PMC:7228307 / 46049-46329 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T2","span":{"begin":88,"end":94},"obj":"https://glytoucan.org/Structures/Glycans/G82576YO"},{"id":"T3","span":{"begin":124,"end":130},"obj":"https://glytoucan.org/Structures/Glycans/G82576YO"}],"text":"The typical complex N‐linked glycan attached to N297 of the heavy chain includes a core fucose.85 Antibodies that lack this fucose have approximately 50‐fold improved binding to FcγRIIIa and FcγRIIIb and importantly retain the weak, low‐affinity binding to the inhibitory FcγRIIb."}

{"project":"LitCovid-PubTator","denotations":[{"id":"879","span":{"begin":178,"end":186},"obj":"Gene"},{"id":"880","span":{"begin":191,"end":199},"obj":"Gene"},{"id":"881","span":{"begin":272,"end":279},"obj":"Gene"},{"id":"890","span":{"begin":20,"end":35},"obj":"Chemical"},{"id":"891","span":{"begin":88,"end":94},"obj":"Chemical"},{"id":"892","span":{"begin":124,"end":130},"obj":"Chemical"}],"attributes":[{"id":"A879","pred":"tao:has_database_id","subj":"879","obj":"Gene:2214"},{"id":"A880","pred":"tao:has_database_id","subj":"880","obj":"Gene:2215"},{"id":"A881","pred":"tao:has_database_id","subj":"881","obj":"Gene:2213"},{"id":"A891","pred":"tao:has_database_id","subj":"891","obj":"MESH:D005643"},{"id":"A892","pred":"tao:has_database_id","subj":"892","obj":"MESH:D005643"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The typical complex N‐linked glycan attached to N297 of the heavy chain includes a core fucose.85 Antibodies that lack this fucose have approximately 50‐fold improved binding to FcγRIIIa and FcγRIIIb and importantly retain the weak, low‐affinity binding to the inhibitory FcγRIIb."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T376","span":{"begin":88,"end":94},"obj":"Body_part"},{"id":"T377","span":{"begin":98,"end":108},"obj":"Body_part"},{"id":"T378","span":{"begin":124,"end":130},"obj":"Body_part"}],"attributes":[{"id":"A376","pred":"fma_id","subj":"T376","obj":"http://purl.org/sig/ont/fma/fma82790"},{"id":"A377","pred":"fma_id","subj":"T377","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A378","pred":"fma_id","subj":"T378","obj":"http://purl.org/sig/ont/fma/fma82790"}],"text":"The typical complex N‐linked glycan attached to N297 of the heavy chain includes a core fucose.85 Antibodies that lack this fucose have approximately 50‐fold improved binding to FcγRIIIa and FcγRIIIb and importantly retain the weak, low‐affinity binding to the inhibitory FcγRIIb."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T803","span":{"begin":81,"end":82},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T804","span":{"begin":178,"end":180},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T805","span":{"begin":191,"end":193},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T806","span":{"begin":272,"end":274},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"}],"text":"The typical complex N‐linked glycan attached to N297 of the heavy chain includes a core fucose.85 Antibodies that lack this fucose have approximately 50‐fold improved binding to FcγRIIIa and FcγRIIIb and importantly retain the weak, low‐affinity binding to the inhibitory FcγRIIb."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T235","span":{"begin":88,"end":94},"obj":"Chemical"},{"id":"T236","span":{"begin":124,"end":130},"obj":"Chemical"}],"attributes":[{"id":"A235","pred":"chebi_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/CHEBI_33984"},{"id":"A236","pred":"chebi_id","subj":"T236","obj":"http://purl.obolibrary.org/obo/CHEBI_33984"}],"text":"The typical complex N‐linked glycan attached to N297 of the heavy chain includes a core fucose.85 Antibodies that lack this fucose have approximately 50‐fold improved binding to FcγRIIIa and FcγRIIIb and importantly retain the weak, low‐affinity binding to the inhibitory FcγRIIb."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T48","span":{"begin":88,"end":94},"obj":"Chemical"},{"id":"T49","span":{"begin":124,"end":130},"obj":"Chemical"}],"attributes":[{"id":"A48","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_33984"},{"id":"A49","pred":"chebi_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/CHEBI_33984"}],"text":"The typical complex N‐linked glycan attached to N297 of the heavy chain includes a core fucose.85 Antibodies that lack this fucose have approximately 50‐fold improved binding to FcγRIIIa and FcγRIIIb and importantly retain the weak, low‐affinity binding to the inhibitory FcγRIIb."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"879","span":{"begin":178,"end":186},"obj":"Gene"},{"id":"880","span":{"begin":191,"end":199},"obj":"Gene"},{"id":"881","span":{"begin":272,"end":279},"obj":"Gene"},{"id":"890","span":{"begin":20,"end":35},"obj":"Chemical"},{"id":"891","span":{"begin":88,"end":94},"obj":"Chemical"},{"id":"892","span":{"begin":124,"end":130},"obj":"Chemical"}],"attributes":[{"id":"A879","pred":"pubann:denotes","subj":"879","obj":"Gene:2214"},{"id":"A880","pred":"pubann:denotes","subj":"880","obj":"Gene:2215"},{"id":"A881","pred":"pubann:denotes","subj":"881","obj":"Gene:2213"},{"id":"A891","pred":"pubann:denotes","subj":"891","obj":"MESH:D005643"},{"id":"A892","pred":"pubann:denotes","subj":"892","obj":"MESH:D005643"}],"text":"The typical complex N‐linked glycan attached to N297 of the heavy chain includes a core fucose.85 Antibodies that lack this fucose have approximately 50‐fold improved binding to FcγRIIIa and FcγRIIIb and importantly retain the weak, low‐affinity binding to the inhibitory FcγRIIb."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T269","span":{"begin":0,"end":280},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The typical complex N‐linked glycan attached to N297 of the heavy chain includes a core fucose.85 Antibodies that lack this fucose have approximately 50‐fold improved binding to FcγRIIIa and FcγRIIIb and importantly retain the weak, low‐affinity binding to the inhibitory FcγRIIb."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T375","span":{"begin":88,"end":94},"obj":"Body_part"},{"id":"T376","span":{"begin":98,"end":108},"obj":"Body_part"},{"id":"T377","span":{"begin":124,"end":130},"obj":"Body_part"}],"attributes":[{"id":"A375","pred":"fma_id","subj":"T375","obj":"http://purl.org/sig/ont/fma/fma82790"},{"id":"A376","pred":"fma_id","subj":"T376","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A377","pred":"fma_id","subj":"T377","obj":"http://purl.org/sig/ont/fma/fma82790"}],"text":"The typical complex N‐linked glycan attached to N297 of the heavy chain includes a core fucose.85 Antibodies that lack this fucose have approximately 50‐fold improved binding to FcγRIIIa and FcγRIIIb and importantly retain the weak, low‐affinity binding to the inhibitory FcγRIIb."}

{"project":"LitCovid-sentences","denotations":[{"id":"T269","span":{"begin":0,"end":280},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The typical complex N‐linked glycan attached to N297 of the heavy chain includes a core fucose.85 Antibodies that lack this fucose have approximately 50‐fold improved binding to FcγRIIIa and FcγRIIIb and importantly retain the weak, low‐affinity binding to the inhibitory FcγRIIb."}