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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
6 28-41 Gene denotes interleukin-6 Gene:3569
7 43-47 Gene denotes IL-6 Gene:3569
8 0-10 Species denotes SARS-CoV-2 Tax:2697049
9 107-118 Chemical denotes Tocilizumab MESH:C502936
10 15-23 Disease denotes COVID-19 MESH:C000657245
11 73-77 Disease denotes ARDS MESH:D012128
15 167-171 Gene denotes IL-6 Gene:3569
16 192-202 Species denotes SARS-CoV-2 Tax:2697049
17 207-215 Disease denotes COVID-19 MESH:C000657245
19 220-224 Gene denotes IL-6 Gene:3569
22 338-342 Gene denotes IL-6 Gene:3569
23 388-396 Disease denotes COVID-19 MESH:C000657245
27 449-453 Gene denotes IL-6 Gene:3569
28 455-466 Chemical denotes Ruxolitinib MESH:C540383
29 471-482 Chemical denotes Baricitinib MESH:C000596027
40 847-851 Gene denotes IL-6 Gene:3569
41 903-907 Gene denotes IL-6 Gene:3569
42 1207-1211 Gene denotes IL-6 Gene:3569
43 707-715 Species denotes patients Tax:9606
44 725-733 Species denotes patients Tax:9606
45 657-668 Chemical denotes Tocilizumab MESH:C502936
46 1239-1250 Chemical denotes Ruxolitinib MESH:C540383
47 1255-1266 Chemical denotes Baricinitib
48 516-524 Disease denotes COVID-19 MESH:C000657245
49 702-706 Disease denotes ARDS MESH:D012128
69 2079-2097 Gene denotes C-reactive protein Gene:1401
70 2202-2206 Gene denotes IL1B Gene:3553
71 2208-2213 Gene denotes IL1RA Gene:3554
72 2215-2218 Gene denotes IL6 Gene:3569
73 2220-2223 Gene denotes IL7 Gene:3574
74 2225-2228 Gene denotes IL8 Gene:3576
75 1388-1401 Species denotes Coronaviruses Tax:11118
76 1496-1502 Species denotes humans Tax:9606
77 1575-1585 Species denotes SARS-CoV-2 Tax:2697049
78 1637-1653 Species denotes beta coronavirus Tax:694002
79 1714-1722 Species denotes SARS-CoV Tax:694009
80 1861-1869 Species denotes patients Tax:9606
81 1515-1526 Species denotes respiratory Tax:12814
82 1550-1569 Disease denotes neurologic diseases MESH:D020271
83 1619-1627 Disease denotes COVID-19 MESH:C000657245
84 1730-1765 Disease denotes Acute respiratory distress syndrome MESH:D012128
85 1767-1771 Disease denotes ARDS MESH:D012128
86 1880-1884 Disease denotes ARDS MESH:D012128
87 1935-1943 Disease denotes infected MESH:D007239
110 2913-2928 Gene denotes Interferon beta Gene:3456
111 3193-3208 Gene denotes Interferon beta Gene:3456
112 3574-3589 Gene denotes Interferon beta Gene:3456
113 2420-2428 Species denotes SARS-CoV Tax:694009
114 2432-2440 Species denotes MERS-CoV Tax:1335626
115 2445-2455 Species denotes SARS-CoV-2 Tax:2697049
116 2508-2521 Species denotes coronaviruses Tax:11118
117 2705-2716 Species denotes coronavirus Tax:11118
118 2969-2977 Species denotes MERS-CoV Tax:1335626
119 3295-3300 Species denotes mouse Tax:10090
120 3373-3383 Species denotes SARS-CoV-2 Tax:2697049
121 3387-3395 Species denotes patients Tax:9606
122 3169-3188 Chemical denotes Lopinavir/Ritonavir MESH:C558899
123 3327-3337 Chemical denotes Remdesivir MESH:C000606551
124 3550-3569 Chemical denotes Lopinavir/Ritonavir MESH:C558899
125 2481-2490 Disease denotes mortality MESH:D003643
126 2799-2809 Disease denotes infections MESH:D007239
127 3147-3160 Disease denotes HIV infection MESH:D015658
128 3244-3263 Disease denotes MERS-CoV infections MESH:D018352
129 3306-3319 Disease denotes CoV infection MESH:D018352
130 3430-3432 Disease denotes GS MESH:D011125
131 3708-3716 Disease denotes viraemia
135 3899-3909 Species denotes SARS-CoV-2 Tax:2697049
136 4081-4089 Species denotes SARS-CoV Tax:694009
137 4092-4103 Disease denotes lung injury MESH:D055370
141 4190-4194 Gene denotes IL-6 Gene:3569
142 4215-4225 Species denotes SARS-CoV-2 Tax:2697049
143 4230-4238 Disease denotes COVID-19 MESH:C000657245
151 4239-4243 Gene denotes IL-6 Gene:3569
152 4518-4522 Gene denotes IL-6 Gene:3569
153 4539-4547 Gene denotes IL-1beta Gene:3552
154 4575-4578 Gene denotes TNF Gene:7124
155 4798-4802 Gene denotes IL-6 Gene:3569
156 4552-4566 Disease denotes tumor necrosis MESH:D009336
157 4784-4796 Disease denotes inflammation MESH:D007249
186 4873-4877 Gene denotes IL-6 Gene:3569
187 4973-4976 Gene denotes IL6 Gene:3569
188 5004-5007 Gene denotes CD4 Gene:920
189 5051-5055 Gene denotes IL-6 Gene:3569
190 5181-5185 Gene denotes IL-6 Gene:3569
191 5313-5317 Gene denotes IL-6 Gene:3569
192 5443-5447 Gene denotes IL-6 Gene:3569
193 5615-5619 Gene denotes IL-6 Gene:16193
194 4980-4984 Species denotes mice Tax:10090
195 5091-5106 Species denotes influenza virus Tax:11308
196 5458-5462 Species denotes mice Tax:10090
197 5542-5569 Species denotes Respiratory Syncytial Virus Tax:12814
198 5590-5594 Species denotes mice Tax:10090
199 4930-4939 Species denotes influenza Tax:11320
200 4985-4994 Species denotes influenza Tax:11320
201 5193-5202 Species denotes influenza Tax:11320
202 5349-5358 Species denotes influenza Tax:11320
203 5571-5574 Species denotes RSV Tax:12814
204 4902-4921 Disease denotes infectious diseases MESH:D003141
205 5138-5149 Disease denotes lung damage MESH:D008171
206 5154-5159 Disease denotes death MESH:D003643
207 5211-5223 Disease denotes inflammation MESH:D007249
208 5245-5256 Disease denotes lung damage MESH:D008171
209 5377-5387 Disease denotes infections MESH:D007239
210 5411-5436 Disease denotes Virus-1 (HSV-1) infection MESH:C536395
211 5483-5492 Disease denotes infection MESH:D007239
212 5576-5586 Disease denotes infections MESH:D007239
213 5659-5682 Disease denotes increase of the disease MESH:C535833
254 5756-5769 Gene denotes interleukin 6 Gene:3569
255 5771-5775 Gene denotes IL-6 Gene:3569
256 5781-5794 Gene denotes Interleukin 8 Gene:3576
257 5796-5800 Gene denotes IL 8 Gene:3576
258 5896-5900 Gene denotes IL-6 Gene:3569
259 6093-6097 Gene denotes IL-6 Gene:3569
260 6180-6184 Gene denotes IL-6 Gene:16193
261 6294-6298 Gene denotes IL-6 Gene:3569
262 6513-6517 Gene denotes IL-6 Gene:3569
263 6522-6540 Gene denotes C-reactive protein Gene:1401
264 6542-6545 Gene denotes CRP Gene:1401
265 6937-6950 Gene denotes Interleukin-6 Gene:3569
266 6952-6956 Gene denotes IL-6 Gene:3569
267 6969-6986 Gene denotes Interleukin-1beta Gene:3553
268 6988-6996 Gene denotes IL-1beta Gene:3552
269 7148-7151 Gene denotes CD4 Gene:920
270 5864-5872 Species denotes SARS-CoV Tax:694009
271 5875-5883 Species denotes patients Tax:9606
272 5962-5970 Species denotes SARS-CoV Tax:694009
273 6031-6036 Species denotes human Tax:9606
274 6055-6063 Species denotes SARS-CoV Tax:694009
275 6115-6132 Species denotes influenza A virus Tax:11320
276 6156-6162 Species denotes murine Tax:10090
277 6268-6276 Species denotes SARS-CoV Tax:694009
278 6377-6381 Species denotes mice Tax:10090
279 6417-6427 Species denotes SARS-CoV-2 Tax:2697049
280 6440-6448 Species denotes patients Tax:9606
281 6692-6700 Species denotes patients Tax:9606
282 6737-6747 Species denotes SARS-CoV-2 Tax:2697049
283 5989-6000 Species denotes respiratory Tax:12814
284 6163-6179 Disease denotes viral infections MESH:D001102
285 6327-6339 Disease denotes inflammation MESH:D007249
286 6360-6369 Disease denotes mortality MESH:D003643
287 6431-6439 Disease denotes COVID-19 MESH:C000657245
288 6562-6571 Disease denotes mortality MESH:D003643
289 6576-6590 Disease denotes severe disease MESH:D045169
290 6677-6691 Disease denotes critically ill MESH:D016638
291 6713-6732 Disease denotes respiratory failure MESH:D012131
292 6784-6814 Disease denotes macrophage-activation syndrome MESH:D055501
293 7152-7163 Disease denotes lymphopenia MESH:D008231
327 7197-7201 Gene denotes IL-6 Gene:16193
328 7309-7313 Gene denotes IL-6 Gene:16193
329 7606-7626 Gene denotes Toll Like Receptor 4 Gene:7099
330 7628-7632 Gene denotes TLR4 Gene:7099
331 7756-7760 Gene denotes IL-6 Gene:3569
332 7773-7777 Gene denotes TLR4 Gene:7099
333 8027-8031 Gene denotes AP-1 Gene:3726
334 8036-8039 Gene denotes IRF Gene:84676
335 8122-8126 Gene denotes TLR4 Gene:7099
336 8293-8297 Gene denotes TLR4 Gene:21898
337 8481-8485 Gene denotes TLR4 Gene:21898
338 8643-8663 Gene denotes toll-like-receptor 4 Gene:7099
339 8665-8669 Gene denotes TLR4 Gene:21898
340 8685-8689 Gene denotes TLR4 Gene:21898
341 8708-8712 Gene denotes IL-6 Gene:16193
342 7281-7287 Species denotes murine Tax:10090
343 7414-7422 Species denotes SARS-CoV Tax:694009
344 7519-7525 Species denotes humans Tax:9606
345 7660-7668 Species denotes SARS-CoV Tax:694009
346 8303-8307 Species denotes mice Tax:10090
347 8349-8354 Species denotes mouse Tax:10090
348 8363-8380 Species denotes influenza A virus Tax:11320
349 8430-8435 Species denotes mouse Tax:10090
350 9013-9026 Species denotes coronaviruses Tax:11118
351 8406-8415 Species denotes influenza Tax:11320
352 7904-7922 Chemical denotes lipopolysaccharide MESH:D008070
353 7230-7241 Disease denotes lung injury MESH:D055370
354 7584-7601 Disease denotes acute lung injury MESH:D055371
355 7706-7717 Disease denotes lung injury MESH:D055370
356 8155-8165 Disease denotes infections MESH:D007239
357 8273-8282 Disease denotes infection MESH:D007239
358 8332-8341 Disease denotes infection MESH:D007239
359 8416-8426 Disease denotes infections MESH:D007239
370 9093-9097 Gene denotes IL-6 Gene:3569
371 9161-9165 Gene denotes IL-6 Gene:3569
372 9408-9412 Gene denotes IL-6 Gene:3569
373 9469-9473 Gene denotes IL-6 Gene:3569
374 9567-9571 Gene denotes IL-6 Gene:3569
375 9671-9675 Gene denotes IL-6 Gene:3569
376 9801-9805 Gene denotes IL-6 Gene:3569
377 9061-9069 Species denotes SARS-CoV Tax:694009
378 9251-9259 Species denotes SARS-CoV Tax:694009
379 9425-9430 Species denotes human Tax:9606
389 10146-10150 Gene denotes IL-6 Gene:3569
390 10177-10181 Gene denotes IL-6 Gene:3569
391 10394-10398 Gene denotes IL-6 Gene:3569
392 10264-10272 Species denotes patients Tax:9606
393 9867-9911 Disease denotes Macrophage Activation Syndrome (MAS) disease MESH:D055501
394 9916-9934 Disease denotes COVID-19 pneumonia MESH:C000657245
395 10249-10263 Disease denotes critically ill MESH:D016638
396 10318-10322 Disease denotes ARDS MESH:D012128
397 10402-10422 Disease denotes SARS-CoV-2 infection MESH:C000657245
415 10445-10449 Gene denotes IL-6 Gene:3569
416 10553-10557 Gene denotes IL-6 Gene:3569
417 10738-10742 Gene denotes IL-6 Gene:3569
418 11212-11216 Gene denotes IL-6 Gene:16193
419 11321-11325 Gene denotes IL-6 Gene:16193
420 10470-10478 Species denotes SARS-CoV Tax:694009
421 10600-10610 Species denotes SARS-CoV-2 Tax:2697049
422 10611-10619 Species denotes patients Tax:9606
423 10849-10857 Species denotes patients Tax:9606
424 11307-11313 Species denotes murine Tax:10090
425 10748-10759 Chemical denotes Tocilizumab MESH:C502936
426 10916-10927 Chemical denotes Tocilizumab MESH:C502936
427 10485-10506 Disease denotes SARS-CoV-2 infections MESH:C000657245
428 10882-10895 Disease denotes lung injuries MESH:D055370
429 10971-10991 Disease denotes rheumatoid arthritis MESH:D001172
430 11002-11021 Disease denotes autoimmune diseases MESH:D001327
431 11368-11378 Disease denotes infections MESH:D007239
463 13915-13919 Gene denotes IL-6 Gene:3569
464 12125-12133 Species denotes patients Tax:9606
465 12304-12314 Species denotes SARS-CoV-2 Tax:2697049
466 12455-12463 Species denotes patients Tax:9606
467 12473-12482 Species denotes SARS-CoV2 Tax:2697049
468 12579-12587 Species denotes patients Tax:9606
469 12818-12826 Species denotes patients Tax:9606
470 12881-12889 Species denotes patients Tax:9606
471 13237-13245 Species denotes patients Tax:9606
472 13440-13447 Species denotes Patient Tax:9606
473 12027-12038 Species denotes respiratory Tax:12814
474 13527-13538 Species denotes Respiratory Tax:12814
475 13809-13811 Chemical denotes O2 MESH:D010100
476 11748-11753 Disease denotes COVID MESH:C000657245
477 11776-11784 Disease denotes COVID-19 MESH:C000657245
478 11810-11830 Disease denotes SARS-CoV-2 infection MESH:C000657245
479 11904-11913 Disease denotes pneumonia MESH:D011014
480 11932-11950 Disease denotes COVID-19 pneumonia MESH:C000657245
481 12177-12204 Disease denotes Novel Coronavirus Pneumonia MESH:C000657245
482 12206-12209 Disease denotes NCP MESH:C000657245
483 12263-12288 Disease denotes new coronavirus pneumonia MESH:C000657245
484 12385-12393 Disease denotes COVID-19 MESH:C000657245
485 12832-12847 Disease denotes COVID pneumonia MESH:C000657245
486 12900-12917 Disease denotes pulmonary lesions MESH:D008171
487 12934-12949 Disease denotes COVID pneumonia MESH:C000657245
488 12983-12988 Disease denotes fever MESH:D005334
489 13046-13066 Disease denotes Respiratory distress MESH:D012128
490 13206-13236 Disease denotes mmHgORCritical COVID pneumonia MESH:C000657245
491 13247-13266 Disease denotes Respiratory failure MESH:D012131
492 13399-13417 Disease denotes COVID-19 pneumonia MESH:C000657245
493 13744-13763 Disease denotes respiratory failure MESH:D012131
495 11617-11628 Chemical denotes Tocilizumab MESH:C502936
497 11443-11454 Chemical denotes Tocilizumab MESH:C502936
501 14388-14395 Species denotes patient Tax:9606
502 14378-14386 Disease denotes COVID-19 MESH:C000657245
503 14404-14409 Disease denotes fever MESH:D005334
505 14497-14508 Species denotes respiratory Tax:12814
508 14595-14599 Gene denotes IL-6 Gene:3569
509 14716-14726 Gene denotes fibrinogen Gene:2244
512 14136-14143 Species denotes patient Tax:9606
513 14160-14171 Chemical denotes Tociluzumab
515 14745-14749 Gene denotes IL-6 Gene:3569
532 14835-14839 Gene denotes IL-6 Gene:3569
533 14865-14869 Gene denotes IL-6 Gene:3569
534 14893-14915 Gene denotes Interleukin-6 Receptor Gene:3570
535 14917-14922 Gene denotes IL-6R Gene:3570
536 14947-14951 Gene denotes IL-6 Gene:3569
537 15040-15045 Gene denotes gp130 Gene:3572
538 15075-15080 Gene denotes gp130 Gene:3572
539 15219-15224 Gene denotes GP130 Gene:3572
540 15387-15392 Gene denotes IL-6R Gene:3570
541 15507-15512 Gene denotes IL-6R Gene:3570
542 15514-15517 Gene denotes sIL Gene:6491
543 15556-15561 Gene denotes IL-6R Gene:3570
544 15641-15647 Gene denotes ADAM17 Gene:6868
545 15683-15686 Gene denotes sIL Gene:6491
546 15809-15812 Gene denotes sIL Gene:6491
547 15258-15263 Species denotes human Tax:9606
550 15863-15868 Gene denotes IL-6R Gene:3570
551 15883-15897 Gene denotes membrane bound Gene:19
560 16109-16113 Gene denotes IL-6 Gene:3569
561 16137-16142 Gene denotes gp130 Gene:3572
562 16177-16182 Gene denotes IL-6R Gene:3570
563 16269-16274 Gene denotes IL-6R Gene:3570
564 16318-16323 Gene denotes IL-6R Gene:3570
565 16371-16376 Gene denotes gp130 Gene:3572
566 16429-16433 Gene denotes IL-6 Gene:3569
567 16250-16255 Species denotes human Tax:9606
608 16588-16592 Gene denotes IL-6 Gene:3569
609 16627-16632 Gene denotes IL-6R Gene:3570
610 16768-16772 Gene denotes IL-6 Gene:3569
611 16839-16843 Gene denotes IL-6 Gene:3569
612 16913-16918 Gene denotes gp130 Gene:3572
613 17048-17052 Gene denotes IL-6 Gene:16193
614 17158-17163 Gene denotes IL-6R Gene:16194
615 17262-17267 Gene denotes IL-6R Gene:16194
616 17641-17645 Gene denotes IL-6 Gene:16193
617 18162-18166 Gene denotes IL-6 Gene:16193
618 18200-18205 Gene denotes IL-6R Gene:16194
619 18229-18233 Gene denotes IL-6 Gene:16193
620 18357-18361 Gene denotes IL-6 Gene:16193
621 18638-18641 Gene denotes sIL Gene:6491
622 16612-16626 Gene denotes membrane bound Gene:19
623 16991-16997 Species denotes murine Tax:10090
624 17204-17208 Species denotes mice Tax:10090
625 17889-17894 Species denotes mouse Tax:10090
626 18783-18791 Species denotes patients Tax:9606
627 16944-16949 Species denotes human Tax:9606
628 17143-17147 Species denotes mice Tax:10090
629 17290-17301 Chemical denotes Tocilizumab MESH:C502936
630 16510-16522 Disease denotes inflammation MESH:D007249
631 16527-16533 Disease denotes cancer MESH:D009369
632 17012-17018 Disease denotes sepsis MESH:D018805
633 17191-17196 Disease denotes death MESH:D003643
634 17327-17333 Disease denotes sepsis MESH:D018805
635 17712-17723 Disease denotes lung injury MESH:D055370
636 17731-17749 Disease denotes acute pancreatitis MESH:D010195
637 17830-17842 Disease denotes pancreatitis MESH:D010195
638 17851-17868 Disease denotes acute lung injury MESH:D055371
639 17904-17919 Disease denotes atherosclerosis MESH:D050197
640 17995-18018 Disease denotes atherosclerotic plaques MESH:D050197
641 18408-18429 Disease denotes inflammatory diseases MESH:D007249
642 18434-18440 Disease denotes cancer MESH:D009369
643 18450-18466 Disease denotes multiple myeloma MESH:D009101
644 18571-18599 Disease denotes chronic lymphocytic leukemia MESH:D015451
645 18604-18613 Disease denotes lymphomas MESH:D008223
646 18745-18762 Disease denotes malignant ascites MESH:D001201
647 18768-18782 Disease denotes ovarian cancer MESH:D010051
657 18955-18958 Gene denotes sIL Gene:6491
658 18998-19001 Gene denotes sIL Gene:6491
659 19032-19035 Gene denotes sIL Gene:6491
660 19185-19188 Gene denotes sIL Gene:6491
661 19239-19243 Gene denotes IL-6 Gene:3569
662 19248-19251 Gene denotes sIL Gene:6491
663 19323-19327 Gene denotes IL-6 Gene:3569
664 18889-18894 Species denotes human Tax:9606
665 19075-19085 Disease denotes infections MESH:D007239
674 19441-19446 Gene denotes IL-6R Gene:3570
675 19552-19558 Gene denotes ADAM17 Gene:6868
676 19643-19646 Gene denotes sIL Gene:6491
677 19942-19946 Gene denotes IL-6 Gene:3569
678 19885-19893 Species denotes patients Tax:9606
679 19595-19607 Disease denotes inflammation MESH:D007249
680 19720-19741 Disease denotes inflammatory diseases MESH:D007249
681 19984-20004 Disease denotes SARS-CoV-2 infection MESH:C000657245
696 20028-20032 Gene denotes IL-6 Gene:3569
697 20159-20163 Gene denotes IL-6 Gene:3569
698 20271-20275 Gene denotes IL-6 Gene:3569
699 20317-20322 Gene denotes IL-6R Gene:3570
700 20461-20465 Gene denotes IL-6 Gene:3569
701 20548-20552 Gene denotes IL-6 Gene:3569
702 20656-20660 Gene denotes IL-6 Gene:3569
703 20058-20067 Species denotes influenza Tax:11320
704 20227-20235 Species denotes Listeria Tax:1639
705 20302-20316 Gene denotes membrane bound Gene:19
706 20068-20077 Disease denotes infection MESH:D007239
707 20211-20221 Disease denotes infections MESH:D007239
708 20253-20263 Disease denotes infections MESH:D007239
709 20847-20866 Disease denotes bacterial infection MESH:D001424
744 20960-20964 Gene denotes IL-6 Gene:3569
745 21076-21080 Gene denotes IL-6 Gene:3569
746 21218-21222 Gene denotes IL-6 Gene:3569
747 21297-21301 Gene denotes IL-6 Gene:3569
748 21650-21663 Gene denotes interleukin-6 Gene:16193
749 21780-21784 Gene denotes IL-6 Gene:16193
750 21867-21871 Gene denotes IL-6 Gene:16193
751 21944-21949 Gene denotes IL-6R Gene:16194
752 22060-22064 Gene denotes IL-6 Gene:16193
753 22123-22128 Gene denotes IL-6R Gene:16194
754 22203-22207 Gene denotes IL-6 Gene:16193
755 20985-20993 Species denotes patients Tax:9606
756 21703-21709 Species denotes murine Tax:10090
757 21928-21934 Species denotes murine Tax:10090
758 21960-21964 Species denotes mice Tax:10090
759 22097-22102 Species denotes mouse Tax:10090
760 22142-22146 Species denotes mice Tax:10090
761 22271-22275 Species denotes mice Tax:10090
762 22412-22416 Species denotes mice Tax:10090
763 20976-20984 Disease denotes COVID-19 MESH:C000657245
764 21408-21429 Disease denotes inflammatory diseases MESH:D007249
765 21439-21462 Disease denotes intestinal inflammation MESH:D007249
766 21464-21484 Disease denotes rheumatoid arthritis MESH:D001172
767 21486-21524 Disease denotes lupus erythematosus, neuroinflammation MESH:D008180
768 21529-21535 Disease denotes cancer MESH:D009369
769 21587-21599 Disease denotes inflammation MESH:D007249
770 21609-21615 Disease denotes sepsis MESH:D018805
771 21724-21730 Disease denotes sepsis MESH:D018805
772 21746-21755 Disease denotes infection MESH:D007239
773 21827-21834 Disease denotes Malaria MESH:D008288
774 21844-21853 Disease denotes infection MESH:D007239
775 21969-21978 Disease denotes infection MESH:D007239
776 22042-22049 Disease denotes malaria MESH:D008288
777 22391-22408 Disease denotes malaria lethality MESH:D008288
784 22423-22427 Gene denotes IL-6 Gene:16193
785 22743-22748 Gene denotes IL-6R Gene:3570
786 22787-22791 Gene denotes IL-6 Gene:16193
787 22547-22559 Disease denotes inflammation MESH:D007249
788 22936-22947 Disease denotes lung injury MESH:D055370
789 22996-23008 Disease denotes pancreatitis MESH:D010195
794 23053-23057 Gene denotes IL-6 Gene:3569
795 23099-23104 Gene denotes IL-6R Gene:3570
796 23084-23098 Gene denotes membrane bound Gene:19
797 23253-23263 Disease denotes infections MESH:D007239
810 23680-23684 Gene denotes IL-6 Gene:3569
811 23781-23785 Gene denotes IL-6 Gene:3569
812 23828-23832 Gene denotes IL-6 Gene:3569
813 23798-23806 Species denotes patients Tax:9606
814 24040-24050 Species denotes SARS-CoV-2 Tax:2697049
815 23936-23945 Species denotes influenza Tax:11320
816 23974-23985 Chemical denotes Tocilizumab MESH:C502936
817 23544-23552 Disease denotes COVID-19 MESH:C000657245
818 23789-23797 Disease denotes COVID-19 MESH:C000657245
819 23812-23816 Disease denotes ARDS MESH:D012128
820 23882-23890 Disease denotes COVID-19 MESH:C000657245
821 23946-23955 Disease denotes infection MESH:D007239
824 24689-24694 Gene denotes mIL6R Gene:16194
825 24884-24895 Chemical denotes Tocilizumab MESH:C502936
835 24417-24421 Gene denotes IL-6 Gene:3569
836 24510-24514 Gene denotes IL-6 Gene:3569
837 24123-24131 Species denotes patients Tax:9606
838 24187-24197 Species denotes SARS-CoV-2 Tax:2697049
839 24226-24234 Species denotes patients Tax:9606
840 24266-24277 Chemical denotes Tocilizumab MESH:C502936
841 24492-24503 Chemical denotes Tocilizumab MESH:C502936
842 24114-24122 Disease denotes COVID-19 MESH:C000657245
843 24217-24225 Disease denotes COVID-19 MESH:C000657245
847 24986-24990 Gene denotes IL-6 Gene:3569
848 25037-25048 Chemical denotes Baricitinib MESH:C000596027
849 25053-25064 Chemical denotes Ruxolitinib MESH:C540383
857 25128-25132 Gene denotes IL-6 Gene:3569
858 25242-25246 Gene denotes IL-6 Gene:3569
859 25250-25255 Gene denotes IL-6R Gene:3570
860 25443-25448 Gene denotes STAT1 Gene:6772
861 25450-25455 Gene denotes STAT3 Gene:6774
862 25528-25558 Gene denotes phosphatidyl-inositol-3-kinase Gene:5293
863 25624-25628 Gene denotes IL-6 Gene:3569
892 25841-25848 Gene denotes JAK 1/2 Gene:3716
893 26020-26024 Gene denotes JAK2 Gene:3717
894 26151-26155 Gene denotes JAK2 Gene:3717
895 26177-26181 Gene denotes JAK1 Gene:3716
896 26273-26277 Gene denotes JAK3 Gene:3718
897 26785-26789 Gene denotes IL-6 Gene:3569
898 26999-27003 Gene denotes IL-6 Gene:3569
899 27177-27181 Gene denotes IL-6 Gene:3569
900 26825-26830 Species denotes human Tax:9606
901 27289-27297 Species denotes patients Tax:9606
902 25873-25884 Chemical denotes Ruxolitinib MESH:C540383
903 25886-25897 Chemical denotes Ruxolitinib MESH:C540383
904 26308-26319 Chemical denotes ruxolitinib MESH:C540383
905 26854-26865 Chemical denotes ruxolitinib MESH:C540383
906 27060-27071 Chemical denotes ruxolitinib MESH:C540383
907 27159-27170 Chemical denotes Ruxolitinib MESH:C540383
908 27197-27208 Chemical denotes Tocilizumab MESH:C502936
909 27308-27315 Chemical denotes CINC424
910 27317-27328 Chemical denotes RUXOLITINIB MESH:C540383
911 26033-26061 Disease denotes myeloproliferative neoplasms MESH:D009196
912 26073-26108 Disease denotes myelofibrosis and polycythemia vera MESH:D011087
