PMC:7228307 / 40532-40944
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 682 | 155-159 | Gene | denotes | HER2 | Gene:2064 |
| 683 | 181-185 | Gene | denotes | EGFR | Gene:1956 |
| 693 | 259-263 | Gene | denotes | FcγR | Gene:2213 |
| 694 | 22-26 | Gene | denotes | FcγR | Gene:2213 |
| 695 | 207-212 | Species | denotes | human | Tax:9606 |
| 696 | 114-123 | Chemical | denotes | rituximab | MESH:D000069283 |
| 697 | 137-148 | Chemical | denotes | trastuzumab | MESH:D000068878 |
| 698 | 165-174 | Chemical | denotes | cetuximab | MESH:D000068818 |
| 701 | 69-74 | Disease | denotes | tumor | MESH:D009369 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T352 | 218-226 | Body_part | denotes | backbone | http://purl.org/sig/ont/fma/fma13478 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T64 | 57-61 | Disease | denotes | ADCC | http://purl.obolibrary.org/obo/MONDO_0008734 |
| T65 | 69-74 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T722 | 22-24 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T723 | 205-206 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T724 | 207-212 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T725 | 243-253 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activating |
| T726 | 259-261 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T727 | 299-307 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T211 | 27-35 | Chemical | denotes | effector | http://purl.obolibrary.org/obo/CHEBI_35224 |
| T212 | 114-123 | Chemical | denotes | rituximab | http://purl.obolibrary.org/obo/CHEBI_64357 |
LitCovid-sample-PD-IDO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T206 | 36-45 | http://purl.obolibrary.org/obo/BFO_0000034 | denotes | functions |
LitCovid-sample-Pubtator
| Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
|---|---|---|---|---|---|
| 682 | 155-159 | Gene | denotes | HER2 | Gene:2064 |
| 683 | 181-185 | Gene | denotes | EGFR | Gene:1956 |
| 693 | 259-263 | Gene | denotes | FcγR | Gene:2213 |
| 694 | 22-26 | Gene | denotes | FcγR | Gene:2213 |
| 695 | 207-212 | Species | denotes | human | Tax:9606 |
| 696 | 114-123 | Chemical | denotes | rituximab | MESH:D000069283 |
| 697 | 137-148 | Chemical | denotes | trastuzumab | MESH:D000068878 |
| 698 | 165-174 | Chemical | denotes | cetuximab | MESH:D000068818 |
| 701 | 69-74 | Disease | denotes | tumor | MESH:D009369 |
LitCovid-sample-PD-NCBITaxon
| Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
|---|---|---|---|---|---|
| T42 | 207-212 | Species | denotes | human | NCBItxid:9606 |
LitCovid-sample-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T229 | 0-412 | Sentence | denotes | They may also harness FcγR effector functions, including ADCC in the tumor microenvironment.78 The approved mAbs, rituximab (anti‐CD20), trastuzumab (anti‐HER2) and cetuximab (anti‐EGFR), are formatted on a human IgG1 backbone and all require activating‐type FcγR engagement for optimal therapeutic activity.79, 80 This presents an example where context of therapeutic use is critical for therapeutic mAb design. |
LitCovid-sample-UniProt
| Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
|---|---|---|---|---|---|
| T386 | 130-134 | Protein | denotes | CD20 | https://www.uniprot.org/uniprot/Q3C2E2|https://www.uniprot.org/uniprot/Q13963|https://www.uniprot.org/uniprot/P19437|https://www.uniprot.org/uniprot/P11836|https://www.uniprot.org/uniprot/P08984|https://www.uniprot.org/uniprot/B4DT24|https://www.uniprot.org/uniprot/A6NMS4 |
LitCovid-sample-PD-FMA
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T351 | 218-226 | Body_part | denotes | backbone | http://purl.org/sig/ont/fma/fma13478 |
LitCovid-sample-PD-GO-BP-0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T103 | 57-61 | http://purl.obolibrary.org/obo/GO_0001788 | denotes | ADCC |
| T104 | 181-185 | http://purl.obolibrary.org/obo/GO_0005006 | denotes | EGFR |
LitCovid-sample-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T22 | 69-74 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
LitCovid-sample-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T12 | 69-74 | Phenotype | denotes | tumor | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-sample-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T103 | 57-61 | http://purl.obolibrary.org/obo/GO_0001788 | denotes | ADCC |
| T104 | 181-185 | http://purl.obolibrary.org/obo/GO_0005006 | denotes | EGFR |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T103 | 57-61 | http://purl.obolibrary.org/obo/GO_0001788 | denotes | ADCC |
| T104 | 181-185 | http://purl.obolibrary.org/obo/GO_0005006 | denotes | EGFR |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T229 | 0-412 | Sentence | denotes | They may also harness FcγR effector functions, including ADCC in the tumor microenvironment.78 The approved mAbs, rituximab (anti‐CD20), trastuzumab (anti‐HER2) and cetuximab (anti‐EGFR), are formatted on a human IgG1 backbone and all require activating‐type FcγR engagement for optimal therapeutic activity.79, 80 This presents an example where context of therapeutic use is critical for therapeutic mAb design. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T12 | 69-74 | Phenotype | denotes | tumor | http://purl.obolibrary.org/obo/HP_0002664 |