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PMC:7228307 / 18745-19996 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
382 218-222 Gene denotes FcγR Gene:2213
383 422-429 Gene denotes FcγRIIb Gene:2213
384 643-650 Gene denotes FcγRIIb Gene:2213
385 680-687 Gene denotes FcγRIIb Gene:2213
386 1092-1099 Gene denotes FcγRIIb Gene:2213
387 56-60 Gene denotes FcγR Gene:2213

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T202 29-34 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T203 124-142 Body_part denotes hematopoietic cell http://purl.org/sig/ont/fma/fma83598
T204 138-142 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T205 252-257 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T206 452-477 Body_part denotes follicular dendritic cell http://purl.org/sig/ont/fma/fma83037
T207 473-477 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T208 493-499 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T209 504-509 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T210 510-521 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T211 550-555 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T212 556-566 Body_part denotes sinusoidal http://purl.org/sig/ont/fma/fma63131
T213 567-584 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T214 579-584 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T215 773-778 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T216 871-877 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T10 504-509 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T11 510-521 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T12 550-555 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T13 871-877 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T30 334-337 Disease denotes MOA http://purl.obolibrary.org/obo/MONDO_0016702

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T367 29-34 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T368 56-58 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T369 124-142 http://purl.obolibrary.org/obo/CL_0000988 denotes hematopoietic cell
T370 218-220 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T371 252-257 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T372 422-424 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T373 463-477 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cell
T374 479-485 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T375 493-499 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T376 493-499 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T377 493-499 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T378 493-499 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T379 504-509 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T380 504-509 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T381 510-521 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T382 550-555 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T383 550-555 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T384 567-584 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T385 643-645 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T386 680-682 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T387 720-729 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T388 773-778 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T389 976-977 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T390 1041-1046 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T391 1092-1094 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T87 1050-1064 Chemical denotes macromolecules http://purl.obolibrary.org/obo/CHEBI_33839
T88 1205-1214 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T15 174-188 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigations http://purl.bioontology.org/ontology/MEDDRA/10062026

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T115 29-34 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T116 138-142 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T117 143-151 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T118 252-257 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T119 314-322 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T120 473-477 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T121 579-584 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T122 730-738 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T123 773-778 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T124 1041-1046 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T125 1205-1214 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T14 1050-1064 Chemical denotes macromolecules http://purl.obolibrary.org/obo/CHEBI_33839

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
382 218-222 Gene denotes FcγR Gene:2213
383 422-429 Gene denotes FcγRIIb Gene:2213
384 643-650 Gene denotes FcγRIIb Gene:2213
385 680-687 Gene denotes FcγRIIb Gene:2213
386 1092-1099 Gene denotes FcγRIIb Gene:2213

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T118 0-34 Sentence denotes Expression on nonhemopoietic cells
T119 35-258 Sentence denotes The immunobiology of FcγR is studied and understood almost exclusively in the context of hematopoietic cell function but relatively recent investigations have identified and explored FcγR expression on nonhemopoietic cells.
T120 259-363 Sentence denotes These studies suggest important roles in normal immune function and in the MOA of some therapeutic mAbs.
T121 364-522 Sentence denotes The most extensively characterized receptor expression is FcγRIIb which is expressed on follicular dendritic cell, airway smooth muscle and liver endothelium.
T122 523-913 Sentence denotes Its abundant expression on liver sinusoidal endothelial cells (LSECs) is estimated to represent the majority of in vivo FcγRIIb expression.17, 29, 30, 31 As FcγRIIb lacks intrinsic proinflammatory signaling function, its role on these nonhemopoietic cells involves immune complex handling without the danger of, or the need for, induction of local tissue destructive inflammatory responses.
T123 914-1251 Sentence denotes On LSEC its major role appears to be immune complex sweeping, a process of removal of small immune complexes such as opsonized virus or macromolecules.17 This scavenging role by FcγRIIb on LSEC can be exploited in principle by mAbs forming small soluble complexes with their targets such as antiviral, anticytokine or similar antibodies.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T10 504-509 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T11 510-521 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T12 550-555 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T13 871-877 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T94 486-492 Protein denotes smooth https://www.uniprot.org/uniprot/Q9VPM8|https://www.uniprot.org/uniprot/P91682|https://www.uniprot.org/uniprot/B7FNK1

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T201 29-34 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T202 124-142 Body_part denotes hematopoietic cell http://purl.org/sig/ont/fma/fma83598
T203 138-142 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T204 252-257 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T205 452-477 Body_part denotes follicular dendritic cell http://purl.org/sig/ont/fma/fma83037
T206 473-477 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T207 493-499 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T208 504-509 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T209 510-521 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T210 550-555 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T211 556-566 Body_part denotes sinusoidal http://purl.org/sig/ont/fma/fma63131
T212 567-584 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T213 579-584 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T214 773-778 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T215 871-877 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T6 486-499 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T7 493-499 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T8 504-509 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T9 550-555 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T43 720-729 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T44 890-912 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T43 720-729 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T44 890-912 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T43 720-729 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T44 890-912 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T118 0-34 Sentence denotes Expression on nonhemopoietic cells
T119 35-258 Sentence denotes The immunobiology of FcγR is studied and understood almost exclusively in the context of hematopoietic cell function but relatively recent investigations have identified and explored FcγR expression on nonhemopoietic cells.
T120 259-363 Sentence denotes These studies suggest important roles in normal immune function and in the MOA of some therapeutic mAbs.
T121 364-522 Sentence denotes The most extensively characterized receptor expression is FcγRIIb which is expressed on follicular dendritic cell, airway smooth muscle and liver endothelium.
T122 523-913 Sentence denotes Its abundant expression on liver sinusoidal endothelial cells (LSECs) is estimated to represent the majority of in vivo FcγRIIb expression.17, 29, 30, 31 As FcγRIIb lacks intrinsic proinflammatory signaling function, its role on these nonhemopoietic cells involves immune complex handling without the danger of, or the need for, induction of local tissue destructive inflammatory responses.
T123 914-1251 Sentence denotes On LSEC its major role appears to be immune complex sweeping, a process of removal of small immune complexes such as opsonized virus or macromolecules.17 This scavenging role by FcγRIIb on LSEC can be exploited in principle by mAbs forming small soluble complexes with their targets such as antiviral, anticytokine or similar antibodies.