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PMC:7228307 / 30969-33795 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
544 807-812 Gene denotes FcγRI Gene:2214
545 1072-1077 Gene denotes FcγRI Gene:2214
546 1143-1155 Gene denotes interferon‐γ Gene:3458
547 510-514 Gene denotes FcγR Gene:2213
548 370-374 Gene denotes FcγR Gene:2213
549 1212-1224 Disease denotes inflammation MESH:D007249
554 1417-1421 Gene denotes IgG3 Gene:3502
555 1672-1679 Gene denotes FcγRIIb Gene:2213
556 1721-1728 Gene denotes FcγRIII Gene:2214
557 1239-1244 Species denotes human Tax:9606
562 1931-1939 Gene denotes FcγRIIIa Gene:2214
563 1860-1864 Gene denotes FcγR Gene:2213
564 2035-2048 Chemical denotes phenylalanine MESH:D010649
565 2049-2055 Chemical denotes valine MESH:D014633
572 2294-2301 Gene denotes FcγRIIb Gene:2213
573 2342-2347 Gene denotes FcγRI Gene:2214
574 2479-2486 Gene denotes FcγRIIa Gene:2212
575 2214-2218 Gene denotes FcγR Gene:2213
576 2565-2574 Chemical denotes histidine MESH:D006639
577 2795-2803 Chemical denotes arginine MESH:D001120

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T308 0-3 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T309 145-148 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T310 181-184 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T311 331-343 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T312 331-335 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T313 642-645 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T314 755-758 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T315 885-888 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T316 986-989 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T317 1000-1003 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T318 1126-1131 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T319 1245-1248 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T320 1314-1324 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T321 2035-2048 Body_part denotes phenylalanine http://purl.org/sig/ont/fma/fma82754
T322 2049-2055 Body_part denotes valine http://purl.org/sig/ont/fma/fma82766
T323 2089-2092 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T324 2565-2574 Body_part denotes histidine http://purl.org/sig/ont/fma/fma82755
T325 2598-2601 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T326 2795-2803 Body_part denotes arginine http://purl.org/sig/ont/fma/fma82763

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T55 1212-1224 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T601 45-47 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T602 55-57 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T603 58-60 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T604 149-151 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T605 331-335 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T606 370-372 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T607 472-474 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T608 510-512 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T609 556-558 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T610 559-561 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T611 807-809 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T612 1072-1074 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T613 1126-1131 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T614 1239-1248 http://purl.obolibrary.org/obo/CLO_0053695 denotes human IgG
T615 1473-1475 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T616 1476-1478 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T617 1649-1651 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T618 1652-1654 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T619 1672-1674 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T620 1721-1723 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T621 1766-1767 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T622 1860-1862 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T623 1931-1933 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T624 2115-2117 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T625 2159-2161 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T626 2214-2216 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T627 2237-2240 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T628 2269-2273 http://purl.obolibrary.org/obo/CLO_0007437 denotes m –1
T629 2269-2273 http://purl.obolibrary.org/obo/CLO_0007448 denotes m –1
T630 2269-2273 http://purl.obolibrary.org/obo/CLO_0007449 denotes m –1
T631 2269-2273 http://purl.obolibrary.org/obo/CLO_0050175 denotes m –1
T632 2269-2273 http://purl.obolibrary.org/obo/CLO_0052399 denotes m –1
T633 2294-2296 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T634 2315-2316 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T635 2342-2344 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T636 2363-2367 http://purl.obolibrary.org/obo/CLO_0007437 denotes m –1
T637 2363-2367 http://purl.obolibrary.org/obo/CLO_0007448 denotes m –1
T638 2363-2367 http://purl.obolibrary.org/obo/CLO_0007449 denotes m –1
T639 2363-2367 http://purl.obolibrary.org/obo/CLO_0050175 denotes m –1
T640 2363-2367 http://purl.obolibrary.org/obo/CLO_0052399 denotes m –1
T641 2384-2385 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T642 2436-2444 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T643 2479-2481 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T644 2521-2525 http://purl.obolibrary.org/obo/CLO_0007437 denotes m –1
T645 2521-2525 http://purl.obolibrary.org/obo/CLO_0007448 denotes m –1
T646 2521-2525 http://purl.obolibrary.org/obo/CLO_0007449 denotes m –1
T647 2521-2525 http://purl.obolibrary.org/obo/CLO_0050175 denotes m –1
T648 2521-2525 http://purl.obolibrary.org/obo/CLO_0052399 denotes m –1
T649 2621-2623 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T650 2705-2708 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T651 2723-2731 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T652 2766-2768 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T161 240-247 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T162 322-330 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T163 375-384 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T164 810-812 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T166 1075-1077 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T168 1143-1153 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T169 1314-1324 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T170 1314-1319 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T171 1320-1324 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T172 1438-1445 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T173 1523-1525 Chemical denotes KD http://purl.obolibrary.org/obo/CHEBI_73601
T174 2035-2048 Chemical denotes phenylalanine http://purl.obolibrary.org/obo/CHEBI_28044|http://purl.obolibrary.org/obo/CHEBI_58095
T176 2049-2055 Chemical denotes valine http://purl.obolibrary.org/obo/CHEBI_27266
T177 2331-2337 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T178 2345-2347 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T180 2565-2574 Chemical denotes histidine http://purl.obolibrary.org/obo/CHEBI_27570
T181 2795-2803 Chemical denotes arginine http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_32696

