PMC:7219429 / 20737-25140
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T121 | 290-297 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T122 | 328-340 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T123 | 458-470 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T124 | 506-513 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T125 | 603-615 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T126 | 628-643 | Body_part | denotes | plasma membrane | http://purl.org/sig/ont/fma/fma63841 |
| T127 | 890-897 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T128 | 910-921 | Body_part | denotes | Ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T129 | 1033-1038 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T130 | 1083-1090 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T131 | 1122-1134 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T132 | 1183-1194 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T133 | 1227-1234 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T134 | 1265-1277 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T135 | 1392-1403 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T136 | 1574-1581 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T137 | 1618-1629 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T138 | 1725-1732 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T139 | 2286-2297 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T140 | 2588-2599 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T141 | 2641-2652 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T142 | 2763-2774 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T143 | 2868-2883 | Body_part | denotes | plasma membrane | http://purl.org/sig/ont/fma/fma63841 |
| T144 | 2892-2897 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T145 | 3054-3061 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T146 | 3118-3129 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T147 | 3233-3237 | Body_part | denotes | head | http://purl.org/sig/ont/fma/fma7154 |
| T148 | 3365-3372 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T149 | 3435-3450 | Body_part | denotes | protein complex | http://purl.org/sig/ont/fma/fma67906 |
| T150 | 3527-3534 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T151 | 3852-3859 | Body_part | denotes | alanine | http://purl.org/sig/ont/fma/fma82749 |
| T152 | 4115-4120 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T153 | 4285-4296 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T154 | 4389-4402 | Body_part | denotes | cell membrane | http://purl.org/sig/ont/fma/fma63841 |
| T155 | 4389-4393 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T14 | 3233-3237 | Body_part | denotes | head | http://purl.obolibrary.org/obo/UBERON_0000033 |
| T15 | 4192-4196 | Body_part | denotes | wing | http://purl.obolibrary.org/obo/UBERON_0000023 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T79 | 150-158 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T80 | 161-170 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T81 | 250-259 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T82 | 873-881 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T83 | 1066-1074 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T84 | 1210-1218 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T85 | 1557-1565 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T86 | 1708-1716 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T87 | 4355-4363 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T204 | 201-206 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T205 | 575-580 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T206 | 628-634 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T207 | 635-643 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T208 | 716-717 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T209 | 853-854 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T210 | 907-908 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T211 | 973-974 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T212 | 1358-1363 | http://purl.obolibrary.org/obo/CLO_0050605 | denotes | (d) 4 |
| T213 | 1390-1391 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T214 | 2039-2040 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T215 | 2058-2059 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T216 | 2257-2258 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T217 | 2284-2285 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T218 | 2433-2434 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T219 | 2757-2762 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T220 | 2854-2859 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T221 | 2868-2874 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T222 | 2875-2883 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T223 | 2892-2897 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T224 | 3017-3019 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T225 | 3042-3047 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T226 | 3180-3181 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T227 | 3233-3237 | http://purl.obolibrary.org/obo/UBERON_0000033 | denotes | head |
| T228 | 3233-3237 | http://www.ebi.ac.uk/efo/EFO_0000964 | denotes | head |
| T229 | 3353-3358 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T230 | 3415-3416 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T231 | 3435-3450 | http://purl.obolibrary.org/obo/GO_0043234 | denotes | protein complex |
