PMC:7228307 / 11234-12573 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7228307","sourcedb":"PMC","sourceid":"7228307","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7228307","text":"Table 2 Properties of FcγR.\nReceptor Affinity IgG specificity Cell distribution\nFcγRI High IgG1, IgG3, IgG4 Induced by interferon‐γ on monocytes, neutrophils, macrophages, dendritic cell subpopulations; mast cells\nFcγRIIa Low IgG1, IgG3, but IgG2 binding limited to the FcγRIIa‐H131 form, ~70% people) All leukocytes and platelets except T and B lymphocytes\nFcγRIIc a Low IgG1, IgG3, IgG4 NK cells\nFcγRIIIa Low IgG1, IgG3. NK cells, macrophages, subpopulation of circulating monocytes, myeloid dendritic cells, neutrophils at very low levels\nBinding avidity reduced by Phe at position 158\nFcγRIIIb Low IgG1, IgG3 Neutrophils\nFcγRIIb Low IgG1, IgG3, IgG4 B lymphocytes, some monocytes (can be upregulated); basophils; eosinophils? Plasmacytoid and myeloid dendritic cells; NK cells only of individuals with FcγRIIIb gene copy number variation\nAirway smooth muscle, LSEC, placenta, follicular dendritic cell\nIg, immunoglobulin; NK cell, natural killer cell.\na Expressed in 20% of people.\nJohn Wiley \u0026 Sons, Ltd This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health 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