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PMC:7228307 / 40282-41938 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
680 232-236 Gene denotes HER2 Gene:2064
681 243-247 Gene denotes EGFR Gene:1956
682 405-409 Gene denotes HER2 Gene:2064
683 431-435 Gene denotes EGFR Gene:1956
684 715-723 Gene denotes FcγRIIIa Gene:2214
685 744-751 Gene denotes FcγRIIb Gene:2213
686 804-811 Gene denotes FcγRIIb Gene:2213
687 826-831 Gene denotes FcγRI Gene:2214
688 833-840 Gene denotes FcγRIIa Gene:2212
689 997-1004 Gene denotes FcγRIIb Gene:2213
690 1281-1285 Gene denotes FcγR Gene:2213
691 1047-1051 Gene denotes FcγR Gene:2213
692 704-708 Gene denotes FcγR Gene:2213
693 509-513 Gene denotes FcγR Gene:2213
694 272-276 Gene denotes FcγR Gene:2213
695 457-462 Species denotes human Tax:9606
696 364-373 Chemical denotes rituximab MESH:D000069283
697 387-398 Chemical denotes trastuzumab MESH:D000068878
698 415-424 Chemical denotes cetuximab MESH:D000068818
699 0-20 Disease denotes Cytotoxic mAb cancer MESH:D064420
700 147-166 Disease denotes death of the cancer MESH:D009369
701 319-324 Disease denotes tumor MESH:D009369
702 872-877 Disease denotes tumor MESH:D009369
703 929-935 Disease denotes cancer MESH:D009369

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T350 142-146 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T351 167-171 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T352 468-476 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T353 783-788 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T354 891-901 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T355 936-940 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T356 1118-1122 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T357 1154-1158 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T358 1317-1321 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T62 14-20 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T63 160-166 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T64 307-311 Disease denotes ADCC http://purl.obolibrary.org/obo/MONDO_0008734
T65 319-324 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T66 872-877 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T67 929-935 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T719 142-146 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T720 167-171 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T721 216-225 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T722 272-274 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T723 455-456 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T724 457-462 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T725 493-503 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T726 509-511 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T727 549-557 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T728 693-703 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T729 704-706 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T730 715-717 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T731 744-746 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T732 783-793 http://purl.obolibrary.org/obo/GO_0005623 denotes cells will
T733 804-806 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T734 826-828 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T735 833-835 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T736 845-847 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T737 870-871 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T738 936-940 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T739 997-999 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T740 1019-1028 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T741 1036-1046 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T742 1047-1049 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T743 1118-1122 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T744 1154-1158 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T745 1247-1257 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T746 1259-1260 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T747 1281-1283 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T748 1317-1321 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T749 1327-1328 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T750 1412-1420 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T751 1456-1457 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T752 1570-1571 http://purl.obolibrary.org/obo/CLO_0001020 denotes A

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T211 277-285 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T212 364-373 Chemical denotes rituximab http://purl.obolibrary.org/obo/CHEBI_64357
T213 774-782 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T214 829-831 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T216 1109-1117 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T217 1308-1316 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T203 46-53 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T204 142-146 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T205 167-171 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T206 286-295 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T207 783-793 http://purl.obolibrary.org/obo/CL_0000000 denotes cells will
T208 936-940 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T209 1118-1122 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T210 1154-1158 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T211 1317-1321 http://purl.obolibrary.org/obo/CL_0000000 denotes cell

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
680 232-236 Gene denotes HER2 Gene:2064
681 243-247 Gene denotes EGFR Gene:1956
682 405-409 Gene denotes HER2 Gene:2064
683 431-435 Gene denotes EGFR Gene:1956
684 715-723 Gene denotes FcγRIIIa Gene:2214
685 744-751 Gene denotes FcγRIIb Gene:2213
686 804-811 Gene denotes FcγRIIb Gene:2213
687 826-831 Gene denotes FcγRI Gene:2214
688 833-840 Gene denotes FcγRIIa Gene:2212
689 997-1004 Gene denotes FcγRIIb Gene:2213
690 1281-1285 Gene denotes FcγR Gene:2213
691 1047-1051 Gene denotes FcγR Gene:2213
692 704-708 Gene denotes FcγR Gene:2213
693 509-513 Gene denotes FcγR Gene:2213
694 272-276 Gene denotes FcγR Gene:2213
695 457-462 Species denotes human Tax:9606
696 364-373 Chemical denotes rituximab MESH:D000069283
697 387-398 Chemical denotes trastuzumab MESH:D000068878
698 415-424 Chemical denotes cetuximab MESH:D000068818
699 0-20 Disease denotes Cytotoxic mAb cancer MESH:D064420
700 147-166 Disease denotes death of the cancer MESH:D009369
701 319-324 Disease denotes tumor MESH:D009369
702 872-877 Disease denotes tumor MESH:D009369
703 929-935 Disease denotes cancer MESH:D009369

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T42 457-462 Species denotes human NCBItxid:9606

