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PMC:7228307 / 42876-46017 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
793 232-258 Gene denotes Matrix Metalloproteinase 9 Gene:4318
794 260-264 Gene denotes MMP9 Gene:4318
795 642-649 Gene denotes FcγRIII Gene:2214
796 1067-1074 Gene denotes FcγRIII Gene:2214
797 1271-1275 Gene denotes HER2 Gene:2064
798 1338-1345 Gene denotes FcγRIII Gene:2214
799 1394-1423 Gene denotes C–C chemokine receptor type 4 Gene:1233
800 1425-1429 Gene denotes CCR4 Gene:1233
801 1472-1479 Gene denotes FcγRIII Gene:2214
802 1614-1621 Gene denotes FcγRIII Gene:2214
803 1666-1670 Gene denotes PD‐1 Gene:5133
804 1806-1813 Gene denotes FcγRIII Gene:2214
805 1918-1925 Gene denotes FcγRIII Gene:2214
806 1974-1978 Gene denotes PD‐1 Gene:5133
807 2106-2113 Gene denotes FcγRIII Gene:2214
808 2726-2733 Gene denotes FcγRIII Gene:2214
809 2523-2527 Gene denotes FcγR Gene:2213
810 2498-2502 Gene denotes FcγR Gene:2213
811 2319-2323 Gene denotes FcγR Gene:2213
812 2221-2225 Gene denotes FcγR Gene:2213
813 864-868 Gene denotes FcγR Gene:2213
814 540-544 Gene denotes FcγR Gene:2213
815 447-451 Gene denotes FcγR Gene:2213
816 2606-2610 Gene denotes PD‐1 Gene:5133
817 2377-2381 Gene denotes PD‐1 Gene:5133
818 779-784 Gene denotes PD‐L1 Gene:29126
819 497-502 Gene denotes PD‐L1 Gene:29126
820 688-713 Disease denotes ear nose throat disorders MESH:D004427
821 976-995 Disease denotes Metabolic disorders MESH:D008659
822 1221-1246 Disease denotes musculoskeletal disorders MESH:D009140
823 1707-1725 Disease denotes Infectious disease MESH:D003141
824 2015-2024 Disease denotes Infection MESH:D007239
825 2127-2150 Disease denotes Hematological disorders MESH:D006402
826 2333-2352 Disease denotes Metabolic disorders MESH:D008659
827 2618-2623 Mutation denotes S228P rs1469294455
828 792-797 Mutation denotes L234F p.L234F
829 799-804 Mutation denotes L235E p.L235E
830 806-811 Mutation denotes P331S p.P331S
831 525-530 Mutation denotes N297A p.N297A
832 375-380 Mutation denotes L234F p.L234F
833 382-387 Mutation denotes L235E p.L235E
834 389-394 Mutation denotes P331S p.P331S
835 2389-2394 Mutation denotes S228P rs1469294455
836 1986-1991 Mutation denotes S228P rs1469294455
837 1283-1288 Mutation denotes F243L p.F243L
838 1290-1295 Mutation denotes L235V p.L235V
839 1297-1302 Mutation denotes R292P p.R292P
840 1304-1309 Mutation denotes Y300L p.Y300L
841 1311-1316 Mutation denotes P396L p.P396L
842 1580-1585 Mutation denotes S239D p.S239D
843 1587-1592 Mutation denotes I332E p.I332E
844 1678-1683 Mutation denotes S228P rs1469294455
845 1884-1889 Mutation denotes P247I p.P247I
846 1891-1896 Mutation denotes A339Q p.A339Q
847 1167-1172 Mutation denotes S228P rs1469294455
848 2298-2303 Mutation denotes L234A p.L234A
849 2410-2415 Mutation denotes L235A p.L235A
850 2200-2205 Mutation denotes L234A p.L234A
851 2305-2310 Mutation denotes L235A p.L235A
852 947-952 Mutation denotes S228P rs1469294455
853 2396-2401 Mutation denotes E233P p.E233P
854 2403-2408 Mutation denotes F234V rs755807976
855 2207-2212 Mutation denotes L235A p.L235A
856 2417-2422 Mutation denotes D265A p.D265A
857 2424-2429 Mutation denotes L309V p.L309V
858 2431-2436 Mutation denotes R409K p.R409K
859 273-278 Mutation denotes S228P rs1469294455
861 2916-2924 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T361 125-128 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T362 129-137 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T363 587-600 Body_part denotes Interleukin 5 http://purl.org/sig/ont/fma/fma264830
T364 587-598 Body_part denotes Interleukin http://purl.org/sig/ont/fma/fma86578
T365 688-691 Body_part denotes ear http://purl.org/sig/ont/fma/fma52780
T366 692-696 Body_part denotes nose http://purl.org/sig/ont/fma/fma46472
T367 697-703 Body_part denotes throat http://purl.org/sig/ont/fma/fma228738
T368 930-937 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T369 1088-1110 Body_part denotes Central nervous system http://purl.org/sig/ont/fma/fma55675
T370 1144-1155 Body_part denotes Interleukin http://purl.org/sig/ont/fma/fma86578
T371 1398-1407 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T372 1493-1515 Body_part denotes Central nervous system http://purl.org/sig/ont/fma/fma55675
T373 2747-2769 Body_part denotes Central nervous system http://purl.org/sig/ont/fma/fma55675
T374 2791-2793 Body_part denotes Ig http://purl.org/sig/ont/fma/fma62871
T375 2795-2809 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T22 688-691 Body_part denotes ear http://purl.obolibrary.org/obo/UBERON_0001690
