PMC:7228307 / 1587-2551 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7228307","sourcedb":"PMC","sourceid":"7228307","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7228307","text":"cused glycan or protein engineering of the Fc to increase affinity and/or tailor specificity for selective engagement of individual activating FcγRs or the inhibitory FcγRIIb or alternatively, for the ablation of FcγR interaction altogether. This review touches on recent aspects of FcγR and IgG immunobiology and its relationship with the present and future actions of therapeutic mAbs.\n\nFragment crystallizable (Fc) receptors for immunoglobulin (Ig)G activate and modulate a powerful network of inflammatory, host‐protective effector functions that are central to effective and balanced immune responses. These responses are also harnessed—or avoided—by therapeutic monoclonal antibodies. The use and manipulation of IgG2, IgG4 as well as IgG1 for optimized activating or inhibitory FcγR effector functions will underpin the development of potent \"next‐gen\" antibody therapeutics.\n\nIntroduction\nThe regulatory approval of the first therapeutic monoclonal antibod","divisions":[{"label":"abstract","span":{"begin":389,"end":882}},{"label":"p","span":{"begin":389,"end":882}},{"label":"title","span":{"begin":884,"end":896}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"16","span":{"begin":167,"end":174},"obj":"Gene"},{"id":"17","span":{"begin":283,"end":287},"obj":"Gene"},{"id":"18","span":{"begin":213,"end":217},"obj":"Gene"},{"id":"25","span":{"begin":6,"end":12},"obj":"Chemical"},{"id":"31","span":{"begin":785,"end":789},"obj":"Gene"}],"attributes":[{"id":"A16","pred":"tao:has_database_id","subj":"16","obj":"Gene:2213"},{"id":"A17","pred":"tao:has_database_id","subj":"17","obj":"Gene:2213"},{"id":"A18","pred":"tao:has_database_id","subj":"18","obj":"Gene:2213"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"MESH:D011134"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"Gene:2213"},{"subj":"16","pred":"source","obj":"LitCovid-PubTator"},{"subj":"17","pred":"source","obj":"LitCovid-PubTator"},{"subj":"18","pred":"source","obj":"LitCovid-PubTator"},{"subj":"25","pred":"source","obj":"LitCovid-PubTator"},{"subj":"31","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T8","span":{"begin":16,"end":23},"obj":"Body_part"},{"id":"T9","span":{"begin":292,"end":295},"obj":"Body_part"},{"id":"T10","span":{"begin":432,"end":446},"obj":"Body_part"},{"id":"T11","span":{"begin":447,"end":452},"obj":"Body_part"},{"id":"T12","span":{"begin":448,"end":450},"obj":"Body_part"},{"id":"T13","span":{"begin":860,"end":868},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma62871"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T19","span":{"begin":43,"end":45},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T20","span":{"begin":132,"end":142},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T21","span":{"begin":143,"end":145},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T22","span":{"begin":146,"end":148},"obj":"http://purl.obolibrary.org/obo/CLO_0008882"},{"id":"T23","span":{"begin":167,"end":169},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T24","span":{"begin":213,"end":215},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T25","span":{"begin":283,"end":285},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T26","span":{"begin":414,"end":416},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T27","span":{"begin":453,"end":461},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T28","span":{"begin":475,"end":476},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T29","span":{"begin":760,"end":770},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T30","span":{"begin":785,"end":787},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"}],"attributes":[{"subj":"T19","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T6","span":{"begin":16,"end":23},"obj":"Chemical"},{"id":"T7","span":{"begin":527,"end":535},"obj":"Chemical"},{"id":"T8","span":{"begin":790,"end":798},"obj":"Chemical"}],"attributes":[{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T3","span":{"begin":432,"end":446},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T4","span":{"begin":448,"end":450},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A3","pred":"meddra_id","subj":"T3","obj":"http://purl.bioontology.org/ontology/MEDDRA/10021496"},{"id":"A4","pred":"meddra_id","subj":"T4","obj":"http://purl.bioontology.org/ontology/MEDDRA/10021496"},{"subj":"T3","pred":"source","obj":"LitCovid-sample-MedDRA"},{"subj":"T4","pred":"source","obj":"LitCovid-sample-MedDRA"}]},{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T9","span":{"begin":511,"end":515},"obj":"http://purl.obolibrary.org/obo/IDO_0000531"},{"id":"T10","span":{"begin":536,"end