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T227 0-92 Sentence denotes Cytotoxic mAb cancer therapeutics can control disease progression by one or more mechanisms.
T228 93-249 Sentence denotes Their MOAs include direct induction of apoptotic cell death of the cancer cell (anti‐CD20, anti‐CD52) or blocking receptor signaling (anti‐HER2, anti‐EGFR).
T229 250-662 Sentence denotes They may also harness FcγR effector functions, including ADCC in the tumor microenvironment.78 The approved mAbs, rituximab (anti‐CD20), trastuzumab (anti‐HER2) and cetuximab (anti‐EGFR), are formatted on a human IgG1 backbone and all require activating‐type FcγR engagement for optimal therapeutic activity.79, 80 This presents an example where context of therapeutic use is critical for therapeutic mAb design.
T230 663-752 Sentence denotes IgG1 antibodies bind both the activating FcγR (e.g. FcγRIIIa) and the inhibitory FcγRIIb.
T231 753-902 Sentence denotes In some environments effector cells will coexpress FcγRIIb together with FcγRI, FcγRIIa and FcγIIIa, as may occur on a tumor‐infiltrating macrophage.
T232 903-1159 Sentence denotes Therapy with an IgG1 anti‐cancer cell mAb may then be compromised by the inhibitory action of FcγRIIb upon the ITAM signaling of the activating FcγR as both types of receptor would be coengaged on  such an effector cell by the mAb bound to the target cell.
T233 1160-1206 Sentence denotes This leads to reduced therapeutic mAb potency.
T234 1207-1656 Sentence denotes Thus, the relative contributions of the activating (A) and inhibitory (I) FcγR to the response by an effector cell, the A‐to‐I ratio, may be an important determinant in clinical outcome of therapeutic mAb activity,76, 81, 82 that is, the higher the A‐to‐I ratio, the greater the proinflammatory response induced by the therapeutic mAb or conversely the lower the A‐to‐I ratio, the greater the inhibition or dampening of the proinflammatory response.

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T372 178-182 Protein denotes CD20 https://www.uniprot.org/uniprot/Q3C2E2|https://www.uniprot.org/uniprot/Q13963|https://www.uniprot.org/uniprot/P19437|https://www.uniprot.org/uniprot/P11836|https://www.uniprot.org/uniprot/P08984|https://www.uniprot.org/uniprot/B4DT24|https://www.uniprot.org/uniprot/A6NMS4
T379 189-193 Protein denotes CD52 https://www.uniprot.org/uniprot/Q9BW46|https://www.uniprot.org/uniprot/Q64389|https://www.uniprot.org/uniprot/Q63064|https://www.uniprot.org/uniprot/Q5T138|https://www.uniprot.org/uniprot/Q28896|https://www.uniprot.org/uniprot/P32763|https://www.uniprot.org/uniprot/P31358
T386 380-384 Protein denotes CD20 https://www.uniprot.org/uniprot/Q3C2E2|https://www.uniprot.org/uniprot/Q13963|https://www.uniprot.org/uniprot/P19437|https://www.uniprot.org/uniprot/P11836|https://www.uniprot.org/uniprot/P08984|https://www.uniprot.org/uniprot/B4DT24|https://www.uniprot.org/uniprot/A6NMS4

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T349 142-146 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T350 167-171 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T351 468-476 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T352 783-788 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T353 891-901 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T354 936-940 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T355 1118-1122 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T356 1154-1158 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T357 1317-1321 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T98 132-152 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptotic cell death
T99 142-152 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T100 147-152 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T101 216-225 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T102 243-247 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T103 307-311 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T104 431-435 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T105 1019-1028 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T20 14-20 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T21 160-166 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T22 319-324 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T23 872-877 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T24 929-935 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T10 14-20 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T11 160-166 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T12 319-324 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T13 872-877 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T14 929-935 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T99 132-152 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptotic cell death
T100 142-152 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T101 216-225 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T102 243-247 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T103 307-311 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T104 431-435 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T105 1019-1028 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T99 132-152 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptotic cell death
T100 142-152 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T101 216-225 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T102 243-247 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T103 307-311 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T104 431-435 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T105 1019-1028 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T227 0-92 Sentence denotes Cytotoxic mAb cancer therapeutics can control disease progression by one or more mechanisms.
T228 93-249 Sentence denotes Their MOAs include direct induction of apoptotic cell death of the cancer cell (anti‐CD20, anti‐CD52) or blocking receptor signaling (anti‐HER2, anti‐EGFR).
T229 250-662 Sentence denotes They may also harness FcγR effector functions, including ADCC in the tumor microenvironment.78 The approved mAbs, rituximab (anti‐CD20), trastuzumab (anti‐HER2) and cetuximab (anti‐EGFR), are formatted on a human IgG1 backbone and all require activating‐type FcγR engagement for optimal therapeutic activity.79, 80 This presents an example where context of therapeutic use is critical for therapeutic mAb design.
T230 663-752 Sentence denotes IgG1 antibodies bind both the activating FcγR (e.g. FcγRIIIa) and the inhibitory FcγRIIb.
T231 753-902 Sentence denotes In some environments effector cells will coexpress FcγRIIb together with FcγRI, FcγRIIa and FcγIIIa, as may occur on a tumor‐infiltrating macrophage.
T232 903-1159 Sentence denotes Therapy with an IgG1 anti‐cancer cell mAb may then be compromised by the inhibitory action of FcγRIIb upon the ITAM signaling of the activating FcγR as both types of receptor would be coengaged on  such an effector cell by the mAb bound to the target cell.
T233 1160-1206 Sentence denotes This leads to reduced therapeutic mAb potency.
T234 1207-1656 Sentence denotes Thus, the relative contributions of the activating (A) and inhibitory (I) FcγR to the response by an effector cell, the A‐to‐I ratio, may be an important determinant in clinical outcome of therapeutic mAb activity,76, 81, 82 that is, the higher the A‐to‐I ratio, the greater the proinflammatory response induced by the therapeutic mAb or conversely the lower the A‐to‐I ratio, the greater the inhibition or dampening of the proinflammatory response.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T10 14-20 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T11 160-166 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T12 319-324 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T13 872-877 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T14 929-935 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664