PMC:7228307 / 12629-13372 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"246","span":{"begin":588,"end":593},"obj":"Gene"},{"id":"247","span":{"begin":595,"end":602},"obj":"Gene"},{"id":"248","span":{"begin":613,"end":616},"obj":"Gene"},{"id":"249","span":{"begin":252,"end":255},"obj":"Gene"},{"id":"250","span":{"begin":111,"end":115},"obj":"Gene"},{"id":"251","span":{"begin":14,"end":18},"obj":"Gene"},{"id":"252","span":{"begin":604,"end":611},"obj":"Gene"},{"id":"253","span":{"begin":236,"end":243},"obj":"Gene"},{"id":"254","span":{"begin":331,"end":340},"obj":"Chemical"},{"id":"255","span":{"begin":570,"end":580},"obj":"Chemical"}],"attributes":[{"id":"A246","pred":"tao:has_database_id","subj":"246","obj":"Gene:2214"},{"id":"A247","pred":"tao:has_database_id","subj":"247","obj":"Gene:2213"},{"id":"A248","pred":"tao:has_database_id","subj":"248","obj":"Gene:51430"},{"id":"A249","pred":"tao:has_database_id","subj":"249","obj":"Gene:51430"},{"id":"A250","pred":"tao:has_database_id","subj":"250","obj":"Gene:2213"},{"id":"A251","pred":"tao:has_database_id","subj":"251","obj":"Gene:2213"},{"id":"A252","pred":"tao:has_database_id","subj":"252","obj":"Gene:9103"},{"id":"A253","pred":"tao:has_database_id","subj":"253","obj":"Gene:2212"},{"id":"A254","pred":"tao:has_database_id","subj":"254","obj":"MESH:D004220"},{"id":"A255","pred":"tao:has_database_id","subj":"255","obj":"MESH:D004220"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T132","span":{"begin":0,"end":3},"obj":"Body_part"},{"id":"T133","span":{"begin":722,"end":725},"obj":"Body_part"}],"attributes":[{"id":"A132","pred":"fma_id","subj":"T132","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A133","pred":"fma_id","subj":"T133","obj":"http://purl.org/sig/ont/fma/fma62872"}],"text":"IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T229","span":{"begin":14,"end":16},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T230","span":{"begin":79,"end":81},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T231","span":{"begin":111,"end":113},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T232","span":{"begin":162,"end":164},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T233","span":{"begin":236,"end":238},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T234","span":{"begin":252,"end":255},"obj":"http://purl.obolibrary.org/obo/CLO_0002408"},{"id":"T235","span":{"begin":530,"end":531},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T236","span":{"begin":588,"end":590},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T237","span":{"begin":595,"end":597},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T238","span":{"begin":604,"end":606},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T239","span":{"begin":613,"end":616},"obj":"http://purl.obolibrary.org/obo/CLO_0002408"}],"text":"IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T58","span":{"begin":32,"end":37},"obj":"Chemical"},{"id":"T59","span":{"begin":130,"end":135},"obj":"Chemical"},{"id":"T60","span":{"begin":331,"end":340},"obj":"Chemical"},{"id":"T61","span":{"begin":509,"end":517},"obj":"Chemical"},{"id":"T62","span":{"begin":570,"end":580},"obj":"Chemical"},{"id":"T64","span":{"begin":591,"end":593},"obj":"Chemical"},{"id":"T66","span":{"begin":726,"end":734},"obj":"Chemical"}],"attributes":[{"id":"A58","pred":"chebi_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/CHEBI_30212"},{"id":"A59","pred":"chebi_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/CHEBI_30212"},{"id":"A60","pred":"chebi_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/CHEBI_48343"},{"id":"A61","pred":"chebi_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A62","pred":"chebi_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/CHEBI_35489"},{"id":"A63","pred":"chebi_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/CHEBI_48343"},{"id":"A64","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_73814"},{"id":"A65","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_8753"},{"id":"A66","pred":"chebi_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"}],"text":"IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange"}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T9","span":{"begin":331,"end":340},"obj":"Chemical"},{"id":"T10","span":{"begin":570,"end":580},"obj":"Chemical"}],"attributes":[{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_48343"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_