PMC:7228307 / 1207-1656 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"19","span":{"begin":178,"end":182},"obj":"Gene"},{"id":"24","span":{"begin":31,"end":41},"obj":"Species"},{"id":"25","span":{"begin":386,"end":392},"obj":"Chemical"}],"attributes":[{"id":"A19","pred":"tao:has_database_id","subj":"19","obj":"Gene:2213"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Tax:2697049"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"MESH:D011134"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ratory syndrome coronavirus 2 (SARS‐CoV‐2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual FcγR function and the complexity of the relationships between FcγRs and antibodies is fueling efforts to develop more potent “next‐gen” therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity an"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T8","span":{"begin":396,"end":403},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"ratory syndrome coronavirus 2 (SARS‐CoV‐2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual FcγR function and the complexity of the relationships between FcγRs and antibodies is fueling efforts to develop more potent “next‐gen” therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity an"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T7","span":{"begin":31,"end":35},"obj":"Disease"}],"attributes":[{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"ratory syndrome coronavirus 2 (SARS‐CoV‐2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual FcγR function and the complexity of the relationships between FcγRs and antibodies is fueling efforts to develop more potent “next‐gen” therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity an"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T14","span":{"begin":116,"end":117},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T15","span":{"begin":178,"end":180},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T16","span":{"begin":240,"end":242},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T17","span":{"begin":243,"end":245},"obj":"http://purl.obolibrary.org/obo/CLO_0008882"},{"id":"T18","span":{"begin":378,"end":385},"obj":"http://purl.obolibrary.org/obo/CLO_0009985"},{"id":"T19","span":{"begin":423,"end":425},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"}],"text":"ratory syndrome coronavirus 2 (SARS‐CoV‐2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual FcγR function and the complexity of the relationships between FcγRs and antibodies is fueling efforts to develop more potent “next‐gen” therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity an"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T6","span":{"begin":396,"end":403},"obj":"Chemical"}],"attributes":[{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"ratory syndrome coronavirus 2 (SARS‐CoV‐2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual FcγR function and the complexity of the relationships between FcγRs and antibodies is fueling efforts to develop more potent “next‐gen” therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity an"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T8","span":{"begin":183,"end":191},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"}],"text":"ratory syndrome coronavirus 2 (SARS‐CoV‐2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual FcγR function and the complexity of the relationships between FcγRs and antibodies is fueling efforts to develop more potent “next‐gen” therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity an"}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T2","span":{"begin":396,"end":403},"obj":"Chemical"}],"attributes":[{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"ratory syndrome coronavirus 2 (SARS‐CoV‐2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual FcγR function and the complexity of the relationships between FcγRs and antibodies is fueling efforts to develop more potent “next‐gen” therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity an"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"19","span":{"begin":178,"end":182},"obj":"Gene"},{"id":"24","span":{"begin":31,"end":41},"obj":"Species"},{"id":"25","span":{"begin":386,"end":392},"obj":"Chemical"}],"attributes":[{"id":"A19","pred":"pubann:denotes","subj":"19","obj":"Gene:2213"},{"id":"A24","pred":"pubann:denotes","subj":"24","obj":"Tax:2697049"},{"id":"A25","pred":"pubann:denotes","subj":"25","obj":"MESH:D011134"}],"text":"ratory syndrome coronavirus 2 (SARS‐CoV‐2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual FcγR function and the complexity of the relationships between FcγRs and antibodies is fueling efforts to develop more potent “next‐gen” therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity an"}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T3","span":{"begin":31,"end":41},"obj":"Species"}],"attributes":[{"id":"A3","pred":"ncbi_taxonomy_id","subj":"T3","obj":"NCBItxid:2697049"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"ratory syndrome coronavirus 2 (SARS‐CoV‐2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual FcγR function and the complexity of the relationships between FcγRs and antibodies is fueling efforts to develop more potent “next‐gen” therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity an"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T11","span":{"begin":116,"end":337},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ratory syndrome coronavirus 2 (SARS‐CoV‐2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual FcγR function and the complexity of the relationships between FcγRs and antibodies is fueling efforts to develop more potent “next‐gen” therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity an"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T8","span":{"begin":396,"end":403},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"ratory syndrome coronavirus 2 (SARS‐CoV‐2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual FcγR function and the complexity of the relationships between FcγRs and antibodies is fueling efforts to develop more potent “next‐gen” therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity an"}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T5","span":{"begin":31,"end":41},"obj":"Disease"}],"attributes":[{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"ratory syndrome coronavirus 2 (SARS‐CoV‐2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual FcγR function and the complexity of the relationships between FcγRs and antibodies is fueling efforts to develop more potent “next‐gen” therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity an"}

{"project":"LitCovid-sentences","denotations":[{"id":"T11","span":{"begin":116,"end":337},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ratory syndrome coronavirus 2 (SARS‐CoV‐2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual FcγR function and the complexity of the relationships between FcγRs and antibodies is fueling efforts to develop more potent “next‐gen” therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity an"}