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PMC:7219429 / 29597-30795 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T187 440-455 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T188 574-581 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T189 611-623 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T190 790-801 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T191 886-894 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T192 1160-1172 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T101 82-90 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 93-102 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T103 163-171 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T104 411-419 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T105 422-431 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T106 557-565 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T274 244-249 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T275 440-446 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T276 447-455 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T277 657-658 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T278 880-885 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T279 1057-1064 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T280 1119-1127 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T559 29-32 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T560 61-70 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T561 205-213 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T562 215-218 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T563 316-325 Chemical denotes cofactors http://purl.obolibrary.org/obo/CHEBI_23357
T564 344-349 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T565 574-581 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T566 611-623 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T567 628-631 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T568 790-801 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T569 802-812 Chemical denotes saccharide http://purl.obolibrary.org/obo/CHEBI_16646
T570 859-862 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T571 886-894 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T572 985-989 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T573 1069-1078 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T574 1094-1097 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T575 1119-1127 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T576 1160-1172 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T215 0-13 Sentence denotes 5 Conclusion
T216 14-181 Sentence denotes In conclusion, ATM and CLQ-OH have synergistic antiviral effects on SARS-CoV-2 infection, which supports the use of this combination therapy for the COVID-19 pandemic.
T217 182-326 Sentence denotes In this bitherapy, one molecule (ATM) is directed against the virus, while the other (CLQ-OH) is directed against cellular attachment cofactors.
T218 327-525 Sentence denotes However, the two drugs are predicted to act in synergy to prevent the first step of SARS-CoV-2 infection, at the plasma membrane level, where therapeutic intervention is likely to be most efficient.
T219 526-716 Sentence denotes The conserved QFN triad of the SARS-CoV-2 spike protein, which is recognized by both gangliosides and ATM, should be considered as a target for neutralizing antibodies in vaccine strategies.
T220 717-1028 Sentence denotes The molecular modelling approaches used here are based on the search for ganglioside saccharide mimicry and might be useful to identify other ATM binding sites on virus proteins, and more generally to predict the efficacy of any potential repurposed and/or innovative drug candidates before clinical evaluation.
T221 1029-1198 Sentence denotes In this respect, we suggest testing the antiviral association of ATM with short synthetic peptides specifically designed to target gangliosides without toxicity [17,33].

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
821 568-573 Gene denotes spike Gene:43740568
822 557-567 Species denotes SARS-CoV-2 Tax:2697049
823 29-32 Chemical denotes ATM MESH:D017963
824 37-43 Chemical denotes CLQ-OH
825 268-274 Chemical denotes CLQ-OH
826 540-543 Chemical denotes QFN
827 611-623 Chemical denotes gangliosides MESH:D005732
828 790-812 Chemical denotes ganglioside saccharide
829 1160-1172 Chemical denotes gangliosides MESH:D005732
830 87-102 Disease denotes CoV-2 infection MESH:C000657245
831 163-171 Disease denotes COVID-19 MESH:C000657245
832 411-431 Disease denotes SARS-CoV-2 infection MESH:C000657245
833 1181-1189 Disease denotes toxicity MESH:D064420

2_test

Id Subject Object Predicate Lexical cue
32405156-27352802-48151042 1194-1196 27352802 denotes 33
T72900 1194-1196 27352802 denotes 33