T23 692-696 Body_part denotes nose http://purl.obolibrary.org/obo/UBERON_0000004
T24 697-703 Body_part denotes throat http://purl.obolibrary.org/obo/UBERON_0000341
T25 1088-1110 Body_part denotes Central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T26 1096-1110 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T27 1493-1515 Body_part denotes Central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T28 1501-1515 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T29 2747-2769 Body_part denotes Central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T30 2755-2769 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T71 688-713 Disease denotes ear nose throat disorders http://purl.obolibrary.org/obo/MONDO_0024623
T72 976-995 Disease denotes Metabolic disorders http://purl.obolibrary.org/obo/MONDO_0005066
T73 1221-1246 Disease denotes musculoskeletal disorders http://purl.obolibrary.org/obo/MONDO_0002081
T74 1707-1725 Disease denotes Infectious disease http://purl.obolibrary.org/obo/MONDO_0005550
T75 2015-2024 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T76 2127-2150 Disease denotes Hematological disorders http://purl.obolibrary.org/obo/MONDO_0005570
T77 2333-2352 Disease denotes Metabolic disorders http://purl.obolibrary.org/obo/MONDO_0005066
T78 2916-2924 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T767 9-11 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T768 139-141 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T769 447-449 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T770 497-502 http://purl.obolibrary.org/obo/CLO_0008407 denotes PD‐L1
T771 540-542 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T772 642-644 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T773 688-691 http://www.ebi.ac.uk/efo/EFO_0000826 denotes ear
T774 692-696 http://www.ebi.ac.uk/efo/EFO_0000828 denotes nose
T775 779-784 http://purl.obolibrary.org/obo/CLO_0008407 denotes PD‐L1
T776 864-866 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T777 1021-1025 http://purl.obolibrary.org/obo/CLO_0053432 denotes CD19
T778 1067-1069 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T779 1088-1110 http://purl.obolibrary.org/obo/UBERON_0001017 denotes Central nervous system
T780 1088-1110 http://www.ebi.ac.uk/efo/EFO_0000302 denotes Central nervous system
T781 1088-1110 http://www.ebi.ac.uk/efo/EFO_0000908 denotes Central nervous system
T782 1338-1340 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T783 1472-1474 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T784 1493-1515 http://purl.obolibrary.org/obo/UBERON_0001017 denotes Central nervous system
T785 1493-1515 http://www.ebi.ac.uk/efo/EFO_0000302 denotes Central nervous system
T786 1493-1515 http://www.ebi.ac.uk/efo/EFO_0000908 denotes Central nervous system
T787 1568-1572 http://purl.obolibrary.org/obo/CLO_0053432 denotes CD19
T788 1614-1616 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T789 1806-1808 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T790 1918-1920 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T791 2106-2108 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T792 2221-2223 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T793 2287-2290 http://purl.obolibrary.org/obo/CLO_0052882 denotes CD3
T794 2287-2290 http://purl.obolibrary.org/obo/CLO_0053434 denotes CD3
T795 2319-2321 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T796 2498-2500 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T797 2523-2525 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T798 2726-2728 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T799 2747-2769 http://purl.obolibrary.org/obo/UBERON_0001017 denotes Central nervous system
T800 2747-2769 http://www.ebi.ac.uk/efo/EFO_0000302 denotes Central nervous system
T801 2747-2769 http://www.ebi.ac.uk/efo/EFO_0000908 denotes Central nervous system

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T222 346-351 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T223 352-356 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T224 497-499 Chemical denotes PD http://purl.obolibrary.org/obo/CHEBI_74756
T225 779-781 Chemical denotes PD http://purl.obolibrary.org/obo/CHEBI_74756
T226 930-937 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T227 1666-1668 Chemical denotes PD http://purl.obolibrary.org/obo/CHEBI_74756
T228 1959-1972 Chemical denotes Pembrolizumab http://purl.obolibrary.org/obo/CHEBI_82976
T229 1974-1976 Chemical denotes PD http://purl.obolibrary.org/obo/CHEBI_74756
