PMC:7219429 / 27443-28198
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T178 | 105-117 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T179 | 203-208 | Body_part | denotes | sugar | http://purl.org/sig/ont/fma/fma82737 |
| T180 | 230-241 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T181 | 270-277 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T182 | 310-315 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T183 | 341-352 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T184 | 561-572 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T94 | 84-88 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T260 | 4-6 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
| T261 | 164-167 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T262 | 293-298 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T263 | 385-390 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T264 | 391-399 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T265 | 420-421 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T266 | 501-506 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T267 | 531-536 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T512 | 4-6 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
| T513 | 70-73 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T514 | 105-117 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T515 | 153-156 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T516 | 199-202 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T519 | 230-241 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T520 | 270-277 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T521 | 310-315 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T522 | 341-352 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T523 | 461-466 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T524 | 519-522 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T525 | 561-572 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T526 | 590-595 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T34 | 199-202 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T200 | 0-152 | Sentence | denotes | The MD simulations in the current study indicate that both CLQ-OH and ATM may block SARS-CoV2 binding to gangliosides via mirror competitive mechanisms. |
| T201 | 153-322 | Sentence | denotes | ATM, which has some molecular similarity with GM1 sugar, can thus occupy the ganglioside-binding domain of the spike protein and neutralize virus binding to lipid rafts. |
| T202 | 323-446 | Sentence | denotes | CLQ-OH covers the ganglioside surface, and thus also prevents virus-membrane interaction through a complementary mechanism. |
| T203 | 447-581 | Sentence | denotes | Each of these drugs might be efficient alone to block virus attachment, ATM through virus binding, CLQ-OH through ganglioside binding. |
| T204 | 582-755 | Sentence | denotes | As both drugs interfere with the same mechanism but with distinct molecular targets, they are expected to work together in synergy, as indicated by recent clinical data [3]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 757 | 264-269 | Gene | denotes | spike | Gene:43740568 |
| 758 | 84-93 | Species | denotes | SARS-CoV2 | Tax:2697049 |
| 759 | 59-65 | Chemical | denotes | CLQ-OH | |
| 760 | 105-117 | Chemical | denotes | gangliosides | MESH:D005732 |
| 761 | 199-208 | Chemical | denotes | GM1 sugar | |
| 762 | 230-241 | Chemical | denotes | ganglioside | MESH:D005732 |
| 763 | 310-315 | Chemical | denotes | lipid | MESH:D008055 |
| 764 | 323-329 | Chemical | denotes | CLQ-OH | |
| 765 | 341-352 | Chemical | denotes | ganglioside | MESH:D005732 |
| 766 | 546-552 | Chemical | denotes | CLQ-OH | |
| 767 | 561-572 | Chemical | denotes | ganglioside | MESH:D005732 |