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T188 331-335 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T189 1126-1131 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T190 1203-1208 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T191 1385-1395 http://purl.obolibrary.org/obo/BFO_0000034 denotes functional
T192 2101-2105 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T193 2425-2435 http://purl.obolibrary.org/obo/BFO_0000034 denotes functional
T194 2610-2614 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T195 2712-2722 http://purl.obolibrary.org/obo/BFO_0000034 denotes functional

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T29 1314-1324 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T30 2035-2048 Chemical denotes phenylalanine http://purl.obolibrary.org/obo/CHEBI_28044|http://purl.obolibrary.org/obo/CHEBI_58095
T32 2049-2055 Chemical denotes valine http://purl.obolibrary.org/obo/CHEBI_27266
T33 2565-2574 Chemical denotes histidine http://purl.obolibrary.org/obo/CHEBI_27570
T34 2795-2803 Chemical denotes arginine http://purl.obolibrary.org/obo/CHEBI_32696|http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
544 807-812 Gene denotes FcγRI Gene:2214
545 1072-1077 Gene denotes FcγRI Gene:2214
546 1143-1155 Gene denotes interferon‐γ Gene:3458
547 510-514 Gene denotes FcγR Gene:2213
548 370-374 Gene denotes FcγR Gene:2213
549 1212-1224 Disease denotes inflammation MESH:D007249
554 1417-1421 Gene denotes IgG3 Gene:3502
555 1672-1679 Gene denotes FcγRIIb Gene:2213
556 1721-1728 Gene denotes FcγRIII Gene:2214
557 1239-1244 Species denotes human Tax:9606
562 1931-1939 Gene denotes FcγRIIIa Gene:2214
563 1860-1864 Gene denotes FcγR Gene:2213
564 2035-2048 Chemical denotes phenylalanine MESH:D010649
565 2049-2055 Chemical denotes valine MESH:D014633
572 2294-2301 Gene denotes FcγRIIb Gene:2213
573 2342-2347 Gene denotes FcγRI Gene:2214
574 2479-2486 Gene denotes FcγRIIa Gene:2212
575 2214-2218 Gene denotes FcγR Gene:2213
576 2565-2574 Chemical denotes histidine MESH:D006639
577 2795-2803 Chemical denotes arginine MESH:D001120

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T38 1239-1244 Species denotes human NCBItxid:9606