T230 2186-2188 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T232 2360-2362 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T233 2377-2379 Chemical denotes PD http://purl.obolibrary.org/obo/CHEBI_74756
T234 2606-2608 Chemical denotes PD http://purl.obolibrary.org/obo/CHEBI_74756

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T18 2791-2793 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Ig http://purl.bioontology.org/ontology/MEDDRA/10021496
T19 2795-2809 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes immunoglobulin http://purl.bioontology.org/ontology/MEDDRA/10021496

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T213 704-713 http://purl.obolibrary.org/obo/OGMS_0000045 denotes disorders
T214 986-995 http://purl.obolibrary.org/obo/OGMS_0000045 denotes disorders
T215 1237-1246 http://purl.obolibrary.org/obo/OGMS_0000045 denotes disorders
T216 1707-1725 http://purl.obolibrary.org/obo/IDO_0000436 denotes Infectious disease
T217 1718-1725 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T218 2015-2024 http://purl.obolibrary.org/obo/IDO_0000586 denotes Infection
T219 2141-2150 http://purl.obolibrary.org/obo/OGMS_0000045 denotes disorders
T220 2343-2352 http://purl.obolibrary.org/obo/OGMS_0000045 denotes disorders

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T47 930-937 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes pubann:has_HGVS_notation
793 232-258 Gene denotes Matrix Metalloproteinase 9 Gene:4318
794 260-264 Gene denotes MMP9 Gene:4318
795 642-649 Gene denotes FcγRIII Gene:2214
796 1067-1074 Gene denotes FcγRIII Gene:2214
798 1338-1345 Gene denotes FcγRIII Gene:2214
799 1394-1423 Gene denotes C–C chemokine receptor type 4 Gene:1233
800 1425-1429 Gene denotes CCR4 Gene:1233
801 1472-1479 Gene denotes FcγRIII Gene:2214
802 1614-1621 Gene denotes FcγRIII Gene:2214
803 1666-1670 Gene denotes PD‐1 Gene:5133
804 1806-1813 Gene denotes FcγRIII Gene:2214
805 1918-1925 Gene denotes FcγRIII Gene:2214
806 1974-1978 Gene denotes PD‐1 Gene:5133
807 2106-2113 Gene denotes FcγRIII Gene:2214
808 2726-2733 Gene denotes FcγRIII Gene:2214
809 2523-2527 Gene denotes FcγR Gene:2213
810 2498-2502 Gene denotes FcγR Gene:2213
811 2319-2323 Gene denotes FcγR Gene:2213
812 2221-2225 Gene denotes FcγR Gene:2213
813 864-868 Gene denotes FcγR Gene:2213
814 540-544 Gene denotes FcγR Gene:2213
815 447-451 Gene denotes FcγR Gene:2213
816 2606-2610 Gene denotes PD‐1 Gene:5133
817 2377-2381 Gene denotes PD‐1 Gene:5133
818 779-784 Gene denotes PD‐L1 Gene:29126
819 497-502 Gene denotes PD‐L1 Gene:29126
820 688-713 Disease denotes ear nose throat disorders MESH:D004427
821 976-995 Disease denotes Metabolic disorders MESH:D008659
822 1221-1246 Disease denotes musculoskeletal disorders MESH:D009140
823 1707-1725 Disease denotes Infectious disease MESH:D003141
824 2015-2024 Disease denotes Infection MESH:D007239
825 2127-2150 Disease denotes Hematological disorders MESH:D006402
826 2333-2352 Disease denotes Metabolic disorders MESH:D008659
827 2618-2623 Mutation denotes S228P rs1469294455
828 792-797 Mutation denotes L234F p.L234F
829 799-804 Mutation denotes L235E p.L235E
830 806-811 Mutation denotes P331S p.P331S
831 525-530 Mutation denotes N297A p.N297A
832 375-380 Mutation denotes L234F p.L234F
833 382-387 Mutation denotes L235E p.L235E
834 389-394 Mutation denotes P331S p.P331S
835 2389-2394 Mutation denotes S228P rs1469294455
836 1986-1991 Mutation denotes S228P rs1469294455
837 1283-1288 Mutation denotes F243L p.F243L
838 1290-1295 Mutation denotes L235V p.L235V
839 1297-1302 Mutation denotes R292P p.R292P
840 1304-1309 Mutation denotes Y300L p.Y300L
841 1311-1316 Mutation denotes P396L p.P396L
842 1580-1585 Mutation denotes S239D p.S239D
843 1587-1592 Mutation denotes I332E p.I332E
844 1678-1683 Mutation denotes S228P rs1469294455
845 1884-1889 Mutation denotes P247I p.P247I
846 1891-1896 Mutation denotes A339Q p.A339Q
848 2298-2303 Mutation denotes L234A p.L234A
849 2410-2415 Mutation denotes L235A p.L235A
850 2200-2205 Mutation denotes L234A p.L234A
851 2305-2310 Mutation denotes L235A p.L235A
853 2396-2401 Mutation denotes E233P p.E233P
854 2403-2408 Mutation denotes F234V rs755807976
855 2207-2212 Mutation denotes L235A p.L235A
856 2417-2422 Mutation denotes D265A p.D265A
857 2424-2429 Mutation denotes L309V p.L309V
858 2431-2436 Mutation denotes R409K p.R409K

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T43 2916-2924 Species denotes COVID-19 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T242 0-106 Sentence denotes Table 4 Fc or hinge‐engineered monoclonal antibodies (mAbs) approved or in advanced clinical development.
