PMC:7228307 / 28230-28931 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"504","span":{"begin":365,"end":370},"obj":"Gene"},{"id":"505","span":{"begin":130,"end":134},"obj":"Gene"},{"id":"506","span":{"begin":39,"end":43},"obj":"Gene"},{"id":"507","span":{"begin":359,"end":364},"obj":"Species"},{"id":"508","span":{"begin":414,"end":418},"obj":"Species"},{"id":"509","span":{"begin":374,"end":379},"obj":"Species"}],"attributes":[{"id":"A504","pred":"tao:has_database_id","subj":"504","obj":"Gene:2214"},{"id":"A505","pred":"tao:has_database_id","subj":"505","obj":"Gene:2213"},{"id":"A506","pred":"tao:has_database_id","subj":"506","obj":"Gene:2213"},{"id":"A507","pred":"tao:has_database_id","subj":"507","obj":"Tax:9606"},{"id":"A508","pred":"tao:has_database_id","subj":"508","obj":"Tax:10090"},{"id":"A509","pred":"tao:has_database_id","subj":"509","obj":"Tax:9606"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Nonetheless, the active involvement of FcγR in the enhancement of antigen‐specific immunity by uptake of immune complexes through FcγR is historically well documented in experimental systems where FcγRs bind immune complexes and thereby feed antigens into the antigen‐presentation pathways.53 This has been demonstrated in vivo for small immune complexes via human FcγRI on human antigen‐presenting cells54 and in mice.19 Similarly, the capacity of FcγRIIbs to bind and rapidly internalize antigen–antibody complexes suggests that it too may significantly influence feeding antigens into professional antigen‐presenting cells of hematopoietic origin such as dendritic cells and possibly B lymphocytes."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T272","span":{"begin":498,"end":506},"obj":"Body_part"},{"id":"T273","span":{"begin":601,"end":625},"obj":"Body_part"},{"id":"T274","span":{"begin":620,"end":625},"obj":"Body_part"},{"id":"T275","span":{"begin":658,"end":673},"obj":"Body_part"},{"id":"T276","span":{"begin":668,"end":673},"obj":"Body_part"},{"id":"T277","span":{"begin":687,"end":700},"obj":"Body_part"}],"attributes":[{"id":"A272","pred":"fma_id","subj":"T272","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A273","pred":"fma_id","subj":"T273","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A274","pred":"fma_id","subj":"T274","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A275","pred":"fma_id","subj":"T275","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A276","pred":"fma_id","subj":"T276","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A277","pred":"fma_id","subj":"T277","obj":"http://purl.org/sig/ont/fma/fma62869"}],"text":"Nonetheless, the active involvement of FcγR in the enhancement of antigen‐specific immunity by uptake of immune complexes through FcγR is historically well documented in experimental systems where FcγRs bind immune complexes and thereby feed antigens into the antigen‐presentation pathways.53 This has been demonstrated in vivo for small immune complexes via human FcγRI on human antigen‐presenting cells54 and in mice.19 Similarly, the capacity of FcγRIIbs to bind and rapidly internalize antigen–antibody complexes suggests that it too may significantly influence feeding antigens into professional antigen‐presenting cells of hematopoietic origin such as dendritic cells and possibly B lymphocytes."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T539","span":{"begin":17,"end":23},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T540","span":{"begin":39,"end":41},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T541","span":{"begin":130,"end":132},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T542","span":{"begin":197,"end":199},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T543","span":{"begin":200,"end":202},"obj":"http://purl.obolibrary.org/obo/CLO_0008882"},{"id":"T544","span":{"begin":298,"end":301},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T545","span":{"begin":359,"end":364},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T546","span":{"begin":365,"end":367},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T547","span":{"begin":374,"end":379},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T548","span":{"begin":449,"end":451},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T549","span":{"begin":620,"end":625},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T550","span":{"begin":658,"end":673},"obj":"http://purl.obolibrary.org/obo/CL_0000451"},{"id":"T551","span":{"begin":687,"end":688},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"}],"text":"Nonetheless, the