913 26511-26545 Disease denotes hemophagocytic lymphohistiocytosis MESH:D051359
914 26581-26607 Disease denotes hyperinflammatory syndrome MESH:D061325
915 26645-26661 Disease denotes hypercytokinemia
916 26667-26686 Disease denotes multi organ failure MESH:D009102
917 26772-26780 Disease denotes TNF alfa MESH:C536657
918 27008-27016 Disease denotes TNF alfa MESH:C536657
919 27235-27243 Disease denotes COVID-19 MESH:C000657245
929 27625-27629 Gene denotes IL-6 Gene:3569
930 27823-27827 Gene denotes AAK1 Gene:22848
931 27832-27835 Gene denotes GAK Gene:2580
932 27395-27405 Species denotes SARS-CoV-2 Tax:2697049
933 27331-27342 Chemical denotes Baricitinib MESH:C000596027
934 28078-28089 Chemical denotes Baricinitib
935 27734-27749 Disease denotes viral infection MESH:D001102
936 27887-27902 Disease denotes viral infection MESH:D001102
937 28127-28142 Disease denotes viral infection MESH:D001102
939 28267-28271 Gene denotes IL-6 Gene:3569
960 28314-28318 Gene denotes IL-6 Gene:3569
961 28618-28623 Gene denotes IL-6R Gene:3570
962 28751-28755 Gene denotes IL-6 Gene:3569
963 28847-28852 Gene denotes IL-17 Gene:3605
964 28857-28861 Gene denotes IL-6 Gene:3569
965 28323-28332 Chemical denotes sirukumab MESH:C568922
966 28334-28341 Chemical denotes CNTO136 MESH:C568922
967 28344-28354 Chemical denotes olokizumab MESH:C000592400
968 28356-28362 Chemical denotes CP6038
969 28365-28374 Chemical denotes PF-423691
970 28376-28387 Chemical denotes elsilimomab
971 28389-28393 Chemical denotes BE-8
972 28396-28408 Chemical denotes clazakizumab MESH:C000604955
973 28410-28419 Chemical denotes BMS945429 MESH:C000604955
974 28571-28580 Chemical denotes Sarilumab MESH:C000592401
975 28679-28690 Chemical denotes Sarilimumab
976 28784-28802 Chemical denotes glatiramer acetate MESH:D000068717
977 28669-28677 Disease denotes COVID-19 MESH:C000657245
978 28691-28699 Disease denotes COVID-19 MESH:C000657245
979 28898-28921 Disease denotes autoimmune encephalitis MESH:C535841
987 29132-29136 Gene denotes IL-6 Gene:3569
988 29455-29459 Gene denotes IL-6 Gene:3569
989 29024-29034 Species denotes SARS-CoV-2 Tax:2697049
990 29724-29730 Species denotes humans Tax:9606
991 29057-29068 Chemical denotes Tocilizumab MESH:C502936
992 29496-29507 Chemical denotes Ruxolitinib MESH:C540383
993 29512-29522 Chemical denotes Baricitnib

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 28-41 Body_part denotes interleukin-6 http://purl.org/sig/ont/fma/fma264829
T2 789-798 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T3 809-817 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T4 837-846 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T5 1449-1452 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T6 1957-1962 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T7 1970-1981 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T8 1987-1996 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T9 2090-2097 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T10 2102-2108 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T11 2123-2134 Body_part denotes Lymphocytes http://purl.org/sig/ont/fma/fma62863
T12 2184-2192 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T13 2239-2247 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T14 2405-2413 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T15 2574-2582 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T16 2993-2999 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T17 3147-3150 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T18 3664-3677 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T19 3869-3877 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T20 4092-4096 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T21 4282-4287 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T22 4295-4308 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T23 4309-4314 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 4324-4337 Body_part denotes B lymphocytes http://purl.org/sig/ont/fma/fma62869
T25 4339-4352 Body_part denotes T lymphocytes http://purl.org/sig/ont/fma/fma62870
T26 4354-4365 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T27 4367-4382 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T28 4377-4382 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T29 4384-4393 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T30 4395-4405 Body_part denotes mast cells http://purl.org/sig/ont/fma/fma66784
T31 4400-4405 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T32 4419-4430 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T33 4440-4450 Body_part denotes fibroblast http://purl.org/sig/ont/fma/fma63877
T34 4455-4472 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T35 4467-4472 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T36 4731-4740 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T37 4818-4827 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T38 4832-4843 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T39 5011-5015 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T40 5114-5118 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T41 5138-5142 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T42 5245-5249 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T43 5275-5285 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T44 5302-5306 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T45 5729-5734 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T46 5756-5769 Body_part denotes interleukin 6 http://purl.org/sig/ont/fma/fma264829
T47 5756-5767 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T48 5781-5794 Body_part denotes Interleukin 8 http://purl.org/sig/ont/fma/fma264827
T49 5781-5792 Body_part denotes Interleukin http://purl.org/sig/ont/fma/fma86578
T50 5848-5852 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T51 5989-6006 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T52 6037-6053 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T53 6048-6053 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T54 6533-6540 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T55 6784-6794 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T56 6868-6877 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T57 6937-6950 Body_part denotes Interleukin-6 http://purl.org/sig/ont/fma/fma264829
T58 6937-6948 Body_part denotes Interleukin http://purl.org/sig/ont/fma/fma86578
T59 6969-6980 Body_part denotes Interleukin http://purl.org/sig/ont/fma/fma86578
T60 7091-7100 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T61 7104-7113 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T62 7118-7128 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T63 7230-7234 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T64 7491-7503 Body_part denotes phospholipid http://purl.org/sig/ont/fma/fma82779
T65 7560-7568 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T66 7590-7594 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T67 7706-7710 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T68 7722-7730 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T69 7783-7804 Body_part denotes transmembrane protein http://purl.org/sig/ont/fma/fma67858
T70 7904-7922 Body_part denotes lipopolysaccharide http://purl.org/sig/ont/fma/fma82785
T71 7924-7927 Body_part denotes LPS http://purl.org/sig/ont/fma/fma82785
T72 7952-7959 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T73 8065-8074 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T74 8180-8186 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T75 9201-9206 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T76 9211-9220 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T77 9273-9281 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T78 9356-9363 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T79 9438-9453 Body_part denotes epithelial cell http://purl.org/sig/ont/fma/fma66768
T80 9449-9453 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T81 9474-9478 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T82 9512-9519 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T83 9620-9627 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T84 9646-9653 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T85 9739-9746 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T86 9867-9877 Body_part denotes Macrophage http://purl.org/sig/ont/fma/fma63261
T87 10002-10010 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T88 10220-10225 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T89 10232-10235 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T90 10284-10287 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T91 10537-10542 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T92 10584-10588 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T93 10773-10781 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T94 10882-10886 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T95 11135-11139 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T96 12040-12045 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T97 12047-12052 Body_part denotes urine http://purl.org/sig/ont/fma/fma12274
T98 12054-12059 Body_part denotes stool http://purl.org/sig/ont/fma/fma64183
T99 12098-12103 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T100 13587-13592 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T101 14893-14906 Body_part denotes Interleukin-6 http://purl.org/sig/ont/fma/fma264829
T102 14893-14904 Body_part denotes Interleukin http://purl.org/sig/ont/fma/fma86578
T103 15193-15196 Body_part denotes MAP http://purl.org/sig/ont/fma/fma67847
T104 15245-15250 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T105 15258-15268 Body_part denotes human body http://purl.org/sig/ont/fma/fma305853
T106 15311-15322 Body_part denotes hepatocytes http://purl.org/sig/ont/fma/fma14515
T107 15329-15339 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T108 15345-15361 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T109 15356-15361 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T110 15394-15401 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T111 15619-15624 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T112 15733-15737 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T113 16151-16156 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T114 16237-16242 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T115 16250-16260 Body_part denotes human body http://purl.org/sig/ont/fma/fma305853
T116 16300-16305 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T117 16357-16362 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T118 16420-16425 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T119 16898-16905 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T120 16950-16964 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T121 16965-16973 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T122 17625-17630 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T123 17712-17716 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T124 17857-17861 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T125 18122-18129 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T126 18314-18321 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T127 18579-18590 Body_part denotes lymphocytic http://purl.org/sig/ont/fma/fma62863
T128 18876-18881 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T129 18889-18899 Body_part denotes human body http://purl.org/sig/ont/fma/fma305853
T130 19061-19066 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T131 19293-19298 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T132 19335-19340 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T133 19347-19364 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T134 19359-19364 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T135 19369-19389 Body_part denotes smooth muscles cells http://purl.org/sig/ont/fma/fma14072
T136 19376-19383 Body_part denotes muscles http://purl.org/sig/ont/fma/fma32558
T137 19384-19389 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T138 20361-20365 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T139 20603-20609 Body_part denotes spleen http://purl.org/sig/ont/fma/fma7196
T140 20614-20619 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T141 20695-20702 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T142 20837-20841 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T143 20920-20927 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T144 21439-21449 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T145 21650-21663 Body_part denotes interleukin-6 http://purl.org/sig/ont/fma/fma264829
T146 22030-22035 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T147 22250-22257 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T148 22484-22496 Body_part denotes granulocytes http://purl.org/sig/ont/fma/fma62854
T149 22501-22512 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T150 22629-22638 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T151 22648-22665 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T152 22660-22665 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T153 22680-22685 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T154 22687-22704 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T155 22699-22704 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T156 22836-22848 Body_part denotes granulocytes http://purl.org/sig/ont/fma/fma62854
T157 22853-22864 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T158 22909-22915 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T159 22936-22940 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T160 23168-23178 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T161 23207-23222 Body_part denotes epithelial cell http://purl.org/sig/ont/fma/fma66768
T162 23218-23222 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T163 23397-23402 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T164 23420-23424 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T165 23454-23472 Body_part denotes regulatory T-cells http://purl.org/sig/ont/fma/fma84070
T166 23467-23472 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T167 23631-23635 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T168 23636-23643 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T169 23662-23667 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T170 23869-23878 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T171 25501-25508 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T172 25528-25549 Body_part denotes phosphatidyl-inositol http://purl.org/sig/ont/fma/fma85436
T173 26257-26266 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T174 26489-26499 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T175 26673-26678 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T176 26754-26763 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T177 26831-26842 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T178 26918-26922 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T179 26937-26946 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T180 26988-26997 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T181 27080-27087 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T182 27092-27096 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T183 27582-27591 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T184 27684-27692 Body_part denotes clathrin http://purl.org/sig/ont/fma/fma62262
T185 27753-27758 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T186 28190-28195 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T187 28601-28609 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T188 28869-28891 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T189 28998-29006 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1957-1962 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T2 2993-2999 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 3664-3677 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T4 4092-4096 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T5 4295-4308 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T6 5114-5118 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 5138-5142 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T8 5245-5249 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T9 5302-5306 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T10 5848-5852 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T11 5989-6006 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T12 7230-7234 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T13 7590-7594 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T14 7706-7710 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T15 8180-8186 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T16 10220-10225 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T17 10537-10542 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T18 10584-10588 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T19 10882-10886 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T20 11135-11139 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T21 12040-12045 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T22 12047-12052 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T23 12054-12059 Body_part denotes stool http://purl.obolibrary.org/obo/UBERON_0001988
T24 12067-12079 Body_part denotes bodily fluid http://purl.obolibrary.org/obo/UBERON_0006314
T25 12098-12103 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443
T26 13347-13353 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T27 13587-13592 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443
T28 17625-17630 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T29 17712-17716 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T30 17857-17861 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T31 19061-19066 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T32 20603-20609 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T33 20614-20619 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T34 22030-22035 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T35 22909-22915 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T36 22936-22940 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T37 23631-23635 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T38 26673-26678 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T39 28869-28891 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T40 28877-28891 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 0-8 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 15-23 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 73-77 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T4 192-200 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 207-215 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T6 388-396 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 516-524 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 702-706 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T9 1550-1569 Disease denotes neurologic diseases http://purl.obolibrary.org/obo/MONDO_0005071
T10 1575-1583 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 1619-1627 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T12 1714-1722 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 1730-1765 Disease denotes Acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T14 1736-1765 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T15 1767-1771 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T16 1880-1884 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T17 2420-2428 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 2445-2453 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T19 2799-2809 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T20 3147-3160 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T21 3151-3160 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T22 3253-3263 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T23 3310-3319 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T24 3373-3381 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T25 3430-3432 Disease denotes GS http://purl.obolibrary.org/obo/MONDO_0005773
T26 3899-3907 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T27 4081-4089 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 4097-4103 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T29 4215-4223 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T30 4230-4238 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T31 4552-4557 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T32 4773-4783 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T33 4784-4796 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T34 4902-4912 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T35 4930-4939 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T36 4985-4994 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T37 5091-5100 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T38 5193-5202 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T39 5211-5223 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T40 5349-5358 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T41 5377-5387 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T42 5396-5410 Disease denotes Herpes Simplex http://purl.obolibrary.org/obo/MONDO_0004609
T43 5427-5436 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T44 5483-5492 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T45 5576-5589 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T46 5864-5872 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 5962-5970 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 6055-6063 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 6115-6124 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T50 6163-6179 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T51 6268-6276 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T52 6327-6339 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T53 6417-6425 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T54 6431-6439 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T55 6713-6732 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T56 6737-6745 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T57 6784-6814 Disease denotes macrophage-activation syndrome http://purl.obolibrary.org/obo/MONDO_0015545
T58 7152-7163 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T59 7224-7241 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T61 7235-7241 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T62 7243-7246 Disease denotes ALI http://purl.obolibrary.org/obo/MONDO_0006502
T63 7350-7353 Disease denotes ALI http://purl.obolibrary.org/obo/MONDO_0006502
