PMC:7219429 / 21534-22690 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T127","span":{"begin":93,"end":100},"obj":"Body_part"},{"id":"T128","span":{"begin":113,"end":124},"obj":"Body_part"},{"id":"T129","span":{"begin":236,"end":241},"obj":"Body_part"},{"id":"T130","span":{"begin":286,"end":293},"obj":"Body_part"},{"id":"T131","span":{"begin":325,"end":337},"obj":"Body_part"},{"id":"T132","span":{"begin":386,"end":397},"obj":"Body_part"},{"id":"T133","span":{"begin":430,"end":437},"obj":"Body_part"},{"id":"T134","span":{"begin":468,"end":480},"obj":"Body_part"},{"id":"T135","span":{"begin":595,"end":606},"obj":"Body_part"},{"id":"T136","span":{"begin":777,"end":784},"obj":"Body_part"},{"id":"T137","span":{"begin":821,"end":832},"obj":"Body_part"},{"id":"T138","span":{"begin":928,"end":935},"obj":"Body_part"}],"attributes":[{"id":"A127","pred":"fma_id","subj":"T127","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A128","pred":"fma_id","subj":"T128","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A129","pred":"fma_id","subj":"T129","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A130","pred":"fma_id","subj":"T130","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A131","pred":"fma_id","subj":"T131","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A132","pred":"fma_id","subj":"T132","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A133","pred":"fma_id","subj":"T133","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A134","pred":"fma_id","subj":"T134","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A135","pred":"fma_id","subj":"T135","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A136","pred":"fma_id","subj":"T136","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A137","pred":"fma_id","subj":"T137","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A138","pred":"fma_id","subj":"T138","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer. Note that both ATM and gangliosides share the same binding region. (c) ATM prevents ganglioside binding to the SARS-CoV-2 spike protein trimer. CLQ-OH, once bound to gangliosides (blue and orange surfaces), also prevents any interaction with the viral spike. (d) 4 CLQ-OH molecules bound to a ganglioside dimer. Each GM1 molecule is blocked by two CLQ-OH molecules (blue and orange surfaces), which wrap around the saccharide part. (e) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to GM1. Note that the ganglioside interacts with Q-134 and F-135, but not with D-138. (f) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to ATM. In this case, the binding site includes D-138 in addition to Q-134 and F-135. Note that N-137, which interacts with both ATM and GM1, is not visible in these representations as it is located behind."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T82","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T83","span":{"begin":269,"end":277},"obj":"Disease"},{"id":"T84","span":{"begin":413,"end":421},"obj":"Disease"},{"id":"T85","span":{"begin":760,"end":768},"obj":"Disease"},{"id":"T86","span":{"begin":911,"end":919},"obj":"Disease"}],"attributes":[{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A84","pred":"mondo_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A85","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A86","pred":"mondo_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer. Note that both ATM and gangliosides share the same binding region. (c) ATM prevents ganglioside binding to the SARS-CoV-2 spike protein trimer. CLQ-OH, once bound to gangliosides (blue and orange surfaces), also prevents any interaction with the viral spike. (d) 4 CLQ-OH molecules bound to a ganglioside dimer. Each GM1 molecule is blocked by two CLQ-OH molecules (blue and orange surfaces), which wrap around the saccharide part. (e) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to GM1. Note that the ganglioside interacts with Q-134 and F-135, but not with D-138. (f) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to ATM. In this case, the binding site includes D-138 in addition to Q-134 and F-135. Note that N-137, which interacts with both ATM and GM1, is not visible in these representations as it is located behind."