active involvement of FcγR in the enhancement of antigen‐specific immunity by uptake of immune complexes through FcγR is historically well documented in experimental systems where FcγRs bind immune complexes and thereby feed antigens into the antigen‐presentation pathways.53 This has been demonstrated in vivo for small immune complexes via human FcγRI on human antigen‐presenting cells54 and in mice.19 Similarly, the capacity of FcγRIIbs to bind and rapidly internalize antigen–antibody complexes suggests that it too may significantly influence feeding antigens into professional antigen‐presenting cells of hematopoietic origin such as dendritic cells and possibly B lymphocytes."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T146","span":{"begin":66,"end":73},"obj":"Chemical"},{"id":"T147","span":{"begin":242,"end":250},"obj":"Chemical"},{"id":"T148","span":{"begin":260,"end":267},"obj":"Chemical"},{"id":"T149","span":{"begin":368,"end":370},"obj":"Chemical"},{"id":"T151","span":{"begin":380,"end":387},"obj":"Chemical"},{"id":"T152","span":{"begin":490,"end":497},"obj":"Chemical"},{"id":"T153","span":{"begin":574,"end":582},"obj":"Chemical"},{"id":"T154","span":{"begin":601,"end":608},"obj":"Chemical"}],"attributes":[{"id":"A146","pred":"chebi_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A147","pred":"chebi_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A148","pred":"chebi_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A149","pred":"chebi_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/CHEBI_73814"},{"id":"A150","pred":"chebi_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/CHEBI_8753"},{"id":"A151","pred":"chebi_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A152","pred":"chebi_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A153","pred":"chebi_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A154","pred":"chebi_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"}],"text":"Nonetheless, the active involvement of FcγR in the enhancement of antigen‐specific immunity by uptake of immune complexes through FcγR is historically well documented in experimental systems where FcγRs bind immune complexes and thereby feed antigens into the antigen‐presentation pathways.53 This has been demonstrated in vivo for small immune complexes via human FcγRI on human antigen‐presenting cells54 and in mice.19 Similarly, the capacity of FcγRIIbs to bind and rapidly internalize antigen–antibody complexes suggests that it too may significantly influence feeding antigens into professional antigen‐presenting cells of hematopoietic origin such as dendritic cells and possibly B lymphocytes."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T166","span":{"begin":620,"end":625},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T167","span":{"begin":668,"end":673},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"Nonetheless, the active involvement of FcγR in the enhancement of antigen‐specific immunity by uptake of immune complexes through FcγR is historically well documented in experimental systems where FcγRs bind immune complexes and thereby feed antigens into the antigen‐presentation pathways.53 This has been demonstrated in vivo for small immune complexes via human FcγRI on human antigen‐presenting cells54 and in mice.19 Similarly, the capacity of FcγRIIbs to bind and rapidly internalize antigen–antibody complexes suggests that it too may significantly influence feeding antigens into professional antigen‐presenting cells of hematopoietic origin such as dendritic cells and possibly B lymphocytes."