PMC:7219429 / 3637-4242 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T18","span":{"begin":446,"end":455},"obj":"Body_part"},{"id":"T19","span":{"begin":575,"end":587},"obj":"Body_part"},{"id":"T20","span":{"begin":575,"end":579},"obj":"Body_part"}],"attributes":[{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Both CLQ-OH and ATM are repositioned drugs and their antiviral mechanism of action, particularly in combination, remains mostly unclear. In vitro studies have shown that CLQ-OH inhibits SARS-CoV-2 [4], [5], [6]. Far less is known about the antiviral effects of ATM, which has been suggested to interfere with influenza virus internalization [7]. Interestingly, CLQ is also considered as an inhibitor of endocytic pathways through an elevation of endosomal pH [8]. However, several reports indicate that CLQ could also prevent virus attachment through a direct effect on host-cell surface molecules [9,10]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T19","span":{"begin":186,"end":194},"obj":"Disease"},{"id":"T20","span":{"begin":309,"end":318},"obj":"Disease"}],"attributes":[{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"}],"text":"Both CLQ-OH and ATM are repositioned drugs and their antiviral mechanism of action, particularly in combination, remains mostly unclear. In vitro studies have shown that CLQ-OH inhibits SARS-CoV-2 [4], [5], [6]. Far less is known about the antiviral effects of ATM, which has been suggested to interfere with influenza virus internalization [7]. Interestingly, CLQ is also considered as an inhibitor of endocytic pathways through an elevation of endosomal pH [8]. However, several reports indicate that CLQ could also prevent virus attachment through a direct effect on host-cell surface molecules [9,10]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T39","span":{"begin":198,"end":204},"obj":"http://purl.obolibrary.org/obo/CLO_0053799"},{"id":"T40","span":{"begin":272,"end":275},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T41","span":{"begin":319,"end":324},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T42","span":{"begin":526,"end":531},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T43","span":{"begin":551,"end":552},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T44","span":{"begin":575,"end":579},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Both CLQ-OH and ATM are repositioned drugs and their antiviral mechanism of action, particularly in combination, remains mostly unclear. In vitro studies have shown that CLQ-OH inhibits SARS-CoV-2 [4], [5], [6]. Far less is known about the antiviral effects of ATM, which has been suggested to interfere with influenza virus internalization [7]. Interestingly, CLQ is also considered as an inhibitor of endocytic pathways through an elevation of endosomal pH [8]. However, several reports indicate that CLQ could also prevent virus attachment through a direct effect on host-cell surface molecules [9,10]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T52","span":{"begin":16,"end":19},"obj":"Chemical"},{"id":"T53","span":{"begin":37,"end":42},"obj":"Chemical"},{"id":"T54","span":{"begin":53,"end":62},"obj":"Chemical"},{"id":"T55","span":{"begin":240,"end":249},"obj":"Chemical"},{"id":"T56","span":{"begin":261,"end":264},"obj":"Chemical"},{"id":"T57","span":{"begin":390,"end":399},"obj":"Chemical"},{"id":"T58","span":{"begin":588,"end":597},"obj":"Chemical"}],"attributes":[{"id":"A52","pred":"chebi_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A53","pred":"chebi_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A54","pred":"chebi_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A55","pred":"chebi_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A56","pred":"chebi_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A57","pred":"chebi_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A58","pred":"chebi_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"}],"text":"Both CLQ-OH and ATM are repositioned drugs and their antiviral mechanism of action, particularly in combination, remains mostly unclear. In vitro studies have shown that CLQ-OH inhibits SARS-CoV-2 [4], [5], [6]. Far less is known about the antiviral effects of ATM, which has been suggested to interfere with influenza virus internalization [7]. Interestingly, CLQ is also considered as an inhibitor of endocytic pathways through an elevation of endosomal pH [8]. However, several reports indicate that CLQ could also prevent virus attachment through a direct effect on host-cell surface molecules [9,10]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T32","span":{"begin":0,"end":136},"obj":"Sentence"},{"id":"T33","span":{"begin":137,"end":211},"obj":"Sentence"},{"id":"T34","span":{"begin":212,"end":345},"obj":"Sentence"},{"id":"T35","span":{"begin":346,"end":463},"obj":"Sentence"},{"id":"T36","span":{"begin":464,"end":605},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Both CLQ-OH and ATM are repositioned drugs and their antiviral mechanism of action, particularly in combination, remains mostly unclear. In vitro studies have shown that CLQ-OH inhibits SARS-CoV-2 [4], [5], [6]. Far less is known about the antiviral effects of ATM, which has been suggested to interfere with influenza virus internalization [7]. Interestingly, CLQ is also considered as an inhibitor of endocytic pathways through an elevation of endosomal pH [8]. However, several reports indicate that CLQ could also prevent virus attachment through a direct effect on host-cell surface molecules [9,10]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"140","span":{"begin":186,"end":196},"obj":"Species"},{"id":"141","span":{"begin":309,"end":324},"obj":"Species"},{"id":"142","span":{"begin":5,"end":11},"obj":"Chemical"},{"id":"143","span":{"begin":170,"end":176},"obj":"Chemical"}],"attributes":[{"id":"A140","pred":"tao:has_database_id","subj":"140","obj":"Tax:2697049"},{"id":"A141","pred":"tao:has_database_id","subj":"141","obj":"Tax:11308"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Both CLQ-OH and ATM are repositioned drugs and their antiviral mechanism of action, particularly in combination, remains mostly unclear. In vitro studies have shown that CLQ-OH inhibits SARS-CoV-2 [4], [5], [6]. Far less is known about the antiviral effects of ATM, which has been suggested to interfere with influenza virus internalization [7]. Interestingly, CLQ is also considered as an inhibitor of endocytic pathways through an elevation of endosomal pH [8]. However, several reports indicate that CLQ could also prevent virus attachment through a direct effect on host-cell surface molecules [9,10]."}

{"project":"2_test","denotations":[{"id":"32405156-32194981-48150997","span":{"begin":198,"end":199},"obj":"32194981"},{"id":"32405156-32020029-48150998","span":{"begin":208,"end":209},"obj":"32020029"},{"id":"32405156-31300721-48150999","span":{"begin":342,"end":343},"obj":"31300721"},{"id":"32405156-29940786-48151000","span":{"begin":460,"end":461},"obj":"29940786"},{"id":"32405156-16115318-48151001","span":{"begin":599,"end":600},"obj":"16115318"},{"id":"T9574","span":{"begin":198,"end":199},"obj":"32194981"},{"id":"T58552","span":{"begin":208,"end":209},"obj":"32020029"},{"id":"T1073","span":{"begin":342,"end":343},"obj":"31300721"},{"id":"T97119","span":{"begin":460,"end":461},"obj":"29940786"},{"id":"T35781","span":{"begin":599,"end":600},"obj":"16115318"}],"text":"Both CLQ-OH and ATM are repositioned drugs and their antiviral mechanism of action, particularly in combination, remains mostly unclear. In vitro studies have shown that CLQ-OH inhibits SARS-CoV-2 [4], [5], [6]. Far less is known about the antiviral effects of ATM, which has been suggested to interfere with influenza virus internalization [7]. Interestingly, CLQ is also considered as an inhibitor of endocytic pathways through an elevation of endosomal pH [8]. However, several reports indicate that CLQ could also prevent virus attachment through a direct effect on host-cell surface molecules [9,10]."}