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T209","span":{"begin":56,"end":57},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T210","span":{"begin":110,"end":111},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T211","span":{"begin":176,"end":177},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T212","span":{"begin":561,"end":566},"obj":"http://purl.obolibrary.org/obo/CLO_0050605"},{"id":"T213","span":{"begin":593,"end":594},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer. Note that both ATM and gangliosides share the same binding region. (c) ATM prevents ganglioside binding to the SARS-CoV-2 spike protein trimer. CLQ-OH, once bound to gangliosides (blue and orange surfaces), also prevents any interaction with the viral spike. (d) 4 CLQ-OH molecules bound to a ganglioside dimer. Each GM1 molecule is blocked by two CLQ-OH molecules (blue and orange surfaces), which wrap around the saccharide part. (e) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to GM1. Note that the ganglioside interacts with Q-134 and F-135, but not with D-138. (f) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to ATM. In this case, the binding site includes D-138 in addition to Q-134 and F-135. Note that N-137, which interacts with both ATM and GM1, is not visible in these representations as it is located behind."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T396","span":{"begin":7,"end":10},"obj":"Chemical"},{"id":"T397","span":{"begin":59,"end":62},"obj":"Chemical"},{"id":"T398","span":{"begin":93,"end":100},"obj":"Chemical"},{"id":"T399","span":{"begin":113,"end":124},"obj":"Chemical"},{"id":"T400","span":{"begin":159,"end":162},"obj":"Chemical"},{"id":"T403","span":{"begin":163,"end":172},"obj":"Chemical"},{"id":"T404","span":{"begin":236,"end":241},"obj":"Chemical"},{"id":"T405","span":{"begin":286,"end":293},"obj":"Chemical"},{"id":"T406","span":{"begin":317,"end":320},"obj":"Chemical"},{"id":"T407","span":{"begin":325,"end":337},"obj":"Chemical"},{"id":"T408","span":{"begin":373,"end":376},"obj":"Chemical"},{"id":"T409","span":{"begin":386,"end":397},"obj":"Chemical"},{"id":"T410","span":{"begin":430,"end":437},"obj":"Chemical"},{"id":"T411","span":{"begin":468,"end":480},"obj":"Chemical"},{"id":"T412","span":{"begin":574,"end":583},"obj":"Chemical"},{"id":"T413","span":{"begin":595,"end":606},"obj":"Chemical"},{"id":"T414","span":{"begin":619,"end":622},"obj":"Chemical"},{"id":"T417","span":{"begin":623,"end":631},"obj":"Chemical"},{"id":"T418","span":{"begin":657,"end":666},"obj":"Chemical"},{"id":"T419","span":{"begin":717,"end":727},"obj":"Chemical"},{"id":"T420","span":{"begin":777,"end":784},"obj":"Chemical"},{"id":"T421","span":{"begin":802,"end":805},"obj":"Chemical"},{"id":"T424","span":{"begin":821,"end":832},"obj":"Chemical"},{"id":"T425","span":{"begin":928,"end":935},"obj":"Chemical"},{"id":"T426","span":{"begin":953,"end":956},"obj":"Chemical"},{"id":"T427","span":{"begin":1079,"end":1082},"obj":"Chemical"},{"id":"T428","span":{"begin":1087,"end":1090},"obj":"Chemical"}],"attributes":[{"id":"A396","pred":"chebi_id","subj":"T396","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A397","pred":"chebi_id","subj":"T397","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A398","pred":"chebi_id","subj":"T398","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A399","pred":"chebi_id","subj":"T399","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A400","pred":"chebi_id","subj":"T400","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A401","pred":"chebi_id","subj":"T400","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A402","pred":"chebi_id","subj":"T400","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A403","pred":"chebi_id","subj":"T403","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A404","pred":"chebi_id","subj":"T404","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A405","pred":"chebi_id","subj":"T405","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A406","pred":"chebi_id","subj":"T406","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A407","pred":"chebi_id","subj":"T407","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A408","pred":"chebi_id","subj":"T408","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A409","pred":"chebi_id","subj":"T409","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A410","pred":"chebi_id","subj":"T410","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A411","pred":"chebi_id","subj":"T411","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A412","pred":"chebi_id","subj":"T412","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A413","pred":"chebi_id","subj":"T413","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A414","pred":"chebi_id","subj":"T414","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A415","pred":"chebi_id","subj":"T414","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A416","pred":"chebi_id","subj":"T414","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A417","pred":"chebi_id","subj":"T417","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A418","pred":"chebi_id","subj":"T418","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A