
PMC:7219429 / 25156-26385
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T156 | 277-284 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T157 | 423-430 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T158 | 431-442 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
T159 | 551-562 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
T160 | 655-667 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
T161 | 845-861 | Body_part | denotes | oligosaccharides | http://purl.org/sig/ont/fma/fma82742 |
T162 | 908-920 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
T163 | 1009-1021 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
T164 | 1134-1146 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
T165 | 1206-1211 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T237 | 72-77 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T238 | 211-212 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T239 | 259-261 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
T240 | 579-587 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T241 | 668-671 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T242 | 672-673 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T243 | 1025-1033 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T244 | 1075-1077 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
T245 | 1204-1205 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T477 | 121-130 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T478 | 154-157 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
T479 | 259-261 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
T480 | 277-284 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T481 | 285-291 | Chemical | denotes | ligand | http://purl.obolibrary.org/obo/CHEBI_52214 |
T482 | 423-430 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T483 | 431-442 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
T484 | 514-519 | Chemical | denotes | water | http://purl.obolibrary.org/obo/CHEBI_15377 |
T485 | 528-538 | Chemical | denotes | saccharide | http://purl.obolibrary.org/obo/CHEBI_16646 |
T486 | 551-562 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
T487 | 597-605 | Chemical | denotes | ceramide | http://purl.obolibrary.org/obo/CHEBI_17761|http://purl.obolibrary.org/obo/CHEBI_52639 |
T489 | 636-644 | Chemical | denotes | ceramide | http://purl.obolibrary.org/obo/CHEBI_17761|http://purl.obolibrary.org/obo/CHEBI_52639 |
T491 | 655-667 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
T492 | 695-705 | Chemical | denotes | saccharide | http://purl.obolibrary.org/obo/CHEBI_16646 |
T493 | 845-861 | Chemical | denotes | oligosaccharides | http://purl.obolibrary.org/obo/CHEBI_50699 |
T494 | 908-920 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
T495 | 1009-1021 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
T496 | 1075-1077 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
T497 | 1134-1146 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
T498 | 1161-1172 | Chemical | denotes | cholesterol | http://purl.obolibrary.org/obo/CHEBI_16113 |
T499 | 1177-1190 | Chemical | denotes | sphingomyelin | http://purl.obolibrary.org/obo/CHEBI_17636|http://purl.obolibrary.org/obo/CHEBI_64583 |
T501 | 1206-1211 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5 | 72-95 | http://purl.obolibrary.org/obo/GO_0019048 | denotes | virus-host interactions |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T186 | 0-184 | Sentence | denotes | In this study, molecular modelling approaches specifically dedicated to virus-host interactions were used to unravel the antiviral mechanism of action of ATM and CLQ-OH in combination. |
T187 | 185-349 | Sentence | denotes | The study method included a first round of molecular docking, followed by MD simulations of protein-ligand interactions to assess the robustness of each model [25]. |
T188 | 350-616 | Sentence | denotes | Such computer-assisted simulations are particularly helpful for studying protein-ganglioside interactions as crystallographic approaches are usually limited to the water-soluble saccharide part of the ganglioside, neglecting the membrane embedded-ceramide part [31]. |
T189 | 617-814 | Sentence | denotes | Unfortunately, the ceramide moiety of gangliosides has a marked effect on the saccharide part with which it interacts, resulting in significant restriction of its conformational possibilities [32]. |
T190 | 815-921 | Sentence | denotes | Therefore, data obtained with oligosaccharides cannot be systematically transposed to intact gangliosides. |
T191 | 922-1070 | Sentence | denotes | Molecular modelling approaches circumvented this difficulty and enabled study of whole gangliosides in membrane-compatible conformations [16,32,33]. |
T192 | 1071-1229 | Sentence | denotes | The MD simulations performed in the present study were done on gangliosides surrounded by cholesterol and sphingomyelin, which mimic a lipid raft environment. |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
696 | 162-168 | Chemical | denotes | CLQ-OH | |
697 | 431-442 | Chemical | denotes | ganglioside | MESH:D005732 |
698 | 514-519 | Chemical | denotes | water | MESH:D014867 |
699 | 528-538 | Chemical | denotes | saccharide | MESH:D002241 |
700 | 551-562 | Chemical | denotes | ganglioside | MESH:D005732 |
701 | 597-605 | Chemical | denotes | ceramide | MESH:D002518 |
702 | 636-644 | Chemical | denotes | ceramide | MESH:D002518 |
703 | 655-667 | Chemical | denotes | gangliosides | MESH:D005732 |
704 | 695-705 | Chemical | denotes | saccharide | MESH:D002241 |
705 | 845-861 | Chemical | denotes | oligosaccharides | MESH:D009844 |
706 | 908-920 | Chemical | denotes | gangliosides | MESH:D005732 |
707 | 1009-1021 | Chemical | denotes | gangliosides | MESH:D005732 |
708 | 1134-1146 | Chemical | denotes | gangliosides | MESH:D005732 |
709 | 1161-1172 | Chemical | denotes | cholesterol | MESH:D002784 |
710 | 1177-1190 | Chemical | denotes | sphingomyelin | MESH:D013109 |
711 | 1206-1211 | Chemical | denotes | lipid | MESH:D008055 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32405156-30236283-48151027 | 345-347 | 30236283 | denotes | 25 |
32405156-23807078-48151028 | 612-614 | 23807078 | denotes | 31 |
32405156-23772214-48151029 | 810-812 | 23772214 | denotes | 32 |
32405156-31431523-48151030 | 1060-1062 | 31431523 | denotes | 16 |
32405156-23772214-48151031 | 1063-1065 | 23772214 | denotes | 32 |
32405156-27352802-48151032 | 1066-1068 | 27352802 | denotes | 33 |
T72401 | 345-347 | 30236283 | denotes | 25 |
T44542 | 612-614 | 23807078 | denotes | 31 |
T20321 | 810-812 | 23772214 | denotes | 32 |
T12506 | 1060-1062 | 31431523 | denotes | 16 |
T69993 | 1063-1065 | 23772214 | denotes | 32 |
T86224 | 1066-1068 | 27352802 | denotes | 33 |