PMC:7228307 / 33148-33795 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7228307","sourcedb":"PMC","sourceid":"7228307","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7228307","text":"IgG4 and IgG2 have more restricted FcγR specificity. IgG4 has low affinity (KA = ~2 × 105 m –1) for the inhibitory FcγRIIb, but is also a high‐affinity ligand for FcγRI (KA = ~4 × 108 m –1). IgG2 exhibits a highly restricted specificity, showing functional activity with only one polymorphic form of FcγRIIa (binding affinity KA = ~4.5 × 105 m –1) which is permitted by the presence of histidine at position 131 of its IgG‐binding site. This FcγRIIa–H131 form is expressed in approximately 70% of the population, whereas IgG2 has no functional activity on the other common allelic form, FcγRIIa‐R131, which contains arginine at position 131.11, 61","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"572","span":{"begin":115,"end":122},"obj":"Gene"},{"id":"573","span":{"begin":163,"end":168},"obj":"Gene"},{"id":"574","span":{"begin":300,"end":307},"obj":"Gene"},{"id":"575","span":{"begin":35,"end":39},"obj":"Gene"},{"id":"576","span":{"begin":386,"end":395},"obj":"Chemical"},{"id":"577","span":{"begin":616,"end":624},"obj":"Chemical"}],"attributes":[{"id":"A572","pred":"tao:has_database_id","subj":"572","obj":"Gene:2213"},{"id":"A573","pred":"tao:has_database_id","subj":"573","obj":"Gene:2214"},{"id":"A574","pred":"tao:has_database_id","subj":"574","obj":"Gene:2212"},{"id":"A575","pred":"tao:has_database_id","subj":"575","obj":"Gene:2213"},{"id":"A576","pred":"tao:has_database_id","subj":"576","obj":"MESH:D006639"},{"id":"A577","pred":"tao:has_database_id","subj":"577","obj":"MESH:D001120"},{"subj":"572","pred":"source","obj":"LitCovid-PubTator"},{"subj":"573","pred":"source","obj":"LitCovid-PubTator"},{"subj":"574","pred":"source","obj":"LitCovid-PubTator"},{"subj":"575","pred":"source","obj":"LitCovid-PubTator"},{"subj":"576","pred":"source","obj":"LitCovid-PubTator"},{"subj":"577","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T324","span":{"begin":386,"end":395},"obj":"Body_part"},{"id":"T325","span":{"begin":419,"end":422},"obj":"Body_part"},{"id":"T326","span":{"begin":616,"end":624},"obj":"Body_part"}],"attributes":[{"id":"A324","pred":"fma_id","subj":"T324","obj":"http://purl.org/sig/ont/fma/fma82755"},{"id":"A325","pred":"fma_id","subj":"T325","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A326","pred":"fma_id","subj":"T326","obj":"http://purl.org/sig/ont/fma/fma82763"},{"subj":"T324","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T325","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T326","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T626","span":{"begin":35,"end":37},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T627","span":{"begin":58,"end":61},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T628","span":{"begin":90,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0007437"},{"id":"T629","span":{"begin":90,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0007448"},{"id":"T630","span":{"begin":90,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0007449"},{"id":"T631","span":{"begin":90,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0050175"},{"id":"T632","span":{"begin":90,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0052399"},{"id":"T633","span":{"begin":115,"end":117},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T634","span":{"begin":136,"end":137},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T635","span":{"begin":163,"end":165},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T636","span":{"begin":184,"end":188},"obj":"http://purl.obolibrary.org/obo/CLO_0007437"},{"id":"T637","span":{"begin":184,"end":188},"obj":"http://purl.obolibrary.org/obo/CLO_0007448"},{"id":"T638","span":{"begin":184,"end":188},"obj":"http://purl.obolibrary.org/obo/CLO_0007449"},{"id":"T639","span":{"begin":184,"end":188},"obj":"http://purl.obolibrary.org/obo/CLO_0050175"},{"id":"T640","span":{"begin":184,"end":188},"obj":"http://purl.obolibrary.org/obo/CLO_0052399"},{"id":"T641","span":{"begin":205,"end":206},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T642","span":{"begin":257,"end":265},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T643","span":{"begin":300,"end":302},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T644","span":{"begin":342,"end":346},"obj":"http://purl.obolibrary.org/obo/CLO_0007437"},{"id":"T645","span":{"begin":342,"end":346},"obj":"http://purl.obolibrary.org/obo/CLO_0007448"},{"id":"T646","span":{"begin":342,"end":346},"obj":"http://purl.obolibrary.org/obo/CLO_0007449"},{"id":"T647","span":{"begin":342,"end":346},"obj":"http://purl.obolibrary.org/obo/CLO_0050175"},{"id":"T648","span":{"begin":342,"end":346},"obj":"http://purl.obolibrary.org/obo/CLO_0052399"},{"id":"T649","span":{"begin":442,"end":444},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T650","span":{"begin":526,"end":529},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T651","span":{"begin":544,"end":552},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T652","span":{"begin":587,"end":589},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"}],"attributes":[{"subj":"T626","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T627","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T628","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T629","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T630","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T631","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T632","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T633","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T634","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T635","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T636","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T637","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T638","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T639","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T640","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T641","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T642","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T643","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T644","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T645","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T646","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T647","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T648","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T649","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T650","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T651","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T652","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T177","span":{"begin":152,"end":158},"obj":"Chemical"},{"id":"T178","span":{"begin":166,"end":168},"obj":"Chemical"},{"id":"T180","span":{"begin":386,"end":395},"obj":"Chemical"},{"id":"T181","span":{"begin":616,"end":624},"obj":"Chemical"}],"attributes":[{"id":"A177","pred":"chebi_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A178","pred":"chebi_id","subj":"T178","obj":"http://purl.obolibrary.org/obo/CHEBI_73814"},{"id":"A179","pred":"chebi_id","subj":"T178","obj":"http://purl.obolibrary.org/obo/CHEBI_8753"},{"id":"A180","pred":"chebi_id","subj":"T180","obj":"http://purl.obolibrary.org/obo/CHEBI_27570"},{"id":"A181","pred":"chebi_id","subj":"T181","obj":"http://purl.obolibrary.org/obo/CHEBI_16467"},{"id":"A182","pred":"chebi_id","subj":"T181","obj":"http://purl.obolibrary.org/obo/CHEBI_29016"},{"id":"A183","pred":"chebi_id","subj":"T181","obj":"http://purl.obolibrary.org/obo/CHEBI_32696"},{"subj":"T177","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T178","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T180","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T181","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T193","span":{"begin":246,"end":256},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"},{"id":"T194","span":{"begin":431,"end":435},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"},{"id":"T195","span":{"begin":533,"end":543},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"}],"attributes":[{"subj":"T193","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T194","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T195","pred":"source","obj":"LitCovid-sample-PD-IDO"}]},{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T33","span":{"begin":386,"end":395},"obj":"Chemical"},{"id":"T34","span":{"begin":616,"end":624},"obj":"Chemical"}],"attributes":[{"id":"A33","pred":"chebi_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/CHEBI_27570"},{"id":"A34","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_32696"},{"id":"A35