T64 7414-7422 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T65 7584-7601 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T67 7595-7601 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T68 7660-7668 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 7700-7717 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T71 7711-7717 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T72 8155-8165 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T73 8273-8282 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T74 8332-8341 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T75 8363-8372 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T76 8406-8415 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T77 8416-8426 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T78 9061-9069 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T79 9251-9259 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T80 9867-9897 Disease denotes Macrophage Activation Syndrome http://purl.obolibrary.org/obo/MONDO_0015545
T81 9899-9902 Disease denotes MAS http://purl.obolibrary.org/obo/MONDO_0015545
T82 9916-9924 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T83 9925-9934 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T84 10318-10322 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T85 10402-10410 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T86 10413-10422 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T87 10470-10478 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T88 10485-10493 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T89 10496-10506 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T90 10600-10608 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T91 10971-10991 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T92 10982-10991 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T93 11002-11021 Disease denotes autoimmune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T94 11368-11378 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T95 11776-11784 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T96 11810-11818 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T97 11821-11830 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T98 11904-11913 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T99 11932-11940 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T100 11941-11950 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T101 12195-12204 Disease denotes Pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T102 12279-12288 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T103 12304-12312 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T104 12385-12393 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T105 12473-12477 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T106 12838-12847 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T107 12940-12949 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T108 13227-13236 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T109 13247-13266 Disease denotes Respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T110 13399-13407 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T111 13408-13417 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T112 14207-14217 Disease denotes Infectious http://purl.obolibrary.org/obo/MONDO_0005550
T113 14378-14386 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T114 16510-16522 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T115 16527-16533 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T116 17334-17344 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T117 17706-17723 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T119 17717-17723 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T120 17731-17749 Disease denotes acute pancreatitis http://purl.obolibrary.org/obo/MONDO_0006515
T121 17737-17749 Disease denotes pancreatitis http://purl.obolibrary.org/obo/MONDO_0004982
T122 17830-17842 Disease denotes pancreatitis http://purl.obolibrary.org/obo/MONDO_0004982
T123 17851-17868 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T125 17862-17868 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T126 17904-17919 Disease denotes atherosclerosis http://purl.obolibrary.org/obo/MONDO_0005311
T127 18408-18429 Disease denotes inflammatory diseases http://purl.obolibrary.org/obo/MONDO_0021166
T128 18434-18440 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T129 18450-18466 Disease denotes multiple myeloma http://purl.obolibrary.org/obo/MONDO_0009693
T130 18459-18466 Disease denotes myeloma http://purl.obolibrary.org/obo/MONDO_0005170
T131 18571-18599 Disease denotes chronic lymphocytic leukemia http://purl.obolibrary.org/obo/MONDO_0004948
T132 18579-18599 Disease denotes lymphocytic leukemia http://purl.obolibrary.org/obo/MONDO_0005402
T133 18591-18599 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T134 18768-18782 Disease denotes ovarian cancer http://purl.obolibrary.org/obo/MONDO_0008170
T135 18776-18782 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T136 19075-19085 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T137 19595-19607 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T138 19612-19622 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T139 19720-19741 Disease denotes inflammatory diseases http://purl.obolibrary.org/obo/MONDO_0021166
T140 19984-19992 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T141 19995-20004 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T142 20058-20077 Disease denotes influenza infection http://purl.obolibrary.org/obo/MONDO_0005812
T143 20068-20077 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T144 20211-20221 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T145 20253-20263 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T146 20517-20528 Disease denotes listeriosis http://purl.obolibrary.org/obo/MONDO_0005828
T147 20847-20866 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113
T148 20857-20866 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T149 20976-20984 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T150 21408-21429 Disease denotes inflammatory diseases http://purl.obolibrary.org/obo/MONDO_0021166
T151 21439-21462 Disease denotes intestinal inflammation http://purl.obolibrary.org/obo/MONDO_0002269
T152 21450-21462 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T153 21464-21484 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T154 21475-21484 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T155 21486-21505 Disease denotes lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0004670
T156 21507-21524 Disease denotes neuroinflammation http://purl.obolibrary.org/obo/MONDO_0004466
T157 21529-21535 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T158 21587-21599 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T159 21746-21755 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T160 21827-21834 Disease denotes Malaria http://purl.obolibrary.org/obo/MONDO_0005136
T161 21844-21853 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T162 21969-21978 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T163 22042-22049 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T164 22391-22398 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T165 22547-22559 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T166 22930-22947 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T168 22941-22947 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T169 22990-23008 Disease denotes acute pancreatitis http://purl.obolibrary.org/obo/MONDO_0006515
T170 22996-23008 Disease denotes pancreatitis http://purl.obolibrary.org/obo/MONDO_0004982
T171 23253-23263 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T172 23544-23552 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T173 23789-23797 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T174 23812-23816 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T175 23882-23890 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T176 23936-23955 Disease denotes influenza infection http://purl.obolibrary.org/obo/MONDO_0005812
T177 23946-23955 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T178 24040-24048 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T179 24114-24122 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T180 24187-24195 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T181 24217-24225 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T182 26033-26061 Disease denotes myeloproliferative neoplasms http://purl.obolibrary.org/obo/MONDO_0020076
T183 26073-26086 Disease denotes myelofibrosis http://purl.obolibrary.org/obo/MONDO_0009692|http://purl.obolibrary.org/obo/MONDO_0044903
T185 26091-26108 Disease denotes polycythemia vera http://purl.obolibrary.org/obo/MONDO_0009891
T186 26091-26103 Disease denotes polycythemia http://purl.obolibrary.org/obo/MONDO_0005571
T187 26511-26545 Disease denotes hemophagocytic lymphohistiocytosis http://purl.obolibrary.org/obo/MONDO_0015540
T188 26667-26686 Disease denotes multi organ failure http://purl.obolibrary.org/obo/MONDO_0043726
T189 27235-27243 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T190 27395-27403 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T191 27734-27749 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T192 27740-27749 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T193 27887-27902 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T194 27893-27902 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T195 28127-28142 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T196 28133-28142 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T197 28669-28677 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T198 28691-28699 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T199 28898-28921 Disease denotes autoimmune encephalitis http://purl.obolibrary.org/obo/MONDO_0020640
T200 28909-28921 Disease denotes encephalitis http://purl.obolibrary.org/obo/MONDO_0019956
T201 29024-29032 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 28-41 http://purl.obolibrary.org/obo/PR_000001393 denotes interleukin-6
T2 156-157 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 281-290 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T4 349-358 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T5 436-445 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T6 908-911 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T7 1012-1021 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T8 1026-1034 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T9 1052-1061 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T10 1150-1151 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 1453-1460 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T12 1496-1502 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T13 1635-1636 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 1926-1934 http://purl.obolibrary.org/obo/CLO_0001658 denotes actively
T15 1957-1962 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T16 1957-1962 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T17 2038-2047 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T18 2102-2108 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T19 2102-2108 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T20 2102-2108 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T21 2102-2108 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T22 2202-2206 http://purl.obolibrary.org/obo/PR_000001136 denotes IL1B
T23 2225-2228 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL8
T24 2292-2298 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3], [4
T25 2334-2337 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T26 2461-2462 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T27 2572-2573 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 2642-2643 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 2886-2911 http://purl.obolibrary.org/obo/PR_000024990 denotes type I and II interferons
T30 3018-3019 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T31 3272-3273 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T32 3274-3283 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humanized
T33 3295-3300 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T34 3339-3340 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 3468-3476 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T36 3664-3677 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T37 3936-3941 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T38 3978-3979 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T39 4092-4096 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T40 4092-4096 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T41 4158-4160 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T42 4179-4180 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T43 4274-4287 http://purl.obolibrary.org/obo/CL_0000499 denotes stromal cells
T44 4295-4308 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T45 4309-4314 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T46 4324-4325 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T47 4367-4382 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T48 4384-4393 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T49 4400-4405 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T50 4440-4450 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblast
T51 4455-4472 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T52 4484-4494 http://purl.obolibrary.org/obo/CLO_0001658 denotes activators
T53 4818-4827 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T54 4884-4885 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T55 4949-4952 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T56 4971-4972 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T57 5004-5007 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T58 5009-5015 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T59 5101-5106 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T60 5114-5118 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T61 5114-5118 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T62 5130-5137 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extreme
T63 5138-5142 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T64 5138-5142 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T65 5245-5249 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T66 5245-5249 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T67 5302-5306 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T68 5302-5306 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T69 5411-5416 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T70 5509-5511 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T71 5564-5569 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T72 5722-5725 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T73 5727-5734 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T74 5756-5769 http://purl.obolibrary.org/obo/PR_000001393 denotes interleukin 6
T75 5796-5800 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL 8
T76 5848-5852 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T77 5848-5852 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T78 6031-6036 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T79 6037-6047 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T80 6048-6053 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T81 6125-6126 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T82 6127-6132 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T83 6191-6192 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T84 6383-6385 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T85 6644-6646 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T86 6795-6805 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T87 6937-6950 http://purl.obolibrary.org/obo/PR_000001393 denotes Interleukin-6
T88 6969-6986 http://purl.obolibrary.org/obo/PR_000001136 denotes Interleukin-1beta
T89 6999-7001 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T90 7104-7113 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T91 7148-7151 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T92 7165-7167 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T93 7170-7171 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T94 7208-7209 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 7230-7234 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T96 7230-7234 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T97 7279-7280 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T98 7425-7428 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T99 7519-7525 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T100 7530-7537 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T101 7590-7594 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T102 7590-7594 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T103 7706-7710 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T104 7706-7710 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T105 7781-7782 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T106 7969-7973 http://purl.obolibrary.org/obo/CLO_0007623 denotes MD-2
T107 7985-7993 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T108 8027-8029 http://purl.obolibrary.org/obo/CLO_0001547 denotes AP
T109 8349-8354 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T110 8373-8374 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T111 8375-8380 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T112 8382-8384 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T113 8430-8435 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T114 8546-8548 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T115 8749-8751 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T116 8790-8800 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T117 9201-9206 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T118 9322-9330 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T119 9394-9404 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T120 9425-9430 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T121 9431-9437 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T122 9438-9448 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T123 9449-9453 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T124 9474-9478 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T125 9493-9502 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T126 9542-9544 http://purl.obolibrary.org/obo/CLO_0007074 denotes kB
T127 9542-9544 http://purl.obolibrary.org/obo/CLO_0051988 denotes kB
T128 9787-9797 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T129 9878-9888 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activation
T130 9983-9984 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T131 10118-10128 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T132 10192-10195 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T133 10333-10335 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T134 10363-10364 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T135 10584-10588 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T136 10584-10588 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T137 10675-10677 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T138 10686-10687 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T139 10760-10761 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T140 10882-10886 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T141 10882-10886 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T142 11135-11139 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T143 11135-11139 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T144 11878-11890 http://purl.obolibrary.org/obo/OBI_0000968 denotes instrumental
T145 11989-11990 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T146 12040-12045 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T147 12040-12045 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T148 12067-12079 http://purl.obolibrary.org/obo/UBERON_0006314 denotes bodily fluid
T149 12098-12103 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T150 13123-13131 http://purl.obolibrary.org/obo/UBERON_0001637 denotes Arterial
T151 13123-13131 http://www.ebi.ac.uk/efo/EFO_0000814 denotes Arterial
T152 13347-13353 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T153 13546-13548 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T154 13587-13592 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T155 14010-14012 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T156 14034-14036 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T157 14134-14135 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T158 14614-14616 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T159 14777-14786 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T160 14812-14818 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T161 14893-14906 http://purl.obolibrary.org/obo/PR_000001393 denotes Interleukin-6