T243 107-216 Sentence denotes mAb name Target IgG backbone Fc modification Effect on mAb Therapy area Most advanced development stage
T244 217-321 Sentence denotes Andecaliximab Matrix Metalloproteinase 9 (MMP9) IgG4 S228P Stabilize core hinge Oncology Phase III
T245 322-482 Sentence denotes Anifrolumab Interferon alpha/beta receptor 1 IgG1 L234F; L235E; P331S Mimic IgG4 hinge and its CH2/F/G loop; plus ablate FcγR binding Immunology Phase III
T246 483-572 Sentence denotes Atezolizumab PD‐L1 IgG1 Aglycosylated (N297A) Ablate FcγR binding Oncology Marketed
T247 573-766 Sentence denotes Benralizumab Interleukin 5 IgG1 Afucosylated Selectively enhance FcγRIII interaction Respiratory dermatology; ear nose throat disorders; gastrointestinal; hematology; immunology; Marketed
T248 767-896 Sentence denotes Durvalumab PD‐L1 IgG1 L234F; L235E; P331S Mimic IgG4 hinge and its CH2 F/G loop; plus ablate FcγR binding Oncology Marketed
T249 897-1006 Sentence denotes Evinacumab Angiopoietin‐related protein 3 IgG4 S228P Stabilize core hinge Metabolic disorders Phase III
T250 1007-1131 Sentence denotes Inebilizumab CD19 IgG1 Afucosylated Selectively enhance FcγRIII interaction Central nervous system; oncology Phase III
T251 1132-1256 Sentence denotes Ixekizumab Interleukin 17A IgG4 S228P Stabilize core hinge Dermatology; immunology; musculoskeletal disorders Marketed
T252 1257-1378 Sentence denotes Margetuximab HER2 IgG1 F243L; L235V; R292P; Y300L; P396L Selectively enhance FcγRIII interaction Oncology Phase III
T253 1379-1535 Sentence denotes Mogamulizumab C–C chemokine receptor type 4 (CCR4) IgG1 Afucosylated Selectively enhance FcγRIII interaction Central nervous system; oncology Marketed
T254 1536-1654 Sentence denotes Tafasitamab (MOR208 XmAb 5574) CD19 IgG1 S239D; I332E Selectively enhance FcγRIII interaction Oncology Phase III
T255 1655-1745 Sentence denotes Nivolumab PD‐1 IgG4 S228P Stabilize core hinge Infectious disease; oncology Marketed
T256 1746-1857 Sentence denotes Obinutuzumab CD20 IgG1 Afucosylated Selectively enhance FcγRIII interaction Immunology; oncology Marketed
T257 1858-1958 Sentence denotes Ocaratuzumab CD20 IgG1 P247I; A339Q Selectively enhance FcγRIII interaction Oncology Phase III
T258 1959-2044 Sentence denotes Pembrolizumab PD‐1 IgG4 S228P Stabilize core hinge Infection; oncology Marketed
T259 2045-2161 Sentence denotes Roledumab Rhesus D IgG1 Afucosylated Selectively enhance FcγRIII interaction Hematological disorders Phase III
T260 2162-2274 Sentence denotes Spesolimab (BI‐655130) IL‐36R IgG1 L234A; L235A Ablate FcγR binding Gastrointestinal; immunology Phase III
T261 2275-2362 Sentence denotes Teplizumab CD3 IgG1 L234A; L235A Ablate FcγR binding Metabolic disorders Phase II
T262 2363-2583 Sentence denotes Tislelizumab PD‐1 IgG4 S228P; E233P; F234V; L235A; D265A; L309V; R409K Stabilize core hinge; mimic IgG2 lower hinge for restricted FcγR specificity; ablate FcγR binding; stabilize CH3 interaction Oncology Phase III
T263 2584-2666 Sentence denotes Toripalimab (JS 001) PD‐1 IgG4 S228P Stabilize core hinge Oncology Phase III
T264 2667-2790 Sentence denotes Ublituximab CD20 IgG1 Afucosylated Selectively enhance FcγRIII interaction Central nervous system; oncology Phase III
T265 2791-2810 Sentence denotes Ig, immunoglobulin.
T266 2811-2958 Sentence denotes John Wiley & Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response.