":545},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"},{"id":"T11","span":{"begin":589,"end":605},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T12","span":{"begin":799,"end":808},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"}],"attributes":[{"subj":"T9","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T10","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T11","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T12","pred":"source","obj":"LitCovid-sample-PD-IDO"}]},{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T2","span":{"begin":16,"end":23},"obj":"Chemical"}],"attributes":[{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T2","pred":"source","obj":"LitCovid-sample-CHEBI"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"16","span":{"begin":167,"end":174},"obj":"Gene"},{"id":"17","span":{"begin":283,"end":287},"obj":"Gene"},{"id":"18","span":{"begin":213,"end":217},"obj":"Gene"},{"id":"25","span":{"begin":6,"end":12},"obj":"Chemical"},{"id":"31","span":{"begin":785,"end":789},"obj":"Gene"}],"attributes":[{"id":"A16","pred":"pubann:denotes","subj":"16","obj":"Gene:2213"},{"id":"A17","pred":"pubann:denotes","subj":"17","obj":"Gene:2213"},{"id":"A18","pred":"pubann:denotes","subj":"18","obj":"Gene:2213"},{"id":"A25","pred":"pubann:denotes","subj":"25","obj":"MESH:D011134"},{"id":"A31","pred":"pubann:denotes","subj":"31","obj":"Gene:2213"},{"subj":"16","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"17","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"18","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"25","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"31","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T13","span":{"begin":242,"end":387},"obj":"Sentence"},{"id":"T14","span":{"begin":389,"end":606},"obj":"Sentence"},{"id":"T15","span":{"begin":607,"end":690},"obj":"Sentence"},{"id":"T16","span":{"begin":691,"end":882},"obj":"Sentence"},{"id":"T17","span":{"begin":884,"end":896},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T13","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T14","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T15","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T16","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T17","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T8","span":{"begin":16,"end":23},"obj":"Body_part"},{"id":"T9","span":{"begin":292,"end":295},"obj":"Body_part"},{"id":"T10","span":{"begin":432,"end":446},"obj":"Body_part"},{"id":"T11","span":{"begin":447,"end":452},"obj":"Body_part"},{"id":"T12","span":{"begin":448,"end":450},"obj":"Body_part"},{"id":"T13","span":{"begin":860,"end":868},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma62871"},{"subj":"T8","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T9","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T10","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T11","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T12","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T13","pred":"source","obj":"LitCovid-sample-PD-FMA"}]},{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T2","span":{"begin":589,"end":605},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid-sample-PD-GO-BP-0"}]},{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T2","span":{"begin":589,"end":605},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid-sample-GO-BP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":589,"end":605},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T13","span":{"begin":242,"end":387},"obj":"Sentence"},{"id":"T14","span":{"begin":389,"end":606},"obj":"Sentence"},{"id":"T15","span":{"begin":607,"end":690},"obj":"Sentence"},{"id":"T16","span":{"begin":691,"end":882},"obj":"Sentence"},{"id":"T17","span":{"begin":884,"end":896},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T13","pred":"source","obj":"LitCovid-sentences"},{"subj":"T14","pred":"source","obj":"LitCovid-sentences"},{"subj":"T15","pred":"source","obj":"LitCovid-sentences"},{"subj":"T16","pred":"source","obj":"LitCovid-sentences"},{"subj":"T17","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ece493","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ca93ec"},{"id":"LitCovid-PD-CLO","color":"#93ecb0"},{"id":"LitCovid-PD-CHEBI","color":"#ec9693"},{"id":"LitCovid-sample-MedDRA","color":"#93a9ec"},{"id":"LitCovid-sample-PD-IDO","color":"#c3ec93"},{"id":"LitCovid-sample-CHEBI","color":"#ec93dd"},{"id":"LitCovid-sample-Pubtator","color":"#93ece0"},{"id":"LitCovid-sample-sentences","color":"#ecc693"},{"id":"LitCovid-sample-PD-FMA","color":"#ac93ec"},{"id":"LitCovid-sample-PD-GO-BP-0","color":"#93ec93"},{"id":"LitCovid-sample-GO-BP","color":"#ec93ad"},{"id":"LitCovid-PD-GO-BP","color":"#93c7ec"},{"id":"LitCovid-sentences","color":"#e1ec93"}]}]}}