PMC:7219429 / 19457-19838 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T112","span":{"begin":35,"end":42},"obj":"Body_part"},{"id":"T113","span":{"begin":60,"end":65},"obj":"Body_part"},{"id":"T114","span":{"begin":87,"end":99},"obj":"Body_part"},{"id":"T115","span":{"begin":373,"end":380},"obj":"Body_part"}],"attributes":[{"id":"A112","pred":"fma_id","subj":"T112","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A113","pred":"fma_id","subj":"T113","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A114","pred":"fma_id","subj":"T114","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A115","pred":"fma_id","subj":"T115","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Fig. 6 MD simulations of GM1-spike protein interaction in a lipid raft domain. Two GM1 gangliosides were merged with eight cholesterol (chol) and two sphingomyelin (SM) lipids. After initial docking, MD simulations were performed for 50 ns. Two distinct views of the complex are shown. Cholesterol and sphingomyelin stabilize a dimer of GM1 clamped by the NTD of the spike protein."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T72","span":{"begin":356,"end":359},"obj":"Disease"}],"attributes":[{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A73","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"}],"text":"Fig. 6 MD simulations of GM1-spike protein interaction in a lipid raft domain. Two GM1 gangliosides were merged with eight cholesterol (chol) and two sphingomyelin (SM) lipids. After initial docking, MD simulations were performed for 50 ns. Two distinct views of the complex are shown. Cholesterol and sphingomyelin stabilize a dimer of GM1 clamped by the NTD of the spike protein."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T193","span":{"begin":7,"end":9},"obj":"http://purl.obolibrary.org/obo/CLO_0007622"},{"id":"T194","span":{"begin":58,"end":59},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T195","span":{"begin":200,"end":202},"obj":"http://purl.obolibrary.org/obo/CLO_0007622"},{"id":"T196","span":{"begin":326,"end":327},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Fig. 6 MD simulations of GM1-spike protein interaction in a lipid raft domain. Two GM1 gangliosides were merged with eight cholesterol (chol) and two sphingomyelin (SM) lipids. After initial docking, MD simulations were performed for 50 ns. Two distinct views of the complex are shown. Cholesterol and sphingomyelin stabilize a dimer of GM1 clamped by the NTD of the spike protein."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T344","span":{"begin":7,"end":9},"obj":"Chemical"},{"id":"T345","span":{"begin":25,"end":28},"obj":"Chemical"},{"id":"T348","span":{"begin":35,"end":42},"obj":"Chemical"},{"id":"T349","span":{"begin":60,"end":65},"obj":"Chemical"},{"id":"T350","span":{"begin":83,"end":86},"obj":"Chemical"},{"id":"T353","span":{"begin":87,"end":99},"obj":"Chemical"},{"id":"T354","span":{"begin":123,"end":134},"obj":"Chemical"},{"id":"T355","span":{"begin":136,"end":140},"obj":"Chemical"},{"id":"T356","span":{"begin":150,"end":163},"obj":"Chemical"},{"id":"T358","span":{"begin":165,"end":167},"obj":"Chemical"},{"id":"T361","span":{"begin":169,"end":175},"obj":"Chemical"},{"id":"T362","span":{"begin":200,"end":202},"obj":"Chemical"},{"id":"T363","span":{"begin":286,"end":297},"obj":"Chemical"},{"id":"T364","span":{"begin":302,"end":315},"obj":"Chemical"},{"id":"T366","span":{"begin":337,"end":340},"obj":"Chemical"},{"id":"T369","span":{"begin":373,"end":380},"obj":"Chemical"}],"attributes":[{"id":"A344","pred":"chebi_id","subj":"T344","obj":"http://purl.obolibrary.org/obo/CHEBI_74699"},{"id":"A345","pred":"chebi_id","subj":"T345","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A346","pred":"chebi_id","subj":"T345","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A347","pred":"chebi_id","subj":"T345","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A348","pred":"chebi_id","subj":"T348","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A349","pred":"chebi_id","subj":"T349","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A350","pred":"chebi_id","subj":"T350","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A351","pred":"chebi_id","subj":"T350","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A352","pred":"chebi_id","subj":"T350","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A353","pred":"chebi_id","subj":"T353","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A354","pred":"chebi_id","subj":"T354","obj":"http://purl.obolibrary.org/obo/CHEBI_16113"},{"id":"A355","pred":"chebi_id","subj":"T355","obj":"http://purl.obolibrary.org/obo/CHEBI_16113"},{"id":"A356","pred":"chebi_id","subj":"T356","obj":"http://purl.obolibrary.org/obo/CHEBI_17636"},{"id":"A357","pred":"chebi_id","subj":"T356","obj":"http://purl.obolibrary.org/obo/CHEBI_64583"},{"id":"A358","pred":"chebi_id","subj":"T358","obj":"http://purl.obolibrary.org/obo/CHEBI_17076"},{"id":"A359","pred":"chebi_id","subj":"T358","obj":"http://purl.obolibrary.org/obo/CHEBI_74817"},{"id":"A360","pred":"chebi_id","subj":"T358","obj":"http://purl.obolibrary.org/obo/CHEBI_17636"},{"id":"A361","pred":"chebi_id","subj":"T361","