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"504","span":{"begin":365,"end":370},"obj":"Gene"},{"id":"505","span":{"begin":130,"end":134},"obj":"Gene"},{"id":"506","span":{"begin":39,"end":43},"obj":"Gene"},{"id":"507","span":{"begin":359,"end":364},"obj":"Species"},{"id":"508","span":{"begin":414,"end":418},"obj":"Species"},{"id":"509","span":{"begin":374,"end":379},"obj":"Species"}],"attributes":[{"id":"A506","pred":"pubann:denotes","subj":"506","obj":"Gene:2213"},{"id":"A504","pred":"pubann:denotes","subj":"504","obj":"Gene:2214"},{"id":"A505","pred":"pubann:denotes","subj":"505","obj":"Gene:2213"},{"id":"A508","pred":"pubann:denotes","subj":"508","obj":"Tax:10090"},{"id":"A507","pred":"pubann:denotes","subj":"507","obj":"Tax:9606"},{"id":"A509","pred":"pubann:denotes","subj":"509","obj":"Tax:9606"}],"text":"Nonetheless, the active involvement of FcγR in the enhancement of antigen‐specific immunity by uptake of immune complexes through FcγR is historically well documented in experimental systems where FcγRs bind immune complexes and thereby feed antigens into the antigen‐presentation pathways.53 This has been demonstrated in vivo for small immune complexes via human FcγRI on human antigen‐presenting cells54 and in mice.19 Similarly, the capacity of FcγRIIbs to bind and rapidly internalize antigen–antibody complexes suggests that it too may significantly influence feeding antigens into professional antigen‐presenting cells of hematopoietic origin such as dendritic cells and possibly B lymphocytes."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T34","span":{"begin":359,"end":364},"obj":"Species"},{"id":"T35","span":{"begin":374,"end":379},"obj":"Species"},{"id":"T36","span":{"begin":414,"end":418},"obj":"Species"}],"attributes":[{"id":"A35","pred":"ncbi_taxonomy_id","subj":"T35","obj":"NCBItxid:9606"},{"id":"A34","pred":"ncbi_taxonomy_id","subj":"T34","obj":"NCBItxid:9606"},{"id":"A36","pred":"ncbi_taxonomy_id","subj":"T36","obj":"NCBItxid:10095"},{"id":"A37","pred":"ncbi_taxonomy_id","subj":"T36","obj":"NCBItxid:10088"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"Nonetheless, the active involvement of FcγR in the enhancement of antigen‐specific immunity by uptake of immune complexes through FcγR is historically well documented in experimental systems where FcγRs bind immune complexes and thereby feed antigens into the antigen‐presentation pathways.53 This has been demonstrated in vivo for small immune complexes via human FcγRI on human antigen‐presenting cells54 and in mice.19 Similarly, the capacity of FcγRIIbs to bind and rapidly internalize antigen–antibody complexes suggests that it too may significantly influence feeding antigens into professional antigen‐presenting cells of hematopoietic origin such as dendritic cells and possibly B lymphocytes."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T163","span":{"begin":0,"end":701},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Nonetheless, the active involvement of FcγR in the enhancement of antigen‐specific immunity by uptake of immune complexes through FcγR is historically well documented in experimental systems where FcγRs bind immune complexes and thereby feed antigens into the antigen‐presentation pathways.53 This has been demonstrated in vivo for small immune complexes via human FcγRI on human antigen‐presenting cells54 and in mice.19 Similarly, the capacity of FcγRIIbs to bind and rapidly internalize antigen–antibody complexes suggests that it too may significantly influence feeding antigens into professional antigen‐presenting cells of hematopoietic origin such as dendritic cells and possibly B lymphocytes."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T271","span":{"begin":498,"end":506},"obj":"Body_part"},{"id":"T272","span":{"begin":601,"end":625},"obj":"Body_part"},{"id":"T273","span":{"begin":620,"end":625},"obj":"Body_part"},{"id":"T274","span":{"begin":658,"end":673},"obj":"Body_part"},{"id":"T275","span":{"begin":668,"end":673},"obj":"Body_part"},{"id":"T276","span":{"begin":687,"end":700},"obj":"Body_part"}],"attributes":[{"id":"A276","pred":"fma_id","subj":"T276","obj":"http://purl.org/sig/ont/fma/fma62869"},{"id":"A275","pred":"fma_id","subj":"T275","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A271","pred":"fma_id","subj":"T271","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A273","pred":"fma_id","subj":"T273","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A272","pred":"fma_id","subj":"T272","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A274","pred":"fma_id","subj":"T274","obj":"http://purl.org/sig/ont/fma/fma273565"}],"text":"Nonetheless, the active involvement of FcγR in the enhancement of antigen‐specific immunity by uptake of immune complexes through FcγR is historically well documented in experimental systems where FcγRs bind immune complexes and thereby feed antigens into the antigen‐presentation pathways.53 This has been demonstrated in vivo for small immune complexes via human FcγRI on human antigen‐presenting cells54 and in mice.19 Similarly, the capacity of FcγRIIbs to bind and rapidly internalize antigen–antibody complexes suggests that it too may significantly influence feeding antigens into professional antigen‐presenting cells of hematopoietic origin such as dendritic cells and possibly B lymphocytes."