PMC:7219429 / 26386-27442
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T166 | 61-68 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T167 | 169-174 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T168 | 372-384 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T169 | 416-427 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T170 | 559-572 | Body_part | denotes | cell membrane | http://purl.org/sig/ont/fma/fma63841 |
| T171 | 559-563 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T172 | 675-678 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T173 | 730-738 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T174 | 798-815 | Body_part | denotes | glycosphingolipid | http://purl.org/sig/ont/fma/fma82814 |
| T175 | 871-878 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T176 | 949-961 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T177 | 1032-1037 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T88 | 50-58 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T89 | 230-245 | Disease | denotes | virus infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T90 | 236-245 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T91 | 635-650 | Disease | denotes | virus infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T92 | 641-650 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T93 | 837-845 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T246 | 139-141 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T247 | 209-210 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T248 | 230-235 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T249 | 280-285 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T250 | 527-528 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T251 | 548-553 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T252 | 559-563 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T253 | 564-572 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T254 | 635-640 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T255 | 748-749 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T256 | 760-763 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T257 | 766-767 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T258 | 900-907 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T259 | 1021-1028 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T502 | 61-68 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T503 | 169-174 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T504 | 372-384 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T505 | 416-427 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T506 | 730-738 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T507 | 798-815 | Chemical | denotes | glycosphingolipid | http://purl.obolibrary.org/obo/CHEBI_24402 |
| T508 | 816-825 | Chemical | denotes | cofactors | http://purl.obolibrary.org/obo/CHEBI_23357 |
| T509 | 871-878 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T510 | 949-961 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T511 | 1032-1037 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T193 | 0-147 | Sentence | denotes | To date, there are several structural data of the SARS-CoV-2 protein in the prefusion conformation or bound to its primary receptor ACE-2 [11, 20]. |
| T194 | 148-251 | Sentence | denotes | However, ACE-2 is in lipid rafts and raft disruption induces a marked decrease of virus infection [15]. |
| T195 | 252-385 | Sentence | denotes | Thus, it is likely that the virus interacts with the raft surface through multivalent contacts involving both ACE-2 and gangliosides. |
| T196 | 386-521 | Sentence | denotes | The fact that the RBD and the ganglioside-binding domain belong to distinct parts of the trimeric spike is consistent with this notion. |
| T197 | 522-662 | Sentence | denotes | Such a complex network of virus-host cell membrane interactions is also consistent with previously characterized virus infection strategies. |
| T198 | 663-831 | Sentence | denotes | Indeed, the HIV-1 fusion process driven by gp120 and gp41 envelope proteins involves a receptor (CD4), a coreceptor (chiefly CCR5) and glycosphingolipid cofactors [39]. |
| T199 | 832-1056 | Sentence | denotes | Like SARS-CoV-2, the pentameric capsid protein of SV40, and polyoma viruses display three distinct binding sites for gangliosides, which serve as critical receptors for these non-enveloped viruses in lipid raft domains [40]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 729 | 132-137 | Gene | denotes | ACE-2 | Gene:59272 |
| 730 | 157-162 | Gene | denotes | ACE-2 | Gene:59272 |
| 731 | 362-367 | Gene | denotes | ACE-2 | Gene:59272 |
| 732 | 706-711 | Gene | denotes | gp120 | Gene:3700 |
| 733 | 760-763 | Gene | denotes | CD4 | Gene:920 |
| 734 | 788-792 | Gene | denotes | CCR5 | Gene:1234 |
| 735 | 484-489 | Gene | denotes | spike | Gene:43740568 |
| 736 | 50-60 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 737 | 675-680 | Species | denotes | HIV-1 | Tax:11676 |
| 738 | 837-847 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 739 | 169-174 | Chemical | denotes | lipid | MESH:D008055 |
| 740 | 372-384 | Chemical | denotes | gangliosides | MESH:D005732 |
| 741 | 416-427 | Chemical | denotes | ganglioside | MESH:D005732 |
| 742 | 949-961 | Chemical | denotes | gangliosides | MESH:D005732 |
| 743 | 1032-1037 | Chemical | denotes | lipid | MESH:D008055 |
| 744 | 218-245 | Disease | denotes | decrease of virus infection | MESH:D001102 |
| 745 | 635-650 | Disease | denotes | virus infection | MESH:D001102 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32405156-32132184-48151033 | 139-141 | 32132184 | denotes | 11 |
| 32405156-32075877-48151034 | 143-145 | 32075877 | denotes | 20 |
| 32405156-18814896-48151035 | 247-249 | 18814896 | denotes | 15 |
| 32405156-10233996-48151036 | 827-829 | 10233996 | denotes | 39 |
| 32405156-18353982-48151037 | 1052-1054 | 18353982 | denotes | 40 |
| T12821 | 139-141 | 32132184 | denotes | 11 |
| T54020 | 143-145 | 32075877 | denotes | 20 |
| T89246 | 247-249 | 18814896 | denotes | 15 |
| T51159 | 827-829 | 10233996 | denotes | 39 |
| T64785 | 1052-1054 | 18353982 | denotes | 40 |