PMC:7228307 / 20680-21313 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"402","span":{"begin":27,"end":35},"obj":"Gene"},{"id":"403","span":{"begin":130,"end":133},"obj":"Gene"}],"attributes":[{"id":"A402","pred":"tao:has_database_id","subj":"402","obj":"Gene:1555"},{"id":"A403","pred":"tao:has_database_id","subj":"403","obj":"Gene:613"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T223","span":{"begin":70,"end":74},"obj":"Body_part"},{"id":"T224","span":{"begin":230,"end":238},"obj":"Body_part"},{"id":"T225","span":{"begin":265,"end":276},"obj":"Body_part"},{"id":"T226","span":{"begin":361,"end":369},"obj":"Body_part"},{"id":"T227","span":{"begin":454,"end":462},"obj":"Body_part"},{"id":"T228","span":{"begin":480,"end":488},"obj":"Body_part"},{"id":"T229","span":{"begin":538,"end":543},"obj":"Body_part"},{"id":"T230","span":{"begin":547,"end":554},"obj":"Body_part"},{"id":"T231","span":{"begin":555,"end":563},"obj":"Body_part"},{"id":"T232","span":{"begin":617,"end":621},"obj":"Body_part"}],"attributes":[{"id":"A223","pred":"fma_id","subj":"T223","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A224","pred":"fma_id","subj":"T224","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A225","pred":"fma_id","subj":"T225","obj":"http://purl.org/sig/ont/fma/fma66835"},{"id":"A226","pred":"fma_id","subj":"T226","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A227","pred":"fma_id","subj":"T227","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A228","pred":"fma_id","subj":"T228","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A229","pred":"fma_id","subj":"T229","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A230","pred":"fma_id","subj":"T230","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A231","pred":"fma_id","subj":"T231","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A232","pred":"fma_id","subj":"T232","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T14","span":{"begin":277,"end":281},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0002415"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T411","span":{"begin":20,"end":22},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T412","span":{"begin":23,"end":25},"obj":"http://purl.obolibrary.org/obo/CLO_0008882"},{"id":"T413","span":{"begin":27,"end":29},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T414","span":{"begin":40,"end":42},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T415","span":{"begin":70,"end":74},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T416","span":{"begin":113,"end":122},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T417","span":{"begin":141,"end":151},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T418","span":{"begin":157,"end":159},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T419","span":{"begin":160,"end":162},"obj":"http://purl.obolibrary.org/obo/CLO_0008882"},{"id":"T420","span":{"begin":177,"end":179},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T421","span":{"begin":277,"end":281},"obj":"http://purl.obolibrary.org/obo/UBERON_0002415"},{"id":"T422","span":{"begin":326,"end":328},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T423","span":{"begin":390,"end":399},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T424","span":{"begin":400,"end":416},"obj":"http://purl.obolibrary.org/obo/GO_0043235"},{"id":"T425","span":{"begin":617,"end":621},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T426","span":{"begin":622,"end":632},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T96","span":{"begin":230,"end":238},"obj":"Chemical"},{"id":"T97","span":{"begin":361,"end":369},"obj":"Chemical"},{"id":"T98","span":{"begin":454,"end":462},"obj":"Chemical"},{"id":"T99","span":{"begin":480,"end":488},"obj":"Chemical"},{"id":"T100","span":{"begin":538,"end":543},"obj":"Chemical"},{"id":"T101","span":{"begin":547,"end":554},"obj":"Chemical"},{"id":"T102","span":{"begin":555,"end":563},"obj":"Chemical"}],"attributes":[{"id":"A96","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A97","pred":"chebi_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A99","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A100","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A101","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A102","pred":"chebi_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T16","span":{"begin":538,"end":543},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A16","pred":"meddra_id","subj":"T16","obj":"http://purl.bioontology.org/ontology/MEDDRA/10024587"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T129","span":{"begin":70,"end":74},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T130","span":{"begin":186,"end":194},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"},{"id":"T131","span":{"begin":617,"end":621},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T16","span":{"begin":230,"end":238},"obj":"Chemical"},{"id":"T17","span":{"begin":361,"end":369},"obj":"Chemical"},{"id":"T18","span