> top > docs > PMC:7228307 > spans > 21315-33795 > annotations

PMC:7228307 / 21315-33795 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
405 162-166 Gene denotes FcγR Gene:2213
410 504-508 Gene denotes FcγR Gene:2213
411 1193-1197 Gene denotes FcγR Gene:2213
412 760-764 Gene denotes FcγR Gene:2213
413 630-634 Gene denotes FcγR Gene:2213
418 2093-2098 Disease denotes flush MESH:D005483
419 2333-2345 Disease denotes cytotoxicity MESH:D064420
420 2396-2408 Disease denotes cytotoxicity MESH:D064420
421 2515-2520 Disease denotes flush MESH:D005483
426 3011-3015 Gene denotes FcγR Gene:2213
427 2902-2906 Gene denotes FcγR Gene:2213
428 2852-2856 Chemical denotes ADCP
429 2835-2847 Disease denotes cytotoxicity MESH:D064420
432 3165-3169 Gene denotes FcγR Gene:2213
433 3413-3419 Chemical denotes glycan MESH:D011134
443 3813-3821 Gene denotes FcγRIIIa Gene:2214
444 4074-4081 Gene denotes FcγRIIa Gene:2212
445 4086-4091 Gene denotes FcγRI Gene:2214
446 4292-4299 Gene denotes FcγRIII Gene:2214
447 4322-4329 Gene denotes FcγRIIa Gene:2212
448 4334-4339 Gene denotes FcγRI Gene:2214
449 3717-3721 Gene denotes FcγR Gene:2213
450 4190-4198 Species denotes patients Tax:9606
451 4021-4027 Disease denotes cancer MESH:D009369
463 4525-4532 Gene denotes FcγRIIb Gene:2213
464 4692-4699 Gene denotes FcγRIIb Gene:2213
465 4832-4835 Gene denotes BCR Gene:613
466 4913-4921 Gene denotes FcγRIIb1 Gene:1555
467 4992-4997 Gene denotes FcγRI Gene:2214
468 4999-5006 Gene denotes FcγRIIa Gene:2212
469 5017-5024 Gene denotes FcγRIII Gene:2214
470 5346-5349 Gene denotes BCR Gene:613
471 5478-5481 Gene denotes BCR Gene:613
472 5541-5549 Gene denotes FcγRIIB1 Gene:1555
473 5008-5015 Gene denotes FcγRIIc Gene:9103
481 5910-5917 Gene denotes FcγRIIb Gene:14130
482 6150-6157 Gene denotes FcγRIIb Gene:14130
483 5875-5879 Gene denotes FcγR Gene:2213
484 5737-5741 Gene denotes FcγR Gene:2213
485 5650-5656 Species denotes humans Tax:9606
486 6185-6189 Species denotes mice Tax:10090
487 6194-6200 Species denotes humans Tax:9606
493 6810-6814 Gene denotes FcγR Gene:2213
494 6690-6694 Species denotes mice Tax:10090
495 6768-6776 Species denotes patients Tax:9606
496 6726-6739 Disease denotes recall memory MESH:D008569
497 6868-6873 Disease denotes tumor MESH:D009369
504 7280-7285 Gene denotes FcγRI Gene:2214
505 7045-7049 Gene denotes FcγR Gene:2213
506 6954-6958 Gene denotes FcγR Gene:2213
507 7274-7279 Species denotes human Tax:9606
508 7329-7333 Species denotes mice Tax:10090
509 7289-7294 Species denotes human Tax:9606
511 7707-7714 Gene denotes FcγRIIb Gene:2213
513 7933-7940 Gene denotes FcγRIIb Gene:2213
515 8160-8164 Gene denotes FcγR Gene:2213
524 9256-9261 Gene denotes CD357 Gene:8784
525 9093-9097 Gene denotes FcγR Gene:2213
526 9055-9059 Gene denotes FcγR Gene:2213
527 8916-8920 Gene denotes FcγR Gene:2213
528 8545-8549 Gene denotes FcγR Gene:2213
529 8277-8281 Gene denotes FcγR Gene:2213
530 8172-8176 Gene denotes FcγR Gene:2213
531 8224-8236 Species denotes participants Tax:9606
535 9307-9311 Gene denotes FcγR Gene:2213
536 9534-9545 Chemical denotes daratumumab MESH:C556306
537 9475-9480 Disease denotes death MESH:D003643
544 10461-10466 Gene denotes FcγRI Gene:2214
545 10726-10731 Gene denotes FcγRI Gene:2214
546 10797-10809 Gene denotes interferon‐γ Gene:3458
547 10164-10168 Gene denotes FcγR Gene:2213
548 10024-10028 Gene denotes FcγR Gene:2213
549 10866-10878 Disease denotes inflammation MESH:D007249
554 11071-11075 Gene denotes IgG3 Gene:3502
555 11326-11333 Gene denotes FcγRIIb Gene:2213
556 11375-11382 Gene denotes FcγRIII Gene:2214
557 10893-10898 Species denotes human Tax:9606
562 11585-11593 Gene denotes FcγRIIIa Gene:2214
563 11514-11518 Gene denotes FcγR Gene:2213
564 11689-11702 Chemical denotes phenylalanine MESH:D010649
565 11703-11709 Chemical denotes valine MESH:D014633
572 11948-11955 Gene denotes FcγRIIb Gene:2213
573 11996-12001 Gene denotes FcγRI Gene:2214
574 12133-12140 Gene denotes FcγRIIa Gene:2212
575 11868-11872 Gene denotes FcγR Gene:2213
576 12219-12228 Chemical denotes histidine MESH:D006639
577 12449-12457 Chemical denotes arginine MESH:D001120

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T233 358-361 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T234 416-421 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T235 586-589 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T236 1269-1274 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T237 1303-1321 Body_part denotes actin cytoskeleton http://purl.org/sig/ont/fma/fma84684
T238 1344-1361 Body_part denotes glycosaminoglycan http://purl.org/sig/ont/fma/fma63011
T239 1362-1372 Body_part denotes glycocalyx http://purl.org/sig/ont/fma/fma66838
T240 1417-1430 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T241 1603-1607 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T242 1856-1860 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T243 2244-2252 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T244 2379-2387 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T245 2536-2549 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T246 2536-2540 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T247 2908-2913 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T248 3190-3203 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T249 3190-3194 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T250 3825-3833 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T251 3828-3833 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T252 3870-3881 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T253 3922-3929 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T254 3925-3929 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T255 4373-4377 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T256 4498-4502 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T257 4757-4761 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T258 4934-4938 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T259 4950-4960 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T260 5048-5051 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875
T261 5077-5080 Body_part denotes IgA http://purl.org/sig/ont/fma/fma62874
T262 5248-5252 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T263 5291-5296 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T264 5377-5381 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T265 5562-5566 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T266 6085-6091 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T267 6331-6334 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T268 6436-6445 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T269 6449-6452 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875
T270 6479-6487 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T271 6541-6549 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T272 7413-7421 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T273 7516-7540 Body_part denotes antigen‐presenting cells http://purl.org/sig/ont/fma/fma273565
T274 7535-7540 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T275 7573-7588 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T276 7583-7588 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T277 7602-7615 Body_part denotes B lymphocytes http://purl.org/sig/ont/fma/fma62869
T278 7642-7674 Body_part denotes major histocompatibility complex http://purl.org/sig/ont/fma/fma84079
T279 7722-7728 Body_part denotes stroma http://purl.org/sig/ont/fma/fma81494
T280 7737-7763 Body_part denotes follicular dendritic cells http://purl.org/sig/ont/fma/fma83037
T281 7758-7763 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T282 7775-7783 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T283 7814-7822 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T284 7840-7852 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T285 7840-7844 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T286 7893-7898 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T287 8029-8040 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T288 8141-8145 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T289 8166-8171 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T290 8188-8193 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T291 8295-8298 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T292 8337-8349 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T293 8337-8341 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T294 8362-8366 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T295 8481-8485 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T296 8588-8592 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T297 8694-8698 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T298 8756-8760 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T299 8881-8885 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T300 8933-8938 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T301 8956-8965 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T302 8983-8987 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T303 9002-9010 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T304 9071-9076 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T305 9376-9380 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T306 9493-9497 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T307 9609-9614 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T308 9654-9657 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T309 9799-9802 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T310 9835-9838 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T311 9985-9997 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T312 9985-9989 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T313 10296-10299 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T314 10409-10412 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T315 10539-10542 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T316 10640-10643 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T317 10654-10657 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T318 10780-10785 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T319 10899-10902 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T320 10968-10978 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T321 11689-11702 Body_part denotes phenylalanine http://purl.org/sig/ont/fma/fma82754
T322 11703-11709 Body_part denotes valine http://purl.org/sig/ont/fma/fma82766
T323 11743-11746 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T324 12219-12228 Body_part denotes histidine http://purl.org/sig/ont/fma/fma82755
T325 12252-12255 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T326 12449-12457 Body_part denotes arginine http://purl.org/sig/ont/fma/fma82763

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T15 2231-2235 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915
T16 2366-2370 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915
T17 6085-6091 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T18 7722-7728 Body_part denotes stroma http://purl.obolibrary.org/obo/UBERON_0003891

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T31 1099-1103 Disease denotes ADCC http://purl.obolibrary.org/obo/MONDO_0008734
T32 2013-2017 Disease denotes ADCC http://purl.obolibrary.org/obo/MONDO_0008734
T33 2022-2026 Disease denotes ADCP http://purl.obolibrary.org/obo/MONDO_0022697
T34 2030-2034 Disease denotes ADCC http://purl.obolibrary.org/obo/MONDO_0008734
T35 2291-2295 Disease denotes ADCC http://purl.obolibrary.org/obo/MONDO_0008734
T36 2456-2460 Disease denotes ADCP http://purl.obolibrary.org/obo/MONDO_0022697
T37 2571-2575 Disease denotes ADCP http://purl.obolibrary.org/obo/MONDO_0022697
T38 2720-2724 Disease denotes ADCC http://purl.obolibrary.org/obo/MONDO_0008734
T39 2729-2733 Disease denotes ADCP http://purl.obolibrary.org/obo/MONDO_0022697
T40 2852-2856 Disease denotes ADCP http://purl.obolibrary.org/obo/MONDO_0022697
T41 3040-3043 Disease denotes MOA http://purl.obolibrary.org/obo/MONDO_0016702
T42 3649-3653 Disease denotes ADCC http://purl.obolibrary.org/obo/MONDO_0008734
T43 3671-3675 Disease denotes ADCC http://purl.obolibrary.org/obo/MONDO_0008734
T44 3680-3684 Disease denotes ADCP http://purl.obolibrary.org/obo/MONDO_0022697
T45 3930-3934 Disease denotes ADCC http://purl.obolibrary.org/obo/MONDO_0008734
T46 3979-3982 Disease denotes MOA http://purl.obolibrary.org/obo/MONDO_0016702
T47 4021-4027 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T48 4050-4054 Disease denotes ADCP http://purl.obolibrary.org/obo/MONDO_0022697
T49 4183-4186 Disease denotes MOA http://purl.obolibrary.org/obo/MONDO_0016702
T50 5206-5209 Disease denotes MOA http://purl.obolibrary.org/obo/MONDO_0016702
T51 6354-6357 Disease denotes MOA http://purl.obolibrary.org/obo/MONDO_0016702
T52 6868-6873 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T53 8244-8247 Disease denotes MOA http://purl.obolibrary.org/obo/MONDO_0016702
T54 9527-9530 Disease denotes MOA http://purl.obolibrary.org/obo/MONDO_0016702
T55 10866-10878 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T427 0-2 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T428 100-102 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T429 162-164 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T430 416-421 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T431 455-456 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T432 504-506 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T433 524-525 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T434 590-592 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T435 630-632 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T436 645-646 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T437 760-762 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T438 838-840 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T439 850-852 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T440 893-895 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T441 953-955 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T442 969-970 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T443 1184-1186 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T444 1193-1195 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T445 1269-1274 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T446 1440-1444 http://purl.obolibrary.org/obo/PR_000001307 denotes CD44