T162 14977-14986 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T163 14987-14988 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T164 15006-15012 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T165 15138-15144 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T166 15161-15171 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T167 15214-15216 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T168 15245-15250 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T169 15258-15263 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T170 15345-15355 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T171 15356-15361 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T172 15441-15442 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T173 15459-15467 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T174 15489-15490 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T175 15619-15624 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T176 15649-15651 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T177 15660-15661 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T178 15839-15845 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T179 15883-15891 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T180 15934-15943 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T181 15991-15997 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T182 16072-16081 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T183 16127-16136 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T184 16151-16156 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T185 16184-16186 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T186 16231-16232 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T187 16237-16242 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T188 16250-16255 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T189 16300-16305 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T190 16357-16362 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T191 16420-16425 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T192 16440-16449 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T193 16451-16453 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T194 16462-16471 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T195 16557-16563 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T196 16612-16620 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T197 16642-16651 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T198 16666-16667 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T199 16723-16732 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T200 16773-16781 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T201 16850-16859 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T202 16889-16890 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T203 16928-16930 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T204 16942-16943 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T205 16944-16949 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T206 16989-16990 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T207 17059-17068 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T208 17223-17224 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T209 17325-17326 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T210 17392-17401 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T211 17482-17491 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T212 17657-17658 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T213 17712-17716 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T214 17712-17716 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T215 17778-17787 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T216 17857-17861 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T217 17857-17861 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T218 17887-17888 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T219 17889-17894 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T220 18075-18084 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T221 18167-18176 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T222 18185-18193 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T223 18240-18249 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T224 18876-18881 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T225 18889-18894 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T226 19061-19066 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T227 19061-19066 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T228 19224-19225 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T229 19261-19270 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T230 19293-19298 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T231 19335-19340 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T232 19347-19364 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T233 19369-19389 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscles cells
T234 19447-19452 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T235 19502-19503 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T236 19573-19574 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T237 19815-19824 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T238 19899-19900 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T239 20078-20081 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T240 20172-20181 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T241 20284-20293 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T242 20302-20310 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T243 20472-20481 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T244 20489-20491 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T245 20501-20507 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T246 20560-20561 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T247 20603-20609 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T248 20614-20619 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T249 20614-20619 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T250 20667-20676 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T251 20789-20798 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T252 20868-20870 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T253 20931-20932 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T254 21155-21164 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T255 21182-21185 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T256 21229-21238 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T257 21320-21329 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T258 21439-21449 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T259 21439-21449 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T260 21550-21553 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T261 21650-21663 http://purl.obolibrary.org/obo/PR_000001393 denotes interleukin-6
T262 21670-21679 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T263 21701-21702 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T264 21791-21800 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T265 21801-21804 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T266 21926-21927 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T267 22030-22035 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T268 22030-22035 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T269 22071-22080 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T270 22097-22102 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T271 22214-22223 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T272 22334-22343 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T273 22365-22374 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T274 22434-22443 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T275 22593-22602 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T276 22648-22665 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T277 22680-22685 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T278 22687-22704 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T279 22728-22736 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T280 22800-22809 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T281 22865-22868 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T282 22936-22940 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T283 22936-22940 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T284 22958-22959 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T285 23066-23075 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T286 23084-23092 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T287 23168-23178 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T288 23168-23178 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T289 23207-23217 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T290 23218-23222 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T291 23289-23298 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T292 23336-23337 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T293 23385-23402 http://purl.obolibrary.org/obo/CL_0000842 denotes mononuclear cells
T294 23418-23424 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T295 23454-23472 http://purl.obolibrary.org/obo/CL_0000815 denotes regulatory T-cells
T296 23631-23635 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T297 23631-23635 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T298 23662-23667 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T299 23691-23700 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T300 23728-23729 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T301 23760-23769 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T302 23869-23878 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T303 23894-23895 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T304 24051-24053 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T305 24091-24094 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T306 24104-24110 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T307 24396-24405 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T308 24616-24625 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T309 24651-24659 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T310 24760-24769 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T311 24952-24961 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T312 24991-24997 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T313 25080-25089 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T314 25106-25115 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T315 25149-25159 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T316 25301-25307 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T317 25326-25332 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T318 25375-25381 http://purl.obolibrary.org/obo/SO_0000418 denotes Signal
T319 25397-25406 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T320 25491-25500 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T321 25779-25788 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T322 25901-25902 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T323 26130-26138 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T324 26203-26204 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T325 26223-26232 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T326 26358-26366 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T327 26500-26510 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T328 26673-26678 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T329 26696-26699 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T330 26825-26830 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T331 26875-26878 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T332 27141-27142 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T333 27274-27280 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T334 27343-27346 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T335 27456-27457 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T336 27490-27499 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T337 27655-27658 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T338 27753-27758 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T339 27832-27835 http://purl.obolibrary.org/obo/CLO_0037126 denotes GAK
T340 27862-27865 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T341 27952-27955 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T342 28090-28091 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T343 28190-28195 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T344 28548-28550 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T345 28634-28640 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T346 28644-28645 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T347 28869-28891 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T348 28869-28891 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T349 28869-28891 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T350 29144-29145 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T351 29175-29178 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T352 29299-29308 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T353 29349-29350 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T354 29469-29479 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T355 29724-29730 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 43-45 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T3 167-169 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T5 220-222 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T7 338-340 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T9 449-451 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T11 645-650 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T12 847-849 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T14 903-905 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T16 1207-1209 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T18 1212-1230 Chemical denotes pathway inhibitors http://purl.obolibrary.org/obo/CHEBI_76932
T19 1220-1230 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T20 1637-1641 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T21 1657-1662 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T22 2090-2097 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T23 2225-2228 Chemical denotes IL8 http://purl.obolibrary.org/obo/CHEBI_138181
T24 2728-2737 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T25 2897-2899 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T26 2924-2928 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T27 3128-3138 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T28 3169-3178 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T29 3204-3208 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T30 3341-3345 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T31 3430-3432 Chemical denotes GS http://purl.obolibrary.org/obo/CHEBI_73516
T32 3550-3559 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T33 3585-3589 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T34 3771-3786 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T35 3936-3941 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T36 3992-4007 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T37 4052-4066 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T38 4190-4192 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T40 4239-4241 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T42 4518-4520 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T44 4539-4541 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T46 4677-4691 Chemical denotes prostaglandins http://purl.obolibrary.org/obo/CHEBI_26333
T47 4798-4800 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T49 4873-4875 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T51 5051-5053 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T53 5181-5183 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T55 5313-5315 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T57 5443-5445 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T59 5615-5617 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T61 5771-5773 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T63 5796-5798 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T65 5896-5898 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T67 6093-6095 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T69 6180-6182 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T71 6294-6296 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T73 6513-6515 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T75 6533-6540 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T76 6952-6954 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T78 6988-6990 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T80 7197-7199 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T82 7309-7311 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T84 7369-7373 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T85 7482-7503 Chemical denotes oxidized phospholipid http://purl.obolibrary.org/obo/CHEBI_60156
T86 7491-7503 Chemical denotes phospholipid http://purl.obolibrary.org/obo/CHEBI_16247
T87 7505-7509 Chemical denotes OxPL http://purl.obolibrary.org/obo/CHEBI_60156
T88 7539-7544 Chemical denotes OxPLs http://purl.obolibrary.org/obo/CHEBI_60156
T89 7756-7758 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T91 7797-7804 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T92 7889-7898 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T93 7904-7922 Chemical denotes lipopolysaccharide http://purl.obolibrary.org/obo/CHEBI_16412
T94 7924-7927 Chemical denotes LPS http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981
T97 7952-7959 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T98 7969-7971 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T99 8027-8029 Chemical denotes AP http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_73393|http://purl.obolibrary.org/obo/CHEBI_81686
T102 8491-8502 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T103 8708-8710 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T105 9093-9095 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T107 9161-9163 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T109 9273-9281 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T110 9356-9363 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T111 9408-9410 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T113 9469-9471 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T115 9512-9519 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T116 9539-9541 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T119 9567-9569 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T121 9631-9638 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T122 9646-9653 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T123 9671-9673 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T125 9739-9746 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T126 9801-9803 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T128 10146-10148 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T130 10177-10179 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T132 10394-10396 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T134 10445-10447 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T136 10553-10555 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T138 10738-10740 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T140 10790-10792 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T142 11212-11214 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T144 11217-11222 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T145 11321-11323 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T147 12507-12513 Chemical denotes Oxygen http://purl.obolibrary.org/obo/CHEBI_15379
T148 13088-13094 Chemical denotes Oxygen http://purl.obolibrary.org/obo/CHEBI_15379
T149 13152-13158 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T150 13187-13193 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T151 13724-13735 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T152 13809-13811 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T153 13915-13917 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T155 14595-14597 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T157 14745-14747 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T159 14835-14837 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T161 14865-14867 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T163 14877-14882 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T164 14917-14919 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T166 14947-14949 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T168 15026-15030 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T169 15193-15196 Chemical denotes MAP http://purl.obolibrary.org/obo/CHEBI_6716
T170 15270-15272 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T172 15372-15374 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T174 15387-15389 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T176 15394-15401 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T177 15507-15509 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T179 15556-15558 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T181 15863-15865 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T183 16109-16111 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T185 16177-16179 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T187 16269-16271 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T189 16318-16320 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T191 16429-16431 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T193 16588-16590 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T195 16627-16629 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T197 16768-16770 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T199 16839-16841 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T201 16860-16869 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T202 16898-16905 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T203 17048-17050 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T205 17158-17160 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T207 17262-17264 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T209 17279-17284 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T210 17641-17643 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T212 18122-18129 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T213 18162-18164 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T215 18200-18202 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T217 18229-18231 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T219 18314-18321 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T220 18357-18359 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T222 18713-18716 Chemical denotes BAL http://purl.obolibrary.org/obo/CHEBI_64198
T223 19239-19241 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T225 19323-19325 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T227 19441-19443 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T229 19470-19472 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T231 19942-19944 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T233 20028-20030 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T235 20159-20161 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T237 20271-20273 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T239 20317-20319 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T241 20461-20463 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T243 20548-20550 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T245 20656-20658 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T247 20695-20702 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T248 20920-20927 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T249 20943-20952 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T250 20960-20962 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T252 21076-21078 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T254 21218-21220 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T256 21297-21299 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T258 21780-21782 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T260 21867-21869 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T262 21944-21946 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T264 22060-22062 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T266 22123-22125 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T268 22203-22205 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T270 22250-22257 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T271 22423-22425 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T273 22639-22642 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T275 22743-22745 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T277 22787-22789 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T279 23053-23055 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T281 23099-23101 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T283 23680-23682 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T285 23781-23783 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T287 23828-23830 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T289 24417-24419 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T291 24510-24512 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T293 24674-24676 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T295 24811-24813 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T297 24986-24988 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T299 25128-25130 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T301 25242-25244 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T303 25250-25252 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T305 25483-25490 Chemical denotes mitogen http://purl.obolibrary.org/obo/CHEBI_52290