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A362","pred":"chebi_id","subj":"T362","obj":"http://purl.obolibrary.org/obo/CHEBI_74699"},{"id":"A363","pred":"chebi_id","subj":"T363","obj":"http://purl.obolibrary.org/obo/CHEBI_16113"},{"id":"A364","pred":"chebi_id","subj":"T364","obj":"http://purl.obolibrary.org/obo/CHEBI_17636"},{"id":"A365","pred":"chebi_id","subj":"T364","obj":"http://purl.obolibrary.org/obo/CHEBI_64583"},{"id":"A366","pred":"chebi_id","subj":"T366","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A367","pred":"chebi_id","subj":"T366","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A368","pred":"chebi_id","subj":"T366","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A369","pred":"chebi_id","subj":"T369","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Fig. 6 MD simulations of GM1-spike protein interaction in a lipid raft domain. Two GM1 gangliosides were merged with eight cholesterol (chol) and two sphingomyelin (SM) lipids. After initial docking, MD simulations were performed for 50 ns. Two distinct views of the complex are shown. Cholesterol and sphingomyelin stabilize a dimer of GM1 clamped by the NTD of the spike protein."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T21","span":{"begin":25,"end":28},"obj":"GlycoEpitope"},{"id":"T22","span":{"begin":83,"end":86},"obj":"GlycoEpitope"},{"id":"T23","span":{"begin":337,"end":340},"obj":"GlycoEpitope"}],"attributes":[{"id":"A21","pred":"glyco_epitope_db_id","subj":"T21","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"id":"A22","pred":"glyco_epitope_db_id","subj":"T22","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"id":"A23","pred":"glyco_epitope_db_id","subj":"T23","obj":"http://www.glycoepitope.jp/epitopes/EP0050"}],"text":"Fig. 6 MD simulations of GM1-spike protein interaction in a lipid raft domain. Two GM1 gangliosides were merged with eight cholesterol (chol) and two sphingomyelin (SM) lipids. After initial docking, MD simulations were performed for 50 ns. Two distinct views of the complex are shown. Cholesterol and sphingomyelin stabilize a dimer of GM1 clamped by the NTD of the spike protein."}

{"project":"LitCovid-sentences","denotations":[{"id":"T143","span":{"begin":0,"end":78},"obj":"Sentence"},{"id":"T144","span":{"begin":79,"end":176},"obj":"Sentence"},{"id":"T145","span":{"begin":177,"end":240},"obj":"Sentence"},{"id":"T146","span":{"begin":241,"end":285},"obj":"Sentence"},{"id":"T147","span":{"begin":286,"end":381},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Fig. 6 MD simulations of GM1-spike protein interaction in a lipid raft domain. Two GM1 gangliosides were merged with eight cholesterol (chol) and two sphingomyelin (SM) lipids. After initial docking, MD simulations were performed for 50 ns. Two distinct views of the complex are shown. Cholesterol and sphingomyelin stabilize a dimer of GM1 clamped by the NTD of the spike protein."}

{"project":"LitCovid-PubTator","denotations":[{"id":"457","span":{"begin":367,"end":372},"obj":"Gene"},{"id":"458","span":{"begin":25,"end":28},"obj":"Chemical"},{"id":"459","span":{"begin":60,"end":65},"obj":"Chemical"},{"id":"460","span":{"begin":83,"end":86},"obj":"Chemical"},{"id":"461","span":{"begin":87,"end":99},"obj":"Chemical"},{"id":"462","span":{"begin":123,"end":134},"obj":"Chemical"},{"id":"463","span":{"begin":136,"end":140},"obj":"Chemical"},{"id":"464","span":{"begin":150,"end":163},"obj":"Chemical"},{"id":"465","span":{"begin":165,"end":167},"obj":"Chemical"},{"id":"466","span":{"begin":169,"end":175},"obj":"Chemical"},{"id":"467","span":{"begin":286,"end":297},"obj":"Chemical"},{"id":"468","span":{"begin":302,"end":315},"obj":"Chemical"},{"id":"469","span":{"begin":337,"end":340},"obj":"Chemical"}],"attributes":[{"id":"A457","pred":"tao:has_database_id","subj":"457","obj":"Gene:43740568"},{"id":"A458","pred":"tao:has_database_id","subj":"458","obj":"MESH:D005677"},{"id":"A459","pred":"tao:has_database_id","subj":"459","obj":"MESH:D008055"},{"id":"A460","pred":"tao:has_database_id","subj":"460","obj":"MESH:D005677"},{"id":"A461","pred":"tao:has_database_id","subj":"461","obj":"MESH:D005732"},{"id":"A462","pred":"tao:has_database_id","subj":"462","obj":"MESH:D002784"},{"id":"A463","pred":"tao:has_database_id","subj":"463","obj":"MESH:D002784"},{"id":"A464","pred":"tao:has_database_id","subj":"464","obj":"MESH:D013109"},{"id":"A465","pred":"tao:has_database_id","subj":"465","obj":"MESH:D013109"},{"id":"A466","pred":"tao:has_database_id","subj":"466","obj":"MESH:D008055"},{"id":"A467","pred":"tao:has_database_id","subj":"467","obj":"MESH:D002784"},{"id":"A468","pred":"tao:has_database_id","subj":"468","obj":"MESH:D013109"},{"id":"A469","pred":"tao:has_database_id","subj":"469","obj":"MESH:D005677"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Fig. 6 MD simulations of GM1-spike protein interaction in a lipid raft domain. Two GM1 gangliosides were merged with eight cholesterol (chol) and two sphingomyelin (SM) lipids. After initial docking, MD simulations were performed for 50 ns. Two distinct views of the complex are shown. Cholesterol and sphingomyelin stabilize a dimer of GM1 clamped by the NTD of the spike protein."}