T447 1536-1538 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T448 1539-1541 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T449 1603-1607 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T450 1608-1618 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T451 1706-1708 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T452 1709-1711 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T453 1778-1784 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T454 1856-1860 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T455 1964-1966 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T456 1990-1991 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T457 2125-2133 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T458 2267-2275 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T459 2409-2412 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T460 2536-2540 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T461 2541-2549 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T462 2576-2584 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T463 2644-2652 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T464 2902-2904 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T465 2908-2913 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T466 2945-2953 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T467 3011-3013 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T468 3113-3115 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T469 3165-3167 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T470 3170-3182 http://purl.obolibrary.org/obo/OBI_0000245 denotes organization
T471 3190-3194 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T472 3195-3203 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T473 3391-3393 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T474 3427-3428 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T475 3594-3596 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T476 3609-3611 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T477 3717-3719 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T478 3763-3764 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T479 3813-3815 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T480 3825-3833 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T481 3851-3861 http://purl.obolibrary.org/obo/CL_0000234 denotes phagocytes
T482 3922-3929 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell
T483 4074-4076 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T484 4086-4088 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T485 4092-4094 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T486 4292-4294 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T487 4322-4324 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T488 4334-4336 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T489 4373-4377 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T490 4498-4502 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T491 4503-4513 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T492 4517-4519 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T493 4525-4527 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T494 4627-4636 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T495 4692-4694 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T496 4729-4738 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T497 4755-4761 http://purl.obolibrary.org/obo/CL_0000236 denotes B‐cell
T498 4762-4772 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T499 4913-4915 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T500 4934-4938 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T501 4966-4976 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T502 4992-4994 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T503 4999-5001 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T504 5008-5010 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T505 5017-5019 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T506 5062-5064 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T507 5091-5093 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T508 5153-5155 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T509 5248-5252 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T510 5253-5263 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T511 5291-5296 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T512 5325-5327 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T513 5375-5381 http://purl.obolibrary.org/obo/CL_0000236 denotes B‐cell
T514 5382-5392 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T515 5541-5543 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T516 5562-5566 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T517 5650-5656 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T518 5717-5718 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T519 5737-5739 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T520 5753-5755 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T521 5756-5758 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T522 5763-5766 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T523 5859-5869 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T524 5875-5877 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T525 5910-5912 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T526 5941-5951 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T527 5968-5969 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T528 6070-6072 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T529 6077-6078 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T530 6150-6152 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T531 6194-6200 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T532 6254-6261 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T533 6455-6457 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T534 6561-6562 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T535 6647-6650 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T536 6699-6701 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T537 6777-6779 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T538 6810-6812 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T539 6932-6938 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T540 6954-6956 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T541 7045-7047 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T542 7112-7114 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T543 7115-7117 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T544 7213-7216 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T545 7274-7279 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T546 7280-7282 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T547 7289-7294 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T548 7364-7366 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T549 7535-7540 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T550 7573-7588 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T551 7602-7603 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T552 7630-7631 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T553 7707-7709 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T554 7722-7728 http://purl.obolibrary.org/obo/UBERON_0003891 denotes stroma
T555 7748-7763 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T556 7840-7844 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T557 7891-7898 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T558 7933-7935 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T559 8077-8078 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T560 8141-8145 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T561 8160-8162 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T562 8166-8171 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T563 8172-8174 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T564 8188-8193 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T565 8277-8279 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T566 8337-8341 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T567 8353-8354 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T568 8362-8366 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T569 8406-8408 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T570 8431-8433 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T571 8434-8436 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T572 8472-8473 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T573 8481-8485 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T574 8545-8547 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T575 8588-8592 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T576 8669-8670 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T577 8694-8698 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T578 8754-8760 http://purl.obolibrary.org/obo/CL_0000084 denotes T‐cell
T579 8789-8792 http://purl.obolibrary.org/obo/CLO_0052882 denotes CD3
T580 8789-8792 http://purl.obolibrary.org/obo/CLO_0053434 denotes CD3
T581 8808-8811 http://purl.obolibrary.org/obo/CLO_0052882 denotes CD3
T582 8808-8811 http://purl.obolibrary.org/obo/CLO_0053434 denotes CD3
T583 8879-8885 http://purl.obolibrary.org/obo/CL_0000084 denotes T‐cell
T584 8892-8895 http://purl.obolibrary.org/obo/CLO_0052882 denotes CD3
T585 8892-8895 http://purl.obolibrary.org/obo/CLO_0053434 denotes CD3
T586 8907-8915 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T587 8916-8918 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T588 8933-8938 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T589 8956-8965 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T590 8981-8987 http://purl.obolibrary.org/obo/CL_0000084 denotes T‐cell
T591 9041-9051 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T592 9055-9057 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T593 9071-9076 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T594 9093-9095 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T595 9307-9309 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T596 9367-9368 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T597 9376-9380 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T598 9484-9485 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T599 9493-9497 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T600 9609-9614 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T601 9699-9701 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T602 9709-9711 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T603 9712-9714 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T604 9803-9805 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T605 9985-9989 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T606 10024-10026 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T607 10126-10128 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T608 10164-10166 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T609 10210-10212 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T610 10213-10215 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T611 10461-10463 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T612 10726-10728 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T613 10780-10785 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T614 10893-10902 http://purl.obolibrary.org/obo/CLO_0053695 denotes human IgG
T615 11127-11129 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T616 11130-11132 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T617 11303-11305 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T618 11306-11308 http://purl.obolibrary.org/obo/CLO_0008882 denotes Rs
T619 11326-11328 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T620 11375-11377 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T621 11420-11421 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T622 11514-11516 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T623 11585-11587 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T624 11769-11771 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T625 11813-11815 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T626 11868-11870 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T627 11891-11894 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T628 11923-11927 http://purl.obolibrary.org/obo/CLO_0007437 denotes m –1
T629 11923-11927 http://purl.obolibrary.org/obo/CLO_0007448 denotes m –1
T630 11923-11927 http://purl.obolibrary.org/obo/CLO_0007449 denotes m –1
T631 11923-11927 http://purl.obolibrary.org/obo/CLO_0050175 denotes m –1
T632 11923-11927 http://purl.obolibrary.org/obo/CLO_0052399 denotes m –1
T633 11948-11950 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T634 11969-11970 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T635 11996-11998 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T636 12017-12021 http://purl.obolibrary.org/obo/CLO_0007437 denotes m –1
T637 12017-12021 http://purl.obolibrary.org/obo/CLO_0007448 denotes m –1
T638 12017-12021 http://purl.obolibrary.org/obo/CLO_0007449 denotes m –1
T639 12017-12021 http://purl.obolibrary.org/obo/CLO_0050175 denotes m –1
T640 12017-12021 http://purl.obolibrary.org/obo/CLO_0052399 denotes m –1
T641 12038-12039 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T642 12090-12098 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T643 12133-12135 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T644 12175-12179 http://purl.obolibrary.org/obo/CLO_0007437 denotes m –1
T645 12175-12179 http://purl.obolibrary.org/obo/CLO_0007448 denotes m –1
T646 12175-12179 http://purl.obolibrary.org/obo/CLO_0007449 denotes m –1
T647 12175-12179 http://purl.obolibrary.org/obo/CLO_0050175 denotes m –1
T648 12175-12179 http://purl.obolibrary.org/obo/CLO_0052399 denotes m –1
T649 12275-12277 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T650 12359-12362 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T651 12377-12385 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T652 12420-12422 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T103 167-175 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T104 298-306 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T105 407-415 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T106 548-556 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T107 700-707 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T108 765-773 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T109 999-1006 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T110 1049-1056 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T111 1072-1080 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T112 1260-1268 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T113 1344-1361 Chemical denotes glycosaminoglycan http://purl.obolibrary.org/obo/CHEBI_18085
