PMC:7228307 / 15170-15939 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"305","span":{"begin":0,"end":7},"obj":"Gene"},{"id":"306","span":{"begin":317,"end":322},"obj":"Species"},{"id":"307","span":{"begin":505,"end":510},"obj":"Species"},{"id":"308","span":{"begin":336,"end":341},"obj":"Species"},{"id":"309","span":{"begin":250,"end":267},"obj":"Disease"},{"id":"310","span":{"begin":586,"end":614},"obj":"Disease"},{"id":"311","span":{"begin":668,"end":684},"obj":"Disease"}],"attributes":[{"id":"A305","pred":"tao:has_database_id","subj":"305","obj":"Gene:2212"},{"id":"A306","pred":"tao:has_database_id","subj":"306","obj":"Tax:9606"},{"id":"A307","pred":"tao:has_database_id","subj":"307","obj":"Tax:9606"},{"id":"A308","pred":"tao:has_database_id","subj":"308","obj":"Tax:9606"},{"id":"A309","pred":"tao:has_database_id","subj":"309","obj":"MESH:D013921"},{"id":"A310","pred":"tao:has_database_id","subj":"310","obj":"MESH:D008180"},{"id":"A311","pred":"tao:has_database_id","subj":"311","obj":"MESH:D012130"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T159","span":{"begin":114,"end":124},"obj":"Body_part"},{"id":"T160","span":{"begin":148,"end":157},"obj":"Body_part"},{"id":"T161","span":{"begin":426,"end":437},"obj":"Body_part"},{"id":"T162","span":{"begin":511,"end":521},"obj":"Body_part"},{"id":"T163","span":{"begin":711,"end":721},"obj":"Body_part"},{"id":"T164","span":{"begin":744,"end":746},"obj":"Body_part"}],"attributes":[{"id":"A159","pred":"fma_id","subj":"T159","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A160","pred":"fma_id","subj":"T160","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A161","pred":"fma_id","subj":"T161","obj":"http://purl.org/sig/ont/fma/fma66835"},{"id":"A162","pred":"fma_id","subj":"T162","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A163","pred":"fma_id","subj":"T163","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A164","pred":"fma_id","subj":"T164","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T6","span":{"begin":438,"end":442},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0002415"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T25","span":{"begin":243,"end":267},"obj":"Disease"},{"id":"T27","span":{"begin":586,"end":614},"obj":"Disease"},{"id":"T28","span":{"begin":595,"end":614},"obj":"Disease"},{"id":"T29","span":{"begin":729,"end":740},"obj":"Disease"}],"attributes":[{"id":"A25","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0002048"},{"id":"A26","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0008558"},{"id":"A27","pred":"mondo_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/MONDO_0007915"},{"id":"A28","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0004670"},{"id":"A29","pred":"mondo_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/MONDO_0100053"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T276","span":{"begin":0,"end":2},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T277","span":{"begin":29,"end":37},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9443"},{"id":"T278","span":{"begin":79,"end":81},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T279","span":{"begin":82,"end":84},"obj":"http://purl.obolibrary.org/obo/CLO_0008882"},{"id":"T280","span":{"begin":269,"end":270},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T281","span":{"begin":317,"end":322},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T282","span":{"begin":336,"end":341},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T283","span":{"begin":438,"end":442},"obj":"http://purl.obolibrary.org/obo/UBERON_0002415"},{"id":"T284","span":{"begin":470,"end":472},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T285","span":{"begin":484,"end":485},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T286","span":{"begin":505,"end":510},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T287","span":{"begin":647,"end":656},"obj":"http://purl.obolibrary.org/obo/OBI_0100026"},{"id":"T288","span":{"begin":647,"end":656},"obj":"http://purl.obolibrary.org/obo/UBERON_0000468"},{"id":"T289","span":{"begin":657,"end":659},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T290","span":{"begin":660,"end":661},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T291","span":{"begin":693,"end":694},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T292","span":{"begin":767,"end":769},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T78","span":{"begin":174,"end":182},"obj":"Chemical"}],"attributes":[{"id":"A78","pred":"chebi_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T14","span":{"begin":744,"end":746},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A14","pred":"meddra_id","subj":"T14","obj":"http://purl.bioontology.org/ontology/MEDDRA/10021496"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T93","span":{"begin":114,"end":124},"obj":"http://purl.obolibrary.org/obo/CL_0000738"},{"id":"T94","span":{"begin":183,"end":192},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"},{"id":"T95","span":{"begin":493,"end":501},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"},{"id":"T96","span":{"begin":511,"end":521},"obj":"http://purl.obolibrary.org/obo/CL_0000738"},{"id":"T97","span":{"begin":647,"end":656},"obj":"http://purl.obolibrary.org/obo/OBI_0100026"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"306","span":{"begin":317,"end":322},"obj":"Species"},{"id":"307","span":{"begin":505,"end":510},"obj":"Species"},{"id":"308","span":{"begin":336,"end":341},"obj":"Species"},{"id":"309","span":{"begin":250,"end":267},"obj":"Disease"},{"id":"310","span":{"begin":586,"end":614},"obj":"Disease"},{"id":"311","span":{"begin":668,"end":684},"obj":"Disease"}],"attributes":[{"id":"A311","pred":"pubann:denotes","subj":"311","obj":"MESH:D012130"},{"id":"A307","pred":"pubann:denotes","subj":"307","obj":"Tax:9606"},{"id":"A306","pred":"pubann:denotes","subj":"306","obj":"Tax:9606"},{"id":"A309","pred":"pubann:denotes","subj":"309","obj":"MESH:D013921"},{"id":"A308","pred":"pubann:denotes","subj":"308","obj":"Tax:9606"},{"id":"A310","pred":"pubann:denotes","subj":"310","obj":"MESH:D008180"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T18","span":{"begin":29,"end":37},"obj":"Species"},{"id":"T19","span":{"begin":317,"end":322},"obj":"Species"},{"id":"T20","span":{"begin":336,"end":341},"obj":"Species"},{"id":"T21","span":{"begin":505,"end":510},"obj":"Species"}],"attributes":[{"id":"A19","pred":"ncbi_taxonomy_id","subj":"T19","obj":"NCBItxid:9606"},{"id":"A18","pred":"ncbi_taxonomy_id","subj":"T18","obj":"NCBItxid:9443"},{"id":"A20","pred":"ncbi_taxonomy_id","subj":"T20","obj":"NCBItxid:9606"},{"id":"A21","pred":"ncbi_taxonomy_id","subj":"T21","obj":"NCBItxid:9606"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T94","span":{"begin":0,"end":125},"obj":"Sentence"},{"id":"T95","span":{"begin":126,"end":268},"obj":"Sentence"},{"id":"T96","span":{"begin":269,"end":347},"obj":"Sentence"},{"id":"T97","span":{"begin":348,"end":522},"obj":"Sentence"},{"id":"T98","span":{"begin":523,"end":769},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T6","span":{"begin":438,"end":442},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0002415"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T158","span":{"begin":114,"end":124},"obj":"Body_part"},{"id":"T159","span":{"begin":148,"end":157},"obj":"Body_part"},{"id":"T160","span":{"begin":426,"end":437},"obj":"Body_part"},{"id":"T161","span":{"begin":511,"end":521},"obj":"Body_part"},{"id":"T162","span":{"begin":711,"end":721},"obj":"Body_part"},{"id":"T163","span":{"begin":744,"end":746},"obj":"Body_part"}],"attributes":[{"id":"A160","pred":"fma_id","subj":"T160","obj":"http://purl.org/sig/ont/fma/fma66835"},{"id":"A159","pred":"fma_id","subj":"T159","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A158","pred":"fma_id","subj":"T158","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A163","pred":"fma_id","subj":"T163","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A161","pred":"fma_id","subj":"T161","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A162","pred":"fma_id","subj":"T162","obj":"http://purl.org/sig/ont/fma/fma62860"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T14","span":{"begin":243,"end":267},"obj":"Disease"},{"id":"T15","span":{"begin":586,"end":614},"obj":"Disease"},{"id":"T16","span":{"begin":729,"end":740},"obj":"Disease"}],"attributes":[{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0100053"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0002048"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0007915"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-sample-PD-HP","denotations":[{"id":"T5","span":{"begin":243,"end":267},"obj":"Phenotype"},{"id":"T6","span":{"begin":586,"end":614},"obj":"Phenotype"},{"id":"T7","span":{"begin":729,"end":740},"obj":"Phenotype"}],"attributes":[{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0100845"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0001973"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0002725"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-sentences","denotations":[{"id":"T94","span":{"begin":0,"end":125},"obj":"Sentence"},{"id":"T95","span":{"begin":126,"end":268},"obj":"Sentence"},{"id":"T96","span":{"begin":269,"end":347},"obj":"Sentence"},{"id":"T97","span":{"begin":348,"end":522},"obj":"Sentence"},{"id":"T98","span":{"begin":523,"end":769},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T5","span":{"begin":243,"end":267},"obj":"Phenotype"},{"id":"T6","span":{"begin":586,"end":614},"obj":"Phenotype"},{"id":"T7","span":{"begin":729,"end":740},"obj":"Phenotype"}],"attributes":[{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0001973"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0002725"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0100845"}],"text":"FcγRIIa is expressed only in primates and shows the broadest expression of all FcγRs, being present on all innate leukocytes. It is also present on platelets but its role in effector functions is not established but it is important in certain immune thrombocytopenias. A polymorphic form of this receptor is the only human receptor for human IgG2. This, together with its limited species expression and unique ITAM‐containing cytoplasmic tail (reviewed by Anania et al. 11), suggests a unique function in human leukocytes. Interestingly, polymorphism of the receptor is associated with systemic lupus erythematosus and resistance to Gram‐negative organisms.11 A rare, hyper‐responsive form is a risk factor for neutrophil‐driven anaphylaxis in Ig replacement therapy.22"}