PMC:7219429 / 21527-21835 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T127","span":{"begin":100,"end":107},"obj":"Body_part"},{"id":"T128","span":{"begin":120,"end":131},"obj":"Body_part"},{"id":"T129","span":{"begin":243,"end":248},"obj":"Body_part"},{"id":"T130","span":{"begin":293,"end":300},"obj":"Body_part"}],"attributes":[{"id":"A127","pred":"fma_id","subj":"T127","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A128","pred":"fma_id","subj":"T128","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A129","pred":"fma_id","subj":"T129","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A130","pred":"fma_id","subj":"T130","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Fig. 8 CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T82","span":{"begin":83,"end":91},"obj":"Disease"},{"id":"T83","span":{"begin":276,"end":284},"obj":"Disease"}],"attributes":[{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Fig. 8 CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T209","span":{"begin":63,"end":64},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T210","span":{"begin":117,"end":118},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T211","span":{"begin":183,"end":184},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Fig. 8 CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T396","span":{"begin":14,"end":17},"obj":"Chemical"},{"id":"T397","span":{"begin":66,"end":69},"obj":"Chemical"},{"id":"T398","span":{"begin":100,"end":107},"obj":"Chemical"},{"id":"T399","span":{"begin":120,"end":131},"obj":"Chemical"},{"id":"T400","span":{"begin":166,"end":169},"obj":"Chemical"},{"id":"T403","span":{"begin":170,"end":179},"obj":"Chemical"},{"id":"T404","span":{"begin":243,"end":248},"obj":"Chemical"},{"id":"T405","span":{"begin":293,"end":300},"obj":"Chemical"}],"attributes":[{"id":"A396","pred":"chebi_id","subj":"T396","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A397","pred":"chebi_id","subj":"T397","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A398","pred":"chebi_id","subj":"T398","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A399","pred":"chebi_id","subj":"T399","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A400","pred":"chebi_id","subj":"T400","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A401","pred":"chebi_id","subj":"T400","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A402","pred":"chebi_id","subj":"T400","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A403","pred":"chebi_id","subj":"T403","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A404","pred":"chebi_id","subj":"T404","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A405","pred":"chebi_id","subj":"T405","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Fig. 8 CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T24","span":{"begin":166,"end":169},"obj":"GlycoEpitope"}],"attributes":[{"id":"A24","pred":"glyco_epitope_db_id","subj":"T24","obj":"http://www.glycoepitope.jp/epitopes/EP0050"}],"text":"Fig. 8 CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer."}

{"project":"LitCovid-sentences","denotations":[{"id":"T161","span":{"begin":0,"end":308},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Fig. 8 CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer."}

{"project":"LitCovid-PubTator","denotations":[{"id":"571","span":{"begin":287,"end":292},"obj":"Gene"},{"id":"572","span":{"begin":94,"end":99},"obj":"Gene"},{"id":"573","span":{"begin":83,"end":93},"obj":"Species"},{"id":"574","span":{"begin":276,"end":286},"obj":"Species"},{"id":"578","span":{"begin":7,"end":13},"obj":"Chemical"},{"id":"579","span":{"begin":120,"end":131},"obj":"Chemical"},{"id":"580","span":{"begin":166,"end":169},"obj":"Chemical"},{"id":"581","span":{"begin":243,"end":248},"obj":"Chemical"}],"attributes":[{"id":"A571","pred":"tao:has_database_id","subj":"571","obj":"Gene:43740568"},{"id":"A572","pred":"tao:has_database_id","subj":"572","obj":"Gene:43740568"},{"id":"A573","pred":"tao:has_database_id","subj":"573","obj":"Tax:2697049"},{"id":"A574","pred":"tao:has_database_id","subj":"574","obj":"Tax:2697049"},{"id":"A579","pred":"tao:has_database_id","subj":"579","obj":"MESH:D005732"},{"id":"A580","pred":"tao:has_database_id","subj":"580","obj":"MESH:D005677"},{"id":"A581","pred":"tao:has_database_id","subj":"581","obj":"MESH:D008055"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Fig. 8 CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer."}