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PMC:7228307 / 25840-26882 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
463 0-7 Gene denotes FcγRIIb Gene:2213
464 167-174 Gene denotes FcγRIIb Gene:2213
465 307-310 Gene denotes BCR Gene:613
466 388-396 Gene denotes FcγRIIb1 Gene:1555
467 467-472 Gene denotes FcγRI Gene:2214
468 474-481 Gene denotes FcγRIIa Gene:2212
469 492-499 Gene denotes FcγRIII Gene:2214
470 821-824 Gene denotes BCR Gene:613
471 953-956 Gene denotes BCR Gene:613
472 1016-1024 Gene denotes FcγRIIB1 Gene:1555
473 483-490 Gene denotes FcγRIIc Gene:9103

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T257 232-236 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T258 409-413 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T259 425-435 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T260 523-526 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875
T261 552-555 Body_part denotes IgA http://purl.org/sig/ont/fma/fma62874
T262 723-727 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T263 766-771 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T264 852-856 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T265 1037-1041 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T50 681-684 Disease denotes MOA http://purl.obolibrary.org/obo/MONDO_0016702

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T493 0-2 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T494 102-111 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T495 167-169 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T496 204-213 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T497 230-236 http://purl.obolibrary.org/obo/CL_0000236 denotes B‐cell
T498 237-247 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T499 388-390 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T500 409-413 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T501 441-451 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T502 467-469 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T503 474-476 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T504 483-485 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T505 492-494 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T506 537-539 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T507 566-568 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T508 628-630 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T509 723-727 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T510 728-738 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T511 766-771 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T512 800-802 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T513 850-856 http://purl.obolibrary.org/obo/CL_0000236 denotes B‐cell
T514 857-867 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T515 1016-1018 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T516 1037-1041 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T134 270-277 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T135 470-472 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T137 540-542 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T139 569-571 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T141 739-748 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T142 916-923 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T153 141-149 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T154 232-236 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T155 409-413 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T156 425-435 http://purl.obolibrary.org/obo/CL_0000738 denotes leukocytes
T157 653-661 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T158 723-727 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T159 766-771 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T160 852-856 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T161 1037-1041 http://purl.obolibrary.org/obo/CL_0000000 denotes cell

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
464 167-174 Gene denotes FcγRIIb Gene:2213
465 307-310 Gene denotes BCR Gene:613
466 388-396 Gene denotes FcγRIIb1 Gene:1555
467 467-472 Gene denotes FcγRI Gene:2214
468 474-481 Gene denotes FcγRIIa Gene:2212
469 492-499 Gene denotes FcγRIII Gene:2214
470 821-824 Gene denotes BCR Gene:613
471 953-956 Gene denotes BCR Gene:613
472 1016-1024 Gene denotes FcγRIIB1 Gene:1555
473 483-490 Gene denotes FcγRIIc Gene:9103

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T150 0-124 Sentence denotes FcγRIIb is an immune checkpoint46, 47 and its splice variants are potent modulators of ITAM‐dependent signaling (Figure 1c).
T151 125-223 Sentence denotes This modulatory function occurs only when FcγRIIb is coaggregated with an ITAM signaling receptor.
T152 224-637 Sentence denotes Thus, B‐cell activation by the binding of the antigen in the immune complex to the BCR is regulated by the simultaneous binding of the Fcs of the immune complex to FcγRIIb1 on the same cell. In innate leukocytes, the activating‐type FcR (i.e. FcγRI, FcγRIIa, FcγRIIc, FcγRIII) and the high‐affinity IgE receptor, FcεRI, and the IgA receptor, FcαRI, are all modulated by immune complex co‐engagement with FcγRIIb2.
T153 638-843 Sentence denotes The inhibitory function contributes to the MOA of therapeutic antibodies that target cell‐activating molecules where the target cells also express the inhibitory FcγRIIbs such as the BCR (discussed later).
T154 844-1042 Sentence denotes Thus, B‐cell activation is modulated by the simulatenous binding of the antigen in the immune complex to the BCR and the binding of the Fcs, also in the immune complex, to FcγRIIB1 on the same cell.

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T256 232-236 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T257 409-413 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T258 425-435 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T259 523-526 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875
T260 552-555 Body_part denotes IgA http://purl.org/sig/ont/fma/fma62874
T261 723-727 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T262 766-771 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T263 852-856 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T264 1037-1041 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T12 836-841 http://purl.obolibrary.org/obo/MAT_0000488 denotes later

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T70 102-111 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T71 204-213 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T72 230-247 http://purl.obolibrary.org/obo/GO_0042113 denotes B‐cell activation
T73 232-247 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T74 850-867 http://purl.obolibrary.org/obo/GO_0042113 denotes B‐cell activation
T75 852-867 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T70 102-111 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T71 204-213 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T72 230-247 http://purl.obolibrary.org/obo/GO_0042113 denotes B‐cell activation
T73 232-247 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T74 850-867 http://purl.obolibrary.org/obo/GO_0042113 denotes B‐cell activation
T75 852-867 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T70 102-111 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T71 204-213 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T72 230-247 http://purl.obolibrary.org/obo/GO_0042113 denotes B‐cell activation
T73 232-247 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T74 850-867 http://purl.obolibrary.org/obo/GO_0042113 denotes B‐cell activation
T75 852-867 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T150 0-124 Sentence denotes FcγRIIb is an immune checkpoint46, 47 and its splice variants are potent modulators of ITAM‐dependent signaling (Figure 1c).
T151 125-223 Sentence denotes This modulatory function occurs only when FcγRIIb is coaggregated with an ITAM signaling receptor.
T152 224-637 Sentence denotes Thus, B‐cell activation by the binding of the antigen in the immune complex to the BCR is regulated by the simultaneous binding of the Fcs of the immune complex to FcγRIIb1 on the same cell. In innate leukocytes, the activating‐type FcR (i.e. FcγRI, FcγRIIa, FcγRIIc, FcγRIII) and the high‐affinity IgE receptor, FcεRI, and the IgA receptor, FcαRI, are all modulated by immune complex co‐engagement with FcγRIIb2.
T153 638-843 Sentence denotes The inhibitory function contributes to the MOA of therapeutic antibodies that target cell‐activating molecules where the target cells also express the inhibitory FcγRIIbs such as the BCR (discussed later).
T154 844-1042 Sentence denotes Thus, B‐cell activation is modulated by the simulatenous binding of the antigen in the immune complex to the BCR and the binding of the Fcs, also in the immune complex, to FcγRIIB1 on the same cell.