| T232 | 3690-3692 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T233 | 4134-4139 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T234 | 4215-4220 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T235 | 4389-4393 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T236 | 4394-4402 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T384 | 17-26 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T385 | 38-41 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T386 | 132-135 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T387 | 290-297 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T388 | 328-340 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T389 | 450-453 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T390 | 458-470 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T391 | 506-513 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T392 | 566-569 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T393 | 603-615 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T394 | 765-774 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T395 | 785-788 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T396 | 804-807 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T397 | 856-859 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T398 | 890-897 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T399 | 910-921 | Chemical | denotes | Ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T400 | 956-959 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T403 | 960-969 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T404 | 1033-1038 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T405 | 1083-1090 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T406 | 1114-1117 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T407 | 1122-1134 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T408 | 1170-1173 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T409 | 1183-1194 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T410 | 1227-1234 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T411 | 1265-1277 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T412 | 1371-1380 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T413 | 1392-1403 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T414 | 1416-1419 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T417 | 1420-1428 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T418 | 1454-1463 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T419 | 1514-1524 | Chemical | denotes | saccharide | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T420 | 1574-1581 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T421 | 1599-1602 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T424 | 1618-1629 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T425 | 1725-1732 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T426 | 1750-1753 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T427 | 1876-1879 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T428 | 1884-1887 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T431 | 2012-2015 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T434 | 2082-2085 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T437 | 2101-2110 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T438 | 2180-2183 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T439 | 2221-2227 | Chemical | denotes | lipids | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T440 | 2286-2297 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T441 | 2351-2360 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T442 | 2459-2468 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T443 | 2531-2541 | Chemical | denotes | saccharide | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T444 | 2550-2553 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T447 | 2588-2599 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T448 | 2641-2652 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T449 | 2741-2744 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T450 | 2763-2774 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T451 | 2941-2950 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T452 | 3054-3061 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T453 | 3118-3129 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T454 | 3316-3319 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T455 | 3365-3372 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T456 | 3435-3442 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T457 | 3464-3467 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T460 | 3500-3503 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T461 | 3527-3534 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T462 | 3551-3554 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T463 | 3610-3613 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T466 | 3852-3859 | Chemical | denotes | alanine | http://purl.obolibrary.org/obo/CHEBI_16449 |