","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_16467"},{"id":"A36","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_29016"},{"subj":"T33","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T34","pred":"source","obj":"LitCovid-sample-CHEBI"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"572","span":{"begin":115,"end":122},"obj":"Gene"},{"id":"573","span":{"begin":163,"end":168},"obj":"Gene"},{"id":"574","span":{"begin":300,"end":307},"obj":"Gene"},{"id":"575","span":{"begin":35,"end":39},"obj":"Gene"},{"id":"576","span":{"begin":386,"end":395},"obj":"Chemical"},{"id":"577","span":{"begin":616,"end":624},"obj":"Chemical"}],"attributes":[{"id":"A572","pred":"pubann:denotes","subj":"572","obj":"Gene:2213"},{"id":"A573","pred":"pubann:denotes","subj":"573","obj":"Gene:2214"},{"id":"A574","pred":"pubann:denotes","subj":"574","obj":"Gene:2212"},{"id":"A575","pred":"pubann:denotes","subj":"575","obj":"Gene:2213"},{"id":"A576","pred":"pubann:denotes","subj":"576","obj":"MESH:D006639"},{"id":"A577","pred":"pubann:denotes","subj":"577","obj":"MESH:D001120"},{"subj":"572","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"573","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"574","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"575","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"576","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"577","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T187","span":{"begin":0,"end":52},"obj":"Sentence"},{"id":"T188","span":{"begin":53,"end":190},"obj":"Sentence"},{"id":"T189","span":{"begin":191,"end":436},"obj":"Sentence"},{"id":"T190","span":{"begin":437,"end":647},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T187","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T188","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T189","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T190","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T366","span":{"begin":76,"end":83},"obj":"Protein"}],"attributes":[{"id":"A366","pred":"uniprot_id","subj":"T366","obj":"https://www.uniprot.org/uniprot/Q8WWG8"},{"id":"A367","pred":"uniprot_id","subj":"T366","obj":"https://www.uniprot.org/uniprot/Q63273"},{"id":"A368","pred":"uniprot_id","subj":"T366","obj":"https://www.uniprot.org/uniprot/Q62643"},{"id":"A369","pred":"uniprot_id","subj":"T366","obj":"https://www.uniprot.org/uniprot/Q61626"},{"id":"A370","pred":"uniprot_id","subj":"T366","obj":"https://www.uniprot.org/uniprot/Q16478"},{"id":"A371","pred":"uniprot_id","subj":"T366","obj":"https://www.uniprot.org/uniprot/G5E822"},{"subj":"T366","pred":"source","obj":"LitCovid-sample-UniProt"}]},{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T323","span":{"begin":386,"end":395},"obj":"Body_part"},{"id":"T324","span":{"begin":419,"end":422},"obj":"Body_part"},{"id":"T325","span":{"begin":616,"end":624},"obj":"Body_part"}],"attributes":[{"id":"A323","pred":"fma_id","subj":"T323","obj":"http://purl.org/sig/ont/fma/fma82755"},{"id":"A324","pred":"fma_id","subj":"T324","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A325","pred":"fma_id","subj":"T325","obj":"http://purl.org/sig/ont/fma/fma82763"},{"subj":"T323","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T324","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T325","pred":"source","obj":"LitCovid-sample-PD-FMA"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T187","span":{"begin":0,"end":52},"obj":"Sentence"},{"id":"T188","span":{"begin":53,"end":190},"obj":"Sentence"},{"id":"T189","span":{"begin":191,"end":436},"obj":"Sentence"},{"id":"T190","span":{"begin":437,"end":647},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T187","pred":"source","obj":"LitCovid-sentences"},{"subj":"T188","pred":"source","obj":"LitCovid-sentences"},{"subj":"T189","pred":"source","obj":"LitCovid-sentences"},{"subj":"T190","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93dcec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ece293"},{"id":"LitCovid-PD-CLO","color":"#c893ec"},{"id":"LitCovid-PD-CHEBI","color":"#93ecae"},{"id":"LitCovid-sample-PD-IDO","color":"#ec9493"},{"id":"LitCovid-sample-CHEBI","color":"#93abec"},{"id":"LitCovid-sample-Pubtator","color":"#c5ec93"},{"id":"LitCovid-sample-sentences","color":"#ec93df"},{"id":"LitCovid-sample-UniProt","color":"#93ecde"},{"id":"LitCovid-sample-PD-FMA","color":"#ecc493"},{"id":"LitCovid-sentences","color":"#aa93ec"}]}]}}