T306 25501-25508 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T307 25528-25549 Chemical denotes phosphatidyl-inositol http://purl.obolibrary.org/obo/CHEBI_28874
T308 25528-25540 Chemical denotes phosphatidyl http://purl.obolibrary.org/obo/CHEBI_26025
T309 25541-25549 Chemical denotes inositol http://purl.obolibrary.org/obo/CHEBI_24848
T310 25624-25626 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T312 25862-25867 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T313 25909-25913 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T314 25959-25969 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T315 26308-26319 Chemical denotes ruxolitinib http://purl.obolibrary.org/obo/CHEBI_66919
T316 26785-26787 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T318 26854-26865 Chemical denotes ruxolitinib http://purl.obolibrary.org/obo/CHEBI_66919
T319 26999-27001 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T321 27060-27071 Chemical denotes ruxolitinib http://purl.obolibrary.org/obo/CHEBI_66919
T322 27080-27087 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T323 27177-27179 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T325 27182-27191 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T326 27250-27254 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T327 27500-27509 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T328 27625-27627 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T330 28027-28030 Chemical denotes CYP http://purl.obolibrary.org/obo/CHEBI_38559
T331 28043-28047 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T332 28267-28269 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T334 28272-28277 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T335 28314-28316 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T337 28365-28367 Chemical denotes PF http://purl.obolibrary.org/obo/CHEBI_74795|http://purl.obolibrary.org/obo/CHEBI_90284
T339 28618-28620 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T341 28710-28714 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T342 28751-28753 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T344 28795-28802 Chemical denotes acetate http://purl.obolibrary.org/obo/CHEBI_30089|http://purl.obolibrary.org/obo/CHEBI_47622
T346 28847-28849 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T348 28857-28859 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T350 29132-29134 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T352 29455-29457 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T354 29606-29611 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 281-290 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T2 349-366 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T3 349-358 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T4 776-785 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T5 983-995 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T6 1012-1021 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T7 1052-1061 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T8 2171-2180 http://purl.obolibrary.org/obo/GO_0046903 denotes Secretion
T9 2614-2636 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T10 2656-2668 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T11 4558-4566 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T12 4558-4566 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T13 4558-4566 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T14 4558-4566 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T15 4631-4640 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T16 4784-4796 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T17 5211-5223 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T18 5929-5950 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T19 6163-6179 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T20 6327-6339 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T21 6784-6805 http://purl.obolibrary.org/obo/GO_0042116 denotes macrophage-activation
T22 7357-7373 http://purl.obolibrary.org/obo/GO_0001101 denotes response to acid
T23 7374-7385 http://purl.obolibrary.org/obo/GO_0045333 denotes respiration
T24 7374-7385 http://purl.obolibrary.org/obo/GO_0007585 denotes respiration
T25 7560-7579 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T26 7722-7741 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T27 7994-8015 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factors
T28 7994-8007 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T29 8584-8605 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T30 8713-8722 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T31 8790-8830 http://purl.obolibrary.org/obo/GO_0002218 denotes activation of the innate immune response
T32 8808-8830 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T33 8815-8830 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T34 8954-8975 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T35 9098-9107 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T36 9474-9489 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T37 9676-9685 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T38 9867-9888 http://purl.obolibrary.org/obo/GO_0042116 denotes Macrophage Activation
T39 10002-10020 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine secretion
T40 10011-10020 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T41 10151-10160 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T42 10182-10191 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T43 14777-14799 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling transduction
T44 14777-14786 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T45 14787-14799 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T46 14812-14831 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T47 14819-14831 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T48 14917-14922 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T49 15006-15025 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T50 15013-15025 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T51 15040-15045 http://purl.obolibrary.org/obo/GO_0004921 denotes gp130
T52 15040-15045 http://purl.obolibrary.org/obo/GO_0004915 denotes gp130
T53 15040-15045 http://purl.obolibrary.org/obo/GO_0004897 denotes gp130
T54 15075-15080 http://purl.obolibrary.org/obo/GO_0004921 denotes gp130
T55 15075-15080 http://purl.obolibrary.org/obo/GO_0004915 denotes gp130
T56 15075-15080 http://purl.obolibrary.org/obo/GO_0004897 denotes gp130
T57 15124-15157 http://purl.obolibrary.org/obo/GO_0035556 denotes intracellular signal transduction
T58 15138-15157 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T59 15145-15157 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T60 15219-15224 http://purl.obolibrary.org/obo/GO_0004921 denotes GP130
T61 15219-15224 http://purl.obolibrary.org/obo/GO_0004915 denotes GP130
T62 15219-15224 http://purl.obolibrary.org/obo/GO_0004897 denotes GP130
T63 15387-15392 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T64 15426-15437 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T65 15443-15467 http://purl.obolibrary.org/obo/GO_0008237 denotes metalloprotease activity
T66 15507-15512 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T67 15556-15561 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T68 15756-15767 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T69 15839-15858 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T70 15846-15858 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T71 15863-15868 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T72 15934-15951 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T73 15934-15943 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T74 15991-16010 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T75 15998-16010 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T76 16072-16081 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T77 16137-16142 http://purl.obolibrary.org/obo/GO_0004921 denotes gp130
T78 16137-16142 http://purl.obolibrary.org/obo/GO_0004915 denotes gp130
T79 16137-16142 http://purl.obolibrary.org/obo/GO_0004897 denotes gp130
T80 16177-16182 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T81 16269-16274 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T82 16318-16323 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T83 16371-16376 http://purl.obolibrary.org/obo/GO_0004921 denotes gp130
T84 16371-16376 http://purl.obolibrary.org/obo/GO_0004915 denotes gp130
T85 16371-16376 http://purl.obolibrary.org/obo/GO_0004897 denotes gp130
T86 16440-16449 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T87 16462-16471 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T88 16510-16522 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T89 16627-16632 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T90 16642-16651 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T91 16723-16732 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T92 16850-16859 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T93 16913-16918 http://purl.obolibrary.org/obo/GO_0004921 denotes gp130
T94 16913-16918 http://purl.obolibrary.org/obo/GO_0004915 denotes gp130
T95 16913-16918 http://purl.obolibrary.org/obo/GO_0004897 denotes gp130
T96 17059-17068 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T97 17158-17163 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T98 17262-17267 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T99 17392-17414 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling transduction
T100 17392-17401 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T101 17402-17414 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T102 17442-17463 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T103 17482-17504 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling transduction
T104 17482-17491 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T105 17492-17504 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T106 17531-17557 http://purl.obolibrary.org/obo/GO_0050728 denotes anti-inflammatory response
T107 17536-17557 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T108 17778-17800 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling transduction
T109 17778-17787 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T110 17788-17800 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T111 18075-18092 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T112 18075-18084 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T113 18167-18176 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T114 18200-18205 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T115 18240-18249 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T116 19261-19278 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T117 19261-19270 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T118 19441-19446 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T119 19595-19607 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T120 19815-19832 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T121 19815-19824 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T122 19908-19929 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T123 20172-20181 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T124 20284-20293 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T125 20317-20322 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T126 20472-20481 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T127 20667-20676 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T128 20789-20798 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T129 21155-21172 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T130 21155-21164 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T131 21229-21238 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T132 21320-21329 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T133 21450-21462 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T134 21587-21599 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T135 21670-21679 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T136 21791-21800 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T137 21944-21949 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T138 22071-22080 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T139 22123-22128 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T140 22214-22223 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T141 22334-22343 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T142 22365-22374 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T143 22434-22443 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T144 22547-22559 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T145 22593-22602 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T146 22616-22625 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T147 22743-22748 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T148 22800-22809 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T149 23066-23075 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T150 23099-23104 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T151 23179-23191 http://purl.obolibrary.org/obo/GO_0031099 denotes regeneration
T152 23193-23232 http://purl.obolibrary.org/obo/GO_1904036 denotes inhibition of epithelial cell apoptosis
T153 23207-23232 http://purl.obolibrary.org/obo/GO_1904019 denotes epithelial cell apoptosis
T154 23223-23232 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T155 23223-23232 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T156 23289-23298 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T157 23404-23434 http://purl.obolibrary.org/obo/GO_0070233 denotes inhibition of T-cell apoptosis
T158 23418-23434 http://purl.obolibrary.org/obo/GO_0070231 denotes T-cell apoptosis
T159 23425-23434 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T160 23425-23434 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T161 23440-23488 http://purl.obolibrary.org/obo/GO_0045590 denotes inhibition of regulatory T-cells differentiation
T162 23454-23488 http://purl.obolibrary.org/obo/GO_0045066 denotes regulatory T-cells differentiation
T163 23691-23700 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T164 23760-23777 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T165 23760-23769 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T166 23828-23843 http://purl.obolibrary.org/obo/GO_0032635 denotes IL-6 production
T167 24396-24413 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T168 24396-24405 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T169 24616-24633 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T170 24616-24625 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T171 24760-24777 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T172 24760-24769 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T173 24952-24969 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T174 24952-24961 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T175 24991-25010 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T176 24998-25010 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T177 25080-25089 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T178 25106-25124 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T179 25106-25115 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T180 25192-25204 http://purl.obolibrary.org/obo/GO_0000165 denotes MAPK cascade
T181 25192-25196 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T182 25250-25255 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T183 25287-25320 http://purl.obolibrary.org/obo/GO_0035556 denotes intracellular signal transduction
T184 25301-25320 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T185 25308-25320 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T186 25410-25423 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T187 25517-25521 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T188 25560-25564 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T189 25673-25685 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T190 25779-25796 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T191 25779-25788 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T192 26223-26240 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T193 26223-26232 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T194 26489-26510 http://purl.obolibrary.org/obo/GO_0042116 denotes macrophage activation
T195 27490-27499 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T196 27676-27713 http://purl.obolibrary.org/obo/GO_1900186 denotes inhibit clathrin-mediated endocytosis
T197 27684-27713 http://purl.obolibrary.org/obo/GO_0072583 denotes clathrin-mediated endocytosis
T198 27702-27713 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T199 27734-27749 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T200 27887-27902 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T201 28043-28060 http://purl.obolibrary.org/obo/GO_0015893 denotes drug transporters
T202 28127-28142 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T203 28618-28623 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T204 29266-29287 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T205 29299-29321 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling transduction
T206 29299-29308 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T207 29309-29321 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 809-823 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T2 1736-1756 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T3 2239-2253 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T4 2405-2419 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T5 2574-2588 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T6 3869-3883 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T7 4552-4557 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T8 6713-6732 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T9 6760-6780 Phenotype denotes immune dysregulation http://purl.obolibrary.org/obo/HP_0002958
T10 6883-6903 Phenotype denotes immune dysregulation http://purl.obolibrary.org/obo/HP_0002958
T11 7029-7049 Phenotype denotes immune dysregulation http://purl.obolibrary.org/obo/HP_0002958
T12 7152-7163 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T13 7224-7241 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T14 7243-7246 Phenotype denotes ALI http://www.orpha.net/ORDO/Orphanet_178320
T15 7350-7353 Phenotype denotes ALI http://www.orpha.net/ORDO/Orphanet_178320
T16 7584-7601 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T17 7700-7717 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T18 9925-9934 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T19 10971-10991 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T20 11002-11021 Phenotype denotes autoimmune diseases http://purl.obolibrary.org/obo/HP_0002960
T21 11904-11913 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T22 11941-11950 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T23 12195-12204 Phenotype denotes Pneumonia http://purl.obolibrary.org/obo/HP_0002090
T24 12279-12288 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T25 12838-12847 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T26 12940-12949 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T27 12983-12988 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T28 13046-13066 Phenotype denotes Respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T29 13227-13236 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T30 13247-13266 Phenotype denotes Respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T31 13314-13319 Phenotype denotes Shock http://purl.obolibrary.org/obo/HP_0031273
T32 13408-13417 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T33 13448-13456 Phenotype denotes wheezing http://purl.obolibrary.org/obo/HP_0030828
T34 14404-14409 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T35 16527-16533 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T36 17012-17018 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T37 17327-17333 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T38 17706-17723 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T39 17731-17749 Phenotype denotes acute pancreatitis http://purl.obolibrary.org/obo/HP_0001735
T40 17830-17842 Phenotype denotes pancreatitis http://purl.obolibrary.org/obo/HP_0001733
T41 17851-17868 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T42 17904-17919 Phenotype denotes atherosclerosis http://purl.obolibrary.org/obo/HP_0002621
T43 18434-18440 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T44 18450-18466 Phenotype denotes multiple myeloma http://purl.obolibrary.org/obo/HP_0006775
T45 18571-18599 Phenotype denotes chronic lymphocytic leukemia http://purl.obolibrary.org/obo/HP_0005550
T46 18755-18762 Phenotype denotes ascites http://purl.obolibrary.org/obo/HP_0001541
T47 18768-18782 Phenotype denotes ovarian cancer http://purl.obolibrary.org/obo/HP_0100615
T48 21464-21484 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T49 21529-21535 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T50 21609-21615 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T51 21724-21730 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T52 22930-22947 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T53 22990-23008 Phenotype denotes acute pancreatitis http://purl.obolibrary.org/obo/HP_0001735
T54 24009-24029 Phenotype denotes immune dysregulation http://purl.obolibrary.org/obo/HP_0002958
T55 26073-26086 Phenotype denotes myelofibrosis http://purl.obolibrary.org/obo/HP_0011974
T56 26091-26103 Phenotype denotes polycythemia http://purl.obolibrary.org/obo/HP_0001901
T57 26645-26661 Phenotype denotes hypercytokinemia http://purl.obolibrary.org/obo/HP_0033041
T58 28909-28921 Phenotype denotes encephalitis http://purl.obolibrary.org/obo/HP_0002383
T59 28998-29012 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-24 Sentence denotes SARS-CoV-2 and COVID-19:
T2 25-84 Sentence denotes Is interleukin-6 (IL-6) the ‘culprit lesion’ of ARDS onset?
