PMC:7219429 / 28977-29595
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T185 | 206-217 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T186 | 587-598 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T97 | 300-325 | Disease | denotes | rheumatological disorders | http://purl.obolibrary.org/obo/MONDO_0005554 |
| T98 | 335-340 | Disease | denotes | lupus | http://purl.obolibrary.org/obo/MONDO_0004670 |
| T99 | 345-365 | Disease | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/MONDO_0008383 |
| T100 | 356-365 | Disease | denotes | arthritis | http://purl.obolibrary.org/obo/MONDO_0005578 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T272 | 225-226 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T273 | 430-431 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T539 | 30-33 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T540 | 42-52 | Chemical | denotes | saccharide | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T541 | 61-64 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T544 | 122-142 | Chemical | denotes | macrolide antibiotic | http://purl.obolibrary.org/obo/CHEBI_25105 |
| T545 | 122-131 | Chemical | denotes | macrolide | http://purl.obolibrary.org/obo/CHEBI_25106 |
| T546 | 132-142 | Chemical | denotes | antibiotic | http://purl.obolibrary.org/obo/CHEBI_33281 |
| T547 | 206-221 | Chemical | denotes | ganglioside GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048 |
| T549 | 206-217 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T550 | 218-221 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_73110 |
| T551 | 292-296 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T552 | 383-386 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T555 | 411-414 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T558 | 587-598 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T36 | 61-64 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T37 | 218-221 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T38 | 383-386 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T39 | 406-414 | GlycoEpitope | denotes | anti-GM1 | http://www.glycoepitope.jp/epitopes/AN0713 |
| T40 | 411-414 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 345-365 | Phenotype | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/HP_0001370 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T211 | 0-181 | Sentence | denotes | The molecular mimicry between ATM and the saccharide part of GM1 gives new perspectives on the therapeutic effect of this macrolide antibiotic and this warrants further exploration. |
| T212 | 182-374 | Sentence | denotes | Moreover, the fact that ganglioside GM1 is a molecular target for CLQ-OH might explain the indication of this drug in rheumatological disorders, such as lupus and rheumatoid arthritis [35,36]. |
| T213 | 375-467 | Sentence | denotes | Indeed, GM1 overexpression and anti-GM1 antibodies are a hallmark of these diseases [37,38]. |
| T214 | 468-618 | Sentence | denotes | Thus, our data incidentally indicate that the therapeutic effect of CLQ-OH in these cases could also be related to its ganglioside-binding properties. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 799 | 61-64 | Chemical | denotes | GM1 | MESH:D005677 |
| 800 | 122-131 | Chemical | denotes | macrolide | MESH:D018942 |
| 801 | 206-221 | Chemical | denotes | ganglioside GM1 | MESH:D005677 |
| 802 | 248-254 | Chemical | denotes | CLQ-OH | |
| 803 | 536-542 | Chemical | denotes | CLQ-OH | |
| 804 | 587-598 | Chemical | denotes | ganglioside | MESH:D005732 |
| 805 | 300-325 | Disease | denotes | rheumatological disorders | MESH:D012216 |
| 806 | 335-340 | Disease | denotes | lupus | MESH:D008180 |
| 807 | 345-365 | Disease | denotes | rheumatoid arthritis | MESH:D001172 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32405156-27927040-48151038 | 367-369 | 27927040 | denotes | 35 |
| 32405156-32034323-48151039 | 370-372 | 32034323 | denotes | 36 |
| 32405156-7869176-48151040 | 460-462 | 7869176 | denotes | 37 |
| 32405156-24463447-48151041 | 463-465 | 24463447 | denotes | 38 |
| T46993 | 367-369 | 27927040 | denotes | 35 |
| T37791 | 370-372 | 32034323 | denotes | 36 |
| T3943 | 460-462 | 7869176 | denotes | 37 |
| T30913 | 463-465 | 24463447 | denotes | 38 |