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T173 0-49 Sentence denotes IgG subclasses: specificity and affinity for FcγR
T174 50-273 Sentence denotes Most FcγRs (Table 2) are weak, low‐affinity receptors (affinities in the micromolar range) for IgG‐Fc, irrespective of whether the IgG is uncomplexed, monomeric or when it is complexed with antigen (i.e. an immune complex).
T175 274-515 Sentence denotes The very avid binding of immune complexes to an effector cell surface that displays an array of FcγR molecules is the result of the collective contributions of the low‐affinity interactions of each Fc of the IgGs in the complex with an FcγR.
T176 516-668 Sentence denotes This avidity effect is necessary as the FcγRs operate in vivo in environments of high concentrations of uncomplexed monomeric IgG (normally 3–12 g L–1).
T177 669-759 Sentence denotes Thus, the avid multivalent binding of the complex out competes uncomplexed, monomeric IgG.
T178 760-813 Sentence denotes The notable exception to this is the enigmatic FcγRI.
T179 814-990 Sentence denotes This receptor shows high, nanomolar affinity for uncomplexed monomeric IgG and thus would be expected to be constantly occupied in vivo by the normal circulating monomeric IgG.
T180 991-1058 Sentence denotes However, IgG dissociation permits engagement with immune complexes.
T181 1059-1225 Sentence denotes Furthermore, FcγRI is not expressed or expressed poorly on resting cells, requiring interferon‐γ for induction of its expression, presumably at sites of inflammation.
T182 1226-1407 Sentence denotes Although the human IgG heavy‐chain constant domains have greater than 90% identity, key amino acid differences confer each subclass with unique structural and functional properties.
T183 1408-1479 Sentence denotes IgG1 and IgG3 are “universal” ligands, that is, they bind to all FcγRs.
T184 1480-1802 Sentence denotes Formal measurement of the weak, micromolar KD interactions of the low‐affinity receptors with monomeric IgG1 also revealed differing affinities between the low‐affinity FcγRs, with inhibitory FcγRIIb generally having the lowest affinity and FcγRIII the higher, sometimes referred to as a “moderate” affinity receptor.7, 61
T185 1803-1966 Sentence denotes The strength of IgG1 interaction can also be affected by FcγR polymorphism and in the context of therapeutic mAbs, variation in FcγRIIIa is particularly important.
T186 1967-2178 Sentence denotes The most common and possibly clinically significant polymorphism is phenylalanine/valine variation at position 158 in the IgG‐binding site, wherein FcγRIIIa‐F158 binds IgG1 less well than the FcγRIIIa‐V158 form.
T187 2179-2231 Sentence denotes IgG4 and IgG2 have more restricted FcγR specificity.
T188 2232-2369 Sentence denotes IgG4 has low affinity (KA = ~2 × 105 m –1) for the inhibitory FcγRIIb, but is also a high‐affinity ligand for FcγRI (KA = ~4 × 108 m –1).
T189 2370-2615 Sentence denotes IgG2 exhibits a highly restricted specificity, showing functional activity with only one polymorphic form of FcγRIIa (binding affinity KA = ~4.5 × 105 m –1) which is permitted by the presence of histidine at position 131 of its IgG‐binding site.
T190 2616-2826 Sentence denotes This FcγRIIa–H131 form is expressed in approximately 70% of the population, whereas IgG2 has no functional activity on the other common allelic form, FcγRIIa‐R131, which contains arginine at position 131.11, 61

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T364 1143-1153 Protein denotes interferon https://www.uniprot.org/uniprot/P51527|https://www.uniprot.org/uniprot/P51526
T366 2255-2262 Protein denotes KA = ~2 https://www.uniprot.org/uniprot/Q8WWG8|https://www.uniprot.org/uniprot/Q63273|https://www.uniprot.org/uniprot/Q62643|https://www.uniprot.org/uniprot/Q61626|https://www.uniprot.org/uniprot/Q16478|https://www.uniprot.org/uniprot/G5E822