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T81","span":{"begin":95,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0098657"},{"id":"T82","span":{"begin":260,"end":280},"obj":"http://purl.obolibrary.org/obo/GO_0019882"}],"text":"Nonetheless, the active involvement of FcγR in the enhancement of antigen‐specific immunity by uptake of immune complexes through FcγR is historically well documented in experimental systems where FcγRs bind immune complexes and thereby feed antigens into the antigen‐presentation pathways.53 This has been demonstrated in vivo for small immune complexes via human FcγRI on human antigen‐presenting cells54 and in mice.19 Similarly, the capacity of FcγRIIbs to bind and rapidly internalize antigen–antibody complexes suggests that it too may significantly influence feeding antigens into professional antigen‐presenting cells of hematopoietic origin such as dendritic cells and possibly B lymphocytes."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T82","span":{"begin":95,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0098739"},{"id":"T83","span":{"begin":95,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0098657"},{"id":"T84","span":{"begin":260,"end":280},"obj":"http://purl.obolibrary.org/obo/GO_0019882"}],"text":"Nonetheless, the active involvement of FcγR in the enhancement of antigen‐specific immunity by uptake of immune complexes through FcγR is historically well documented in experimental systems where FcγRs bind immune complexes and thereby feed antigens into the antigen‐presentation pathways.53 This has been demonstrated in vivo for small immune complexes via human FcγRI on human antigen‐presenting cells54 and in mice.19 Similarly, the capacity of FcγRIIbs to bind and rapidly internalize antigen–antibody complexes suggests that it too may significantly influence feeding antigens into professional antigen‐presenting cells of hematopoietic origin such as dendritic cells and possibly B lymphocytes."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T82","span":{"begin":95,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0098739"},{"id":"T83","span":{"begin":95,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0098657"},{"id":"T84","span":{"begin":260,"end":280},"obj":"http://purl.obolibrary.org/obo/GO_0019882"}],"text":"Nonetheless, the active involvement of FcγR in the enhancement of antigen‐specific immunity by uptake of immune complexes through FcγR is historically well documented in experimental systems where FcγRs bind immune complexes and thereby feed antigens into the antigen‐presentation pathways.53 This has been demonstrated in vivo for small immune complexes via human FcγRI on human antigen‐presenting cells54 and in mice.19 Similarly, the capacity of FcγRIIbs to bind and rapidly internalize antigen–antibody complexes suggests that it too may significantly influence feeding antigens into professional antigen‐presenting cells of hematopoietic origin such as dendritic cells and possibly B lymphocytes."}

{"project":"LitCovid-sentences","denotations":[{"id":"T163","span":{"begin":0,"end":701},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Nonetheless, the active involvement of FcγR in the enhancement of antigen‐specific immunity by uptake of immune complexes through FcγR is historically well documented in experimental systems where FcγRs bind immune complexes and thereby feed antigens into the antigen‐presentation pathways.53 This has been demonstrated in vivo for small immune complexes via human FcγRI on human antigen‐presenting cells54 and in mice.19 Similarly, the capacity of FcγRIIbs to bind and rapidly internalize antigen–antibody complexes suggests that it too may significantly influence feeding antigens into professional antigen‐presenting cells of hematopoietic origin such as dendritic cells and possibly B lymphocytes."}