419","pred":"chebi_id","subj":"T419","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A420","pred":"chebi_id","subj":"T420","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A421","pred":"chebi_id","subj":"T421","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A422","pred":"chebi_id","subj":"T421","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A423","pred":"chebi_id","subj":"T421","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A424","pred":"chebi_id","subj":"T424","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A425","pred":"chebi_id","subj":"T425","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A426","pred":"chebi_id","subj":"T426","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A427","pred":"chebi_id","subj":"T427","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A428","pred":"chebi_id","subj":"T428","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A429","pred":"chebi_id","subj":"T428","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A430","pred":"chebi_id","subj":"T428","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"}],"text":"CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer. Note that both ATM and gangliosides share the same binding region. (c) ATM prevents ganglioside binding to the SARS-CoV-2 spike protein trimer. CLQ-OH, once bound to gangliosides (blue and orange surfaces), also prevents any interaction with the viral spike. (d) 4 CLQ-OH molecules bound to a ganglioside dimer. Each GM1 molecule is blocked by two CLQ-OH molecules (blue and orange surfaces), which wrap around the saccharide part. (e) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to GM1. Note that the ganglioside interacts with Q-134 and F-135, but not with D-138. (f) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to ATM. In this case, the binding site includes D-138 in addition to Q-134 and F-135. Note that N-137, which interacts with both ATM and GM1, is not visible in these representations as it is located behind."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T24","span":{"begin":159,"end":162},"obj":"GlycoEpitope"},{"id":"T25","span":{"begin":619,"end":622},"obj":"GlycoEpitope"},{"id":"T26","span":{"begin":802,"end":805},"obj":"GlycoEpitope"},{"id":"T27","span":{"begin":1087,"end":1090},"obj":"GlycoEpitope"}],"attributes":[{"id":"A24","pred":"glyco_epitope_db_id","subj":"T24","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"id":"A25","pred":"glyco_epitope_db_id","subj":"T25","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"id":"A26","pred":"glyco_epitope_db_id","subj":"T26","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"id":"A27","pred":"glyco_epitope_db_id","subj":"T27","obj":"http://www.glycoepitope.jp/epitopes/EP0050"}],"text":"CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer. Note that both ATM and gangliosides share the same binding region. (c) ATM prevents ganglioside binding to the SARS-CoV-2 spike protein trimer. CLQ-OH, once bound to gangliosides (blue and orange surfaces), also prevents any interaction with the viral spike. (d) 4 CLQ-OH molecules bound to a ganglioside dimer. Each GM1 molecule is blocked by two CLQ-OH molecules (blue and orange surfaces), which wrap around the saccharide part. (e) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to GM1. Note that the ganglioside interacts with Q-134 and F-135, but not with D-138. (f) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to ATM. In this case, the binding site includes D-138 in addition to Q-134 and F-135. Note that N-137, which interacts with both ATM and GM1, is not visible in these representations as it is located behind."}

{"project":"LitCovid-sentences","denotations":[{"id":"T162","span":{"begin":302,"end":445},"obj":"Sentence"},{"id":"T163","span":{"begin":446,"end":613},"obj":"Sentence"},{"id":"T164","span":{"begin":614,"end":806},"obj":"Sentence"},{"id":"T165","span":{"begin":807,"end":957},"obj":"Sentence"},{"id":"T166","span":{"begin":958,"end":1035},"obj":"Sentence"},{"id":"T167","span":{"begin":1036,"end":1156},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer. Note that both ATM and gangliosides share the same binding region. (c) ATM prevents ganglioside binding to the SARS-CoV-2 spike protein trimer. CLQ-OH, once bound to gangliosides (blue and orange surfaces), also prevents any interaction with the viral spike. (d) 4 CLQ-OH molecules bound to a ganglioside dimer. Each GM1 molecule is blocked by two CLQ-OH molecules (blue and orange surfaces), which wrap around the saccharide part. (e) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to GM1. Note that the ganglioside interacts with Q-134 and F-135, but not with D-138. (f) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to ATM. In this case, the binding site includes D-138 in addition to Q-134 and F-135. Note that N-137, which interacts with both ATM and GM1, is not visible in these representations as it is located behind."}