35489"},{"id":"A11","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_48343"}],"text":"IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"246","span":{"begin":588,"end":593},"obj":"Gene"},{"id":"247","span":{"begin":595,"end":602},"obj":"Gene"},{"id":"248","span":{"begin":613,"end":616},"obj":"Gene"},{"id":"249","span":{"begin":252,"end":255},"obj":"Gene"},{"id":"250","span":{"begin":111,"end":115},"obj":"Gene"},{"id":"252","span":{"begin":604,"end":611},"obj":"Gene"},{"id":"253","span":{"begin":236,"end":243},"obj":"Gene"},{"id":"254","span":{"begin":331,"end":340},"obj":"Chemical"},{"id":"255","span":{"begin":570,"end":580},"obj":"Chemical"}],"attributes":[{"id":"A253","pred":"pubann:denotes","subj":"253","obj":"Gene:2212"},{"id":"A249","pred":"pubann:denotes","subj":"249","obj":"Gene:51430"},{"id":"A250","pred":"pubann:denotes","subj":"250","obj":"Gene:2213"},{"id":"A247","pred":"pubann:denotes","subj":"247","obj":"Gene:2213"},{"id":"A254","pred":"pubann:denotes","subj":"254","obj":"MESH:D004220"},{"id":"A248","pred":"pubann:denotes","subj":"248","obj":"Gene:51430"},{"id":"A246","pred":"pubann:denotes","subj":"246","obj":"Gene:2214"},{"id":"A255","pred":"pubann:denotes","subj":"255","obj":"MESH:D004220"},{"id":"A252","pred":"pubann:denotes","subj":"252","obj":"Gene:9103"}],"text":"IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T77","span":{"begin":0,"end":100},"obj":"Sentence"},{"id":"T78","span":{"begin":101,"end":211},"obj":"Sentence"},{"id":"T79","span":{"begin":212,"end":229},"obj":"Sentence"},{"id":"T80","span":{"begin":230,"end":366},"obj":"Sentence"},{"id":"T81","span":{"begin":368,"end":449},"obj":"Sentence"},{"id":"T82","span":{"begin":450,"end":581},"obj":"Sentence"},{"id":"T83","span":{"begin":582,"end":743},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T131","span":{"begin":0,"end":3},"obj":"Body_part"},{"id":"T132","span":{"begin":722,"end":725},"obj":"Body_part"}],"attributes":[{"id":"A131","pred":"fma_id","subj":"T131","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A132","pred":"fma_id","subj":"T132","obj":"http://purl.org/sig/ont/fma/fma62872"}],"text":"IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange"}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T34","span":{"begin":518,"end":526},"obj":"http://purl.obolibrary.org/obo/GO_0015297"},{"id":"T35","span":{"begin":735,"end":743},"obj":"http://purl.obolibrary.org/obo/GO_0015297"}],"text":"IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange"}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T34","span":{"begin":518,"end":526},"obj":"http://purl.obolibrary.org/obo/GO_0015297"},{"id":"T35","span":{"begin":735,"end":743},"obj":"http://purl.obolibrary.org/obo/GO_0015297"}],"text":"IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T34","span":{"begin":518,"end":526},"obj":"http://purl.obolibrary.org/obo/GO_0015297"},{"id":"T35","span":{"begin":735,"end":743},"obj":"http://purl.obolibrary.org/obo/GO_0015297"}],"text":"IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange"}

{"project":"LitCovid-sentences","denotations":[{"id":"T77","span":{"begin":0,"end":100},"obj":"Sentence"},{"id":"T78","span":{"begin":101,"end":211},"obj":"Sentence"},{"id":"T79","span":{"begin":212,"end":229},"obj":"Sentence"},{"id":"T80","span":{"begin":230,"end":366},"obj":"Sentence"},{"id":"T81","span":{"begin":368,"end":449},"obj":"Sentence"},{"id":"T82","span":{"begin":450,"end":581},"obj":"Sentence"},{"id":"T83","span":{"begin":582,"end":743},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange"}

{"project":"LitCovid-sample-Glycan","denotations":[{"id":"T2","span":{"begin":107,"end":110},"obj":"https://glytoucan.org/Structures/Glycans/G05518TD"}],"text":"IgG subclass FcγR specificity Light‐chain attachment Hinge characteristics Fc stability Comment\nIgG1 All FcγR Upper hinge Light‐chain attachment Stable Fc is \u003e100× times more stable than IgG4 and IgG2.\nStable core hinge\nIgG2 FcγRIIa His131 CH1 of Fab and/or upper hinge Stable core hinge with additional inter H‐chain disulfide bonds in the upper hinge. Unstable CH3:CH3 Alternative light‐chain attachment creates distinct conformers. Unlike IgG4, the CH3:CH3 instability does not lead to half‐molecule exchange as a result of stable core and upper hinge disulfides.\nIgG4 FcγRI, FcγRIIb, FcγRIIc CH1 of Fab Labile core hinge Unstable CH3:CH3 Combined instability of core hinge and CH3:CH3 permits half‐IgG molecule exchange"}