| T467 | 3892-3895 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T468 | 4014-4017 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T469 | 4115-4120 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T470 | 4173-4176 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T473 | 4198-4201 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T474 | 4285-4296 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T475 | 4316-4321 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T476 | 4341-4351 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T24 | 956-959 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T25 | 1416-1419 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T26 | 1599-1602 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T27 | 1884-1887 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T28 | 2012-2015 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T29 | 2082-2085 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T30 | 2550-2553 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T31 | 3464-3467 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T32 | 3610-3613 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T33 | 4173-4176 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T154 | 0-52 | Sentence | denotes | 3.4 Synergistic antiviral effects of ATM and CLQ-OH |
| T155 | 53-341 | Sentence | denotes | Overall, these molecular modelling studies are consistent with the notion that ATM might inhibit SARS-CoV-2 infection through direct binding to the virus spike and subsequent neutralization of the infection process, which requires spike protein recognition and attachment to gangliosides. |
| T156 | 342-393 | Sentence | denotes | This mechanism of action is illustrated in Fig. 8 . |
| T157 | 394-423 | Sentence | denotes | Comparing the models in Figs. |
| T158 | 424-540 | Sentence | denotes | 8a and 8b shows that both ATM and gangliosides bind to the same site of the spike protein, centred on the QFN triad. |
| T159 | 541-654 | Sentence | denotes | Thus, in the presence of ATM, the virus spike would not reach gangliosides on the host plasma membrane (Fig. 8c). |
| T160 | 655-789 | Sentence | denotes | To the best of our knowledge, it is the first time that such a mechanism of action is proposed to explain the antiviral effect of ATM. |
| T161 | 790-1098 | Sentence | denotes | Fig. 8 CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer. |
| T162 | 1099-1242 | Sentence | denotes | Note that both ATM and gangliosides share the same binding region. (c) ATM prevents ganglioside binding to the SARS-CoV-2 spike protein trimer. |
| T163 | 1243-1410 | Sentence | denotes | CLQ-OH, once bound to gangliosides (blue and orange surfaces), also prevents any interaction with the viral spike. (d) 4 CLQ-OH molecules bound to a ganglioside dimer. |
| T164 | 1411-1603 | Sentence | denotes | Each GM1 molecule is blocked by two CLQ-OH molecules (blue and orange surfaces), which wrap around the saccharide part. (e) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to GM1. |
| T165 | 1604-1754 | Sentence | denotes | Note that the ganglioside interacts with Q-134 and F-135, but not with D-138. (f) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to ATM. |
| T166 | 1755-1832 | Sentence | denotes | In this case, the binding site includes D-138 in addition to Q-134 and F-135. |
| T167 | 1833-1953 | Sentence | denotes | Note that N-137, which interacts with both ATM and GM1, is not visible in these representations as it is located behind. |
| T168 | 1954-2016 | Sentence | denotes | This study also looked at CLQ-OH and its interaction with GM1. |
| T169 | 2017-2116 | Sentence | denotes | We recently published a model describing a complex formed by one GM1 and two CLQ-OH molecules [10]. |
| T170 | 2117-2256 | Sentence | denotes | For comparison, the same molecular modelling approaches as for ATM (in the presence of surrounding raft lipids) were applied to this model. |
| T171 | 2257-2385 | Sentence | denotes | A stable complex formed by a ganglioside dimer, each monomer being associated with two CLQ-OH molecules, was obtained (Fig. 8d). |
| T172 | 2386-2554 | Sentence | denotes | The stability of this complex is reinforced by a rearrangement of CLQ-OH molecules that interact with each other as well as interacting with the saccharide part of GM1. |
| T173 | 2555-2716 | Sentence | denotes | Consequently, the surface of the ganglioside is almost completely masked, so that the ganglioside dimer can no longer be recognized by the viral spike (Fig. 8c). |
| T174 | 2717-2898 | Sentence | denotes | In the presence of both ATM and CLQ-OH, virus-ganglioside interactions are efficiently blocked, preventing any close contact between the virus and the plasma membrane of host cells. |
| T175 | 2899-2979 | Sentence | denotes | The molecular details of this synergistic antiviral effect are worth mentioning. |
| T176 | 2980-2997 | Sentence | denotes | As shown in Figs. |
| T177 | 2998-3136 | Sentence | denotes | 5 and 8e and Table S1, the QFN triad of the virus spike protein is predicted to interact with the central region of the ganglioside dimer. |
| T178 | 3137-3256 | Sentence | denotes | If the dimer is compared metaphorically to a butterfly, this region corresponds to the insect's head between the wings. |
| T179 | 3257-3383 | Sentence | denotes | For its part, CLQ-OH binds to the wings (Fig. 8d), whereas ATM neutralizes the QFN triad of the virus spike protein (Fig. 8f). |
| T180 | 3384-3535 | Sentence | denotes | Indeed, all attempts to obtain a stable raft-spike protein complex aborted when GM1 was covered by CLMQ-OH and when ATM was bound to the spike protein. |
