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PMC:7228307 / 47031-47486 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T4 265-271 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
900 235-243 Species denotes patients Tax:9606
901 116-128 Chemical denotes obinutuzumab MESH:C543332
902 265-271 Chemical denotes fucose MESH:D005643
903 283-292 Chemical denotes rituximab MESH:D000069283
904 366-372 Chemical denotes glycan MESH:D011134
905 206-234 Disease denotes chronic lymphocytic leukemia MESH:D015451

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T383 214-225 Body_part denotes lymphocytic http://purl.org/sig/ont/fma/fma62863
T384 265-271 Body_part denotes fucose http://purl.org/sig/ont/fma/fma82790

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T81 206-234 Disease denotes chronic lymphocytic leukemia http://purl.obolibrary.org/obo/MONDO_0004948
T82 214-234 Disease denotes lymphocytic leukemia http://purl.obolibrary.org/obo/MONDO_0005402
T83 226-234 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T815 405-407 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T238 265-271 Chemical denotes fucose http://purl.obolibrary.org/obo/CHEBI_33984
T239 283-292 Chemical denotes rituximab http://purl.obolibrary.org/obo/CHEBI_64357

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T50 265-271 Chemical denotes fucose http://purl.obolibrary.org/obo/CHEBI_33984

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
900 235-243 Species denotes patients Tax:9606
901 116-128 Chemical denotes obinutuzumab MESH:C543332
902 265-271 Chemical denotes fucose MESH:D005643
903 283-292 Chemical denotes rituximab MESH:D000069283
904 366-372 Chemical denotes glycan MESH:D011134
905 206-234 Disease denotes chronic lymphocytic leukemia MESH:D015451

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T272 0-104 Sentence denotes There are six afucosylated antibodies in late‐stage clinical trials or approved for treatment (Table 4).
T273 105-455 Sentence denotes Notable is obinutuzumab, an afucosyl anti‐CD20 mAb which nearly doubles progression‐free survival in chronic lymphocytic leukemia patients as compared with the fucose‐containing rituximab.68 This dramatic improvement in clinical utility reinforces the value of glycan engineering specifically and of Fc engineering generally in anticancer treatments.

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T589 147-151 Protein denotes CD20 https://www.uniprot.org/uniprot/Q3C2E2|https://www.uniprot.org/uniprot/Q13963|https://www.uniprot.org/uniprot/P19437|https://www.uniprot.org/uniprot/P11836|https://www.uniprot.org/uniprot/P08984|https://www.uniprot.org/uniprot/B4DT24|https://www.uniprot.org/uniprot/A6NMS4

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T382 214-225 Body_part denotes lymphocytic http://purl.org/sig/ont/fma/fma62863
T383 265-271 Body_part denotes fucose http://purl.org/sig/ont/fma/fma82790

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T36 206-234 Disease denotes chronic lymphocytic leukemia http://purl.obolibrary.org/obo/MONDO_0004948

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T32 206-234 Phenotype denotes chronic lymphocytic leukemia http://purl.obolibrary.org/obo/HP_0005550

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T272 0-104 Sentence denotes There are six afucosylated antibodies in late‐stage clinical trials or approved for treatment (Table 4).
T273 105-455 Sentence denotes Notable is obinutuzumab, an afucosyl anti‐CD20 mAb which nearly doubles progression‐free survival in chronic lymphocytic leukemia patients as compared with the fucose‐containing rituximab.68 This dramatic improvement in clinical utility reinforces the value of glycan engineering specifically and of Fc engineering generally in anticancer treatments.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T32 206-234 Phenotype denotes chronic lymphocytic leukemia http://purl.obolibrary.org/obo/HP_0005550