PMC:7228307 / 21882-22556 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7228307","sourcedb":"PMC","sourceid":"7228307","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7228307","text":"Although it is the IgG Fc that interacts with and clusters the FcγR to induce a response, the nature of the Fab interaction with its epitope can strongly influence the likelihood or potency of FcγR effector responses by influencing the density of appropriately presented Fc portions.35 and also the size of the immune complex.36 Furthermore, the display/orientation and geometry of the Fc portions, as a consequence of the fragment antigen‐binding (Fab) interaction with the target epitope, can result in effector responses such as ADCC that differ substantially in potency, presumably because the orientation of the Fc makes FcγR engagement more, or less, accessible.37, 38","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"411","span":{"begin":626,"end":630},"obj":"Gene"},{"id":"412","span":{"begin":193,"end":197},"obj":"Gene"},{"id":"413","span":{"begin":63,"end":67},"obj":"Gene"}],"attributes":[{"id":"A411","pred":"tao:has_database_id","subj":"411","obj":"Gene:2213"},{"id":"A412","pred":"tao:has_database_id","subj":"412","obj":"Gene:2213"},{"id":"A413","pred":"tao:has_database_id","subj":"413","obj":"Gene:2213"},{"subj":"411","pred":"source","obj":"LitCovid-PubTator"},{"subj":"412","pred":"source","obj":"LitCovid-PubTator"},{"subj":"413","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T235","span":{"begin":19,"end":22},"obj":"Body_part"}],"attributes":[{"id":"A235","pred":"fma_id","subj":"T235","obj":"http://purl.org/sig/ont/fma/fma62872"},{"subj":"T235","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T31","span":{"begin":532,"end":536},"obj":"Disease"}],"attributes":[{"id":"A31","pred":"mondo_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/MONDO_0008734"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T434","span":{"begin":23,"end":25},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T435","span":{"begin":63,"end":65},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T436","span":{"begin":78,"end":79},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T437","span":{"begin":193,"end":195},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T438","span":{"begin":271,"end":273},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T439","span":{"begin":283,"end":285},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T440","span":{"begin":326,"end":328},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T441","span":{"begin":386,"end":388},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T442","span":{"begin":402,"end":403},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T443","span":{"begin":617,"end":619},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T444","span":{"begin":626,"end":628},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"}],"attributes":[{"subj":"T434","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T435","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T436","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T437","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T438","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T439","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T440","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T441","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T442","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T443","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T444","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T107","span":{"begin":133,"end":140},"obj":"Chemical"},{"id":"T108","span":{"begin":198,"end":206},"obj":"Chemical"},{"id":"T109","span":{"begin":432,"end":439},"obj":"Chemical"},{"id":"T110","span":{"begin":482,"end":489},"obj":"Chemical"},{"id":"T111","span":{"begin":505,"end":513},"obj":"Chemical"}],"attributes":[{"id":"A107","pred":"chebi_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A108","pred":"chebi_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"id":"A109","pred":"chebi_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A110","pred":"chebi_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A111","pred":"chebi_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"subj":"T107","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T108","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T109","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T110","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T111","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"411","span":{"begin":626,"end":630},"obj":"Gene"},{"id":"412","span":{"begin":193,"end":197},"obj":"Gene"},{"id":"413","span":{"begin":63,"end":67},"obj":"Gene"}],"attributes":[{"id":"A411","pred":"pubann:denotes","subj":"411","obj":"Gene:2213"},{"id":"A412","pred":"pubann:denotes","subj":"412","obj":"Gene:2213"},{"id":"A413","pred":"pubann:denotes","subj":"413","obj":"Gene:2213"},{"subj":"411","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"412","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"413","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T134","span":{"begin":0,"end":674},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T134","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T234","span":{"begin":19,"end":22},"obj":"Body_part"}],"attributes":[{"id":"A234","pred":"fma_id","subj":"T234","obj":"http://purl.org/sig/ont/fma/fma62872"},{"subj":"T234","pred":"source","obj":"LitCovid-sample-PD-FMA"}]},{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T54","span":{"begin":532,"end":536},"obj":"http://purl.obolibrary.org/obo/GO_0001788"}],"attributes":[{"subj":"T54","pred":"source","obj":"LitCovid-sample-PD-GO-BP-0"}]},{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T54","span":{"begin":532,"end":536},"obj":"http://purl.obolibrary.org/obo/GO_0001788"}],"attributes":[{"subj":"T54","pred":"source","obj":"LitCovid-sample-GO-BP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T54","span":{"begin":532,"end":536},"obj":"http://purl.obolibrary.org/obo/GO_0001788"}],"attributes":[{"subj":"T54","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T134","span":{"begin":0,"end":674},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T134","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ecd393","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#b993ec"},{"id":"LitCovid-PD-MONDO","color":"#93ec9f"},{"id":"LitCovid-PD-CLO","color":"#ec93a0"},{"id":"LitCovid-PD-CHEBI","color":"#93baec"},{"id":"LitCovid-sample-Pubtator","color":"#d4ec93"},{"id":"LitCovid-sample-sentences","color":"#ea93ec"},{"id":"LitCovid-sample-PD-FMA","color":"#93ecd0"},{"id":"LitCovid-sample-PD-GO-BP-0","color":"#ecb693"},{"id":"LitCovid-sample-GO-BP","color":"#9b93ec"},{"id":"LitCovid-PD-GO-BP","color":"#a4ec93"},{"id":"LitCovid-sentences","color":"#ec93be"}]}]}}