{"project":"LitCovid-PubTator","denotations":[{"id":"567","span":{"begin":922,"end":927},"obj":"Gene"},{"id":"568","span":{"begin":771,"end":776},"obj":"Gene"},{"id":"569","span":{"begin":554,"end":559},"obj":"Gene"},{"id":"570","span":{"begin":424,"end":429},"obj":"Gene"},{"id":"571","span":{"begin":280,"end":285},"obj":"Gene"},{"id":"572","span":{"begin":87,"end":92},"obj":"Gene"},{"id":"573","span":{"begin":76,"end":86},"obj":"Species"},{"id":"574","span":{"begin":269,"end":279},"obj":"Species"},{"id":"575","span":{"begin":413,"end":423},"obj":"Species"},{"id":"576","span":{"begin":760,"end":770},"obj":"Species"},{"id":"577","span":{"begin":911,"end":921},"obj":"Species"},{"id":"578","span":{"begin":0,"end":6},"obj":"Chemical"},{"id":"579","span":{"begin":113,"end":124},"obj":"Chemical"},{"id":"580","span":{"begin":159,"end":162},"obj":"Chemical"},{"id":"581","span":{"begin":236,"end":241},"obj":"Chemical"},{"id":"582","span":{"begin":325,"end":337},"obj":"Chemical"},{"id":"583","span":{"begin":386,"end":397},"obj":"Chemical"},{"id":"584","span":{"begin":446,"end":452},"obj":"Chemical"},{"id":"585","span":{"begin":468,"end":480},"obj":"Chemical"},{"id":"586","span":{"begin":567,"end":573},"obj":"Chemical"},{"id":"587","span":{"begin":595,"end":606},"obj":"Chemical"},{"id":"588","span":{"begin":619,"end":622},"obj":"Chemical"},{"id":"589","span":{"begin":650,"end":656},"obj":"Chemical"},{"id":"590","span":{"begin":802,"end":805},"obj":"Chemical"},{"id":"591","span":{"begin":821,"end":832},"obj":"Chemical"},{"id":"592","span":{"begin":998,"end":1003},"obj":"Chemical"},{"id":"593","span":{"begin":1019,"end":1024},"obj":"Chemical"},{"id":"594","span":{"begin":1046,"end":1051},"obj":"Chemical"},{"id":"595","span":{"begin":1087,"end":1090},"obj":"Chemical"}],"attributes":[{"id":"A567","pred":"tao:has_database_id","subj":"567","obj":"Gene:43740568"},{"id":"A568","pred":"tao:has_database_id","subj":"568","obj":"Gene:43740568"},{"id":"A569","pred":"tao:has_database_id","subj":"569","obj":"Gene:43740568"},{"id":"A570","pred":"tao:has_database_id","subj":"570","obj":"Gene:43740568"},{"id":"A571","pred":"tao:has_database_id","subj":"571","obj":"Gene:43740568"},{"id":"A572","pred":"tao:has_database_id","subj":"572","obj":"Gene:43740568"},{"id":"A573","pred":"tao:has_database_id","subj":"573","obj":"Tax:2697049"},{"id":"A574","pred":"tao:has_database_id","subj":"574","obj":"Tax:2697049"},{"id":"A575","pred":"tao:has_database_id","subj":"575","obj":"Tax:2697049"},{"id":"A576","pred":"tao:has_database_id","subj":"576","obj":"Tax:2697049"},{"id":"A577","pred":"tao:has_database_id","subj":"577","obj":"Tax:2697049"},{"id":"A579","pred":"tao:has_database_id","subj":"579","obj":"MESH:D005732"},{"id":"A580","pred":"tao:has_database_id","subj":"580","obj":"MESH:D005677"},{"id":"A581","pred":"tao:has_database_id","subj":"581","obj":"MESH:D008055"},{"id":"A582","pred":"tao:has_database_id","subj":"582","obj":"MESH:D005732"},{"id":"A583","pred":"tao:has_database_id","subj":"583","obj":"MESH:D005732"},{"id":"A585","pred":"tao:has_database_id","subj":"585","obj":"MESH:D005732"},{"id":"A587","pred":"tao:has_database_id","subj":"587","obj":"MESH:D005732"},{"id":"A588","pred":"tao:has_database_id","subj":"588","obj":"MESH:D005677"},{"id":"A590","pred":"tao:has_database_id","subj":"590","obj":"MESH:D005677"},{"id":"A591","pred":"tao:has_database_id","subj":"591","obj":"MESH:D005732"},{"id":"A594","pred":"tao:has_database_id","subj":"594","obj":"MESH:C022084"},{"id":"A595","pred":"tao:has_database_id","subj":"595","obj":"MESH:D005677"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer. Note that both ATM and gangliosides share the same binding region. (c) ATM prevents ganglioside binding to the SARS-CoV-2 spike protein trimer. CLQ-OH, once bound to gangliosides (blue and orange surfaces), also prevents any interaction with the viral spike. (d) 4 CLQ-OH molecules bound to a ganglioside dimer. Each GM1 molecule is blocked by two CLQ-OH molecules (blue and orange surfaces), which wrap around the saccharide part. (e) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to GM1. Note that the ganglioside interacts with Q-134 and F-135, but not with D-138. (f) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to ATM. In this case, the binding site includes D-138 in addition to Q-134 and F-135. Note that N-137, which interacts with both ATM and GM1, is not visible in these representations as it is located behind."}