T114 1417-1430 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T115 1589-1596 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T116 1758-1764 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T117 1847-1855 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T118 1905-1912 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T119 2056-2063 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T120 2161-2169 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T121 2244-2252 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T122 2379-2387 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T123 2607-2614 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T124 2686-2693 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T125 3394-3405 Chemical denotes polypeptide http://purl.obolibrary.org/obo/CHEBI_15841
T126 3517-3528 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T127 3577-3585 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T128 3732-3740 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T129 3889-3897 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T130 4089-4091 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T132 4337-4339 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T134 4795-4802 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T135 4995-4997 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T137 5065-5067 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T139 5094-5096 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T141 5264-5273 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T142 5441-5448 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T143 6266-6272 Chemical denotes toxins http://purl.obolibrary.org/obo/CHEBI_27026
T144 6407-6421 Chemical denotes macromolecules http://purl.obolibrary.org/obo/CHEBI_33839
T145 6470-6477 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T146 6981-6988 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T147 7157-7165 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T148 7175-7182 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T149 7283-7285 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T151 7295-7302 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T152 7405-7412 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T153 7489-7497 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T154 7516-7523 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T155 7685-7692 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T156 7806-7813 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T157 7880-7887 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T158 8057-8064 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T159 8303-8312 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T160 8833-8841 Chemical denotes mitogens http://purl.obolibrary.org/obo/CHEBI_52290
T161 9894-9901 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T162 9976-9984 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T163 10029-10038 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T164 10464-10466 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T166 10729-10731 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T168 10797-10807 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T169 10968-10978 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T170 10968-10973 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T171 10974-10978 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T172 11092-11099 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T173 11177-11179 Chemical denotes KD http://purl.obolibrary.org/obo/CHEBI_73601
T174 11689-11702 Chemical denotes phenylalanine http://purl.obolibrary.org/obo/CHEBI_28044|http://purl.obolibrary.org/obo/CHEBI_58095
T176 11703-11709 Chemical denotes valine http://purl.obolibrary.org/obo/CHEBI_27266
T177 11985-11991 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T178 11999-12001 Chemical denotes RI http://purl.obolibrary.org/obo/CHEBI_73814|http://purl.obolibrary.org/obo/CHEBI_8753
T180 12219-12228 Chemical denotes histidine http://purl.obolibrary.org/obo/CHEBI_27570
T181 12449-12457 Chemical denotes arginine http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_32696

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T132 270-277 http://purl.obolibrary.org/obo/BFO_0000019 denotes quality
T133 416-421 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T134 1269-1274 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T135 1382-1390 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T136 1603-1607 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T137 1856-1860 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T138 1861-1869 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T139 1951-1959 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T140 2536-2540 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T141 2908-2913 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T142 3016-3024 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T143 3170-3182 http://purl.obolibrary.org/obo/OBI_0100026 denotes organization
T144 3190-3194 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T145 3434-3442 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T146 3636-3646 http://purl.obolibrary.org/obo/IDO_0000607 denotes productive
T147 3741-3750 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T148 3828-3833 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T149 3898-3907 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T150 3925-3929 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T151 4373-4377 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T152 4498-4502 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T153 4666-4674 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T154 4757-4761 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T155 4934-4938 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T156 4950-4960 http://purl.obolibrary.org/obo/CL_0000738 denotes leukocytes
T157 5178-5186 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T158 5248-5252 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T159 5291-5296 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T160 5377-5381 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T161 5562-5566 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T162 5952-5960 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T163 6254-6261 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T164 6266-6272 http://purl.obolibrary.org/obo/IDO_0000549 denotes toxins
T165 6514-6529 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T166 7535-7540 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T167 7583-7588 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T168 7758-7763 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T169 7840-7844 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T170 7893-7898 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T171 8107-8123 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T172 8141-8145 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T173 8166-8171 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T174 8188-8193 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T175 8337-8341 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T176 8362-8366 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T177 8481-8485 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T178 8588-8592 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T179 8694-8698 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T180 8756-8760 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T181 8881-8885 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T182 8933-8938 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T183 8983-8987 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T184 9071-9076 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T185 9376-9380 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T186 9493-9497 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T187 9609-9614 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T188 9985-9989 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T189 10780-10785 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T190 10857-10862 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T191 11039-11049 http://purl.obolibrary.org/obo/BFO_0000034 denotes functional
T192 11755-11759 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T193 12079-12089 http://purl.obolibrary.org/obo/BFO_0000034 denotes functional
T194 12264-12268 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T195 12366-12376 http://purl.obolibrary.org/obo/BFO_0000034 denotes functional

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T23 1344-1361 Chemical denotes glycosaminoglycan http://purl.obolibrary.org/obo/CHEBI_18085
T24 1417-1430 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T25 2244-2252 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T26 2379-2387 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T27 3394-3405 Chemical denotes polypeptide http://purl.obolibrary.org/obo/CHEBI_15841
T28 6407-6421 Chemical denotes macromolecules http://purl.obolibrary.org/obo/CHEBI_33839
T29 10968-10978 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T30 11689-11702 Chemical denotes phenylalanine http://purl.obolibrary.org/obo/CHEBI_28044|http://purl.obolibrary.org/obo/CHEBI_58095
T32 11703-11709 Chemical denotes valine http://purl.obolibrary.org/obo/CHEBI_27266
T33 12219-12228 Chemical denotes histidine http://purl.obolibrary.org/obo/CHEBI_27570
T34 12449-12457 Chemical denotes arginine http://purl.obolibrary.org/obo/CHEBI_32696|http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
405 162-166 Gene denotes FcγR Gene:2213
410 504-508 Gene denotes FcγR Gene:2213
411 1193-1197 Gene denotes FcγR Gene:2213
412 760-764 Gene denotes FcγR Gene:2213
413 630-634 Gene denotes FcγR Gene:2213
418 2093-2098 Disease denotes flush MESH:D005483
419 2333-2345 Disease denotes cytotoxicity MESH:D064420
420 2396-2408 Disease denotes cytotoxicity MESH:D064420
421 2515-2520 Disease denotes flush MESH:D005483
426 3011-3015 Gene denotes FcγR Gene:2213
427 2902-2906 Gene denotes FcγR Gene:2213
428 2852-2856 Chemical denotes ADCP
429 2835-2847 Disease denotes cytotoxicity MESH:D064420
432 3165-3169 Gene denotes FcγR Gene:2213
433 3413-3419 Chemical denotes glycan MESH:D011134
443 3813-3821 Gene denotes FcγRIIIa Gene:2214
444 4074-4081 Gene denotes FcγRIIa Gene:2212
445 4086-4091 Gene denotes FcγRI Gene:2214
446 4292-4299 Gene denotes FcγRIII Gene:2214
447 4322-4329 Gene denotes FcγRIIa Gene:2212
448 4334-4339 Gene denotes FcγRI Gene:2214
449 3717-3721 Gene denotes FcγR Gene:2213
450 4190-4198 Species denotes patients Tax:9606
451 4021-4027 Disease denotes cancer MESH:D009369
464 4692-4699 Gene denotes FcγRIIb Gene:2213
465 4832-4835 Gene denotes BCR Gene:613
466 4913-4921 Gene denotes FcγRIIb1 Gene:1555
467 4992-4997 Gene denotes FcγRI Gene:2214
468 4999-5006 Gene denotes FcγRIIa Gene:2212
469 5017-5024 Gene denotes FcγRIII Gene:2214
470 5346-5349 Gene denotes BCR Gene:613
471 5478-5481 Gene denotes BCR Gene:613
472 5541-5549 Gene denotes FcγRIIB1 Gene:1555
473 5008-5015 Gene denotes FcγRIIc Gene:9103
481 5910-5917 Gene denotes FcγRIIb Gene:14130
482 6150-6157 Gene denotes FcγRIIb Gene:14130
483 5875-5879 Gene denotes FcγR Gene:2213
484 5737-5741 Gene denotes FcγR Gene:2213
485 5650-5656 Species denotes humans Tax:9606
486 6185-6189 Species denotes mice Tax:10090
487 6194-6200 Species denotes humans Tax:9606
493 6810-6814 Gene denotes FcγR Gene:2213
494 6690-6694 Species denotes mice Tax:10090
495 6768-6776 Species denotes patients Tax:9606
496 6726-6739 Disease denotes recall memory MESH:D008569
497 6868-6873 Disease denotes tumor MESH:D009369
504 7280-7285 Gene denotes FcγRI Gene:2214
505 7045-7049 Gene denotes FcγR Gene:2213
506 6954-6958 Gene denotes FcγR Gene:2213
507 7274-7279 Species denotes human Tax:9606
508 7329-7333 Species denotes mice Tax:10090
509 7289-7294 Species denotes human Tax:9606
511 7707-7714 Gene denotes FcγRIIb Gene:2213
513 7933-7940 Gene denotes FcγRIIb Gene:2213
515 8160-8164 Gene denotes FcγR Gene:2213
524 9256-9261 Gene denotes CD357 Gene:8784
525 9093-9097 Gene denotes FcγR Gene:2213
526 9055-9059 Gene denotes FcγR Gene:2213
527 8916-8920 Gene denotes FcγR Gene:2213
528 8545-8549 Gene denotes FcγR Gene:2213
529 8277-8281 Gene denotes FcγR Gene:2213
530 8148-8164 Gene denotes und mAbs by FcγR Gene:2213
531 8224-8236 Species denotes participants Tax:9606
535 9307-9311 Gene denotes FcγR Gene:2213
536 9534-9545 Chemical denotes daratumumab MESH:C556306
537 9475-9480 Disease denotes death MESH:D003643
544 10461-10466 Gene denotes FcγRI Gene:2214
545 10726-10731 Gene denotes FcγRI Gene:2214
546 10797-10809 Gene denotes interferon‐γ Gene:3458
547 10164-10168 Gene denotes FcγR Gene:2213
548 10024-10028 Gene denotes FcγR Gene:2213
549 10866-10878 Disease denotes inflammation MESH:D007249
554 11071-11075 Gene denotes IgG3 Gene:3502
555 11326-11333 Gene denotes FcγRIIb Gene:2213
556 11375-11382 Gene denotes FcγRIII Gene:2214
557 10893-10898 Species denotes human Tax:9606
562 11585-11593 Gene denotes FcγRIIIa Gene:2214
563 11514-11518 Gene denotes FcγR Gene:2213
564 11689-11702 Chemical denotes phenylalanine MESH:D010649
565 11703-11709 Chemical denotes valine MESH:D014633
572 11948-11955 Gene denotes FcγRIIb Gene:2213
573 11996-12001 Gene denotes FcγRI Gene:2214
574 12133-12140 Gene denotes FcγRIIa Gene:2212
575 11868-11872 Gene denotes FcγR Gene:2213
576 12219-12228 Chemical denotes histidine MESH:D006639
577 12449-12457 Chemical denotes arginine MESH:D001120

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T27 5650-5656 Species denotes humans NCBItxid:9605
T28 6185-6189 Species denotes mice NCBItxid:10095|NCBItxid:10088
T30 6194-6200 Species denotes humans NCBItxid:9605
T31 6254-6261 Species denotes viruses NCBItxid:10239
T32 6690-6694 Species denotes mice NCBItxid:10095|NCBItxid:10088
T34 7274-7279 Species denotes human NCBItxid:9606
T35 7289-7294 Species denotes human NCBItxid:9606
T36 7329-7333 Species denotes mice NCBItxid:10095|NCBItxid:10088
T38 10893-10898 Species denotes human NCBItxid:9606

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T130 0-33 Sentence denotes FcγR‐Dependent Effector Responses
T131 35-126 Sentence denotes Not all opsonized targets are equal: size, distance, valency and Fc geometry affect potency
T132 127-422 Sentence denotes To understand the immunobiology of FcγR effector responses particularly in the therapeutic mAb context, it is important to appreciate that the quality and potency of such effector responses is greatly affected by the nature of the IgG immune complex and/or the state of potential effector cells.
