/obo/GO_0006909 | denotes | phagocytosis |
| T112 | 488-494 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T110 | 435-439 | http://purl.obolibrary.org/obo/GO_0001788 | denotes | ADCC |
| T111 | 444-456 | http://purl.obolibrary.org/obo/GO_0006909 | denotes | phagocytosis |
| T112 | 488-494 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T275 | 0-112 | Sentence | denotes | Alteration of the amino acids in the heavy‐chain Fc can alter IgG specificity and affinity for activating FcγRs. |
| T276 | 113-393 | Sentence | denotes | The anti‐CD19 antibody MOR208 (XmAb 5574) is currently in phase III trials for the treatment of chronic lymphocytic leukemia.92 It contains two mutations in its IgG1 Fc, S329D and I332E, which increases affinity to FcγRIIIa, particularly the “lower‐affinity” FcγRIIIa F158 allele. |
| T277 | 394-511 | Sentence | denotes | The mAb shows increased FcγRIII‐mediated ADCC and phagocytosis in vitro, and reduced lymphoma growth in mouse models. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T33 | 209-237 | Phenotype | denotes | chronic lymphocytic leukemia | http://purl.obolibrary.org/obo/HP_0005550 |
| T34 | 479-487 | Phenotype | denotes | lymphoma | http://purl.obolibrary.org/obo/HP_0002665 |