| T181 | 3536-3792 | Sentence | denotes | In the case of ATM, these data confirm that the QFN triad is critical for GM1 recognition and that although other residues are involved (Fig. 5 and Table S1), the whole binding process is fully controlled by the primary interaction driven by the QFN triad. |
| T182 | 3793-3938 | Sentence | denotes | In agreement with this notion, mutating the QFN triad with alanine residues resulted in an aborted ATM binding process at the post-docking steps. |
| T183 | 3939-4303 | Sentence | denotes | Taken together, these molecular modelling studies indicate that CLQ-OH and ATM, when bound to their respective targets, totally mask the complementary surfaces provided by the lipid raft and the virus spike (Fig. 8c): CLQ-OH binds to GM1 and covers the wing, ATM binds to the virus spike and prevents any interaction with the central area of the ganglioside dimer. |
| T184 | 4304-4403 | Sentence | denotes | Hence, both drugs act as competitive inhibitors of SARS-CoV-2 attachment to the host-cell membrane. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 537 | 46-52 | Chemical | denotes | CLQ-OH | |
| 567 | 1719-1724 | Gene | denotes | spike | Gene:43740568 |
| 568 | 1568-1573 | Gene | denotes | spike | Gene:43740568 |
| 569 | 1351-1356 | Gene | denotes | spike | Gene:43740568 |
| 570 | 1221-1226 | Gene | denotes | spike | Gene:43740568 |
| 571 | 1077-1082 | Gene | denotes | spike | Gene:43740568 |
| 572 | 884-889 | Gene | denotes | spike | Gene:43740568 |
| 573 | 873-883 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 574 | 1066-1076 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 575 | 1210-1220 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 576 | 1557-1567 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 577 | 1708-1718 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 578 | 797-803 | Chemical | denotes | CLQ-OH | |
| 579 | 910-921 | Chemical | denotes | Ganglioside | MESH:D005732 |
| 580 | 956-959 | Chemical | denotes | GM1 | MESH:D005677 |
| 581 | 1033-1038 | Chemical | denotes | lipid | MESH:D008055 |
| 582 | 1122-1134 | Chemical | denotes | gangliosides | MESH:D005732 |
| 583 | 1183-1194 | Chemical | denotes | ganglioside | MESH:D005732 |
| 584 | 1243-1249 | Chemical | denotes | CLQ-OH | |
| 585 | 1265-1277 | Chemical | denotes | gangliosides | MESH:D005732 |
| 586 | 1364-1370 | Chemical | denotes | CLQ-OH | |
| 587 | 1392-1403 | Chemical | denotes | ganglioside | MESH:D005732 |
| 588 | 1416-1419 | Chemical | denotes | GM1 | MESH:D005677 |
| 589 | 1447-1453 | Chemical | denotes | CLQ-OH | |
| 590 | 1599-1602 | Chemical | denotes | GM1 | MESH:D005677 |
| 591 | 1618-1629 | Chemical | denotes | ganglioside | MESH:D005732 |
| 592 | 1795-1800 | Chemical | denotes | D-138 | |
| 593 | 1816-1821 | Chemical | denotes | Q-134 | |
| 594 | 1843-1848 | Chemical | denotes | N-137 | MESH:C022084 |
| 595 | 1884-1887 | Chemical | denotes | GM1 | MESH:D005677 |
| 605 | 500-505 | Gene | denotes | spike | Gene:43740568 |
| 606 | 581-586 | Gene | denotes | spike | Gene:43740568 |
| 607 | 207-212 | Gene | denotes | spike | Gene:43740568 |
| 608 | 284-289 | Gene | denotes | spike | Gene:43740568 |
| 609 | 328-340 | Chemical | denotes | gangliosides | MESH:D005732 |
| 610 | 458-470 | Chemical | denotes | gangliosides | MESH:D005732 |
| 611 | 603-615 | Chemical | denotes | gangliosides | MESH:D005732 |
| 612 | 150-170 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 613 | 250-259 | Disease | denotes | infection | MESH:D007239 |
| 647 | 3048-3053 | Gene | denotes | spike | Gene:43740568 |
| 648 | 3359-3364 | Gene | denotes | spike | Gene:43740568 |
| 649 | 3521-3526 | Gene | denotes | spike | Gene:43740568 |
| 650 | 4221-4226 | Gene | denotes | spike | Gene:43740568 |
| 651 | 4140-4145 | Gene | denotes | spike | Gene:43740568 |
| 652 | 3429-3434 | Gene | denotes | spike | Gene:43740568 |
| 653 | 2700-2705 | Gene | denotes | spike | Gene:43740568 |
| 654 | 4355-4365 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 655 | 1980-1986 | Chemical | denotes | CLQ-OH | |
| 656 | 2012-2015 | Chemical | denotes | GM1 | MESH:D005677 |
| 657 | 2082-2085 | Chemical | denotes | GM1 | MESH:D005677 |
| 658 | 2094-2100 | Chemical | denotes | CLQ-OH | |
| 659 | 2221-2227 | Chemical | denotes | lipids | MESH:D008055 |
| 660 | 2286-2297 | Chemical | denotes | ganglioside | MESH:D005732 |
| 661 | 2344-2350 | Chemical | denotes | CLQ-OH | |
| 662 | 2452-2458 | Chemical | denotes | CLQ-OH | |
| 663 | 2550-2553 | Chemical | denotes | GM1 | MESH:D005677 |
| 664 | 2588-2599 | Chemical | denotes | ganglioside | MESH:D005732 |
| 665 | 2641-2652 | Chemical | denotes | ganglioside | MESH:D005732 |
| 666 | 2749-2755 | Chemical | denotes | CLQ-OH | |
| 667 | 2763-2774 | Chemical | denotes | ganglioside | MESH:D005732 |
| 668 | 3118-3129 | Chemical | denotes | ganglioside | MESH:D005732 |
| 669 | 3271-3277 | Chemical | denotes | CLQ-OH | |
| 670 | 3464-3467 | Chemical | denotes | GM1 | MESH:D005677 |
| 671 | 3483-3490 | Chemical | denotes | CLMQ-OH | |
| 672 | 3584-3587 | Chemical | denotes | QFN | |
| 673 | 3610-3613 | Chemical | denotes | GM1 | MESH:D005677 |
| 674 | 3852-3859 | Chemical | denotes | alanine | MESH:D000409 |
| 675 | 4003-4009 | Chemical | denotes | CLQ-OH | |
| 676 | 4115-4120 | Chemical | denotes | lipid | MESH:D008055 |
| 677 | 4157-4163 | Chemical | denotes | CLQ-OH | |
| 678 | 4173-4176 | Chemical | denotes | GM1 | MESH:D005677 |
| 679 | 4285-4296 | Chemical | denotes | ganglioside | MESH:D005732 |