T133 423-566 Sentence denotes First, opsonization, per se, of a target is not necessarily sufficient to ensure FcγR interaction in a way that initiates an effector response.
T134 567-1241 Sentence denotes Although it is the IgG Fc that interacts with and clusters the FcγR to induce a response, the nature of the Fab interaction with its epitope can strongly influence the likelihood or potency of FcγR effector responses by influencing the density of appropriately presented Fc portions.35 and also the size of the immune complex.36 Furthermore, the display/orientation and geometry of the Fc portions, as a consequence of the fragment antigen‐binding (Fab) interaction with the target epitope, can result in effector responses such as ADCC that differ substantially in potency, presumably because the orientation of the Fc makes FcγR engagement more, or less, accessible.37, 38
T135 1242-1597 Sentence denotes Second, in innate effector cells at rest, the largely linear actin cytoskeleton and the extracellular glycosaminoglycan glycocalyx regulate function by interacting with large glycoproteins, such as CD44, arranging these into ordered “picket” fences.39, 40 These corral receptors, including the FcγRs, and sterically inhibit their interaction with ligands.
T136 1598-2296 Sentence denotes Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC.
T137 2297-2442 Sentence denotes Interestingly, complement‐dependent cytotoxicity which also utilizes pore‐forming proteins for its cytotoxicity has similar distance constraints.
T138 2443-2736 Sentence denotes By contrast, ADCP was poor  when targeting epitopes displayed close or "flush" to the target cell membrane (within ~0.3 nm) but ADCP activity was restored when the epitope was displayed 1.5 nm off the membrane, demonstrating different optimal epitope distance requirements for ADCC and ADCP.42
T139 2737-2932 Sentence denotes Although the action of agonistic/antagonistic mAbs is mechanistically distinct to those eliciting cytotoxicity and ADCP, the distance segregation between target and FcγR+ cells is also important.
T140 2933-3064 Sentence denotes Indeed, the membrane proximal epitopes of CD28 and CD40 are important for the FcγR function in the complex MOA of these mAbs.43, 44
T141 3065-3309 Sentence denotes Clearly, the effects of immune complex valency, Fc density, presentation and geometry together with FcγR organization in the cell membrane suggest that the development of mAbs to certain targets will be heavily influenced by the context of use.
T142 3310-3426 Sentence denotes Thus, improved mAb potency may not necessarily be achieved by engineering of the Fc polypeptide or its glycan alone.
T143 3427-3647 Sentence denotes A more function‐oriented approach early in mAb selection and development by, for example, application of rapid screening technologies that select for effector potency,34 followed by Fc engineering may be more productive.
T144 3649-3670 Sentence denotes ADCC and phagocytosis
T145 3671-3882 Sentence denotes ADCC and ADCP are the most widely appreciated FcγR‐dependent effector functions (Figure 1a, b) and are, respectively, mediated primarily via  FcγRIIIa on NK cells and professional phagocytes such as macrophages.
T146 3883-4036 Sentence denotes These effector functions, particularly NK cell ADCC, are believed to be major components of the MOA of cytotoxic therapeutic mAbs used in cancer therapy.
T147 4037-4210 Sentence denotes In addition, ADCP can also occur via FcγRIIa and FcγRI,45 but the extent to which cytotoxic anticancer therapeutic mAbs depend on these for their MOA in patients is unclear.
T148 4211-4482 Sentence denotes The improvement in clinical utility of mAbs engineered for selectively increased FcγRIII binding suggests that FcγRIIa and FcγRI may be less important in vivo in cell killing effects but perhaps are more important in other aspects of therapeutic efficacy—discussed later.
T149 4484-4524 Sentence denotes Inhibition of cell activation by FcγRIIb
T150 4525-4649 Sentence denotes FcγRIIb is an immune checkpoint46, 47 and its splice variants are potent modulators of ITAM‐dependent signaling (Figure 1c).
T151 4650-4748 Sentence denotes This modulatory function occurs only when FcγRIIb is coaggregated with an ITAM signaling receptor.
T152 4749-5162 Sentence denotes Thus, B‐cell activation by the binding of the antigen in the immune complex to the BCR is regulated by the simultaneous binding of the Fcs of the immune complex to FcγRIIb1 on the same cell. In innate leukocytes, the activating‐type FcR (i.e. FcγRI, FcγRIIa, FcγRIIc, FcγRIII) and the high‐affinity IgE receptor, FcεRI, and the IgA receptor, FcαRI, are all modulated by immune complex co‐engagement with FcγRIIb2.
T153 5163-5368 Sentence denotes The inhibitory function contributes to the MOA of therapeutic antibodies that target cell‐activating molecules where the target cells also express the inhibitory FcγRIIbs such as the BCR (discussed later).
T154 5369-5567 Sentence denotes Thus, B‐cell activation is modulated by the simulatenous binding of the antigen in the immune complex to the BCR and the binding of the Fcs, also in the immune complex, to FcγRIIB1 on the same cell.
T155 5569-5614 Sentence denotes Sweeping: clearance of small immune complexes
T156 5615-5742 Sentence denotes The removal of immune complexes in humans depends primarily on the complement receptor pathway and to a lesser degree the FcγR.
T157 5743-5880 Sentence denotes Among the FcγRs, it has been widely believed that immune complex removal only occurs by phagocytosis/endocytosis of activating‐type FcγR.
T158 5881-6201 Sentence denotes Surprisingly, the inhibitory FcγRIIb, which lacks intrinsic activating function, plays a major role in clearance, and rapidly “sweeps” away small complexes from the circulation (Figure 1d).48, 49 A major tissue involved in the clearance is likely to be the LSEC, where FcγRIIb is expressed abundantly in mice and humans.
T159 6202-6453 Sentence denotes This role is potentially important in resistance to viruses and toxins but may also be key to optimal performance of therapeutic IgG mAbs whose primary MOA is believed to be only neutralization of soluble macromolecules, for example, cytokines or IgE.
T160 6455-6529 Sentence denotes FcγR uptake of antigen: antibody complexes and shaping the immune response
T161 6530-6592 Sentence denotes Monoclonal antibody therapy is a form of passive immunization.
T162 6593-6914 Sentence denotes Indeed, longer‐term vaccine‐like or vaccinal immunity has been demonstrated in anti‐CD20‐treated mice via FcγRIIa50, 51 and in vitro recall memory responses from CD20‐treated patients.52 Although this is dependent on FcγR and anti‐CD20, the mechanism by which long‐term anti‐tumor response is established remains unclear.
T163 6915-7616 Sentence denotes Nonetheless, the active involvement of FcγR in the enhancement of antigen‐specific immunity by uptake of immune complexes through FcγR is historically well documented in experimental systems where FcγRs bind immune complexes and thereby feed antigens into the antigen‐presentation pathways.53 This has been demonstrated in vivo for small immune complexes via human FcγRI on human antigen‐presenting cells54 and in mice.19 Similarly, the capacity of FcγRIIbs to bind and rapidly internalize antigen–antibody complexes suggests that it too may significantly influence feeding antigens into professional antigen‐presenting cells of hematopoietic origin such as dendritic cells and possibly B lymphocytes.
T164 7617-7901 Sentence denotes Although not a classical major histocompatibility complex‐dependent antigen presentation, FcγRIIb on the stroma‐derived follicular dendritic cells influences antibody immunity by recycling antigen–antibody complexes to the cell surface for presentation of intact antigen to B cells.55
T165 7902-8124 Sentence denotes Although somewhat speculative, FcγRIIb’s rapid internalization/sweeping of complexes by the abundant LSEC, which interact with lymphocytes and can present antigen,56 may have a significant role in shaping immune responses.