T267 2959-3141 Sentence denotes It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T22 688-691 Body_part denotes ear http://purl.obolibrary.org/obo/UBERON_0001690
T23 692-696 Body_part denotes nose http://purl.obolibrary.org/obo/UBERON_0000004
T24 697-703 Body_part denotes throat http://purl.obolibrary.org/obo/UBERON_0000341
T25 1088-1110 Body_part denotes Central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T26 1493-1515 Body_part denotes Central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T27 2747-2769 Body_part denotes Central nervous system http://purl.obolibrary.org/obo/UBERON_0001017

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T393 232-258 Protein denotes Matrix Metalloproteinase 9 https://www.uniprot.org/uniprot/Q9UDK2|https://www.uniprot.org/uniprot/Q9UCL1|https://www.uniprot.org/uniprot/Q9UCJ9|https://www.uniprot.org/uniprot/Q9H4Z1|https://www.uniprot.org/uniprot/Q9DC02|https://www.uniprot.org/uniprot/Q8N725|https://www.uniprot.org/uniprot/Q80XI8|https://www.uniprot.org/uniprot/Q3LR70|https://www.uniprot.org/uniprot/Q06788|https://www.uniprot.org/uniprot/P52176|https://www.uniprot.org/uniprot/P50282|https://www.uniprot.org/uniprot/P41246|https://www.uniprot.org/uniprot/P41245|https://www.uniprot.org/uniprot/P14780|https://www.uniprot.org/uniprot/O19130|https://www.uniprot.org/uniprot/O18733|https://www.uniprot.org/uniprot/B2R7V9|https://www.uniprot.org/uniprot/A5PKB8
T411 260-264 Protein denotes MMP9 https://www.uniprot.org/uniprot/Q9UDK2|https://www.uniprot.org/uniprot/Q9UCL1|https://www.uniprot.org/uniprot/Q9UCJ9|https://www.uniprot.org/uniprot/Q9H4Z1|https://www.uniprot.org/uniprot/Q9DC02|https://www.uniprot.org/uniprot/Q8N725|https://www.uniprot.org/uniprot/Q80XI8|https://www.uniprot.org/uniprot/Q3LR70|https://www.uniprot.org/uniprot/Q06788|https://www.uniprot.org/uniprot/P52176|https://www.uniprot.org/uniprot/P50282|https://www.uniprot.org/uniprot/P41246|https://www.uniprot.org/uniprot/P41245|https://www.uniprot.org/uniprot/P14780|https://www.uniprot.org/uniprot/O19130|https://www.uniprot.org/uniprot/O18733|https://www.uniprot.org/uniprot/B2R7V9|https://www.uniprot.org/uniprot/A5PKB8
T429 335-367 Protein denotes Interferon alpha/beta receptor 1 https://www.uniprot.org/uniprot/Q95206|https://www.uniprot.org/uniprot/Q8WTZ2|https://www.uniprot.org/uniprot/Q80UJ3|https://www.uniprot.org/uniprot/Q7M4L2|https://www.uniprot.org/uniprot/Q764M8|https://www.uniprot.org/uniprot/Q6PKD7|https://www.uniprot.org/uniprot/Q53H11|https://www.uniprot.org/uniprot/Q53GW9|https://www.uniprot.org/uniprot/Q28589|https://www.uniprot.org/uniprot/Q04790|https://www.uniprot.org/uniprot/P33896|https://www.uniprot.org/uniprot/P17181|https://www.uniprot.org/uniprot/D3DSF0|https://www.uniprot.org/uniprot/B4DNT3|https://www.uniprot.org/uniprot/B2R6L9
T444 497-502 Protein denotes PD‐L1 https://www.uniprot.org/uniprot/Q9NZQ7|https://www.uniprot.org/uniprot/Q9NUZ5|https://www.uniprot.org/uniprot/Q9EP73|https://www.uniprot.org/uniprot/Q6WEX4|https://www.uniprot.org/uniprot/Q66RK1|https://www.uniprot.org/uniprot/Q2V8D5|https://www.uniprot.org/uniprot/Q14CJ2|https://www.uniprot.org/uniprot/B4DU27|https://www.uniprot.org/uniprot/B2RBA2
T453 587-600 Protein denotes Interleukin 5 https://www.uniprot.org/uniprot/Q9XT91|https://www.uniprot.org/uniprot/Q9MYM5|https://www.uniprot.org/uniprot/Q9ESI9|https://www.uniprot.org/uniprot/Q95J76|https://www.uniprot.org/uniprot/Q62575|https://www.uniprot.org/uniprot/Q28586|https://www.uniprot.org/uniprot/Q13840|https://www.uniprot.org/uniprot/Q08125|https://www.uniprot.org/uniprot/P52173|https://www.uniprot.org/uniprot/P48093|https://www.uniprot.org/uniprot/P46685|https://www.uniprot.org/uniprot/P05113|https://www.uniprot.org/uniprot/P04401|https://www.uniprot.org/uniprot/O77515|https://www.uniprot.org/uniprot/O62740|https://www.uniprot.org/uniprot/O08987|https://www.uniprot.org/uniprot/O02699|https://www.uniprot.org/uniprot/A9QWQ8
T471 779-784 Protein denotes PD‐L1 https://www.uniprot.org/uniprot/Q9NZQ7|https://www.uniprot.org/uniprot/Q9NUZ5|https://www.uniprot.org/uniprot/Q9EP73|https://www.uniprot.org/uniprot/Q6WEX4|https://www.uniprot.org/uniprot/Q66RK1|https://www.uniprot.org/uniprot/Q2V8D5|https://www.uniprot.org/uniprot/Q14CJ2|https://www.uniprot.org/uniprot/B4DU27|https://www.uniprot.org/uniprot/B2RBA2
