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PMC:7228307 / 26884-27768 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
481 341-348 Gene denotes FcγRIIb Gene:14130
482 581-588 Gene denotes FcγRIIb Gene:14130
483 306-310 Gene denotes FcγR Gene:2213
484 168-172 Gene denotes FcγR Gene:2213
485 81-87 Species denotes humans Tax:9606
486 616-620 Species denotes mice Tax:10090
487 625-631 Species denotes humans Tax:9606

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T266 516-522 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T267 762-765 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T268 867-876 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T269 880-883 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T17 516-522 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T51 785-788 Disease denotes MOA http://purl.obolibrary.org/obo/MONDO_0016702

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T517 81-87 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T518 148-149 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T519 168-170 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T520 184-186 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T521 187-189 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T522 194-197 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T523 290-300 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T524 306-308 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T525 341-343 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T526 372-382 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T527 399-400 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T528 501-503 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T529 508-509 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T530 581-583 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T531 625-631 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T532 685-692 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T143 697-703 Chemical denotes toxins http://purl.obolibrary.org/obo/CHEBI_27026
T144 838-852 Chemical denotes macromolecules http://purl.obolibrary.org/obo/CHEBI_33839

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T162 383-391 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T163 685-692 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T164 697-703 http://purl.obolibrary.org/obo/IDO_0000549 denotes toxins

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T28 838-852 Chemical denotes macromolecules http://purl.obolibrary.org/obo/CHEBI_33839

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
481 341-348 Gene denotes FcγRIIb Gene:14130
482 581-588 Gene denotes FcγRIIb Gene:14130
483 306-310 Gene denotes FcγR Gene:2213
484 168-172 Gene denotes FcγR Gene:2213
485 81-87 Species denotes humans Tax:9606
486 616-620 Species denotes mice Tax:10090
487 625-631 Species denotes humans Tax:9606

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T27 81-87 Species denotes humans NCBItxid:9605
T28 616-620 Species denotes mice NCBItxid:10095|NCBItxid:10088
T30 625-631 Species denotes humans NCBItxid:9605
T31 685-692 Species denotes viruses NCBItxid:10239

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T155 0-45 Sentence denotes Sweeping: clearance of small immune complexes
T156 46-173 Sentence denotes The removal of immune complexes in humans depends primarily on the complement receptor pathway and to a lesser degree the FcγR.
T157 174-311 Sentence denotes Among the FcγRs, it has been widely believed that immune complex removal only occurs by phagocytosis/endocytosis of activating‐type FcγR.
T158 312-632 Sentence denotes Surprisingly, the inhibitory FcγRIIb, which lacks intrinsic activating function, plays a major role in clearance, and rapidly “sweeps” away small complexes from the circulation (Figure 1d).48, 49 A major tissue involved in the clearance is likely to be the LSEC, where FcγRIIb is expressed abundantly in mice and humans.
T159 633-884 Sentence denotes This role is potentially important in resistance to viruses and toxins but may also be key to optimal performance of therapeutic IgG mAbs whose primary MOA is believed to be only neutralization of soluble macromolecules, for example, cytokines or IgE.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T17 516-522 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T265 516-522 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T266 762-765 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T267 867-876 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T268 880-883 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T76 262-274 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T77 275-286 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T76 262-274 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T77 275-286 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T76 262-274 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T77 275-286 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T155 0-45 Sentence denotes Sweeping: clearance of small immune complexes
T156 46-173 Sentence denotes The removal of immune complexes in humans depends primarily on the complement receptor pathway and to a lesser degree the FcγR.
T157 174-311 Sentence denotes Among the FcγRs, it has been widely believed that immune complex removal only occurs by phagocytosis/endocytosis of activating‐type FcγR.
T158 312-632 Sentence denotes Surprisingly, the inhibitory FcγRIIb, which lacks intrinsic activating function, plays a major role in clearance, and rapidly “sweeps” away small complexes from the circulation (Figure 1d).48, 49 A major tissue involved in the clearance is likely to be the LSEC, where FcγRIIb is expressed abundantly in mice and humans.
T159 633-884 Sentence denotes This role is potentially important in resistance to viruses and toxins but may also be key to optimal performance of therapeutic IgG mAbs whose primary MOA is believed to be only neutralization of soluble macromolecules, for example, cytokines or IgE.