T166 8126-8171 Sentence denotes Scaffolding of cell‐bound mAbs by FcγR+ cells
T167 8172-8273 Sentence denotes FcγR‐expressing cells can be critical, but passive, participants in the MOA of some mAbs (Figure 1e).
T168 8274-8486 Sentence denotes In FcγR scaffolding, IgG mAb molecules that have opsonized the cell surface of a target cell are additionally cross‐linked by their Fc portions engaging the FcγRs that are arrayed on the surface of a second cell.
T169 8487-8699 Sentence denotes This “super‐cross‐linking” of the target‐bound mAb by the FcγR lattice or “scaffold” on the adjacent cell greatly exceeds the target cross‐linking by the mAb alone, thereby inducing a response in the target cell.
T170 8700-9293 Sentence denotes Scaffolding was originally identified as the basis of T‐cell mitogenesis induced by anti‐CD3 mAb.57, 58 The CD3 mAbs alone were poor mitogens but the “super‐cross‐linking” of the T‐cell‐bound CD3 mAb by the membrane FcγR on adjacent cells, particularly by monocytes, induced rapid T‐cell expansion and cytokine secretion but did not require activation of FcγR‐expressing cells.57 Regrettably, FcγR scaffolding came to prominence and clinical relevance because of its causal role in the catastrophic adverse events resulting from the administration of anti‐CD357 and anti‐CD28 (TGN1412)59 mAbs.
T171 9294-9429 Sentence denotes Nonetheless, FcγR scaffold‐based induction of intracellular responses in a target cell can also lead to beneficial therapeutic effects.
T172 9430-9652 Sentence denotes Such examples are the induction of apoptotic death in a target cell, which is likely part of the MOA of daratumumab in multiple myeloma60 or the controlled agonistic expansion of cells, for example, via CD40 mAb agonism.43
T173 9654-9703 Sentence denotes IgG subclasses: specificity and affinity for FcγR
T174 9704-9927 Sentence denotes Most FcγRs (Table 2) are weak, low‐affinity receptors (affinities in the micromolar range) for IgG‐Fc, irrespective of whether the IgG is uncomplexed, monomeric or when it is complexed with antigen (i.e. an immune complex).
T175 9928-10169 Sentence denotes The very avid binding of immune complexes to an effector cell surface that displays an array of FcγR molecules is the result of the collective contributions of the low‐affinity interactions of each Fc of the IgGs in the complex with an FcγR.
T176 10170-10322 Sentence denotes This avidity effect is necessary as the FcγRs operate in vivo in environments of high concentrations of uncomplexed monomeric IgG (normally 3–12 g L–1).
T177 10323-10413 Sentence denotes Thus, the avid multivalent binding of the complex out competes uncomplexed, monomeric IgG.
T178 10414-10467 Sentence denotes The notable exception to this is the enigmatic FcγRI.
T179 10468-10644 Sentence denotes This receptor shows high, nanomolar affinity for uncomplexed monomeric IgG and thus would be expected to be constantly occupied in vivo by the normal circulating monomeric IgG.
T180 10645-10712 Sentence denotes However, IgG dissociation permits engagement with immune complexes.
T181 10713-10879 Sentence denotes Furthermore, FcγRI is not expressed or expressed poorly on resting cells, requiring interferon‐γ for induction of its expression, presumably at sites of inflammation.
T182 10880-11061 Sentence denotes Although the human IgG heavy‐chain constant domains have greater than 90% identity, key amino acid differences confer each subclass with unique structural and functional properties.
T183 11062-11133 Sentence denotes IgG1 and IgG3 are “universal” ligands, that is, they bind to all FcγRs.
T184 11134-11456 Sentence denotes Formal measurement of the weak, micromolar KD interactions of the low‐affinity receptors with monomeric IgG1 also revealed differing affinities between the low‐affinity FcγRs, with inhibitory FcγRIIb generally having the lowest affinity and FcγRIII the higher, sometimes referred to as a “moderate” affinity receptor.7, 61
T185 11457-11620 Sentence denotes The strength of IgG1 interaction can also be affected by FcγR polymorphism and in the context of therapeutic mAbs, variation in FcγRIIIa is particularly important.
T186 11621-11832 Sentence denotes The most common and possibly clinically significant polymorphism is phenylalanine/valine variation at position 158 in the IgG‐binding site, wherein FcγRIIIa‐F158 binds IgG1 less well than the FcγRIIIa‐V158 form.
T187 11833-11885 Sentence denotes IgG4 and IgG2 have more restricted FcγR specificity.
T188 11886-12023 Sentence denotes IgG4 has low affinity (KA = ~2 × 105 m –1) for the inhibitory FcγRIIb, but is also a high‐affinity ligand for FcγRI (KA = ~4 × 108 m –1).
T189 12024-12269 Sentence denotes IgG2 exhibits a highly restricted specificity, showing functional activity with only one polymorphic form of FcγRIIa (binding affinity KA = ~4.5 × 105 m –1) which is permitted by the presence of histidine at position 131 of its IgG‐binding site.
T190 12270-12480 Sentence denotes This FcγRIIa–H131 form is expressed in approximately 70% of the population, whereas IgG2 has no functional activity on the other common allelic form, FcγRIIa‐R131, which contains arginine at position 131.11, 61

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T15 2231-2235 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915
T16 2366-2370 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915
T17 6085-6091 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T18 7722-7728 Body_part denotes stroma http://purl.obolibrary.org/obo/UBERON_0003891

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T97 1303-1308 Protein denotes actin https://www.uniprot.org/uniprot/Q92193|https://www.uniprot.org/uniprot/Q92192|https://www.uniprot.org/uniprot/Q24733|https://www.uniprot.org/uniprot/Q11212|https://www.uniprot.org/uniprot/P91754|https://www.uniprot.org/uniprot/P90689|https://www.uniprot.org/uniprot/P80709|https://www.uniprot.org/uniprot/P68555|https://www.uniprot.org/uniprot/P45521|https://www.uniprot.org/uniprot/P38136|https://www.uniprot.org/uniprot/P14227|https://www.uniprot.org/uniprot/O17320|https://www.uniprot.org/uniprot/O16808
T110 1417-1430 Protein denotes glycoproteins https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8
T195 1440-1444 Protein denotes CD44 https://www.uniprot.org/uniprot/Q9UJ36|https://www.uniprot.org/uniprot/Q9UCB0|https://www.uniprot.org/uniprot/Q9UC30|https://www.uniprot.org/uniprot/Q9UC29|https://www.uniprot.org/uniprot/Q9UC28|https://www.uniprot.org/uniprot/Q9QYX8|https://www.uniprot.org/uniprot/Q9H5A5|https://www.uniprot.org/uniprot/Q99J14|https://www.uniprot.org/uniprot/Q99021|https://www.uniprot.org/uniprot/Q96J24|https://www.uniprot.org/uniprot/Q92493|https://www.uniprot.org/uniprot/Q8N694|https://www.uniprot.org/uniprot/Q86Z27|https://www.uniprot.org/uniprot/Q86T72|https://www.uniprot.org/uniprot/Q64296|https://www.uniprot.org/uniprot/Q62409|https://www.uniprot.org/uniprot/Q62408|https://www.uniprot.org/uniprot/Q62063|https://www.uniprot.org/uniprot/Q62062|https://www.uniprot.org/uniprot/Q62061|https://www.uniprot.org/uniprot/Q62060|https://www.uniprot.org/uniprot/Q61395|https://www.uniprot.org/uniprot/Q60523|https://www.uniprot.org/uniprot/Q60522|https://www.uniprot.org/uniprot/Q29423|https://www.uniprot.org/uniprot/Q28284|https://www.uniprot.org/uniprot/Q16522|https://www.uniprot.org/uniprot/Q16208|https://www.uniprot.org/uniprot/Q16066|https://www.uniprot.org/uniprot/Q16065|https://www.uniprot.org/uniprot/Q16064|https://www.uniprot.org/uniprot/Q15861|https://www.uniprot.org/uniprot/Q13980|https://www.uniprot.org/uniprot/Q13968|https://www.uniprot.org/uniprot/Q13967|https://www.uniprot.org/uniprot/Q13961|https://www.uniprot.org/uniprot/Q13960|https://www.uniprot.org/uniprot/Q13959|https://www.uniprot.org/uniprot/Q13958|https://www.uniprot.org/uniprot/Q13957|https://www.uniprot.org/uniprot/Q13419|https://www.uniprot.org/uniprot/Q05732|https://www.uniprot.org/uniprot/Q05078|https://www.uniprot.org/uniprot/Q04858|https://www.uniprot.org/uniprot/P26051|https://www.uniprot.org/uniprot/P22511|https://www.uniprot.org/uniprot/P20944|https://www.uniprot.org/uniprot/P16070|https://www.uniprot.org/uniprot/P15379|https://www.uniprot.org/uniprot/P14745|https://www.uniprot.org/uniprot/O95370|https://www.uniprot.org/uniprot/D3DR13|https://www.uniprot.org/uniprot/D3DR12|https://www.uniprot.org/uniprot/B6EAT9|https://www.uniprot.org/uniprot/A5YRN9
T250 2975-2979 Protein denotes CD28 https://www.uniprot.org/uniprot/Q9BYV0|https://www.uniprot.org/uniprot/Q8WXJ2|https://www.uniprot.org/uniprot/Q8NI56|https://www.uniprot.org/uniprot/Q8NI55|https://www.uniprot.org/uniprot/Q8NI54|https://www.uniprot.org/uniprot/Q70WG0|https://www.uniprot.org/uniprot/Q6GSH7|https://www.uniprot.org/uniprot/Q52M23|https://www.uniprot.org/uniprot/Q28071|https://www.uniprot.org/uniprot/Q13964|https://www.uniprot.org/uniprot/P42069|https://www.uniprot.org/uniprot/P31042|https://www.uniprot.org/uniprot/P31041|https://www.uniprot.org/uniprot/P10747|https://www.uniprot.org/uniprot/O02757|https://www.uniprot.org/uniprot/A8KAC1
T266 2984-2988 Protein denotes CD40 https://www.uniprot.org/uniprot/Q9BYU0|https://www.uniprot.org/uniprot/Q99NE3|https://www.uniprot.org/uniprot/Q99NE2|https://www.uniprot.org/uniprot/Q99NE1|https://www.uniprot.org/uniprot/Q99NE0|https://www.uniprot.org/uniprot/Q8SQ34|https://www.uniprot.org/uniprot/Q8K2X6|https://www.uniprot.org/uniprot/Q86YK5|https://www.uniprot.org/uniprot/Q7YRL5|https://www.uniprot.org/uniprot/Q7M4Q8|https://www.uniprot.org/uniprot/Q5U007|https://www.uniprot.org/uniprot/Q5JY15|https://www.uniprot.org/uniprot/Q542B1|https://www.uniprot.org/uniprot/Q53GN5|https://www.uniprot.org/uniprot/Q3ZTK5|https://www.uniprot.org/uniprot/Q3UBH3|https://www.uniprot.org/uniprot/Q3U7C9|https://www.uniprot.org/uniprot/Q3U799|https://www.uniprot.org/uniprot/Q3TSL2|https://www.uniprot.org/uniprot/Q3TS33|https://www.uniprot.org/uniprot/Q3LRP1|https://www.uniprot.org/uniprot/Q28203|https://www.uniprot.org/uniprot/P27512|https://www.uniprot.org/uniprot/P25942|https://www.uniprot.org/uniprot/E1P5S9|https://www.uniprot.org/uniprot/A7YWS9
T292 6677-6681 Protein denotes CD20 https://www.uniprot.org/uniprot/Q3C2E2|https://www.uniprot.org/uniprot/Q13963|https://www.uniprot.org/uniprot/P19437|https://www.uniprot.org/uniprot/P11836|https://www.uniprot.org/uniprot/P08984|https://www.uniprot.org/uniprot/B4DT24|https://www.uniprot.org/uniprot/A6NMS4
T299 6755-6759 Protein denotes CD20 https://www.uniprot.org/uniprot/Q3C2E2|https://www.uniprot.org/uniprot/Q13963|https://www.uniprot.org/uniprot/P19437|https://www.uniprot.org/uniprot/P11836|https://www.uniprot.org/uniprot/P08984|https://www.uniprot.org/uniprot/B4DT24|https://www.uniprot.org/uniprot/A6NMS4
T306 6824-6828 Protein denotes CD20 https://www.uniprot.org/uniprot/Q3C2E2|https://www.uniprot.org/uniprot/Q13963|https://www.uniprot.org/uniprot/P19437|https://www.uniprot.org/uniprot/P11836|https://www.uniprot.org/uniprot/P08984|https://www.uniprot.org/uniprot/B4DT24|https://www.uniprot.org/uniprot/A6NMS4
T313 9256-9261 Protein denotes CD357 https://www.uniprot.org/uniprot/Q9Y5U5|https://www.uniprot.org/uniprot/Q9NYJ9|https://www.uniprot.org/uniprot/Q9JKR3|https://www.uniprot.org/uniprot/Q9JKR2|https://www.uniprot.org/uniprot/Q9JKR1|https://www.uniprot.org/uniprot/Q5U0I4|https://www.uniprot.org/uniprot/O95851|https://www.uniprot.org/uniprot/O35714|https://www.uniprot.org/uniprot/B1AME1