T3 85-119 Sentence denotes What is there besides Tocilizumab?
T4 120-128 Sentence denotes SGP130Fc
T5 130-140 Sentence denotes Highlights
T6 141-216 Sentence denotes • Evidence of a role for IL-6 in the pathology of SARS-CoV-2 and COVID-19.
T7 217-309 Sentence denotes • IL-6 pathways: the classic (anti-inflammatory) and the trans-signaling (pro-inflammatory)
T8 310-397 Sentence denotes • SGP130Fc could block the IL-6 trans-signaling pathway(pro-inflammatory) in COVID-19.
T9 398-454 Sentence denotes • Inhibition of the JAK/STAT pathway activated by IL-6:
T10 455-483 Sentence denotes Ruxolitinib and Baricitinib.
T11 485-493 Sentence denotes Abstract
T12 494-716 Sentence denotes Since the outbreak of COVID-19 many studies have been published showing possible therapies, here the author discusses the end of stage disease related drugs, like Tocilizumab which is currently being used in ARDS patients.
T13 717-876 Sentence denotes In some patients, disease progression leads to an enormous secretion of cytokines, known as cytokine storm, among those cytokines IL-6 plays an important role.
T14 877-1191 Sentence denotes Here the author shows how IL-6 has both pro and anti-inflammatory properties, depending on the pathway of transduction: soluble (trans-signaling) or membrane-related (classic signaling), and suggests how targeting only the pro-inflammatory pathway, with SGP130Fc, could be a better option then targeting them both.
T15 1192-1370 Sentence denotes Other possible IL-6 pathway inhibitors such as Ruxolitinib and Baricinitib are then analyzed, underlying how they lack the benefit of targeting only the pro-inflammatory pathway.
T16 1372-1387 Sentence denotes 1 Introduction
T17 1388-1574 Sentence denotes Coronaviruses are enveloped, positive-sense, single stranded RNA viruses that are distributed broadly among humans which cause respiratory, enteric, hepatic, and neurologic diseases [1].
T18 1575-1729 Sentence denotes SARS-CoV-2 is the agent responsible for the COVID-19, it is a beta coronavirus of group 2B with over 70% similarity in genetic sequence to SARS-CoV-1 [2].
T19 1730-1944 Sentence denotes Acute respiratory distress syndrome (ARDS) is not an uncommon complication when disease can’t be controlled [3], the percentage of patients requiring ARDS treatment is about 10% for those who are actively infected.
T20 1945-2122 Sentence denotes Total white blood count, lymphocytes, and platelets are lower than the average with extended activated thromboplastin time, increased C-reactive protein and muscle enzyme level.
T21 2123-2170 Sentence denotes Lymphocytes decrease with diseases progression.
T22 2171-2300 Sentence denotes Secretion of cytokine, such as IL1B, IL1RA, IL6, IL7, IL8, known as cytokine storm, is associated with disease severity [3], [4].
T23 2301-2372 Sentence denotes Therapeutic choices once disease has progressed will be discussed here.
T24 2374-2419 Sentence denotes 2 Immunotherapy: fighting the cytokine storm
T25 2420-2669 Sentence denotes SARS-CoV-1, MERS-CoV and SARS-CoV-2 show a relatively higher mortality rates then other coronaviruses, all of which are associated with the presence of a cytokine storm, this might suggest that inflammatory responses play a role in the pathogenesis.
T26 2670-2814 Sentence denotes If that is the case, targeting the coronavirus alone with antiviral therapy might not be sufficient to reverse highly pathogenic infections [5].
T27 2815-2912 Sentence denotes These observations led to explore the usage of therapies that included type I and II interferons.
T28 2913-3017 Sentence denotes Interferon beta displayed the best efficacy in reducing MERS-CoV replication in tissue culture [6], [7].
T29 3018-3268 Sentence denotes A randomized control trial is ongoing in South Arabia (MIRACLE Trial) to determine whether the combination of antivirals used in HIV infection such as Lopinavir/Ritonavir and Interferon beta could improve clinical outcomes in MERS-CoV infections [8].
T30 3269-3735 Sentence denotes In a humanized transgenic mouse MERS-CoV infection model, Remdesivir (a drug already being used against SARS-CoV-2 in patients with severe and moderate disease, GS-US-540-5773/4 Studies) showed more activity and efficacy in prophylactic and therapeutic use then the combination of Lopinavir/Ritonavir and Interferon beta [9], this points towards the necessity to explore other options regarding immune system modulation and how control of viraemia is also essential.
T31 3736-3910 Sentence denotes The use of immunosuppressants like corticosteroids is quite controversial, for some it may be reasonable to counteract the effect of cytokine storm induced by the SARS-CoV-2.
T32 3911-4162 Sentence denotes Although the recent open label study from Wu and colleagues showed a benefit for corticosteroids, for now clinical evidence does not support corticosteroid treatment for SARS-CoV-1 lung injury, as it could result in delayed viral clearance [10], [11].
T33 4164-4238 Sentence denotes 3 Evidence of a role for IL-6 in the pathology of SARS-CoV-2 and COVID-19
T34 4239-4478 Sentence denotes IL-6 can be produced by almost all stromal cells and by immune system cells, such as B lymphocytes, T lymphocytes, macrophages, dendritic cells, monocytes, mast cells and many non-lymphocytes, such as fibroblast and endothelial cells [12].
T35 4479-4746 Sentence denotes Main activators of the Interleuking-6 (IL-6) expression are IL-1beta and tumor necrosis factor (TNF-alfa), but many other factors can contribute to its secretion such as Toll-like receptors (TLRs), prostaglandins, adipokines, stress response and other cytokines [13].
T36 4747-4872 Sentence denotes In the early stage of the infectious inflammation, IL-6 is produced by monocytes and macrophages stimulated by the TLRs [14].
T37 4873-5042 Sentence denotes IL-6 plays a crucial role in infectious diseases such as influenza where it has been shown how in a IL6-/- mice influenza specific CD4+ T cell response is impaired [15].
T38 5043-5165 Sentence denotes Loss of IL-6 results also in persistence of the influenza virus in the lung leading to extreme lung damage and death [16].
T39 5166-5312 Sentence denotes This shows how IL-6 limits influenza-induced inflammation and protects against lung damage [17] by promoting neutrophil survival in the lung [16].
T40 5313-5513 Sentence denotes IL-6 crucial role is not limited to influenza but also in other infections such as Herpes Simplex Virus-1 (HSV-1) infection where IL-6 deficient mice show an increase in infection susceptibility [18].
T41 5514-5740 Sentence denotes In other scenarios, such as Respiratory Syncytial Virus (RSV) infections in mice, early depletion of IL-6, but not late, resulted in significant increase of the disease with an associated influx of cytotoxic CD8+ T cells [19].
T42 5741-5884 Sentence denotes High levels of interleukin 6 (IL-6) and Interleukin 8 (IL 8) were found in the acute stage associated with lung lesions in SARS-CoV-1 patients.
T43 5885-6012 Sentence denotes Especially IL-6 can induce the hyper-innate inflammatory response due to the SARS-CoV-1 invasion of the respiratory tract [20].
T44 6013-6138 Sentence denotes Interestingly, in human epithelial cells, SARS-CoV-1 was able to induce greater IL-6 when compared to influenza A virus [21].
T45 6139-6393 Sentence denotes Although in some murine viral infections IL-6 plays a protective and essential role in the resolution process, in others like in SARS-CoV-1 high levels of IL-6 were associated with severe inflammation and correlated with mortality in the mice [22], [23].
T46 6394-6648 Sentence denotes This happens also with SARS-CoV-2 in COVID-19 patients: some retrospective and meta-analysis studies show how elevated IL-6 and C-reactive protein (CRP) correlate with mortality and severe disease in comparison to moderate disease [24], [25], [26], [27].
T47 6649-6878 Sentence denotes More evidence suggests that critically ill patients with severe respiratory failure and SARS-CoV-2 have either immune dysregulation or macrophage-activation syndrome, both of which are characterized by pro-inflammatory cytokines.
T48 6879-7003 Sentence denotes The immune dysregulation, in particular, is driven by the Interleukin-6 (IL-6) and not by Interleukin-1beta (IL-1beta) [27].
T49 7004-7169 Sentence denotes Two key features of this immune dysregulation are: over-production of pro-inflammatory cytokines by monocytes and lymphocyte dysregulation with CD4 lymphopenia [27].
T50 7170-7386 Sentence denotes A relevant study shows how IL-6 plays a major role in acute lung injury (ALI), proof of that was obtained in a murine model, where loss of IL-6 showed to alleviate the severity of ALI in response to acid respiration.
T51 7387-7538 Sentence denotes Moreover, it was shown how SARS-CoV-1 has the ability of inducing production of compounds like oxidized phospholipid (OxPL) both in humans and animals.
T52 7539-7639 Sentence denotes OxPLs in turn induce cytokine production and acute lung injury via Toll Like Receptor 4 (TLR4) [28].
T53 7640-7772 Sentence denotes This is evidence of SARS-CoV-1 ability to indirectly induce acute lung injury and cytokine production, like that of IL-6 [28], [29].
T54 7773-7979 Sentence denotes TLR4 is a transmembrane protein that belongs to the pattern recognition receptor family (PRR family), it recognizes molecules like lipopolysaccharide (LPS) thanks to an accessory protein known as MD-2 [30].
T55 7980-8121 Sentence denotes TLRs activate transcription factors like NFkB, AP-1 and IRF inducing proinflammatory cytokines expressions and Interferon 1 [31], [32], [33].
T56 8122-8283 Sentence denotes TLR4 is associated not only with infections but also with tissue damage, and this damage-dependent pathway may be amplified in the acute stages of the infection.
T57 8284-8386 Sentence denotes Of note, TLR4-null mice are highly resistant to infection by the mouse adapted influenza A virus [34].
T58 8387-8550 Sentence denotes Protection against influenza infections in mouse models was shown to be achieved by targeting TLR4 with antagonists or with specific anti-receptor antibodies [35].
T59 8551-8671 Sentence denotes Another option in targeting host inflammatory response could then be targeting the cellular toll-like-receptor 4 (TLR4).
T60 8672-8753 Sentence denotes Furthermore, TLR4 seems to regulate IL-6 secretion through the NFkB pathway [36].
T61 8754-8831 Sentence denotes This again points towards excessive activation of the innate immune response.
T62 8832-9032 Sentence denotes Another proof of that is the damage shown to the pulmonary interstitial arteriolar walls that is more associated with the inflammatory response rather than the pathogenic effect of coronaviruses [37].
T63 9033-9240 Sentence denotes An interesting fact is that SARS-CoV-1 can directly promote IL-6 secretion, this of course is not the only way it happens since IL-6 can be induced by so many types of cells and cytokines as mentioned above.
T64 9241-9468 Sentence denotes Among all SARS-CoV-1 structural proteins (nucleocapsid N, spike S, envelop E and membrane M) only the nucleocapsid protein (N) significantly induced the activation of IL-6 promoter in human airway epithelial cell cultures [38].
T65 9469-9639 Sentence denotes IL-6 gene expression is activated by the N protein which binds to the NF-kB regulatory element on IL-6 promoter and facilitates its translocation from cytosol to nucleus.