T480 909-939 Protein denotes Angiopoietin‐related protein 3 https://www.uniprot.org/uniprot/Q9Y5C1|https://www.uniprot.org/uniprot/Q9R182|https://www.uniprot.org/uniprot/B2RCW1|https://www.uniprot.org/uniprot/B1ALJ0|https://www.uniprot.org/uniprot/A0JLS0
T485 1021-1025 Protein denotes CD19 https://www.uniprot.org/uniprot/Q9BRD6|https://www.uniprot.org/uniprot/Q96S68|https://www.uniprot.org/uniprot/Q542B2|https://www.uniprot.org/uniprot/Q3LRP3|https://www.uniprot.org/uniprot/P25918|https://www.uniprot.org/uniprot/P25917|https://www.uniprot.org/uniprot/P15391|https://www.uniprot.org/uniprot/F5H635|https://www.uniprot.org/uniprot/A0N0P9
T494 1144-1159 Protein denotes Interleukin 17A https://www.uniprot.org/uniprot/Q95L56|https://www.uniprot.org/uniprot/Q687Y7|https://www.uniprot.org/uniprot/Q62386|https://www.uniprot.org/uniprot/Q61453|https://www.uniprot.org/uniprot/Q60I29|https://www.uniprot.org/uniprot/Q60971|https://www.uniprot.org/uniprot/Q5T2P0|https://www.uniprot.org/uniprot/Q16552
T502 1396-1423 Protein denotes C chemokine receptor type 4 https://www.uniprot.org/uniprot/Q9ULY7|https://www.uniprot.org/uniprot/Q9ULY6|https://www.uniprot.org/uniprot/Q8MJW8|https://www.uniprot.org/uniprot/Q14A03|https://www.uniprot.org/uniprot/P51680|https://www.uniprot.org/uniprot/P51679
T508 1425-1429 Protein denotes CCR4 https://www.uniprot.org/uniprot/Q9ULY7|https://www.uniprot.org/uniprot/Q9ULY6|https://www.uniprot.org/uniprot/Q8MJW8|https://www.uniprot.org/uniprot/Q14A03|https://www.uniprot.org/uniprot/P51680|https://www.uniprot.org/uniprot/P51679
T514 1568-1572 Protein denotes CD19 https://www.uniprot.org/uniprot/Q9BRD6|https://www.uniprot.org/uniprot/Q96S68|https://www.uniprot.org/uniprot/Q542B2|https://www.uniprot.org/uniprot/Q3LRP3|https://www.uniprot.org/uniprot/P25918|https://www.uniprot.org/uniprot/P25917|https://www.uniprot.org/uniprot/P15391|https://www.uniprot.org/uniprot/F5H635|https://www.uniprot.org/uniprot/A0N0P9
T523 1666-1670 Protein denotes PD‐1 https://www.uniprot.org/uniprot/Q7M4M5|https://www.uniprot.org/uniprot/Q6NZ54|https://www.uniprot.org/uniprot/Q3KQW2|https://www.uniprot.org/uniprot/P18621|https://www.uniprot.org/uniprot/J3QL51|https://www.uniprot.org/uniprot/B5ME31|https://www.uniprot.org/uniprot/B4E3C2|https://www.uniprot.org/uniprot/B2R4H3
T531 1760-1764 Protein denotes CD20 https://www.uniprot.org/uniprot/Q3C2E2|https://www.uniprot.org/uniprot/Q13963|https://www.uniprot.org/uniprot/P19437|https://www.uniprot.org/uniprot/P11836|https://www.uniprot.org/uniprot/P08984|https://www.uniprot.org/uniprot/B4DT24|https://www.uniprot.org/uniprot/A6NMS4
T538 1872-1876 Protein denotes CD20 https://www.uniprot.org/uniprot/Q3C2E2|https://www.uniprot.org/uniprot/Q13963|https://www.uniprot.org/uniprot/P19437|https://www.uniprot.org/uniprot/P11836|https://www.uniprot.org/uniprot/P08984|https://www.uniprot.org/uniprot/B4DT24|https://www.uniprot.org/uniprot/A6NMS4
T545 1974-1978 Protein denotes PD‐1 https://www.uniprot.org/uniprot/Q7M4M5|https://www.uniprot.org/uniprot/Q6NZ54|https://www.uniprot.org/uniprot/Q3KQW2|https://www.uniprot.org/uniprot/P18621|https://www.uniprot.org/uniprot/J3QL51|https://www.uniprot.org/uniprot/B5ME31|https://www.uniprot.org/uniprot/B4E3C2|https://www.uniprot.org/uniprot/B2R4H3
T553 2186-2192 Protein denotes IL‐36R https://www.uniprot.org/uniprot/Q9HB29|https://www.uniprot.org/uniprot/Q587I8|https://www.uniprot.org/uniprot/Q53TU8|https://www.uniprot.org/uniprot/Q45H74|https://www.uniprot.org/uniprot/Q13525|https://www.uniprot.org/uniprot/A4FU63
T559 2377-2381 Protein denotes PD‐1 https://www.uniprot.org/uniprot/Q7M4M5|https://www.uniprot.org/uniprot/Q6NZ54|https://www.uniprot.org/uniprot/Q3KQW2|https://www.uniprot.org/uniprot/P18621|https://www.uniprot.org/uniprot/J3QL51|https://www.uniprot.org/uniprot/B5ME31|https://www.uniprot.org/uniprot/B4E3C2|https://www.uniprot.org/uniprot/B2R4H3
T567 2606-2610 Protein denotes PD‐1 https://www.uniprot.org/uniprot/Q7M4M5|https://www.uniprot.org/uniprot/Q6NZ54|https://www.uniprot.org/uniprot/Q3KQW2|https://www.uniprot.org/uniprot/P18621|https://www.uniprot.org/uniprot/J3QL51|https://www.uniprot.org/uniprot/B5ME31|https://www.uniprot.org/uniprot/B4E3C2|https://www.uniprot.org/uniprot/B2R4H3
