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PMC:7219429 / 5579-10044 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T35 62-69 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T36 1575-1582 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T37 2965-2976 Body_part denotes Ganglioside http://purl.org/sig/ont/fma/fma82816
T38 3008-3019 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T39 3054-3064 Body_part denotes Glycolipid http://purl.org/sig/ont/fma/fma82780
T40 3115-3125 Body_part denotes glycolipid http://purl.org/sig/ont/fma/fma82780
T41 3233-3244 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T42 3485-3496 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T43 3582-3584 Body_part denotes Å3 http://purl.org/sig/ont/fma/fma66599
T44 3826-3837 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T45 3960-3972 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T46 3986-3991 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T47 4158-4165 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T48 4265-4280 Body_part denotes protein complex http://purl.org/sig/ont/fma/fma67906

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T29 45-53 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T30 179-181 Disease denotes RS http://purl.obolibrary.org/obo/MONDO_0010725
T31 1508-1511 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T33 1558-1566 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T34 1729-1732 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T36 4141-4149 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T62 179-181 http://purl.obolibrary.org/obo/CLO_0008882 denotes RS
T63 424-425 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T64 492-494 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T65 832-834 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T66 1137-1139 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T67 1373-1375 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T68 1407-1412 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T69 1590-1591 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T70 1661-1662 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T71 1881-1886 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T72 1907-1908 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73 1939-1940 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T74 1987-1988 http://purl.obolibrary.org/obo/CLO_0001020 denotes Å
T75 2157-2159 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T76 2215-2217 http://purl.obolibrary.org/obo/CLO_0008491 denotes ps
T77 2231-2233 http://purl.obolibrary.org/obo/CLO_0008491 denotes ps
T78 2365-2367 http://purl.obolibrary.org/obo/CLO_0008491 denotes ps
T79 2410-2412 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T80 2590-2591 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T81 3266-3274 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T82 3312-3313 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T83 3407-3415 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T84 3513-3514 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T85 3582-3584 http://purl.obolibrary.org/obo/CLO_0001577 denotes Å3
T86 3597-3598 http://purl.obolibrary.org/obo/CLO_0001020 denotes Å
T87 3607-3608 http://purl.obolibrary.org/obo/CLO_0001020 denotes Å
T88 3617-3618 http://purl.obolibrary.org/obo/CLO_0001020 denotes Å
T89 3894-3896 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T90 3912-3913 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T91 3976-3977 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T92 3997-4005 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T93 4173-4174 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T94 4193-4195 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T95 4265-4280 http://purl.obolibrary.org/obo/GO_0043234 denotes protein complex
T96 4332-4334 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T97 4405-4413 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T76 62-69 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T77 179-181 Chemical denotes RS http://purl.obolibrary.org/obo/CHEBI_73819
T78 213-218 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T79 219-225 Chemical denotes pentyl http://purl.obolibrary.org/obo/CHEBI_25902
T80 227-232 Chemical denotes ethyl http://purl.obolibrary.org/obo/CHEBI_37807|http://purl.obolibrary.org/obo/CHEBI_62801
T82 233-238 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T83 239-246 Chemical denotes ethanol http://purl.obolibrary.org/obo/CHEBI_16236
T84 289-300 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T85 447-450 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T86 530-537 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T87 556-559 Chemical denotes oxy http://purl.obolibrary.org/obo/CHEBI_29354
T88 562-567 Chemical denotes ethyl http://purl.obolibrary.org/obo/CHEBI_37807|http://purl.obolibrary.org/obo/CHEBI_62801
T90 606-613 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T91 616-623 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T93 646-649 Chemical denotes oxy http://purl.obolibrary.org/obo/CHEBI_29354
