PMC:7228307 / 39412-39881 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"653","span":{"begin":430,"end":434},"obj":"Gene"},{"id":"654","span":{"begin":378,"end":382},"obj":"Gene"},{"id":"655","span":{"begin":87,"end":95},"obj":"Species"}],"attributes":[{"id":"A653","pred":"tao:has_database_id","subj":"653","obj":"Gene:2213"},{"id":"A654","pred":"tao:has_database_id","subj":"654","obj":"Gene:2213"},{"id":"A655","pred":"tao:has_database_id","subj":"655","obj":"Tax:9606"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"They have been used as the backbone for therapeutic mAbs either because recruitment of patients’ effector functions was unlikely to be necessary for the primary MOA of the mAb or is possibly detrimental to the desired therapeutic effect.75 However, the use of these unmodified “inert” subclasses is not without consequences and underscores the need for Fc engineering to modify FcγR interactions—See the “Attenuating and ablating FcγR related functions of IgG” section."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T347","span":{"begin":27,"end":35},"obj":"Body_part"},{"id":"T348","span":{"begin":456,"end":459},"obj":"Body_part"}],"attributes":[{"id":"A347","pred":"fma_id","subj":"T347","obj":"http://purl.org/sig/ont/fma/fma13478"},{"id":"A348","pred":"fma_id","subj":"T348","obj":"http://purl.org/sig/ont/fma/fma62872"}],"text":"They have been used as the backbone for therapeutic mAbs either because recruitment of patients’ effector functions was unlikely to be necessary for the primary MOA of the mAb or is possibly detrimental to the desired therapeutic effect.75 However, the use of these unmodified “inert” subclasses is not without consequences and underscores the need for Fc engineering to modify FcγR interactions—See the “Attenuating and ablating FcγR related functions of IgG” section."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T60","span":{"begin":161,"end":164},"obj":"Disease"}],"attributes":[{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0016702"}],"text":"They have been used as the backbone for therapeutic mAbs either because recruitment of patients’ effector functions was unlikely to be necessary for the primary MOA of the mAb or is possibly detrimental to the desired therapeutic effect.75 However, the use of these unmodified “inert” subclasses is not without consequences and underscores the need for Fc engineering to modify FcγR interactions—See the “Attenuating and ablating FcγR related functions of IgG” section."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T713","span":{"begin":353,"end":355},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T714","span":{"begin":378,"end":380},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T715","span":{"begin":430,"end":432},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"}],"text":"They have been used as the backbone for therapeutic mAbs either because recruitment of patients’ effector functions was unlikely to be necessary for the primary MOA of the mAb or is possibly detrimental to the desired therapeutic effect.75 However, the use of these unmodified “inert” subclasses is not without consequences and underscores the need for Fc engineering to modify FcγR interactions—See the “Attenuating and ablating FcγR related functions of IgG” section."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T210","span":{"begin":97,"end":105},"obj":"Chemical"}],"attributes":[{"id":"A210","pred":"chebi_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"}],"text":"They have been used as the backbone for therapeutic mAbs either because recruitment of patients’ effector functions was unlikely to be necessary for the primary MOA of the mAb or is possibly detrimental to the desired therapeutic effect.75 However, the use of these unmodified “inert” subclasses is not without consequences and underscores the need for Fc engineering to modify FcγR interactions—See the “Attenuating and ablating FcγR related functions of IgG” section."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T201","span":{"begin":106,"end":115},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"},{"id":"T202","span":{"begin":443,"end":452},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"}],"text":"They have been used as the backbone for therapeutic mAbs either because recruitment of patients’ effector functions was unlikely to be necessary for the primary MOA of the mAb or is possibly detrimental to the desired therapeutic effect.75 However, the use of these unmodified “inert” subclasses is not without consequences and underscores the need for Fc engineering to modify FcγR interactions—See the “Attenuating and ablating FcγR related functions of IgG” section."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"653","span":{"begin":430,"end":434},"obj":"Gene"},{"id":"654","span":{"begin":378,"end":382},"obj":"Gene"},{"id":"655","span":{"begin":87,"end":95},"obj":"Species"},{"id":"979","span":{"begin":430,"end":434},"obj":"Gene"}],"attributes":[{"id":"A653","pred":"pubann:denotes","subj":"653","obj":"Gene:2213"},{"id":"A654","pred":"pubann:denotes","subj":"654","obj":"Gene:2213"},{"id":"A655","pred":"pubann:denotes","subj":"655","obj":"Tax:9606"},{"id":"A979","pred":"pubann:denotes","subj":"979","obj":"Gene:2213"}],"text":"They have been used as the backbone for therapeutic mAbs either because recruitment of patients’ effector functions was unlikely to be necessary for the primary MOA of the mAb or is possibly detrimental to the desired therapeutic effect.75 However, the use of these unmodified “inert” subclasses is not without consequences and underscores the need for Fc engineering to modify FcγR interactions—See the “Attenuating and ablating FcγR related functions of IgG” section."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T223","span":{"begin":0,"end":469},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"They have been used as the backbone for therapeutic mAbs either because recruitment of patients’ effector functions was unlikely to be necessary for the primary MOA of the mAb or is possibly detrimental to the desired therapeutic effect.75 However, the use of these unmodified “inert” subclasses is not without consequences and underscores the need for Fc engineering to modify FcγR interactions—See the “Attenuating and ablating FcγR related functions of IgG” section."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T346","span":{"begin":27,"end":35},"obj":"Body_part"},{"id":"T347","span":{"begin":456,"end":459},"obj":"Body_part"}],"attributes":[{"id":"A346","pred":"fma_id","subj":"T346","obj":"http://purl.org/sig/ont/fma/fma13478"},{"id":"A347","pred":"fma_id","subj":"T347","obj":"http://purl.org/sig/ont/fma/fma62872"}],"text":"They have been used as the backbone for therapeutic mAbs either because recruitment of patients’ effector functions was unlikely to be necessary for the primary MOA of the mAb or is possibly detrimental to the desired therapeutic effect.75 However, the use of these unmodified “inert” subclasses is not without consequences and underscores the need for Fc engineering to modify FcγR interactions—See the “Attenuating and ablating FcγR related functions of IgG” section."}

{"project":"LitCovid-sentences","denotations":[{"id":"T223","span":{"begin":0,"end":469},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"They have been used as the backbone for therapeutic mAbs either because recruitment of patients’ effector functions was unlikely to be necessary for the primary MOA of the mAb or is possibly detrimental to the desired therapeutic effect.75 However, the use of these unmodified “inert” subclasses is not without consequences and underscores the need for Fc engineering to modify FcγR interactions—See the “Attenuating and ablating FcγR related functions of IgG” section."}