T575 2680-2684 Protein denotes CD20 https://www.uniprot.org/uniprot/Q3C2E2|https://www.uniprot.org/uniprot/Q13963|https://www.uniprot.org/uniprot/P19437|https://www.uniprot.org/uniprot/P11836|https://www.uniprot.org/uniprot/P08984|https://www.uniprot.org/uniprot/B4DT24|https://www.uniprot.org/uniprot/A6NMS4

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T360 125-128 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T361 129-137 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T362 587-600 Body_part denotes Interleukin 5 http://purl.org/sig/ont/fma/fma264830
T363 587-598 Body_part denotes Interleukin http://purl.org/sig/ont/fma/fma86578
T364 688-691 Body_part denotes ear http://purl.org/sig/ont/fma/fma52780
T365 692-696 Body_part denotes nose http://purl.org/sig/ont/fma/fma46472
T366 697-703 Body_part denotes throat http://purl.org/sig/ont/fma/fma228738
T367 930-937 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T368 1088-1110 Body_part denotes Central nervous system http://purl.org/sig/ont/fma/fma55675
T369 1144-1155 Body_part denotes Interleukin http://purl.org/sig/ont/fma/fma86578
T370 1398-1407 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T371 1493-1515 Body_part denotes Central nervous system http://purl.org/sig/ont/fma/fma55675
T372 2747-2769 Body_part denotes Central nervous system http://purl.org/sig/ont/fma/fma55675
T373 2791-2793 Body_part denotes Ig http://purl.org/sig/ont/fma/fma62871
T374 2795-2809 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T13 688-691 http://purl.obolibrary.org/obo/MAT_0000317 denotes ear
T14 688-691 http://purl.obolibrary.org/obo/MAT_0000233 denotes ear
T15 688-691 http://purl.obolibrary.org/obo/MAT_0000138 denotes ear
T16 692-696 http://purl.obolibrary.org/obo/MAT_0000139 denotes nose
T17 1088-1110 http://purl.obolibrary.org/obo/MAT_0000457 denotes Central nervous system
T18 1096-1110 http://purl.obolibrary.org/obo/MAT_0000026 denotes nervous system
T19 1493-1515 http://purl.obolibrary.org/obo/MAT_0000457 denotes Central nervous system
T20 1501-1515 http://purl.obolibrary.org/obo/MAT_0000026 denotes nervous system
T21 2747-2769 http://purl.obolibrary.org/obo/MAT_0000457 denotes Central nervous system
T22 2755-2769 http://purl.obolibrary.org/obo/MAT_0000026 denotes nervous system

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T27 688-713 Disease denotes ear nose throat disorders http://purl.obolibrary.org/obo/MONDO_0024623
T28 976-995 Disease denotes Metabolic disorders http://purl.obolibrary.org/obo/MONDO_0005066
T29 1221-1246 Disease denotes musculoskeletal disorders http://purl.obolibrary.org/obo/MONDO_0002081
T30 1707-1725 Disease denotes Infectious disease http://purl.obolibrary.org/obo/MONDO_0005550
T31 2015-2024 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T32 2127-2150 Disease denotes Hematological disorders http://purl.obolibrary.org/obo/MONDO_0005570
T33 2333-2352 Disease denotes Metabolic disorders http://purl.obolibrary.org/obo/MONDO_0005066
T34 2916-2924 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T17 302-310 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T18 554-562 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T19 878-886 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T20 1112-1120 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T21 1359-1367 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T22 1517-1525 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T23 1635-1643 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T24 1727-1735 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T25 1839-1847 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T26 1939-1947 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T27 2026-2034 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T28 2564-2572 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T29 2647-2655 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T30 2771-2779 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T242 0-106 Sentence denotes Table 4 Fc or hinge‐engineered monoclonal antibodies (mAbs) approved or in advanced clinical development.