T94 734-737 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T95 773-776 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T96 798-807 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T97 1199-1202 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T98 1373-1375 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T99 1458-1461 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T100 1575-1582 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T101 1642-1646 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T102 1696-1699 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T103 1700-1709 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T104 2055-2061 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T105 2157-2159 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T106 2410-2412 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T107 2965-2980 Chemical denotes Ganglioside GM1 http://purl.obolibrary.org/obo/CHEBI_61048
T108 2965-2976 Chemical denotes Ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T109 2977-2980 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_73110
T111 3008-3023 Chemical denotes ganglioside GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048
T113 3008-3019 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T114 3020-3023 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_73110
T115 3054-3064 Chemical denotes Glycolipid http://purl.obolibrary.org/obo/CHEBI_33563
T116 3115-3125 Chemical denotes glycolipid http://purl.obolibrary.org/obo/CHEBI_33563
T117 3233-3244 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T118 3364-3367 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T121 3368-3376 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T122 3425-3433 Chemical denotes ceramide http://purl.obolibrary.org/obo/CHEBI_17761|http://purl.obolibrary.org/obo/CHEBI_52639
T124 3462-3472 Chemical denotes saccharide http://purl.obolibrary.org/obo/CHEBI_16646
T125 3485-3496 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T126 3547-3552 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T127 3553-3562 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T128 3826-3841 Chemical denotes ganglioside GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048
T130 3826-3837 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T131 3838-3841 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_73110
T132 3868-3877 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T133 3894-3896 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T134 3956-3959 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T137 3960-3972 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T138 3986-3991 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T139 4018-4021 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T142 4022-4031 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T143 4055-4066 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T144 4075-4088 Chemical denotes sphingomyelin http://purl.obolibrary.org/obo/CHEBI_17636|http://purl.obolibrary.org/obo/CHEBI_64583
T146 4089-4095 Chemical denotes lipids http://purl.obolibrary.org/obo/CHEBI_18059
T147 4158-4165 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T148 4193-4195 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T149 4255-4258 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T150 4265-4272 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T151 4332-4334 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T152 4377-4380 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T155 4458-4464 Chemical denotes lipids http://purl.obolibrary.org/obo/CHEBI_18059

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T2 416-423 http://purl.obolibrary.org/obo/GO_0030290 denotes saposin

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T3 2977-2980 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T4 3020-3023 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T5 3364-3367 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T6 3838-3841 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T7 3956-3959 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T8 4018-4021 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T9 4377-4380 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T43 0-24 Sentence denotes 2 Materials and Methods
T44 26-40 Sentence denotes 2.1 Pdb files
T45 41-146 Sentence denotes The SARS-CoV-2 spike protein trimer in the prefusion conformation was obtained from pdb file # 6VSB [20].
T46 147-247 Sentence denotes Hydroxychloroquine (CLQ-OH) is (RS)-2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol.
T47 248-350 Sentence denotes CLQ-OH was generated by hydroxylation of chloroquine (CLQ) and validated as previously described [10].
T48 351-432 Sentence denotes CLQ was retrieved from pdb file # 4V2O (CLQ co-crystallized with saposin B) [21].
T49 433-713 Sentence denotes Azithromycin (ATM) is (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one.
T50 714-836 Sentence denotes The 3D structure of ATM was obtained from pdb file # 5UXD (ATM co-crystallized with macrolide 2′-phosphotransferase) [22].
T51 838-886 Sentence denotes 2.2 Molecular modelling and visualization tools
T52 887-1151 Sentence denotes Molecular modelling studies were performed using Hyperchem (http://www.hyper.com), Deep View/Swiss-Pdb viewer (https://spdbv.vital-it.ch) and Molegro Molecular viewer (http://molexus.io/molegro-molecular-viewer) as described previously [[16], [17], [18], [19],23].
T53 1152-1261 Sentence denotes Lennard-Jones parameters and atomic charges of ATM obtained from pdb file # 5UXD were checked with Hyperchem.
T54 1262-1434 Sentence denotes The molecular modelling protocol consisted of docking, equilibration, and subsequent 50-ns molecular dynamics (MD) simulations with CHARMM force field [16,24] in Hyperchem.
