PMC:7228307 / 22913-23611 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"418","span":{"begin":495,"end":500},"obj":"Disease"}],"attributes":[{"id":"A418","pred":"tao:has_database_id","subj":"418","obj":"MESH:D005483"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T241","span":{"begin":5,"end":9},"obj":"Body_part"},{"id":"T242","span":{"begin":258,"end":262},"obj":"Body_part"},{"id":"T243","span":{"begin":646,"end":654},"obj":"Body_part"}],"attributes":[{"id":"A241","pred":"fma_id","subj":"T241","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A242","pred":"fma_id","subj":"T242","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A243","pred":"fma_id","subj":"T243","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T15","span":{"begin":633,"end":637},"obj":"Body_part"}],"attributes":[{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0008915"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T32","span":{"begin":415,"end":419},"obj":"Disease"},{"id":"T33","span":{"begin":424,"end":428},"obj":"Disease"},{"id":"T34","span":{"begin":432,"end":436},"obj":"Disease"},{"id":"T35","span":{"begin":693,"end":697},"obj":"Disease"}],"attributes":[{"id":"A32","pred":"mondo_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/MONDO_0008734"},{"id":"A33","pred":"mondo_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/MONDO_0022697"},{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0008734"},{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0008734"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T449","span":{"begin":5,"end":9},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T450","span":{"begin":10,"end":20},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T451","span":{"begin":108,"end":110},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T452","span":{"begin":111,"end":113},"obj":"http://purl.obolibrary.org/obo/CLO_0008882"},{"id":"T453","span":{"begin":180,"end":186},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T454","span":{"begin":258,"end":262},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T455","span":{"begin":366,"end":368},"obj":"http://purl.obolibrary.org/obo/CLO_0053794"},{"id":"T456","span":{"begin":392,"end":393},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T457","span":{"begin":527,"end":535},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T458","span":{"begin":669,"end":677},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T116","span":{"begin":160,"end":166},"obj":"Chemical"},{"id":"T117","span":{"begin":249,"end":257},"obj":"Chemical"},{"id":"T118","span":{"begin":307,"end":314},"obj":"Chemical"},{"id":"T119","span":{"begin":458,"end":465},"obj":"Chemical"},{"id":"T120","span":{"begin":563,"end":571},"obj":"Chemical"},{"id":"T121","span":{"begin":646,"end":654},"obj":"Chemical"}],"attributes":[{"id":"A116","pred":"chebi_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A117","pred":"chebi_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"id":"A118","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A119","pred":"chebi_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A120","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T136","span":{"begin":5,"end":9},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T137","span":{"begin":258,"end":262},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T138","span":{"begin":263,"end":271},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"},{"id":"T139","span":{"begin":353,"end":361},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T25","span":{"begin":646,"end":654},"obj":"Chemical"}],"attributes":[{"id":"A25","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"418","span":{"begin":495,"end":500},"obj":"Disease"}],"attributes":[{"id":"A418","pred":"pubann:denotes","subj":"418","obj":"MESH:D005483"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T136","span":{"begin":0,"end":698},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T15","span":{"begin":633,"end":637},"obj":"Body_part"}],"attributes":[{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0008915"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T240","span":{"begin":5,"end":9},"obj":"Body_part"},{"id":"T241","span":{"begin":258,"end":262},"obj":"Body_part"},{"id":"T242","span":{"begin":646,"end":654},"obj":"Body_part"}],"attributes":[{"id":"A240","pred":"fma_id","subj":"T240","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A241","pred":"fma_id","subj":"T241","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A242","pred":"fma_id","subj":"T242","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T55","span":{"begin":5,"end":20},"obj":"http://purl.obolibrary.org/obo/GO_0001775"},{"id":"T56","span":{"begin":160,"end":175},"obj":"http://purl.obolibrary.org/obo/GO_1990256"},{"id":"T57","span":{"begin":415,"end":419},"obj":"http://purl.obolibrary.org/obo/GO_0001788"},{"id":"T58","span":{"begin":432,"end":436},"obj":"http://purl.obolibrary.org/obo/GO_0001788"},{"id":"T59","span":{"begin":548,"end":559},"obj":"http://purl.obolibrary.org/obo/GO_0000746"},{"id":"T60","span":{"begin":693,"end":697},"obj":"http://purl.obolibrary.org/obo/GO_0001788"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T55","span":{"begin":5,"end":20},"obj":"http://purl.obolibrary.org/obo/GO_0001775"},{"id":"T56","span":{"begin":160,"end":175},"obj":"http://purl.obolibrary.org/obo/GO_1990256"},{"id":"T57","span":{"begin":415,"end":419},"obj":"http://purl.obolibrary.org/obo/GO_0001788"},{"id":"T58","span":{"begin":432,"end":436},"obj":"http://purl.obolibrary.org/obo/GO_0001788"},{"id":"T59","span":{"begin":548,"end":559},"obj":"http://purl.obolibrary.org/obo/GO_0000746"},{"id":"T60","span":{"begin":693,"end":697},"obj":"http://purl.obolibrary.org/obo/GO_0001788"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T55","span":{"begin":5,"end":20},"obj":"http://purl.obolibrary.org/obo/GO_0001775"},{"id":"T56","span":{"begin":160,"end":175},"obj":"http://purl.obolibrary.org/obo/GO_1990256"},{"id":"T57","span":{"begin":415,"end":419},"obj":"http://purl.obolibrary.org/obo/GO_0001788"},{"id":"T58","span":{"begin":432,"end":436},"obj":"http://purl.obolibrary.org/obo/GO_0001788"},{"id":"T59","span":{"begin":548,"end":559},"obj":"http://purl.obolibrary.org/obo/GO_0000746"},{"id":"T60","span":{"begin":693,"end":697},"obj":"http://purl.obolibrary.org/obo/GO_0001788"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}

{"project":"LitCovid-sentences","denotations":[{"id":"T136","span":{"begin":0,"end":698},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC."}