T322 9271-9275 Protein denotes CD28 https://www.uniprot.org/uniprot/Q9BYV0|https://www.uniprot.org/uniprot/Q8WXJ2|https://www.uniprot.org/uniprot/Q8NI56|https://www.uniprot.org/uniprot/Q8NI55|https://www.uniprot.org/uniprot/Q8NI54|https://www.uniprot.org/uniprot/Q70WG0|https://www.uniprot.org/uniprot/Q6GSH7|https://www.uniprot.org/uniprot/Q52M23|https://www.uniprot.org/uniprot/Q28071|https://www.uniprot.org/uniprot/Q13964|https://www.uniprot.org/uniprot/P42069|https://www.uniprot.org/uniprot/P31042|https://www.uniprot.org/uniprot/P31041|https://www.uniprot.org/uniprot/P10747|https://www.uniprot.org/uniprot/O02757|https://www.uniprot.org/uniprot/A8KAC1
T338 9633-9637 Protein denotes CD40 https://www.uniprot.org/uniprot/Q9BYU0|https://www.uniprot.org/uniprot/Q99NE3|https://www.uniprot.org/uniprot/Q99NE2|https://www.uniprot.org/uniprot/Q99NE1|https://www.uniprot.org/uniprot/Q99NE0|https://www.uniprot.org/uniprot/Q8SQ34|https://www.uniprot.org/uniprot/Q8K2X6|https://www.uniprot.org/uniprot/Q86YK5|https://www.uniprot.org/uniprot/Q7YRL5|https://www.uniprot.org/uniprot/Q7M4Q8|https://www.uniprot.org/uniprot/Q5U007|https://www.uniprot.org/uniprot/Q5JY15|https://www.uniprot.org/uniprot/Q542B1|https://www.uniprot.org/uniprot/Q53GN5|https://www.uniprot.org/uniprot/Q3ZTK5|https://www.uniprot.org/uniprot/Q3UBH3|https://www.uniprot.org/uniprot/Q3U7C9|https://www.uniprot.org/uniprot/Q3U799|https://www.uniprot.org/uniprot/Q3TSL2|https://www.uniprot.org/uniprot/Q3TS33|https://www.uniprot.org/uniprot/Q3LRP1|https://www.uniprot.org/uniprot/Q28203|https://www.uniprot.org/uniprot/P27512|https://www.uniprot.org/uniprot/P25942|https://www.uniprot.org/uniprot/E1P5S9|https://www.uniprot.org/uniprot/A7YWS9
T364 10797-10807 Protein denotes interferon https://www.uniprot.org/uniprot/P51527|https://www.uniprot.org/uniprot/P51526
T366 11909-11916 Protein denotes KA = ~2 https://www.uniprot.org/uniprot/Q8WWG8|https://www.uniprot.org/uniprot/Q63273|https://www.uniprot.org/uniprot/Q62643|https://www.uniprot.org/uniprot/Q61626|https://www.uniprot.org/uniprot/Q16478|https://www.uniprot.org/uniprot/G5E822

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T232 358-361 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T233 416-421 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T234 586-589 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T235 1269-1274 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T236 1303-1321 Body_part denotes actin cytoskeleton http://purl.org/sig/ont/fma/fma84684
T237 1344-1361 Body_part denotes glycosaminoglycan http://purl.org/sig/ont/fma/fma63011
T238 1362-1372 Body_part denotes glycocalyx http://purl.org/sig/ont/fma/fma66838
T239 1417-1430 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T240 1603-1607 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T241 1856-1860 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T242 2244-2252 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T243 2379-2387 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T244 2536-2549 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T245 2536-2540 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T246 2908-2913 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T247 3190-3203 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T248 3190-3194 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T249 3825-3833 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T250 3828-3833 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T251 3870-3881 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T252 3922-3929 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T253 3925-3929 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T254 4373-4377 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T255 4498-4502 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T256 4757-4761 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T257 4934-4938 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T258 4950-4960 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T259 5048-5051 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875
T260 5077-5080 Body_part denotes IgA http://purl.org/sig/ont/fma/fma62874
T261 5248-5252 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T262 5291-5296 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T263 5377-5381 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T264 5562-5566 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T265 6085-6091 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T266 6331-6334 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T267 6436-6445 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T268 6449-6452 Body_part denotes IgE http://purl.org/sig/ont/fma/fma62875
T269 6479-6487 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T270 6541-6549 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T271 7413-7421 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T272 7516-7540 Body_part denotes antigen‐presenting cells http://purl.org/sig/ont/fma/fma273565
T273 7535-7540 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T274 7573-7588 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T275 7583-7588 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T276 7602-7615 Body_part denotes B lymphocytes http://purl.org/sig/ont/fma/fma62869
T277 7642-7674 Body_part denotes major histocompatibility complex http://purl.org/sig/ont/fma/fma84079
T278 7722-7728 Body_part denotes stroma http://purl.org/sig/ont/fma/fma81494
T279 7737-7763 Body_part denotes follicular dendritic cells http://purl.org/sig/ont/fma/fma83037
T280 7758-7763 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T281 7775-7783 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T282 7814-7822 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T283 7840-7852 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T284 7840-7844 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T285 7893-7898 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T286 8029-8040 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T287 8141-8145 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T288 8166-8171 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T289 8188-8193 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T290 8295-8298 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T291 8337-8349 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T292 8337-8341 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T293 8362-8366 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T294 8481-8485 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T295 8588-8592 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T296 8694-8698 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T297 8756-8760 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T298 8881-8885 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T299 8933-8938 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T300 8956-8965 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T301 8983-8987 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T302 9002-9010 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T303 9071-9076 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T304 9376-9380 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T305 9493-9497 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T306 9609-9614 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T307 9654-9657 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T308 9799-9802 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T309 9835-9838 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T310 9985-9997 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T311 9985-9989 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T312 10296-10299 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T313 10409-10412 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T314 10539-10542 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T315 10640-10643 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T316 10654-10657 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T317 10780-10785 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T318 10899-10902 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T319 10968-10978 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T320 11689-11702 Body_part denotes phenylalanine http://purl.org/sig/ont/fma/fma82754
T321 11703-11709 Body_part denotes valine http://purl.org/sig/ont/fma/fma82766
T322 11743-11746 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T323 12219-12228 Body_part denotes histidine http://purl.org/sig/ont/fma/fma82755
T324 12252-12255 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T325 12449-12457 Body_part denotes arginine http://purl.org/sig/ont/fma/fma82763

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T10 2954-2962 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T11 4476-4481 http://purl.obolibrary.org/obo/MAT_0000488 denotes later
T12 5361-5366 http://purl.obolibrary.org/obo/MAT_0000488 denotes later

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T53 430-442 http://purl.obolibrary.org/obo/GO_0008228 denotes opsonization
T54 1099-1103 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T55 1603-1618 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T56 1758-1773 http://purl.obolibrary.org/obo/GO_1990256 denotes ligand, cluster
T57 2013-2017 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T58 2030-2034 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T59 2146-2157 http://purl.obolibrary.org/obo/GO_0000746 denotes conjugation
T60 2291-2295 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T61 2312-2345 http://purl.obolibrary.org/obo/GO_0097278 denotes complement‐dependent cytotoxicity
T62 2720-2724 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T63 3649-3653 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T64 3658-3670 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T65 3671-3675 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T66 3930-3934 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T67 4373-4385 http://purl.obolibrary.org/obo/GO_0001906 denotes cell killing
T68 4484-4513 http://purl.obolibrary.org/obo/GO_0050866 denotes Inhibition of cell activation
T69 4498-4513 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T70 4627-4636 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T71 4729-4738 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T72 4755-4772 http://purl.obolibrary.org/obo/GO_0042113 denotes B‐cell activation
T73 4757-4772 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T74 5375-5392 http://purl.obolibrary.org/obo/GO_0042113 denotes B‐cell activation
T75 5377-5392 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T76 5831-5843 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T77 5844-5855 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T78 6460-6466 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T79 6514-6529 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T80 6733-6739 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T81 7010-7016 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T82 7175-7195 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen‐presentation
