PMC:7228307 / 46705-47030 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"886","span":{"begin":94,"end":101},"obj":"Gene"},{"id":"887","span":{"begin":238,"end":246},"obj":"Gene"},{"id":"888","span":{"begin":292,"end":299},"obj":"Gene"},{"id":"889","span":{"begin":222,"end":230},"obj":"Gene"}],"attributes":[{"id":"A886","pred":"tao:has_database_id","subj":"886","obj":"Gene:2214"},{"id":"A887","pred":"tao:has_database_id","subj":"887","obj":"Gene:2214"},{"id":"A888","pred":"tao:has_database_id","subj":"888","obj":"Gene:2212"},{"id":"A889","pred":"tao:has_database_id","subj":"889","obj":"Gene:2215"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Compared with their unmodified counterparts, the afucosyl mAbs showed dramatic improvement of FcγRIII‐related effector responses such as stronger NK cell‐mediated ADCC, or enhanced neutrophil‐mediated phagocytosis through FcγRIIIb and/or FcγRIIIa.23 However, certain neutrophil functions via FcγRIIa may be compromised.90, 91"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T379","span":{"begin":146,"end":153},"obj":"Body_part"},{"id":"T380","span":{"begin":149,"end":153},"obj":"Body_part"},{"id":"T381","span":{"begin":181,"end":191},"obj":"Body_part"},{"id":"T382","span":{"begin":267,"end":277},"obj":"Body_part"}],"attributes":[{"id":"A379","pred":"fma_id","subj":"T379","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A380","pred":"fma_id","subj":"T380","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A381","pred":"fma_id","subj":"T381","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A382","pred":"fma_id","subj":"T382","obj":"http://purl.org/sig/ont/fma/fma62860"}],"text":"Compared with their unmodified counterparts, the afucosyl mAbs showed dramatic improvement of FcγRIII‐related effector responses such as stronger NK cell‐mediated ADCC, or enhanced neutrophil‐mediated phagocytosis through FcγRIIIb and/or FcγRIIIa.23 However, certain neutrophil functions via FcγRIIa may be compromised.90, 91"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T80","span":{"begin":163,"end":167},"obj":"Disease"}],"attributes":[{"id":"A80","pred":"mondo_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/MONDO_0008734"}],"text":"Compared with their unmodified counterparts, the afucosyl mAbs showed dramatic improvement of FcγRIII‐related effector responses such as stronger NK cell‐mediated ADCC, or enhanced neutrophil‐mediated phagocytosis through FcγRIIIb and/or FcγRIIIa.23 However, certain neutrophil functions via FcγRIIa may be compromised.90, 91"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T810","span":{"begin":94,"end":96},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T811","span":{"begin":146,"end":153},"obj":"http://purl.obolibrary.org/obo/CL_0000623"},{"id":"T812","span":{"begin":222,"end":224},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T813","span":{"begin":238,"end":240},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T814","span":{"begin":292,"end":294},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"}],"text":"Compared with their unmodified counterparts, the afucosyl mAbs showed dramatic improvement of FcγRIII‐related effector responses such as stronger NK cell‐mediated ADCC, or enhanced neutrophil‐mediated phagocytosis through FcγRIIIb and/or FcγRIIIa.23 However, certain neutrophil functions via FcγRIIa may be compromised.90, 91"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T237","span":{"begin":110,"end":118},"obj":"Chemical"}],"attributes":[{"id":"A237","pred":"chebi_id","subj":"T237","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"}],"text":"Compared with their unmodified counterparts, the afucosyl mAbs showed dramatic improvement of FcγRIII‐related effector responses such as stronger NK cell‐mediated ADCC, or enhanced neutrophil‐mediated phagocytosis through FcγRIIIb and/or FcγRIIIa.23 However, certain neutrophil functions via FcγRIIa may be compromised.90, 91"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T221","span":{"begin":149,"end":153},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T222","span":{"begin":278,"end":287},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"}],"text":"Compared with their unmodified counterparts, the afucosyl mAbs showed dramatic improvement of FcγRIII‐related effector responses such as stronger NK cell‐mediated ADCC, or enhanced neutrophil‐mediated phagocytosis through FcγRIIIb and/or FcγRIIIa.23 However, certain neutrophil functions via FcγRIIa may be compromised.90, 