T66 9640-9811 Sentence denotes The N protein is essential for IL-6 secretion to happen, since deletion of the C-terminus of the N protein resulted in the loss of function in the activation of IL-6 [38].
T67 9812-9935 Sentence denotes More evidence is emerging of many similarities between Macrophage Activation Syndrome (MAS) disease and COVID-19 pneumonia.
T68 9936-10021 Sentence denotes Similarities include pathological findings and a “second wave” of cytokine secretion.
T69 10022-10166 Sentence denotes The loss of “front line” anti-viral defence mechanism may be responsible for this “second wave” activation, thus prolonging IL-6 secretion [39].
T70 10167-10423 Sentence denotes Sustained IL-6 secretion has also been correlated to serum viral RNA load [40] in critically ill patients, and viral RNA load is in turn correlated to ARDS severity [41]: all evidence pointing to a possible detrimental role of IL-6 in SARS-CoV-2 infection.
T71 10424-10915 Sentence denotes Since high levels of IL-6 are associated with SARS-CoV-1 and SARS-CoV-2 infections as shown above and since high serum levels of IL-6 have been associated with lung lesions in SARS-CoV-2 patients in the acute and later stages [20], [24], [25], [26], [27], [42], a valid option could be targeting the expression of IL-6 with Tocilizumab a monoclonal antibody against IL-6 Receptor: this option is currently being used in some patients in Italy with important lung injuries (TOCIVID-19 study).
T72 10916-11027 Sentence denotes Tocilizumab is currently approved for the treatment of rheumatoid arthritis and other autoimmune diseases [43].
T73 11028-11148 Sentence denotes This option should be approached only when there are radiological and clinical signs of progression of the lung lesions.
T74 11149-11415 Sentence denotes Time decision as when to start clinical administration of anti-IL-6 drugs is maybe the most important decision in this scenario, since as mentioned before in murine models IL-6 is essential in the early stages of other infections to control disease progression [19].
T75 11416-11563 Sentence denotes The inclusion criteria for Tocilizumab administration for the TOCIVID trial in Italy, and for trials in other countries are summarized in Table 1 .
T76 11564-11662 Sentence denotes Table 1 This table summarizes inclusion criteria for Tocilizumab trials in the respective country.
T77 11663-11762 Sentence denotes TOCIVID (Italy) COVACTA (USA) ChiCTR2000029765 (China) 2020COVID-19TCZ (Belgium) TOC-COVID(Germany)
T78 11763-12482 Sentence denotes Diagnosis of COVID-19 Virological diagnosis of SARS-CoV-2 infection (real-time PCR)ANDHospitalized due to clinical/instrumental diagnosis of pneumonia Hospitalized with COVID-19 pneumonia confirmed per WHO criteria (including a positive PCR of any specimen; e.g., respiratory, blood, urine, stool, other bodily fluid) AND evidenced by chest X-ray or CT scan The patients who were diagnosed with the common type of Novel Coronavirus Pneumonia (NCP) (including severe risk factors) AND severe cases of new coronavirus pneumonia PCR documented SARS-CoV-2 carriage in nasopharyngeal sample OR evocative thoracic scanimages of COVID-19 associated with typical clinical presentationANDHospitalized patients Proof of SARS-CoV2
T79 12483-13043 Sentence denotes Severity of the disease Oxygen saturation at rest in ambient air ≤ 93% (valid for not intubated patients and for both phase 2 and observational cohort)ORIntubated (<24 h before registration, eligible for phase 2 only, more than 24 h before registration eligible for observational cohort only) SPO2 </=93%ORPaO2/FiO2 < 300 mmHg Regular patients with COVID pneumonia (including severe risk factors): patients with dual pulmonary lesions based on common COVID pneumonia clinical symptoms accompanied by fever or no feverANDSevere cases, with any of the following:
T80 13044-13794 Sentence denotes 1 Respiratory distress (≧30 breaths/min); 2 Oxygen saturation ≤ 93% at rest; 3 Arterial partial pressure of oxygen (PaO2)/fraction of inspired oxygen (FiO2) ≦300 mmHgORCritical COVID pneumonia patients:–Respiratory failure occurs and mechanical ventilation is required;–Shock;–Combined failure of other organs that requires ICU monitoring Signs of severe COVID-19 pneumonia (3 of the followings)–Patient wheezing or unable to speak in full sentences while at rest/with minimaleffort–Respiratory rate > 22–PaO2 < 65 mmHg or SpO2 < 90%–Repeated chest imaging is significantly worsening(despite being on standard of care, which may include anti-viral treatment, low dose steroidsand antibiotics) Severe respiratory failure:a. ambient air SpO2 ≤ 92% orb.
T81 13795-13820 Sentence denotes Need of ≥ 6 l O2/min orc.
T82 13821-13856 Sentence denotes NIV (non-invasive ventilation) ord.
T83 13857-13894 Sentence denotes IMV (invasive mechanical ventilation)
T84 13895-13977 Sentence denotes Laboratory findings IL-6 elevated (using Elisa method, using the same company kit)
T85 13978-14068 Sentence denotes Age No age limit No age limit ≥ 18 and ≤ 85 years old ≥ 18 and ≤ 75 years old No age limit
T86 14069-14477 Sentence denotes Here instead are the recommendation criteria used to decide when a patient should be given Tociluzumab, written by the Italian Society of Infectious and tropical diseases (SIMIT, Società Italiana di Malattie Infettive e Tropicali) last update to 13 March 2020:– End of the initial phase of high viral load of COVID-19 (patient with no fever for more than 72 h and/or more than 7 days from the symptoms onset)
T87 14478-14573 Sentence denotes – Worsening of the respiratory condition requiring invasive or non invasive ventilation support
T88 14574-14727 Sentence denotes – Elevated levels of IL-6 (more than 40 pg/ml); or high levels of D-Dimer and/or PCR and/or ferritin and/or progressive increasingly level of fibrinogen.
T89 14729-14807 Sentence denotes 4 SGP130Fc and IL-6: the classic and the trans-signaling transduction pathway
T90 14808-14924 Sentence denotes The signal transduction of IL-6 is induced by binding of IL-6 to its alpha receptor, Interleukin-6 Receptor (IL-6R).
T91 14925-15070 Sentence denotes The complex formed by IL-6 and its receptor in turn activates a homodimer of the signal transduction beta-receptor gp130 with high affinity [44].
T92 15071-15218 Sentence denotes The gp130 receptor thereupon dimerizes and initiates intracellular signal transduction by activating the JAK/STAT and ras/MAP kinase pathways [45].
T93 15219-15269 Sentence denotes GP130 is expressed on all cells of the human body.
T94 15270-15367 Sentence denotes IL-6 Receptor instead is mainly found on hepatocytes, some leukocytes, and epithelial cells [46].
T95 15368-15527 Sentence denotes The IL-6 Receptor (IL-6R) protein is subjected to limited proteolysis by a metalloprotease activity which gives rises to a soluble form of IL-6R (sIL-6R) [47].
T96 15528-15659 Sentence denotes The majority of the soluble IL-6R found in the circulation is proteolytically cleaved from cells by the protease ADAM17 [48], [49].
T97 15660-15834 Sentence denotes A minor portion of the sIL-6R is generated from an alternatively spliced mRNA [50], but limited proteolysis remains the major mechanism by which the sIL-6R is generated [51].
T98 15835-15958 Sentence denotes For signal transduction the IL-6R can either be membrane bound (classic pathway) or soluble (trans-signaling pathway) [51].
T99 15959-16058 Sentence denotes Those two different pathways of signal transduction seem to have different and divergent functions.
T100 16059-16188 Sentence denotes In the trans signaling, the complex of sIL-6R and IL-6 binds to and activates gp130 even on cells that do not express IL-6R [52].
T101 16189-16346 Sentence denotes This is an important mechanism since only a few cells in the human body express IL-6R, whereas the majority of cells do not show IL-6R expression [53], [54].
T102 16347-16455 Sentence denotes Since all cells express gp130, all of them are in theory possible target cells of IL-6 trans signaling [52].
T103 16456-16551 Sentence denotes Trans-signaling is believed to be involved in chronic inflammation and cancer development [55].
T104 16552-16985 Sentence denotes Some animal models showed that when IL-6 was acting via the membrane bound IL-6R (classic signaling) it did so in a protective way, they also showed that inhibiting trans-signaling was superior to global blockade of IL-6 activity by neutralizing antibodies [56], this was done using the IL-6 trans-signaling inhibitor sgp130Fc, which is a fusion protein of the gp130 with the Fc portion of a human immunoglobulin antibody [57], [58].
T105 16986-17112 Sentence denotes In a murine polymicrobial sepsis model, selective blockade of IL-6 trans-signaling with sgp130Fc improved survival up to 100%.
T106 17113-17214 Sentence denotes Interestingly, treating these mice with anti-IL-6R antibodies did not prevent death of the mice [56].
T107 17215-17351 Sentence denotes This is a first hint of how targeting both the IL-6R forms with drugs like Tocilizumab might not be enough in a sepsis infectious model.
T108 17352-17564 Sentence denotes Furthermore, it all points to the trans-signaling transduction being the harmful one (pro-inflammatory response), and the classic signaling transduction being the protective one (anti-inflammatory response) [59].
T109 17565-17874 Sentence denotes More evidence of that in some studies showing that elevated serum levels of IL-6, which are a marker of disease severity in the inflammatory acute lung injury during acute pancreatitis, were mediated by the trans-signaling transduction way, as sgp130Fc blocked the pancreatitis induced acute lung injury [60].
T110 17875-18108 Sentence denotes Moreover in a mouse model of atherosclerosis sgp130Fc showed to reduce disease and showed significant regression of the atherosclerotic plaques, thus underlying the pro-inflammatory role of the trans-signaling pathway once more [61].
T111 18109-18215 Sentence denotes The sgp130Fc protein was shown not to interfere with IL-6 signaling via the membrane-bound IL-6R (mIL6-R).
T112 18216-18327 Sentence denotes In contrast, IL-6 trans-signaling is completely blocked both in vitro and in vivo by the sgp130Fc protein [46].
T113 18328-18619 Sentence denotes Higher levels of the soluble IL-6 receptor(sIL-6R) are usually found in chronic inflammatory diseases and cancer [55], in multiple myeloma for example high sIL-6R levels were correlated with poor survival [62], sIL6R levels are also higher in chronic lymphocytic leukemia and lymphomas [63].
T114 18620-18842 Sentence denotes Locally increased sIL-6R concentrations were also found in the bronchoalveolar lavage fluid (BAL) of asthmatics [64], and in malignant ascites from ovarian cancer patients, where it was associated with poor prognosis [65].
T115 18843-19067 Sentence denotes Since sgp130 is expressed in all cells of the human body, under normal circumstances it is in molar excess over sIL-6R, therefore the concentration of the sIL-6R limits the capacity of the sIL-6R/sgp130 complex in the blood.
T116 19068-19220 Sentence denotes During infections and inflammatory states, the concentration of sgp130 does not change, but the concentration of the sIL-6R increases up to 5 fold [66].
T117 19221-19395 Sentence denotes As a consequence, IL-6 and sIL-6R trans-signaling pathway stimulate all cells, which normally are not IL-6 target cells, like endothelial cells and smooth muscles cells [67].
T118 19396-19664 Sentence denotes Recent studies about polymorphism within the IL-6R genes, showed how some IL-6 Receptor variants could be a much better substrate for the shedding protease ADAM17, resulting in a reduced response to inflammation and infectious states, in terms of sIL-6R increase [68].
T119 19665-19747 Sentence denotes Those individuals are also protected from many chronic inflammatory diseases [69].
T120 19748-20005 Sentence denotes This is another evidence of the pro-inflammatory role of the trans-signaling pathway and it could also be the explanation as to why some patients show a higher inflammatory response mediated by IL-6, similarly to what is happening with SARS-CoV-2 infection.
T121 20006-20116 Sentence denotes The essential role of IL-6 in fighting and clearing influenza infection has already been discussed above [19].
T122 20117-20182 Sentence denotes This protective role could be mediated by IL-6 classic signaling.
T123 20183-20390 Sentence denotes This also happens for other infections like Listeria and mycobacteria infections, where IL-6 classic signaling via the membrane bound IL-6R is responsible for the defense of the body against these pathogens.
T124 20391-20493 Sentence denotes Furthermore this defense is not affected by the selective blockade of IL-6 trans-signaling [70], [71].
T125 20494-20620 Sentence denotes In the animal model of listeriosis global blockade of IL-6 led to a dramatic increase in bacterial titers in spleen and liver.
T126 20621-20872 Sentence denotes In contrast, selective blockade of IL-6 trans-signaling with the sgp130Fc protein did not result in increased bacterial titers, and thus was concluded that the classic signaling was involved in the protection of the body from bacterial infection [71].
T127 20873-21178 Sentence denotes This shows the possibility to use the sgp130Fc protein as a potential inhibitor of the IL-6 pathway in COVID-19 patients, since it could preserve the regenerative and anti-inflammatory properties of the IL-6 classic pathway, and block the pro-inflammatory actions mediated by trans-signaling pathway [46].
T128 21179-21372 Sentence denotes It has been shown that the blockade of IL-6 trans-signaling using sgp130Fc was as efficient as the global blockade of IL-6 classic and trans-signaling using specific monoclonal antibodies [72].
T129 21373-21742 Sentence denotes SGP130Fc is mainly used in chronic inflammatory diseases (such as intestinal inflammation, rheumatoid arthritis, lupus erythematosus, neuroinflammation and cancer [51]), but it has shown its efficacy also in acute inflammation [57] and sepsis [73], where selective blockade of interleukin-6 trans-signaling improved survival in a murine polymicrobial sepsis model [56].
T130 21743-21922 Sentence denotes An infection where the inhibition of IL-6 trans-signaling has shown its efficacy is Malaria, another infection during which IL-6 levels correlate with the severity of the disease.
T131 21923-22050 Sentence denotes In a murine model of IL-6R deficient mice the infection showed an increase in survival of otherwise lethal blood-stage malaria.
T132 22051-22175 Sentence denotes Inducing IL-6 trans-signaling by injection of mouse recombinant soluble IL-6R in deficient mice restores the lethal outcome.
T133 22176-22305 Sentence denotes In contrast, inhibition of IL-6 trans-signaling via injection of sgp130Fc protein in wild type mice results in 40% survival rate.
T134 22306-22422 Sentence denotes This demonstrate that trans-signaling, rather than classic signaling, contributes to malaria lethality in mice [74].
T135 22423-22671 Sentence denotes IL-6 trans-signaling is also involved in the infiltration of granulocytes and macrophages during the late phase of an acute inflammation, and this happens when the trans-signaling triggers the secretion of chemokine MCP-1 in endothelial cells [57].
T136 22672-22815 Sentence denotes As most cells, endothelial cells lack the expression of membrane-bound IL-6R (mIL6-R) and are then unresponsive to IL-6 classic-signaling [75].