T83 7642-7674 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T84 7685-7705 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen presentation
T85 8107-8123 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T86 8983-8997 http://purl.obolibrary.org/obo/GO_0016049 denotes cell expansion
T87 9002-9020 http://purl.obolibrary.org/obo/GO_0050663 denotes cytokine secretion
T88 9011-9020 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T89 9475-9480 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T90 10866-10878 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T17 4021-4027 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T18 6868-6873 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T19 10866-10878 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T8 4021-4027 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T9 6868-6873 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T53 430-442 http://purl.obolibrary.org/obo/GO_0008228 denotes opsonization
T54 1099-1103 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T55 1603-1618 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T56 1758-1773 http://purl.obolibrary.org/obo/GO_1990256 denotes ligand, cluster
T57 2013-2017 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T58 2030-2034 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T59 2146-2157 http://purl.obolibrary.org/obo/GO_0000746 denotes conjugation
T60 2291-2295 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T61 2312-2345 http://purl.obolibrary.org/obo/GO_0097278 denotes complement‐dependent cytotoxicity
T62 2720-2724 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T63 3649-3653 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T64 3658-3670 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T65 3671-3675 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T66 3930-3934 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T67 4373-4385 http://purl.obolibrary.org/obo/GO_0001906 denotes cell killing
T68 4484-4513 http://purl.obolibrary.org/obo/GO_0050866 denotes Inhibition of cell activation
T69 4498-4513 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T70 4627-4636 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T71 4729-4738 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T72 4755-4772 http://purl.obolibrary.org/obo/GO_0042113 denotes B‐cell activation
T73 4757-4772 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T74 5375-5392 http://purl.obolibrary.org/obo/GO_0042113 denotes B‐cell activation
T75 5377-5392 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T76 5831-5843 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T77 5844-5855 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T78 6460-6466 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T79 6460-6466 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T80 6514-6529 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T81 6733-6739 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T82 7010-7016 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T83 7010-7016 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T84 7175-7195 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen‐presentation
T85 7642-7674 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T86 7685-7705 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen presentation
T87 8107-8123 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T88 8983-8997 http://purl.obolibrary.org/obo/GO_0016049 denotes cell expansion
T89 9002-9020 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine secretion
T90 9011-9020 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T91 10866-10878 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T53 430-442 http://purl.obolibrary.org/obo/GO_0008228 denotes opsonization
T54 1099-1103 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T55 1603-1618 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T56 1758-1773 http://purl.obolibrary.org/obo/GO_1990256 denotes ligand, cluster
T57 2013-2017 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T58 2030-2034 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T59 2146-2157 http://purl.obolibrary.org/obo/GO_0000746 denotes conjugation
T60 2291-2295 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T61 2312-2345 http://purl.obolibrary.org/obo/GO_0097278 denotes complement‐dependent cytotoxicity
T62 2720-2724 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T63 3649-3653 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T64 3658-3670 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T65 3671-3675 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T66 3930-3934 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T67 4373-4385 http://purl.obolibrary.org/obo/GO_0001906 denotes cell killing
T68 4484-4513 http://purl.obolibrary.org/obo/GO_0050866 denotes Inhibition of cell activation
T69 4498-4513 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T70 4627-4636 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T71 4729-4738 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T72 4755-4772 http://purl.obolibrary.org/obo/GO_0042113 denotes B‐cell activation
T73 4757-4772 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T74 5375-5392 http://purl.obolibrary.org/obo/GO_0042113 denotes B‐cell activation
T75 5377-5392 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T76 5831-5843 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T77 5844-5855 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T78 6460-6466 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T79 6460-6466 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T80 6514-6529 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T81 6733-6739 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T82 7010-7016 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T83 7010-7016 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T84 7175-7195 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen‐presentation
T85 7642-7674 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T86 7685-7705 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen presentation
T87 8107-8123 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T88 8983-8997 http://purl.obolibrary.org/obo/GO_0016049 denotes cell expansion
T89 9002-9020 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine secretion
T90 9011-9020 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T91 10866-10878 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T130 0-33 Sentence denotes FcγR‐Dependent Effector Responses
T131 35-126 Sentence denotes Not all opsonized targets are equal: size, distance, valency and Fc geometry affect potency
T132 127-422 Sentence denotes To understand the immunobiology of FcγR effector responses particularly in the therapeutic mAb context, it is important to appreciate that the quality and potency of such effector responses is greatly affected by the nature of the IgG immune complex and/or the state of potential effector cells.
T133 423-566 Sentence denotes First, opsonization, per se, of a target is not necessarily sufficient to ensure FcγR interaction in a way that initiates an effector response.
T134 567-1241 Sentence denotes Although it is the IgG Fc that interacts with and clusters the FcγR to induce a response, the nature of the Fab interaction with its epitope can strongly influence the likelihood or potency of FcγR effector responses by influencing the density of appropriately presented Fc portions.35 and also the size of the immune complex.36 Furthermore, the display/orientation and geometry of the Fc portions, as a consequence of the fragment antigen‐binding (Fab) interaction with the target epitope, can result in effector responses such as ADCC that differ substantially in potency, presumably because the orientation of the Fc makes FcγR engagement more, or less, accessible.37, 38
T135 1242-1597 Sentence denotes Second, in innate effector cells at rest, the largely linear actin cytoskeleton and the extracellular glycosaminoglycan glycocalyx regulate function by interacting with large glycoproteins, such as CD44, arranging these into ordered “picket” fences.39, 40 These corral receptors, including the FcγRs, and sterically inhibit their interaction with ligands.
T136 1598-2296 Sentence denotes Upon cell activation, cytoskeletal remodeling is associated with the loss of the receptor corrals, allowing FcγRs and other receptors to freely diffuse, engage ligand, cluster and signal.39 The influence of such surface constraints on receptors and effector cell function helps explain some of the observed epitope distance requirements for optimal mAb function,39, 41 which were apparent in a comparative study of ADCC and ADCP.42 ADCC was optimal when the epitope was displayed close, 0.3 nm “flush” or 1.5 nm, to the target membrane where close conjugation of effector and target by the mAb presumably facilitates the delivery of pore‐forming proteins to the target membrane as required by ADCC.
T137 2297-2442 Sentence denotes Interestingly, complement‐dependent cytotoxicity which also utilizes pore‐forming proteins for its cytotoxicity has similar distance constraints.
T138 2443-2736 Sentence denotes By contrast, ADCP was poor  when targeting epitopes displayed close or "flush" to the target cell membrane (within ~0.3 nm) but ADCP activity was restored when the epitope was displayed 1.5 nm off the membrane, demonstrating different optimal epitope distance requirements for ADCC and ADCP.42
T139 2737-2932 Sentence denotes Although the action of agonistic/antagonistic mAbs is mechanistically distinct to those eliciting cytotoxicity and ADCP, the distance segregation between target and FcγR+ cells is also important.
T140 2933-3064 Sentence denotes Indeed, the membrane proximal epitopes of CD28 and CD40 are important for the FcγR function in the complex MOA of these mAbs.43, 44
T141 3065-3309 Sentence denotes Clearly, the effects of immune complex valency, Fc density, presentation and geometry together with FcγR organization in the cell membrane suggest that the development of mAbs to certain targets will be heavily influenced by the context of use.
T142 3310-3426 Sentence denotes Thus, improved mAb potency may not necessarily be achieved by engineering of the Fc polypeptide or its glycan alone.
T143 3427-3647 Sentence denotes A more function‐oriented approach early in mAb selection and development by, for example, application of rapid screening technologies that select for effector potency,34 followed by Fc engineering may be more productive.
T144 3649-3670 Sentence denotes ADCC and phagocytosis
T145 3671-3882 Sentence denotes ADCC and ADCP are the most widely appreciated FcγR‐dependent effector functions (Figure 1a, b) and are, respectively, mediated primarily via  FcγRIIIa on NK cells and professional phagocytes such as macrophages.
T146 3883-4036 Sentence denotes These effector functions, particularly NK cell ADCC, are believed to be major components of the MOA of cytotoxic therapeutic mAbs used in cancer therapy.