":{"begin":454,"end":462},"obj":"Chemical"},{"id":"T19","span":{"begin":480,"end":488},"obj":"Chemical"},{"id":"T20","span":{"begin":538,"end":543},"obj":"Chemical"},{"id":"T21","span":{"begin":547,"end":554},"obj":"Chemical"},{"id":"T22","span":{"begin":555,"end":563},"obj":"Chemical"}],"attributes":[{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A21","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A18","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A16","pred":"chebi_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A19","pred":"chebi_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A20","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A17","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"403","span":{"begin":130,"end":133},"obj":"Gene"}],"attributes":[{"id":"A403","pred":"pubann:denotes","subj":"403","obj":"Gene:613"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T129","span":{"begin":0,"end":633},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T14","span":{"begin":277,"end":281},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0002415"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T222","span":{"begin":70,"end":74},"obj":"Body_part"},{"id":"T223","span":{"begin":230,"end":238},"obj":"Body_part"},{"id":"T224","span":{"begin":265,"end":276},"obj":"Body_part"},{"id":"T225","span":{"begin":361,"end":369},"obj":"Body_part"},{"id":"T226","span":{"begin":454,"end":462},"obj":"Body_part"},{"id":"T227","span":{"begin":480,"end":488},"obj":"Body_part"},{"id":"T228","span":{"begin":538,"end":543},"obj":"Body_part"},{"id":"T229","span":{"begin":547,"end":554},"obj":"Body_part"},{"id":"T230","span":{"begin":555,"end":563},"obj":"Body_part"},{"id":"T231","span":{"begin":617,"end":621},"obj":"Body_part"}],"attributes":[{"id":"A229","pred":"fma_id","subj":"T229","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A224","pred":"fma_id","subj":"T224","obj":"http://purl.org/sig/ont/fma/fma66835"},{"id":"A231","pred":"fma_id","subj":"T231","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A228","pred":"fma_id","subj":"T228","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A226","pred":"fma_id","subj":"T226","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A222","pred":"fma_id","subj":"T222","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A230","pred":"fma_id","subj":"T230","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A223","pred":"fma_id","subj":"T223","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A225","pred":"fma_id","subj":"T225","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A227","pred":"fma_id","subj":"T227","obj":"http://purl.org/sig/ont/fma/fma82768"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T48","span":{"begin":113,"end":122},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T49","span":{"begin":390,"end":399},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T50","span":{"begin":489,"end":504},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T51","span":{"begin":564,"end":576},"obj":"http://purl.obolibrary.org/obo/GO_0016791"},{"id":"T52","span":{"begin":617,"end":632},"obj":"http://purl.obolibrary.org/obo/GO_0001775"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T48","span":{"begin":113,"end":122},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T49","span":{"begin":390,"end":399},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T50","span":{"begin":489,"end":504},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T51","span":{"begin":564,"end":576},"obj":"http://purl.obolibrary.org/obo/GO_0016791"},{"id":"T52","span":{"begin":617,"end":632},"obj":"http://purl.obolibrary.org/obo/GO_0001775"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T48","span":{"begin":113,"end":122},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T49","span":{"begin":390,"end":399},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T50","span":{"begin":489,"end":504},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T51","span":{"begin":564,"end":576},"obj":"http://purl.obolibrary.org/obo/GO_0016791"},{"id":"T52","span":{"begin":617,"end":632},"obj":"http://purl.obolibrary.org/obo/GO_0001775"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}

{"project":"LitCovid-sentences","denotations":[{"id":"T129","span":{"begin":0,"end":633},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The inhibitory‐type FcγRs, FcγRIIb1 and FcγRIIb2, whose expression is cell lineage restricted, modulate the ITAM signaling of the BCR or the activating‐type FcγRs, respectively.11 Their function is dependent on the immunoreceptor tyrosine inhibition motif in their cytoplasmic tail.32, 33 This checkpoint action requires that FcγRIIbs are coaggregated with the tyrosine‐phosphorylated ITAM‐signaling receptor complex which results also in immunoreceptor tyrosine inhibition motif tyrosine phosphorylation and consequential recruitment of lipid or protein tyrosine phosphatases that powerfully dampen the ITAM‐induced cell activation."}