PMC:7228307 / 20038-20679 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"395","span":{"begin":476,"end":479},"obj":"Gene"},{"id":"396","span":{"begin":171,"end":174},"obj":"Gene"},{"id":"397","span":{"begin":417,"end":421},"obj":"Gene"},{"id":"398","span":{"begin":62,"end":66},"obj":"Gene"},{"id":"399","span":{"begin":539,"end":547},"obj":"Chemical"}],"attributes":[{"id":"A395","pred":"tao:has_database_id","subj":"395","obj":"Gene:613"},{"id":"A396","pred":"tao:has_database_id","subj":"396","obj":"Gene:613"},{"id":"A397","pred":"tao:has_database_id","subj":"397","obj":"Gene:2213"},{"id":"A398","pred":"tao:has_database_id","subj":"398","obj":"Gene:2213"},{"id":"A399","pred":"tao:has_database_id","subj":"399","obj":"MESH:D014443"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Effector functions that are initiated via the activating‐type FcγR occur by signaling via the ITAM pathway of immune receptors. This well‐characterized pathway is used by BCR and T‐cell antigen receptors, the IgE receptor FcεRI and IgA receptor FcαRI (reviewed extensively by Hogarth and Pietersz 7 Anania et al. 11 and Getahun and Cambier 32) Induction of an activating signal requires the aggregation of activating FcγR by immune complexes, or by antigen in the case of the BCR. This aggregation at the cell membrane results in specific tyrosine phosphorylation of the ITAM by Src kinases, thus initiating the activation cascade.32, 33, 34"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T217","span":{"begin":181,"end":185},"obj":"Body_part"},{"id":"T218","span":{"begin":209,"end":212},"obj":"Body_part"},{"id":"T219","span":{"begin":232,"end":235},"obj":"Body_part"},{"id":"T220","span":{"begin":505,"end":518},"obj":"Body_part"},{"id":"T221","span":{"begin":505,"end":509},"obj":"Body_part"},{"id":"T222","span":{"begin":539,"end":547},"obj":"Body_part"}],"attributes":[{"id":"A217","pred":"fma_id","subj":"T217","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A218","pred":"fma_id","subj":"T218","obj":"http://purl.org/sig/ont/fma/fma62875"},{"id":"A219","pred":"fma_id","subj":"T219","obj":"http://purl.org/sig/ont/fma/fma62874"},{"id":"A220","pred":"fma_id","subj":"T220","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A221","pred":"fma_id","subj":"T221","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A222","pred":"fma_id","subj":"T222","obj":"http://purl.org/sig/ont/fma/fma82768"}],"text":"Effector functions that are initiated via the activating‐type FcγR occur by signaling via the ITAM pathway of immune receptors. This well‐characterized pathway is used by BCR and T‐cell antigen receptors, the IgE receptor FcεRI and IgA receptor FcαRI (reviewed extensively by Hogarth and Pietersz 7 Anania et al. 11 and Getahun and Cambier 32) Induction of an activating signal requires the aggregation of activating FcγR by immune complexes, or by antigen in the case of the BCR. This aggregation at the cell membrane results in specific tyrosine phosphorylation of the ITAM by Src kinases, thus initiating the activation cascade.32, 33, 34"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T395","span":{"begin":46,"end":56},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T396","span":{"begin":62,"end":64},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T397","span":{"begin":76,"end":85},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T398","span":{"begin":179,"end":185},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T399","span":{"begin":222,"end":224},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T400","span":{"begin":245,"end":247},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T401","span":{"begin":313,"end":315},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T402","span":{"begin":360,"end":370},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T403","span":{"begin":371,"end":377},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T404","span":{"begin":406,"end":416},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T405","span":{"begin":417,"end":419},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T406","span":{"begin":505,"end":509},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T407","span":{"begin":510,"end":518},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T408","span":{"begin":579,"end":582},"obj":"http://purl.obolibrary.org/obo/CLO_0009132"},{"id":"T409","span":{"begin":612,"end":622},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T410","span":{"begin":639,"end":641},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"}],"text":"Effector functions that are initiated via the activating‐type FcγR occur by signaling via the ITAM pathway of immune receptors. This well‐characterized pathway is used by BCR and T‐cell antigen receptors, the IgE receptor FcεRI and IgA receptor FcαRI (reviewed extensively by Hogarth and Pietersz 7 Anania et al. 11 and Getahun and Cambier 32) Induction of an activating signal requires the aggregation of activating FcγR by immune complexes, or by antigen in the case of the BCR. This aggregation at the cell membrane results in specific tyrosine phosphorylation of the ITAM by Src kinases, thus initiating the activation cascade.32, 33, 