T147 4037-4210 Sentence denotes In addition, ADCP can also occur via FcγRIIa and FcγRI,45 but the extent to which cytotoxic anticancer therapeutic mAbs depend on these for their MOA in patients is unclear.
T148 4211-4482 Sentence denotes The improvement in clinical utility of mAbs engineered for selectively increased FcγRIII binding suggests that FcγRIIa and FcγRI may be less important in vivo in cell killing effects but perhaps are more important in other aspects of therapeutic efficacy—discussed later.
T149 4484-4524 Sentence denotes Inhibition of cell activation by FcγRIIb
T150 4525-4649 Sentence denotes FcγRIIb is an immune checkpoint46, 47 and its splice variants are potent modulators of ITAM‐dependent signaling (Figure 1c).
T151 4650-4748 Sentence denotes This modulatory function occurs only when FcγRIIb is coaggregated with an ITAM signaling receptor.
T152 4749-5162 Sentence denotes Thus, B‐cell activation by the binding of the antigen in the immune complex to the BCR is regulated by the simultaneous binding of the Fcs of the immune complex to FcγRIIb1 on the same cell. In innate leukocytes, the activating‐type FcR (i.e. FcγRI, FcγRIIa, FcγRIIc, FcγRIII) and the high‐affinity IgE receptor, FcεRI, and the IgA receptor, FcαRI, are all modulated by immune complex co‐engagement with FcγRIIb2.
T153 5163-5368 Sentence denotes The inhibitory function contributes to the MOA of therapeutic antibodies that target cell‐activating molecules where the target cells also express the inhibitory FcγRIIbs such as the BCR (discussed later).
T154 5369-5567 Sentence denotes Thus, B‐cell activation is modulated by the simulatenous binding of the antigen in the immune complex to the BCR and the binding of the Fcs, also in the immune complex, to FcγRIIB1 on the same cell.
T155 5569-5614 Sentence denotes Sweeping: clearance of small immune complexes
T156 5615-5742 Sentence denotes The removal of immune complexes in humans depends primarily on the complement receptor pathway and to a lesser degree the FcγR.
T157 5743-5880 Sentence denotes Among the FcγRs, it has been widely believed that immune complex removal only occurs by phagocytosis/endocytosis of activating‐type FcγR.
T158 5881-6201 Sentence denotes Surprisingly, the inhibitory FcγRIIb, which lacks intrinsic activating function, plays a major role in clearance, and rapidly “sweeps” away small complexes from the circulation (Figure 1d).48, 49 A major tissue involved in the clearance is likely to be the LSEC, where FcγRIIb is expressed abundantly in mice and humans.
T159 6202-6453 Sentence denotes This role is potentially important in resistance to viruses and toxins but may also be key to optimal performance of therapeutic IgG mAbs whose primary MOA is believed to be only neutralization of soluble macromolecules, for example, cytokines or IgE.
T160 6455-6529 Sentence denotes FcγR uptake of antigen: antibody complexes and shaping the immune response
T161 6530-6592 Sentence denotes Monoclonal antibody therapy is a form of passive immunization.
T162 6593-6914 Sentence denotes Indeed, longer‐term vaccine‐like or vaccinal immunity has been demonstrated in anti‐CD20‐treated mice via FcγRIIa50, 51 and in vitro recall memory responses from CD20‐treated patients.52 Although this is dependent on FcγR and anti‐CD20, the mechanism by which long‐term anti‐tumor response is established remains unclear.
T163 6915-7616 Sentence denotes Nonetheless, the active involvement of FcγR in the enhancement of antigen‐specific immunity by uptake of immune complexes through FcγR is historically well documented in experimental systems where FcγRs bind immune complexes and thereby feed antigens into the antigen‐presentation pathways.53 This has been demonstrated in vivo for small immune complexes via human FcγRI on human antigen‐presenting cells54 and in mice.19 Similarly, the capacity of FcγRIIbs to bind and rapidly internalize antigen–antibody complexes suggests that it too may significantly influence feeding antigens into professional antigen‐presenting cells of hematopoietic origin such as dendritic cells and possibly B lymphocytes.
T164 7617-7901 Sentence denotes Although not a classical major histocompatibility complex‐dependent antigen presentation, FcγRIIb on the stroma‐derived follicular dendritic cells influences antibody immunity by recycling antigen–antibody complexes to the cell surface for presentation of intact antigen to B cells.55
T165 7902-8124 Sentence denotes Although somewhat speculative, FcγRIIb’s rapid internalization/sweeping of complexes by the abundant LSEC, which interact with lymphocytes and can present antigen,56 may have a significant role in shaping immune responses.
T166 8126-8171 Sentence denotes Scaffolding of cell‐bound mAbs by FcγR+ cells
T167 8172-8273 Sentence denotes FcγR‐expressing cells can be critical, but passive, participants in the MOA of some mAbs (Figure 1e).
T168 8274-8486 Sentence denotes In FcγR scaffolding, IgG mAb molecules that have opsonized the cell surface of a target cell are additionally cross‐linked by their Fc portions engaging the FcγRs that are arrayed on the surface of a second cell.
T169 8487-8699 Sentence denotes This “super‐cross‐linking” of the target‐bound mAb by the FcγR lattice or “scaffold” on the adjacent cell greatly exceeds the target cross‐linking by the mAb alone, thereby inducing a response in the target cell.
T170 8700-9293 Sentence denotes Scaffolding was originally identified as the basis of T‐cell mitogenesis induced by anti‐CD3 mAb.57, 58 The CD3 mAbs alone were poor mitogens but the “super‐cross‐linking” of the T‐cell‐bound CD3 mAb by the membrane FcγR on adjacent cells, particularly by monocytes, induced rapid T‐cell expansion and cytokine secretion but did not require activation of FcγR‐expressing cells.57 Regrettably, FcγR scaffolding came to prominence and clinical relevance because of its causal role in the catastrophic adverse events resulting from the administration of anti‐CD357 and anti‐CD28 (TGN1412)59 mAbs.
T171 9294-9429 Sentence denotes Nonetheless, FcγR scaffold‐based induction of intracellular responses in a target cell can also lead to beneficial therapeutic effects.
T172 9430-9652 Sentence denotes Such examples are the induction of apoptotic death in a target cell, which is likely part of the MOA of daratumumab in multiple myeloma60 or the controlled agonistic expansion of cells, for example, via CD40 mAb agonism.43
T173 9654-9703 Sentence denotes IgG subclasses: specificity and affinity for FcγR
T174 9704-9927 Sentence denotes Most FcγRs (Table 2) are weak, low‐affinity receptors (affinities in the micromolar range) for IgG‐Fc, irrespective of whether the IgG is uncomplexed, monomeric or when it is complexed with antigen (i.e. an immune complex).
T175 9928-10169 Sentence denotes The very avid binding of immune complexes to an effector cell surface that displays an array of FcγR molecules is the result of the collective contributions of the low‐affinity interactions of each Fc of the IgGs in the complex with an FcγR.
T176 10170-10322 Sentence denotes This avidity effect is necessary as the FcγRs operate in vivo in environments of high concentrations of uncomplexed monomeric IgG (normally 3–12 g L–1).
T177 10323-10413 Sentence denotes Thus, the avid multivalent binding of the complex out competes uncomplexed, monomeric IgG.
T178 10414-10467 Sentence denotes The notable exception to this is the enigmatic FcγRI.
T179 10468-10644 Sentence denotes This receptor shows high, nanomolar affinity for uncomplexed monomeric IgG and thus would be expected to be constantly occupied in vivo by the normal circulating monomeric IgG.
T180 10645-10712 Sentence denotes However, IgG dissociation permits engagement with immune complexes.
T181 10713-10879 Sentence denotes Furthermore, FcγRI is not expressed or expressed poorly on resting cells, requiring interferon‐γ for induction of its expression, presumably at sites of inflammation.
T182 10880-11061 Sentence denotes Although the human IgG heavy‐chain constant domains have greater than 90% identity, key amino acid differences confer each subclass with unique structural and functional properties.
T183 11062-11133 Sentence denotes IgG1 and IgG3 are “universal” ligands, that is, they bind to all FcγRs.
T184 11134-11456 Sentence denotes Formal measurement of the weak, micromolar KD interactions of the low‐affinity receptors with monomeric IgG1 also revealed differing affinities between the low‐affinity FcγRs, with inhibitory FcγRIIb generally having the lowest affinity and FcγRIII the higher, sometimes referred to as a “moderate” affinity receptor.7, 61
T185 11457-11620 Sentence denotes The strength of IgG1 interaction can also be affected by FcγR polymorphism and in the context of therapeutic mAbs, variation in FcγRIIIa is particularly important.
T186 11621-11832 Sentence denotes The most common and possibly clinically significant polymorphism is phenylalanine/valine variation at position 158 in the IgG‐binding site, wherein FcγRIIIa‐F158 binds IgG1 less well than the FcγRIIIa‐V158 form.
T187 11833-11885 Sentence denotes IgG4 and IgG2 have more restricted FcγR specificity.
T188 11886-12023 Sentence denotes IgG4 has low affinity (KA = ~2 × 105 m –1) for the inhibitory FcγRIIb, but is also a high‐affinity ligand for FcγRI (KA = ~4 × 108 m –1).
T189 12024-12269 Sentence denotes IgG2 exhibits a highly restricted specificity, showing functional activity with only one polymorphic form of FcγRIIa (binding affinity KA = ~4.5 × 105 m –1) which is permitted by the presence of histidine at position 131 of its IgG‐binding site.
T190 12270-12480 Sentence denotes This FcγRIIa–H131 form is expressed in approximately 70% of the population, whereas IgG2 has no functional activity on the other common allelic form, FcγRIIa‐R131, which contains arginine at position 131.11, 61

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T8 4021-4027 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T9 6868-6873 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664