PMC:7224649 / 19396-20005
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 674 | 45-50 | Gene | denotes | IL-6R | Gene:3570 |
| 675 | 156-162 | Gene | denotes | ADAM17 | Gene:6868 |
| 676 | 247-250 | Gene | denotes | sIL | Gene:6491 |
| 677 | 546-550 | Gene | denotes | IL-6 | Gene:3569 |
| 678 | 489-497 | Species | denotes | patients | Tax:9606 |
| 679 | 199-211 | Disease | denotes | inflammation | MESH:D007249 |
| 680 | 324-345 | Disease | denotes | inflammatory diseases | MESH:D007249 |
| 681 | 588-608 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T137 | 199-211 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T138 | 216-226 | Disease | denotes | infectious | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T139 | 324-345 | Disease | denotes | inflammatory diseases | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T140 | 588-596 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T141 | 599-608 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T234 | 51-56 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T235 | 106-107 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T236 | 177-178 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T237 | 419-428 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T238 | 503-504 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T227 | 45-47 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T229 | 74-76 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T231 | 546-548 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T118 | 45-50 | http://purl.obolibrary.org/obo/GO_0004915 | denotes | IL-6R |
| T119 | 199-211 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T120 | 419-436 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathway |
| T121 | 419-428 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T122 | 512-533 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T118 | 0-268 | Sentence | denotes | Recent studies about polymorphism within the IL-6R genes, showed how some IL-6 Receptor variants could be a much better substrate for the shedding protease ADAM17, resulting in a reduced response to inflammation and infectious states, in terms of sIL-6R increase [68]. |
| T119 | 269-351 | Sentence | denotes | Those individuals are also protected from many chronic inflammatory diseases [69]. |
| T120 | 352-609 | Sentence | denotes | This is another evidence of the pro-inflammatory role of the trans-signaling pathway and it could also be the explanation as to why some patients show a higher inflammatory response mediated by IL-6, similarly to what is happening with SARS-CoV-2 infection. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32421092-23593036-24602294 | 347-349 | 23593036 | denotes | 69 |