34"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T89","span":{"begin":186,"end":193},"obj":"Chemical"},{"id":"T90","span":{"begin":225,"end":227},"obj":"Chemical"},{"id":"T92","span":{"begin":248,"end":250},"obj":"Chemical"},{"id":"T94","span":{"begin":449,"end":456},"obj":"Chemical"},{"id":"T95","span":{"begin":539,"end":547},"obj":"Chemical"}],"attributes":[{"id":"A89","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A90","pred":"chebi_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/CHEBI_73814"},{"id":"A91","pred":"chebi_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/CHEBI_8753"},{"id":"A92","pred":"chebi_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/CHEBI_73814"},{"id":"A93","pred":"chebi_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/CHEBI_8753"},{"id":"A94","pred":"chebi_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A95","pred":"chebi_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"}],"text":"Effector functions that are initiated via the activating‐type FcγR occur by signaling via the ITAM pathway of immune receptors. This well‐characterized pathway is used by BCR and T‐cell antigen receptors, the IgE receptor FcεRI and IgA receptor FcαRI (reviewed extensively by Hogarth and Pietersz 7 Anania et al. 11 and Getahun and Cambier 32) Induction of an activating signal requires the aggregation of activating FcγR by immune complexes, or by antigen in the case of the BCR. This aggregation at the cell membrane results in specific tyrosine phosphorylation of the ITAM by Src kinases, thus initiating the activation cascade.32, 33, 34"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T126","span":{"begin":9,"end":18},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"},{"id":"T127","span":{"begin":181,"end":185},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T128","span":{"begin":505,"end":509},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"Effector functions that are initiated via the activating‐type FcγR occur by signaling via the ITAM pathway of immune receptors. This well‐characterized pathway is used by BCR and T‐cell antigen receptors, the IgE receptor FcεRI and IgA receptor FcαRI (reviewed extensively by Hogarth and Pietersz 7 Anania et al. 11 and Getahun and Cambier 32) Induction of an activating signal requires the aggregation of activating FcγR by immune complexes, or by antigen in the case of the BCR. This aggregation at the cell membrane results in specific tyrosine phosphorylation of the ITAM by Src kinases, thus initiating the activation cascade.32, 33, 34"}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T15","span":{"begin":539,"end":547},"obj":"Chemical"}],"attributes":[{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"}],"text":"Effector functions that are initiated via the activating‐type FcγR occur by signaling via the ITAM pathway of immune receptors. This well‐characterized pathway is used by BCR and T‐cell antigen receptors, the IgE receptor FcεRI and IgA receptor FcαRI (reviewed extensively by Hogarth and Pietersz 7 Anania et al. 11 and Getahun and Cambier 32) Induction of an activating signal requires the aggregation of activating FcγR by immune complexes, or by antigen in the case of the BCR. This aggregation at the cell membrane results in specific tyrosine phosphorylation of the ITAM by Src kinases, thus initiating the activation cascade.32, 33, 34"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"395","span":{"begin":476,"end":479},"obj":"Gene"},{"id":"396","span":{"begin":171,"end":174},"obj":"Gene"},{"id":"397","span":{"begin":417,"end":421},"obj":"Gene"},{"id":"398","span":{"begin":62,"end":66},"obj":"Gene"},{"id":"399","span":{"begin":539,"end":547},"obj":"Chemical"}],"attributes":[{"id":"A398","pred":"pubann:denotes","subj":"398","obj":"Gene:2213"},{"id":"A395","pred":"pubann:denotes","subj":"395","obj":"Gene:613"},{"id":"A396","pred":"pubann:denotes","subj":"396","obj":"Gene:613"},{"id":"A397","pred":"pubann:denotes","subj":"397","obj":"Gene:2213"},{"id":"A399","pred":"pubann:denotes","subj":"399","obj":"MESH:D014443"}],"text":"Effector functions that are initiated via the activating‐type FcγR occur by signaling via the ITAM pathway of immune receptors. This well‐characterized pathway is used by BCR and T‐cell antigen receptors, the IgE receptor FcεRI and IgA receptor FcαRI (reviewed extensively by Hogarth and Pietersz 7 Anania et al. 11 and Getahun and Cambier 32) Induction of an activating signal requires the aggregation of activating FcγR by immune complexes, or by antigen in the case of the BCR. This aggregation at the cell membrane results in specific tyrosine phosphorylation of the ITAM by Src kinases, thus initiating the activation cascade.32, 33, 34"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T125","span":{"begin":0,"end":127},"obj":"Sentence"},{"id":"T126","span":{"begin":128,"end":312},"obj":"Sentence"},{"id":"T127","span":{"begin":313,"end":480},"obj":"Sentence"},{"id":"T128","span":{"begin":481,"end":641},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Effector functions that are initiated via the activating‐type FcγR occur by signaling via the ITAM pathway of immune receptors. This well‐characterized pathway is used by BCR and T‐cell antigen receptors, the IgE receptor FcεRI and IgA receptor FcαRI (reviewed extensively by Hogarth and Pietersz 7 Anania et al. 11 and Getahun and Cambier 32) Induction of an activating signal requires the aggregation of activating FcγR by immune complexes, or by antigen in the case of the BCR. This