T55 1435-1647 Sentence denotes The starting point for ATM docking was done by manual positioning on the NTD and receptor-binding domain (RBD) surfaces of SARS-CoV-2 spike protein (chain A) with full consideration of the properties of the drug.
T56 1648-1755 Sentence denotes In addition, a series of 20 randomly positioned ATM molecules covering the whole NTD surface were analysed.
T57 1756-2026 Sentence denotes Energy minimization of each system was then performed with the Polak-Ribière conjugate gradient algorithm, with CHARMM force field in Hyperchem, using a maximum of 3 × 105 steps, and a root-mean-square (RMS) gradient of 0.01 kcal. Å−1.mol−1 as the convergence condition.
T58 2027-2368 Sentence denotes According to the validation ligand-binding protocol [25], the optimized docked structures were used as the initial structures for MD simulations with the following parameters: heat time 5 ps, run time 10 ps, step size 1 fs, starting temperature 0 K, simulation temperature 300 K, temperature step 30 K, bath relaxation time step size 0.1 ps.
T59 2369-2489 Sentence denotes Each complex was submitted to 50-ns long MD trajectories, replicated three times, with convergent trajectories obtained.
T60 2490-2551 Sentence denotes Frames were saved at 10 ns intervals for subsequent analysis.
T61 2552-2725 Sentence denotes The final complex obtained with chain A was reintroduced in the trimeric spike structure (pdb file # 6VSB) with Molegro Molecular viewer and with Deep View Swiss-Pdb viewer.
T62 2726-2775 Sentence denotes Similar results were obtained with both programs.
T63 2776-2889 Sentence denotes The energies of interaction were extracted from the Ligand Energy Inspector function of Molegro Molecular viewer.
T64 2890-2958 Sentence denotes Molecular volumes were calculated by the QSAR function of Hyperchem.
T65 2960-2980 Sentence denotes 2.3 Ganglioside GM1
T66 2981-3439 Sentence denotes The initial coordinates of ganglioside GM1 were obtained from CHARMM-GUI Glycolipid Modeler [24] (http://www.charmmgui.org/?doc=input/glycolipid), which uses the internal coordinate information of common glycosidic torsion angle values, orientates the ganglioside perpendicular to the membrane, and performs Langevin dynamics with a cylindrical restraint potential to keep the whole GM1 molecule cylindrical, particularly the membrane-embedded ceramide part.
T67 3440-3575 Sentence denotes In the next step, the saccharide part of the ganglioside was included in a periodic box solvated with 1128 water molecules (dimensions:
T68 3576-3620 Sentence denotes 34848 Å3 with x = 33 Å, y = 32 Å, z = 33 Å).
T69 3621-3812 Sentence denotes The system was energy-minimized 6 times switching alternatively between runs using steepest descent gradients or Polak-Ribière conjugate gradients until convergence to machine precision [16].
T70 3813-3946 Sentence denotes The dimer of ganglioside GM1 interacting with 4 CLQ-OH molecules was obtained by MD simulations of a previously described model [10].
T71 3947-4096 Sentence denotes To mimic GM1 gangliosides in a typical lipid raft membrane domain, two GM1 molecules were merged with eight cholesterol and two sphingomyelin lipids.
T72 4097-4307 Sentence denotes The whole system was optimized, merged with SARS-CoV-2 spike protein (chain A) and submitted to MD simulations with the same conditions as those used for the ATM-spike protein complex (50-ns run in triplicate).