T243 107-216 Sentence denotes mAb name Target IgG backbone Fc modification Effect on mAb Therapy area Most advanced development stage
T244 217-321 Sentence denotes Andecaliximab Matrix Metalloproteinase 9 (MMP9) IgG4 S228P Stabilize core hinge Oncology Phase III
T245 322-482 Sentence denotes Anifrolumab Interferon alpha/beta receptor 1 IgG1 L234F; L235E; P331S Mimic IgG4 hinge and its CH2/F/G loop; plus ablate FcγR binding Immunology Phase III
T246 483-572 Sentence denotes Atezolizumab PD‐L1 IgG1 Aglycosylated (N297A) Ablate FcγR binding Oncology Marketed
T247 573-766 Sentence denotes Benralizumab Interleukin 5 IgG1 Afucosylated Selectively enhance FcγRIII interaction Respiratory dermatology; ear nose throat disorders; gastrointestinal; hematology; immunology; Marketed
T248 767-896 Sentence denotes Durvalumab PD‐L1 IgG1 L234F; L235E; P331S Mimic IgG4 hinge and its CH2 F/G loop; plus ablate FcγR binding Oncology Marketed
T249 897-1006 Sentence denotes Evinacumab Angiopoietin‐related protein 3 IgG4 S228P Stabilize core hinge Metabolic disorders Phase III
T250 1007-1131 Sentence denotes Inebilizumab CD19 IgG1 Afucosylated Selectively enhance FcγRIII interaction Central nervous system; oncology Phase III
T251 1132-1256 Sentence denotes Ixekizumab Interleukin 17A IgG4 S228P Stabilize core hinge Dermatology; immunology; musculoskeletal disorders Marketed
T252 1257-1378 Sentence denotes Margetuximab HER2 IgG1 F243L; L235V; R292P; Y300L; P396L Selectively enhance FcγRIII interaction Oncology Phase III
T253 1379-1535 Sentence denotes Mogamulizumab C–C chemokine receptor type 4 (CCR4) IgG1 Afucosylated Selectively enhance FcγRIII interaction Central nervous system; oncology Marketed
T254 1536-1654 Sentence denotes Tafasitamab (MOR208 XmAb 5574) CD19 IgG1 S239D; I332E Selectively enhance FcγRIII interaction Oncology Phase III
T255 1655-1745 Sentence denotes Nivolumab PD‐1 IgG4 S228P Stabilize core hinge Infectious disease; oncology Marketed
T256 1746-1857 Sentence denotes Obinutuzumab CD20 IgG1 Afucosylated Selectively enhance FcγRIII interaction Immunology; oncology Marketed
T257 1858-1958 Sentence denotes Ocaratuzumab CD20 IgG1 P247I; A339Q Selectively enhance FcγRIII interaction Oncology Phase III
T258 1959-2044 Sentence denotes Pembrolizumab PD‐1 IgG4 S228P Stabilize core hinge Infection; oncology Marketed
T259 2045-2161 Sentence denotes Roledumab Rhesus D IgG1 Afucosylated Selectively enhance FcγRIII interaction Hematological disorders Phase III
T260 2162-2274 Sentence denotes Spesolimab (BI‐655130) IL‐36R IgG1 L234A; L235A Ablate FcγR binding Gastrointestinal; immunology Phase III
T261 2275-2362 Sentence denotes Teplizumab CD3 IgG1 L234A; L235A Ablate FcγR binding Metabolic disorders Phase II
T262 2363-2583 Sentence denotes Tislelizumab PD‐1 IgG4 S228P; E233P; F234V; L235A; D265A; L309V; R409K Stabilize core hinge; mimic IgG2 lower hinge for restricted FcγR specificity; ablate FcγR binding; stabilize CH3 interaction Oncology Phase III
T263 2584-2666 Sentence denotes Toripalimab (JS 001) PD‐1 IgG4 S228P Stabilize core hinge Oncology Phase III
T264 2667-2790 Sentence denotes Ublituximab CD20 IgG1 Afucosylated Selectively enhance FcγRIII interaction Central nervous system; oncology Phase III
T265 2791-2810 Sentence denotes Ig, immunoglobulin.
T266 2811-2958 Sentence denotes John Wiley & Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response.
T267 2959-3141 Sentence denotes It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T17 302-310 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T18 554-562 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T19 878-886 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T20 1112-1120 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T21 1359-1367 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T22 1517-1525 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T23 1635-1643 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T24 1727-1735 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T25 1839-1847 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T26 1939-1947 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T27 2026-2034 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T28 2564-2572 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T29 2647-2655 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T30 2771-2779 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664