aggregation at the cell membrane results in specific tyrosine phosphorylation of the ITAM by Src kinases, thus initiating the activation cascade.32, 33, 34"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T216","span":{"begin":181,"end":185},"obj":"Body_part"},{"id":"T217","span":{"begin":209,"end":212},"obj":"Body_part"},{"id":"T218","span":{"begin":232,"end":235},"obj":"Body_part"},{"id":"T219","span":{"begin":505,"end":518},"obj":"Body_part"},{"id":"T220","span":{"begin":505,"end":509},"obj":"Body_part"},{"id":"T221","span":{"begin":539,"end":547},"obj":"Body_part"}],"attributes":[{"id":"A219","pred":"fma_id","subj":"T219","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A220","pred":"fma_id","subj":"T220","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A217","pred":"fma_id","subj":"T217","obj":"http://purl.org/sig/ont/fma/fma62875"},{"id":"A216","pred":"fma_id","subj":"T216","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A218","pred":"fma_id","subj":"T218","obj":"http://purl.org/sig/ont/fma/fma62874"},{"id":"A221","pred":"fma_id","subj":"T221","obj":"http://purl.org/sig/ont/fma/fma82768"}],"text":"Effector functions that are initiated via the activating‐type FcγR occur by signaling via the ITAM pathway of immune receptors. This well‐characterized pathway is used by BCR and T‐cell antigen receptors, the IgE receptor FcεRI and IgA receptor FcαRI (reviewed extensively by Hogarth and Pietersz 7 Anania et al. 11 and Getahun and Cambier 32) Induction of an activating signal requires the aggregation of activating FcγR by immune complexes, or by antigen in the case of the BCR. This aggregation at the cell membrane results in specific tyrosine phosphorylation of the ITAM by Src kinases, thus initiating the activation cascade.32, 33, 34"}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T46","span":{"begin":76,"end":85},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T47","span":{"begin":548,"end":563},"obj":"http://purl.obolibrary.org/obo/GO_0016310"}],"text":"Effector functions that are initiated via the activating‐type FcγR occur by signaling via the ITAM pathway of immune receptors. This well‐characterized pathway is used by BCR and T‐cell antigen receptors, the IgE receptor FcεRI and IgA receptor FcαRI (reviewed extensively by Hogarth and Pietersz 7 Anania et al. 11 and Getahun and Cambier 32) Induction of an activating signal requires the aggregation of activating FcγR by immune complexes, or by antigen in the case of the BCR. This aggregation at the cell membrane results in specific tyrosine phosphorylation of the ITAM by Src kinases, thus initiating the activation cascade.32, 33, 34"}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T46","span":{"begin":76,"end":85},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T47","span":{"begin":548,"end":563},"obj":"http://purl.obolibrary.org/obo/GO_0016310"}],"text":"Effector functions that are initiated via the activating‐type FcγR occur by signaling via the ITAM pathway of immune receptors. This well‐characterized pathway is used by BCR and T‐cell antigen receptors, the IgE receptor FcεRI and IgA receptor FcαRI (reviewed extensively by Hogarth and Pietersz 7 Anania et al. 11 and Getahun and Cambier 32) Induction of an activating signal requires the aggregation of activating FcγR by immune complexes, or by antigen in the case of the BCR. This aggregation at the cell membrane results in specific tyrosine phosphorylation of the ITAM by Src kinases, thus initiating the activation cascade.32, 33, 34"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T46","span":{"begin":76,"end":85},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T47","span":{"begin":548,"end":563},"obj":"http://purl.obolibrary.org/obo/GO_0016310"}],"text":"Effector functions that are initiated via the activating‐type FcγR occur by signaling via the ITAM pathway of immune receptors. This well‐characterized pathway is used by BCR and T‐cell antigen receptors, the IgE receptor FcεRI and IgA receptor FcαRI (reviewed extensively by Hogarth and Pietersz 7 Anania et al. 11 and Getahun and Cambier 32) Induction of an activating signal requires the aggregation of activating FcγR by immune complexes, or by antigen in the case of the BCR. This aggregation at the cell membrane results in specific tyrosine phosphorylation of the ITAM by Src kinases, thus initiating the activation cascade.32, 33, 34"}

{"project":"LitCovid-sentences","denotations":[{"id":"T125","span":{"begin":0,"end":127},"obj":"Sentence"},{"id":"T126","span":{"begin":128,"end":312},"obj":"Sentence"},{"id":"T127","span":{"begin":313,"end":480},"obj":"Sentence"},{"id":"T128","span":{"begin":481,"end":641},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Effector functions that are initiated via the activating‐type FcγR occur by signaling via the ITAM pathway of immune receptors. This well‐characterized pathway is used by BCR and T‐cell antigen receptors, the IgE receptor FcεRI and IgA receptor FcαRI (reviewed extensively by Hogarth and Pietersz 7 Anania et al. 11 and Getahun and Cambier 32) Induction of an activating signal requires the aggregation of activating FcγR by immune complexes, or by antigen in the case of the BCR. This aggregation at the cell membrane results in specific tyrosine phosphorylation of the ITAM by Src kinases, thus initiating the activation cascade.32, 33, 34"}