T137 22816-23014 Sentence denotes The infiltration of granulocytes and macrophages has been described as the possible cause of tissue damage in the acute lung injury, which is a severe complication of severe acute pancreatitis [60].
T138 23015-23269 Sentence denotes From these data can be concluded that IL-6 classic signaling via the membrane bound IL-6R is anti-inflammatory and protective, mainly via stimulation of intestinal regeneration, inhibition of epithelial cell apoptosis and defense against infections [46].
T139 23270-23494 Sentence denotes In contrast, trans-signaling via the sIL6-R is believed to act in a rather pro-inflammatory way via recruitment of mononuclear cells, inhibition of T-cell apoptosis, and inhibition of regulatory T-cells differentiation [46].
T140 23495-23817 Sentence denotes Interestingly, clinical pathological analysis of COVID-19 biopsy samples confirmed interstitial mononuclear inflammatory infiltrates in lung tissues, the same type of cells promoted by IL-6 trans-signaling [76], therefore suggesting a possible involvement of trans-signaling pathway of IL-6 in COVID-19 patients with ARDS.
T141 23818-24055 Sentence denotes Moreover, IL-6 production sustained by circulating monocytes in COVID-19 is a different pathway from the one found in influenza infection, proof of that is Tocilizumab partially rescuing the immune dysregulation driven by SARS-CoV-2[27].
T142 24056-24312 Sentence denotes To the author’s knowledge sgp130Fc has not been tested in COVID-19 patients yet, thus the author suggests its possible use against SARS-CoV-2 in severe cases of COVID-19 patients, adopting the same criteria of Tocilizumab as to when to start the treatment.
T143 24313-24509 Sentence denotes This option would provide the benefit of targeting only the pro-inflammatory trans-signaling pathway of IL-6, instead of targeting them both, which is something that happens with Tocilizumab [51].
T144 24510-24577 Sentence denotes IL-6 pathways and possible interventions are summerized in Fig. 1 .
T145 24578-24883 Sentence denotes Fig. 1 This diagram shows the classic signaling pathway (mediated by the membrane-bound form of IL-6 receptor, mIL6R) which is believed to be the anti-inflammatory one and the trans-signaling pathway (mediated by the soluble form of IL-6 receptor, sIL6-R) which is believed to be the pro-inflammatory one.
T146 24884-24970 Sentence denotes Tocilizumab inhibits both of them, SGP130Fc inhibits only the trans-signaling pathway.
T147 24972-25036 Sentence denotes 5 Inhibiting IL-6 signal transduction and the JAK/STAT pathway:
T148 25037-25064 Sentence denotes Baricitinib and Ruxolitinib
T149 25065-25210 Sentence denotes Both the trans-signaling and the classic-signaling pathways of IL-6 converge in the activation of the JAK/STAT pathway and the MAPK cascade [77].
T150 25211-25321 Sentence denotes The next step after binding of IL-6 to IL-6R and sgp130 is then to initiate intracellular signal transduction.
T151 25322-25585 Sentence denotes The signal transfer is performed by the Janus-kinase/Signal transducer and activator of transcription (Jak/STAT)-,mainly STAT1, STAT3 isoforms [78], [79], [80], mitogen-activated protein kinase (MAPK)- and phosphatidyl-inositol-3-kinase (PI3K)-pathway [44], [77].
T152 25586-25805 Sentence denotes Another possible way of counteracting IL-6 action is then to inhibit its intracellular transduction pathway, though in doing so the benefit of specifically targeting the pro-inflammatory trans-signaling pathway is lost.
T153 25806-25885 Sentence denotes This can be done by inhibiting the JAK 1/2 pathway with drugs like Ruxolitinib.
T154 25886-26120 Sentence denotes Ruxolitinib is a small drug belonging to the class of Janus kinase (JAK) inhibitors and currently clinically used in the treatment of JAK2 mutated myeloproliferative neoplasms, including myelofibrosis and polycythemia vera [81], [82].
T155 26121-26272 Sentence denotes It shows activity against the JAK2 isoform and also the JAK1 isoform, which plays a major role in the signaling pathway of inflammatory cytokines [83].
T156 26273-26692 Sentence denotes JAK3 seems to be less sensitive to ruxolitinib [84], it also shows anti-inflammatory activity which may be beneficial in its clinical use [85]; it is also implicated in the suppression of the harmful consequences of macrophage activation hemophagocytic lymphohistiocytosis [86], which is an under-recognized hyperinflammatory syndrome characterized by fulminant and fatal hypercytokinemia with multi organ failure [87].
T157 26693-26871 Sentence denotes It has been proven that the expression of major inflammatory cytokines such as TNF alfa and IL-6 was highly reduced in inflammatory human macrophages exposed to ruxolitinib [85].
T158 26872-27108 Sentence denotes It has also been shown through an analysis of mRNA expression of cytokines by PCR array that the major inflammatory cytokines, IL-6 and TNF alfa, were highly reduced and down-regulated by ruxolitinib at both protein and mRNA level [88].
T159 27109-27244 Sentence denotes All these results point towards a possible use of Ruxolitinib as an IL-6 inhibitor like Tocilizumab in the advanced stages of COVID-19.
T160 27245-27330 Sentence denotes This drug is currently being tested in some patients in Italy (CINC424, RUXOLITINIB).
T161 27331-27449 Sentence denotes Baricitinib has been suggested to be of therapeutic use against SARS-CoV-2 by Artificial Intelligence algorithms [89].
T162 27450-27759 Sentence denotes It is a selective and powerful JAK-STAT signaling inhibitor thus being effective against the consequences of the elevated levels of cytokines, not only being able of lowering IL-6 levels [90], but it also has the potential to inhibit clathrin-mediated endocytosis and thereby inhibit viral infection of cells.
T163 27760-27917 Sentence denotes It targets members of the numb-associated kinase (NAK) family (AAK1 and GAK), the inhibition of which has been shown to reduce viral infection in vitro [91].
T164 27918-28066 Sentence denotes It can be administered orally and has acceptable side effect profile, besides having little interaction with CYP enzymes and drug transporters [89].
T165 28067-28251 Sentence denotes This makes Baricinitib a valid option in every phase of the viral infection, the early stages to reduce viral entry in the cells, and later stages for its anti-inflammatory properties.
T166 28253-28277 Sentence denotes 6 Other anti-IL-6 drugs
T167 28278-28570 Sentence denotes Other monoclonal antibodies against IL-6 are sirukumab (CNTO136), olokizumab (CP6038), PF-423691, elsilimomab (BE-8), clazakizumab (BMS945429), which are in different phases of clinical trials to establish their efficacy and safety in varied disease states [92], [93], [94], [95], [96], [97].
T168 28571-28701 Sentence denotes Sarilumab, another monoclonal antibody against IL-6R, is being tested in a clinical trial against COVID-19 (Sarilimumab COVID-19).
T169 28702-28927 Sentence denotes Another drug that showed potential inhibition of IL-6 related JAK/STAT pathway is glatiramer acetate which showed potential to downregulate both IL-17 and IL-6 in the central nervous system in an autoimmune encephalitis [98].
T170 28929-28943 Sentence denotes 7 Conclusions
T171 28944-29404 Sentence denotes Here the author showed the viable options against the cytokine storm induced by SARS-CoV-2, showing that besides Tocilizumab, other options must be taken into account, and that inhibiting IL-6 is not a simple thing to do, since it has at least two different and divergent pathways; thus suggesting to inhibit only the pro-inflammatory response, the trans-signaling transduction with SGP130Fc, which seems a more reasonable choice then inhibiting both pathways.
T172 29405-29749 Sentence denotes Here also other possible choices in counteracting IL-6 mediated activities are shown, like Ruxolitinib and Baricitnib, in the hope to find new possible strategies and discovering new properties of the drugs already available, since this would mean accelerating clinical trials as their side effects and tolerability in humans are already known.
T173 29751-29784 Sentence denotes Declaration of Competing Interest
T174 29785-29955 Sentence denotes The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

2_test

Id Subject Object Predicate Lexical cue
32421092-22094080-24602228 1571-1572 22094080 denotes 1
32421092-31953166-24602229 1726-1727 31953166 denotes 2
32421092-32078069-24602230 1839-1840 32078069 denotes 3
32421092-32078069-24602231 2292-2293 32078069 denotes 3
32421092-32147628-24602232 2297-2298 32147628 denotes 4
32421092-24096239-24602233 3009-3010 24096239 denotes 6
32421092-24323636-24602234 3014-3015 24323636 denotes 7
32421092-29382391-24602235 3265-3266 29382391 denotes 8
32421092-31924756-24602236 3591-3592 31924756 denotes 9
32421092-30254251-24602237 4474-4476 30254251 denotes 12
32421092-25898198-24602238 4742-4744 25898198 denotes 13
32421092-18389078-24602239 5038-5040 18389078 denotes 15
32421092-22294047-24602240 5161-5163 22294047 denotes 16
32421092-23857287-24602241 5258-5260 23857287 denotes 17
32421092-22294047-24602242 5308-5310 22294047 denotes 16
32421092-18778200-24602243 5509-5511 18778200 denotes 18
32421092-28953978-24602244 5736-5738 28953978 denotes 19
32421092-15472864-24602245 6008-6010 15472864 denotes 20
32421092-16482545-24602246 6134-6136 16482545 denotes 21
32421092-18467696-24602247 6383-6385 18467696 denotes 22
32421092-19853271-24602248 6389-6391 19853271 denotes 23
32421092-18423196-24602249 7635-7637 18423196 denotes 28
32421092-18423196-24602250 7762-7764 18423196 denotes 28
32421092-17465679-24602251 7768-7770 17465679 denotes 29
32421092-19252480-24602252 7975-7977 19252480 denotes 30
32421092-17072332-24602253 8105-8107 17072332 denotes 31
32421092-16932750-24602254 8111-8113 16932750 denotes 32
32421092-16176658-24602255 8117-8119 16176658 denotes 33
32421092-23636320-24602256 8382-8384 23636320 denotes 34
32421092-28106157-24602257 8546-8548 28106157 denotes 35
32421092-28168301-24602258 8749-8751 28168301 denotes 36
32421092-31981224-24602259 9028-9030 31981224 denotes 37
32421092-17490702-24602260 9464-9466 17490702 denotes 38
32421092-17490702-24602261 9807-9809 17490702 denotes 38
32421092-32102625-24602262 10333-10335 32102625 denotes 41
32421092-15472864-24602263 10651-10653 15472864 denotes 20
32421092-15109419-24602264 10681-10683 15109419 denotes 42
32421092-21910626-24602265 11023-11025 21910626 denotes 43
32421092-28953978-24602266 11411-11413 28953978 denotes 19
32421092-24986424-24602267 15066-15068 24986424 denotes 44
32421092-26189695-24602268 15214-15216 26189695 denotes 45
32421092-10093736-24602269 15523-15525 10093736 denotes 47
32421092-28060820-24602270 15649-15651 28060820 denotes 48
32421092-27151651-24602271 15655-15657 27151651 denotes 49
32421092-1633265-24602272 15739-15741 1633265 denotes 50
32421092-28675418-24602273 15830-15832 28675418 denotes 51
32421092-28675418-24602274 15954-15956 28675418 denotes 51
32421092-8002928-24602275 16184-16186 8002928 denotes 52
32421092-2163835-24602276 16336-16338 2163835 denotes 53
32421092-16540526-24602277 16342-16344 16540526 denotes 54
32421092-8002928-24602278 16451-16453 8002928 denotes 52
32421092-24325804-24602279 16547-16549 24325804 denotes 55
32421092-21336117-24602280 16810-16812 21336117 denotes 56
32421092-17989316-24602281 16975-16977 17989316 denotes 57
32421092-17465721-24602282 16981-16983 17465721 denotes 58
32421092-21336117-24602283 17210-17212 21336117 denotes 56
32421092-31992476-24602284 17560-17562 31992476 denotes 59
32421092-23426178-24602285 17870-17872 23426178 denotes 60
32421092-22075248-24602286 18104-18106 22075248 denotes 61
32421092-24325804-24602287 18442-18444 24325804 denotes 55
32421092-8603009-24602288 18534-18536 8603009 denotes 62
32421092-8547132-24602289 18615-18617 8547132 denotes 63
32421092-15668741-24602290 18733-18735 15668741 denotes 64
32421092-21123455-24602291 18838-18840 21123455 denotes 65
32421092-25136784-24602292 19216-19218 25136784 denotes 66
32421092-25749511-24602293 19391-19393 25749511 denotes 67
32421092-23593036-24602294 19743-19745 23593036 denotes 69
32421092-28953978-24602295 20112-20114 28953978 denotes 19
32421092-22387074-24602296 20483-20485 22387074 denotes 70
32421092-23241882-24602297 20489-20491 23241882 denotes 71
32421092-23241882-24602298 20868-20870 23241882 denotes 71
32421092-21881215-24602299 21368-21370 21881215 denotes 72
32421092-28675418-24602300 21537-21539 28675418 denotes 51
32421092-17989316-24602301 21601-21603 17989316 denotes 57
32421092-21148800-24602302 21617-21619 21148800 denotes 73
32421092-21336117-24602303 21738-21740 21336117 denotes 56
32421092-22467660-24602304 22418-22420 22467660 denotes 74
32421092-17989316-24602305 22667-22669 17989316 denotes 57
32421092-9075932-24602306 22811-22813 9075932 denotes 75
32421092-23426178-24602307 23010-23012 23426178 denotes 60
32421092-32085846-24602308 23702-23704 32085846 denotes 76
32421092-28675418-24602309 24505-24507 28675418 denotes 51
32421092-12773095-24602310 25206-25208 12773095 denotes 77
32421092-29405201-24602311 25466-25468 29405201 denotes 78
32421092-28323260-24602312 25472-25474 28323260 denotes 79
32421092-30185178-24602313 25478-25480 30185178 denotes 80
32421092-24986424-24602314 25575-25577 24986424 denotes 44
32421092-12773095-24602315 25581-25583 12773095 denotes 77
32421092-20843246-24602316 26110-26112 20843246 denotes 81
32421092-28028027-24602317 26116-26118 28028027 denotes 82
32421092-20506062-24602318 26268-26270 20506062 denotes 83
32421092-20130243-24602319 26321-26323 20130243 denotes 84
32421092-26185657-24602320 26412-26414 26185657 denotes 85
32421092-27222478-24602321 26547-26549 27222478 denotes 86
32421092-26185657-24602322 26867-26869 26185657 denotes 85
32421092-29202299-24602323 27104-27106 29202299 denotes 88
32421092-29691471-24602324 27638-27640 29691471 denotes 90
32421092-28240606-24602325 27913-27915 28240606 denotes 91
32421092-24550171-24602326 28536-28538 24550171 denotes 92
32421092-24699939-24602327 28542-28544 24699939 denotes 93
32421092-27110697-24602328 28548-28550 27110697 denotes 94
32421092-26138593-24602329 28554-28556 26138593 denotes 95
32421092-29247068-24602330 28560-28562 29247068 denotes 96
32421092-29776017-24602331 28566-28568 29776017 denotes 97
32421092-18804287-24602332 28923-28925 18804287 denotes 98