91"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"886","span":{"begin":94,"end":101},"obj":"Gene"},{"id":"887","span":{"begin":238,"end":246},"obj":"Gene"},{"id":"888","span":{"begin":292,"end":299},"obj":"Gene"},{"id":"889","span":{"begin":222,"end":230},"obj":"Gene"}],"attributes":[{"id":"A886","pred":"pubann:denotes","subj":"886","obj":"Gene:2214"},{"id":"A887","pred":"pubann:denotes","subj":"887","obj":"Gene:2214"},{"id":"A888","pred":"pubann:denotes","subj":"888","obj":"Gene:2212"},{"id":"A889","pred":"pubann:denotes","subj":"889","obj":"Gene:2215"}],"text":"Compared with their unmodified counterparts, the afucosyl mAbs showed dramatic improvement of FcγRIII‐related effector responses such as stronger NK cell‐mediated ADCC, or enhanced neutrophil‐mediated phagocytosis through FcγRIIIb and/or FcγRIIIa.23 However, certain neutrophil functions via FcγRIIa may be compromised.90, 91"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T271","span":{"begin":0,"end":325},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Compared with their unmodified counterparts, the afucosyl mAbs showed dramatic improvement of FcγRIII‐related effector responses such as stronger NK cell‐mediated ADCC, or enhanced neutrophil‐mediated phagocytosis through FcγRIIIb and/or FcγRIIIa.23 However, certain neutrophil functions via FcγRIIa may be compromised.90, 91"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T378","span":{"begin":146,"end":153},"obj":"Body_part"},{"id":"T379","span":{"begin":149,"end":153},"obj":"Body_part"},{"id":"T380","span":{"begin":181,"end":191},"obj":"Body_part"},{"id":"T381","span":{"begin":267,"end":277},"obj":"Body_part"}],"attributes":[{"id":"A378","pred":"fma_id","subj":"T378","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A379","pred":"fma_id","subj":"T379","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A380","pred":"fma_id","subj":"T380","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A381","pred":"fma_id","subj":"T381","obj":"http://purl.org/sig/ont/fma/fma62860"}],"text":"Compared with their unmodified counterparts, the afucosyl mAbs showed dramatic improvement of FcγRIII‐related effector responses such as stronger NK cell‐mediated ADCC, or enhanced neutrophil‐mediated phagocytosis through FcγRIIIb and/or FcγRIIIa.23 However, certain neutrophil functions via FcγRIIa may be compromised.90, 91"}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T108","span":{"begin":163,"end":167},"obj":"http://purl.obolibrary.org/obo/GO_0001788"},{"id":"T109","span":{"begin":201,"end":213},"obj":"http://purl.obolibrary.org/obo/GO_0006909"}],"text":"Compared with their unmodified counterparts, the afucosyl mAbs showed dramatic improvement of FcγRIII‐related effector responses such as stronger NK cell‐mediated ADCC, or enhanced neutrophil‐mediated phagocytosis through FcγRIIIb and/or FcγRIIIa.23 However, certain neutrophil functions via FcγRIIa may be compromised.90, 91"}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T108","span":{"begin":163,"end":167},"obj":"http://purl.obolibrary.org/obo/GO_0001788"},{"id":"T109","span":{"begin":201,"end":213},"obj":"http://purl.obolibrary.org/obo/GO_0006909"}],"text":"Compared with their unmodified counterparts, the afucosyl mAbs showed dramatic improvement of FcγRIII‐related effector responses such as stronger NK cell‐mediated ADCC, or enhanced neutrophil‐mediated phagocytosis through FcγRIIIb and/or FcγRIIIa.23 However, certain neutrophil functions via FcγRIIa may be compromised.90, 91"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T108","span":{"begin":163,"end":167},"obj":"http://purl.obolibrary.org/obo/GO_0001788"},{"id":"T109","span":{"begin":201,"end":213},"obj":"http://purl.obolibrary.org/obo/GO_0006909"}],"text":"Compared with their unmodified counterparts, the afucosyl mAbs showed dramatic improvement of FcγRIII‐related effector responses such as stronger NK cell‐mediated ADCC, or enhanced neutrophil‐mediated phagocytosis through FcγRIIIb and/or FcγRIIIa.23 However, certain neutrophil functions via FcγRIIa may be compromised.90, 91"}

{"project":"LitCovid-sentences","denotations":[{"id":"T271","span":{"begin":0,"end":325},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Compared with their unmodified counterparts, the afucosyl mAbs showed dramatic improvement of FcγRIII‐related effector responses such as stronger NK cell‐mediated ADCC, or enhanced neutrophil‐mediated phagocytosis through FcγRIIIb and/or FcγRIIIa.23 However, certain neutrophil functions via FcγRIIa may be compromised.90, 91"}