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T307 0-3 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T308 145-148 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T309 181-184 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T310 331-343 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T311 331-335 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T312 642-645 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T313 755-758 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T314 885-888 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T315 986-989 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T316 1000-1003 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T317 1126-1131 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T318 1245-1248 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T319 1314-1324 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T320 2035-2048 Body_part denotes phenylalanine http://purl.org/sig/ont/fma/fma82754
T321 2049-2055 Body_part denotes valine http://purl.org/sig/ont/fma/fma82766
T322 2089-2092 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T323 2565-2574 Body_part denotes histidine http://purl.org/sig/ont/fma/fma82755
T324 2598-2601 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T325 2795-2803 Body_part denotes arginine http://purl.org/sig/ont/fma/fma82763

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T90 1212-1224 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T19 1212-1224 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T91 1212-1224 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T91 1212-1224 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T173 0-49 Sentence denotes IgG subclasses: specificity and affinity for FcγR
T174 50-273 Sentence denotes Most FcγRs (Table 2) are weak, low‐affinity receptors (affinities in the micromolar range) for IgG‐Fc, irrespective of whether the IgG is uncomplexed, monomeric or when it is complexed with antigen (i.e. an immune complex).
T175 274-515 Sentence denotes The very avid binding of immune complexes to an effector cell surface that displays an array of FcγR molecules is the result of the collective contributions of the low‐affinity interactions of each Fc of the IgGs in the complex with an FcγR.
T176 516-668 Sentence denotes This avidity effect is necessary as the FcγRs operate in vivo in environments of high concentrations of uncomplexed monomeric IgG (normally 3–12 g L–1).
T177 669-759 Sentence denotes Thus, the avid multivalent binding of the complex out competes uncomplexed, monomeric IgG.
T178 760-813 Sentence denotes The notable exception to this is the enigmatic FcγRI.
T179 814-990 Sentence denotes This receptor shows high, nanomolar affinity for uncomplexed monomeric IgG and thus would be expected to be constantly occupied in vivo by the normal circulating monomeric IgG.
T180 991-1058 Sentence denotes However, IgG dissociation permits engagement with immune complexes.
T181 1059-1225 Sentence denotes Furthermore, FcγRI is not expressed or expressed poorly on resting cells, requiring interferon‐γ for induction of its expression, presumably at sites of inflammation.
T182 1226-1407 Sentence denotes Although the human IgG heavy‐chain constant domains have greater than 90% identity, key amino acid differences confer each subclass with unique structural and functional properties.
T183 1408-1479 Sentence denotes IgG1 and IgG3 are “universal” ligands, that is, they bind to all FcγRs.
T184 1480-1802 Sentence denotes Formal measurement of the weak, micromolar KD interactions of the low‐affinity receptors with monomeric IgG1 also revealed differing affinities between the low‐affinity FcγRs, with inhibitory FcγRIIb generally having the lowest affinity and FcγRIII the higher, sometimes referred to as a “moderate” affinity receptor.7, 61
T185 1803-1966 Sentence denotes The strength of IgG1 interaction can also be affected by FcγR polymorphism and in the context of therapeutic mAbs, variation in FcγRIIIa is particularly important.
T186 1967-2178 Sentence denotes The most common and possibly clinically significant polymorphism is phenylalanine/valine variation at position 158 in the IgG‐binding site, wherein FcγRIIIa‐F158 binds IgG1 less well than the FcγRIIIa‐V158 form.
T187 2179-2231 Sentence denotes IgG4 and IgG2 have more restricted FcγR specificity.
T188 2232-2369 Sentence denotes IgG4 has low affinity (KA = ~2 × 105 m –1) for the inhibitory FcγRIIb, but is also a high‐affinity ligand for FcγRI (KA = ~4 × 108 m –1).
T189 2370-2615 Sentence denotes IgG2 exhibits a highly restricted specificity, showing functional activity with only one polymorphic form of FcγRIIa (binding affinity KA = ~4.5 × 105 m –1) which is permitted by the presence of histidine at position 131 of its IgG‐binding site.
T190 2616-2826 Sentence denotes This FcγRIIa–H131 form is expressed in approximately 70% of the population, whereas IgG2 has no functional activity on the other common allelic form, FcγRIIa‐R131, which contains arginine at position 131.11, 61