T73 4308-4465 Sentence denotes For comparison, similar MD simulations were performed on an isolated GM1 dimer in the CHARMM-GUI membrane-compatible topology but without surrounding lipids.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
189 31-34 Gene denotes Pdb Gene:5131
200 56-61 Gene denotes spike Gene:43740568
201 374-377 Gene denotes pdb Gene:5131
202 125-128 Gene denotes pdb Gene:5131
203 45-55 Species denotes SARS-CoV-2 Tax:2697049
204 147-165 Chemical denotes Hydroxychloroquine MESH:D006886
205 167-173 Chemical denotes CLQ-OH
206 178-246 Chemical denotes (RS)-2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol
207 248-254 Chemical denotes CLQ-OH
208 289-300 Chemical denotes chloroquine MESH:D002738
209 302-305 Chemical denotes CLQ MESH:D002738
212 756-759 Gene denotes pdb Gene:5131
213 798-807 Chemical denotes macrolide MESH:D018942
221 1569-1574 Gene denotes spike Gene:43740568
222 2625-2630 Gene denotes spike Gene:43740568
223 2714-2717 Gene denotes Pdb Gene:5131
224 2642-2645 Gene denotes pdb Gene:5131
225 1217-1220 Gene denotes pdb Gene:5131
226 986-989 Gene denotes Pdb Gene:5131
227 1558-1568 Species denotes SARS-CoV-2 Tax:2697049
229 2965-2980 Chemical denotes Ganglioside GM1 MESH:D005677
252 4152-4157 Gene denotes spike Gene:43740568
253 4141-4151 Species denotes SARS-CoV-2 Tax:2697049
254 4259-4264 Gene denotes spike Gene:43740568
255 3008-3019 Chemical denotes ganglioside MESH:D005732
256 3020-3023 Chemical denotes GM1 MESH:D005677
257 3233-3244 Chemical denotes ganglioside MESH:D005732
258 3364-3367 Chemical denotes GM1 MESH:D005677
259 3425-3433 Chemical denotes ceramide MESH:D002518
260 3462-3472 Chemical denotes saccharide MESH:D002241
261 3485-3496 Chemical denotes ganglioside MESH:D005732
262 3547-3552 Chemical denotes water MESH:D014867
263 3826-3841 Chemical denotes ganglioside GM1 MESH:D005677
264 3861-3867 Chemical denotes CLQ-OH
265 3956-3959 Chemical denotes GM1 MESH:D005677
266 3960-3972 Chemical denotes gangliosides MESH:D005732
267 3986-3991 Chemical denotes lipid MESH:D008055
268 4018-4021 Chemical denotes GM1 MESH:D005677
269 4055-4066 Chemical denotes cholesterol MESH:D002784
270 4377-4380 Chemical denotes GM1 MESH:D005677
271 4458-4464 Chemical denotes lipids MESH:D008055
272 3185-3209 Disease denotes glycosidic torsion angle MESH:C563601
273 4075-4095 Disease denotes sphingomyelin lipids MESH:D052536

2_test

Id Subject Object Predicate Lexical cue
32405156-32075877-48151011 142-144 32075877 denotes 20
32405156-26616259-48151012 428-430 26616259 denotes 21
32405156-31431523-48151013 1125-1127 31431523 denotes 16
32405156-26915987-48151014 1137-1139 26915987 denotes 18
32405156-21756873-48151015 1143-1145 21756873 denotes 19
32405156-28205163-48151016 1147-1149 28205163 denotes 23
32405156-31431523-48151017 1414-1416 31431523 denotes 16
32405156-30525595-48151018 1417-1419 30525595 denotes 24
32405156-30236283-48151019 2080-2082 30236283 denotes 25
32405156-30525595-48151020 3074-3076 30525595 denotes 24
32405156-31431523-48151021 3808-3810 31431523 denotes 16
T51455 142-144 32075877 denotes 20
T56339 428-430 26616259 denotes 21
T19862 1125-1127 31431523 denotes 16
T59147 1137-1139 26915987 denotes 18
T89313 1143-1145 21756873 denotes 19
T99169 1147-1149 28205163 denotes 23
T18657 1414-1416 31431523 denotes 16
T88529 1417-1419 30525595 denotes 24
T26528 2080-2082 30236283 denotes 25
T58286 3074-3076 30525595 denotes 24
T84656 3808-3810 31431523 denotes 16