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PMC:7219429 / 10046-25140 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T49 51-62 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T50 145-150 Body_part denotes sugar http://purl.org/sig/ont/fma/fma82737
T51 424-426 Body_part denotes Å3 http://purl.org/sig/ont/fma/fma66599
T52 518-529 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T53 540-542 Body_part denotes Å3 http://purl.org/sig/ont/fma/fma66599
T54 556-561 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T55 567-578 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T56 840-845 Body_part denotes sugar http://purl.org/sig/ont/fma/fma82737
T57 1113-1120 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T58 1148-1153 Body_part denotes sugar http://purl.org/sig/ont/fma/fma82737
T59 1410-1421 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T60 1662-1664 Body_part denotes Å3 http://purl.org/sig/ont/fma/fma66599
T61 1740-1747 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T62 1870-1881 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T63 1974-1985 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T64 2070-2077 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T65 2089-2100 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T66 2174-2185 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T67 2386-2394 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T68 2642-2653 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T69 2856-2867 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T70 3013-3024 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T71 3047-3058 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T72 3123-3126 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T73 3222-3229 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T74 3363-3368 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T75 3447-3454 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T76 3512-3519 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T77 3585-3592 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T78 3666-3673 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T79 3911-3918 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T80 4222-4232 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T81 4896-4903 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T82 5015-5025 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T83 5172-5179 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T84 5262-5269 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T85 5455-5462 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T86 5636-5643 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T87 6088-6095 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T88 6129-6136 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T89 6183-6190 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T90 6410-6417 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T91 6616-6626 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T92 6810-6817 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T93 7080-7087 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T94 7142-7152 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T95 7359-7364 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T96 7370-7385 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T97 7427-7437 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T98 7478-7482 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T99 7693-7700 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T100 7719-7731 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T101 7737-7742 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T102 7822-7833 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T103 7840-7847 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T104 7906-7918 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T105 8089-8101 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T106 8266-8273 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T107 8333-8343 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T108 8366-8373 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T109 8475-8480 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T110 8583-8595 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T111 8617-8628 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T112 9446-9453 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T113 9471-9476 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T114 9498-9510 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T115 9784-9791 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T116 9800-9810 Body_part denotes Amino acid http://purl.org/sig/ont/fma/fma82739
T117 9838-9849 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T118 9893-9900 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T119 10233-10243 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T120 10463-10468 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T121 10981-10988 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T122 11019-11031 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T123 11149-11161 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T124 11197-11204 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T125 11294-11306 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T126 11319-11334 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T127 11581-11588 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T128 11601-11612 Body_part denotes Ganglioside http://purl.org/sig/ont/fma/fma82816
T129 11724-11729 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T130 11774-11781 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T131 11813-11825 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T132 11874-11885 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T133 11918-11925 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T134 11956-11968 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T135 12083-12094 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T136 12265-12272 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T137 12309-12320 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T138 12416-12423 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T139 12977-12988 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T140 13279-13290 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T141 13332-13343 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T142 13454-13465 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T143 13559-13574 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T144 13583-13588 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T145 13745-13752 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T146 13809-13820 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T147 13924-13928 Body_part denotes head http://purl.org/sig/ont/fma/fma7154
T148 14056-14063 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T149 14126-14141 Body_part denotes protein complex http://purl.org/sig/ont/fma/fma67906
T150 14218-14225 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T151 14543-14550 Body_part denotes alanine http://purl.org/sig/ont/fma/fma82749
T152 14806-14811 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T153 14976-14987 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T154 15080-15093 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T155 15080-15084 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 1239-1243 Body_part denotes tube http://purl.obolibrary.org/obo/UBERON_0000025
T4 2121-2124 Body_part denotes tip http://purl.obolibrary.org/obo/UBERON_2001840
T5 2757-2760 Body_part denotes tip http://purl.obolibrary.org/obo/UBERON_2001840
T6 3266-3282 Body_part denotes attachment sites http://purl.obolibrary.org/obo/UBERON_4200047
T7 3423-3426 Body_part denotes tip http://purl.obolibrary.org/obo/UBERON_2001840
T8 3578-3581 Body_part denotes tip http://purl.obolibrary.org/obo/UBERON_2001840
T9 5238-5241 Body_part denotes tip http://purl.obolibrary.org/obo/UBERON_2001840
T10 5376-5379 Body_part denotes tip http://purl.obolibrary.org/obo/UBERON_2001840
T11 5733-5736 Body_part denotes tip http://purl.obolibrary.org/obo/UBERON_2001840
T12 6793-6796 Body_part denotes tip http://purl.obolibrary.org/obo/UBERON_2001840
T13 10463-10468 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T14 13924-13928 Body_part denotes head http://purl.obolibrary.org/obo/UBERON_0000033
T15 14883-14887 Body_part denotes wing http://purl.obolibrary.org/obo/UBERON_0000023

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T37 1096-1104 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 2007-2010 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T40 2053-2061 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T41 2132-2135 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T43 2270-2278 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 2584-2587 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T46 2605-2608 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T48 3430-3438 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 3495-3503 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T50 3638-3641 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T52 5155-5163 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 5234-5237 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T55 5245-5253 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T56 5372-5375 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T58 5569-5577 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T59 5744-5747 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T61 7676-7684 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T62 8249-8257 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T63 8566-8569 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T65 8822-8830 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T66 9010-9018 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T67 9090-9093 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T69 9129-9137 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T70 9249-9253 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T71 9359-9367 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T72 9767-9770 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T74 9876-9884 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 9949-9957 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T76 10185-10193 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T77 10557-10560 Disease denotes PAM http://purl.obolibrary.org/obo/MONDO_0018959
T78 10673-10676 Disease denotes PAM http://purl.obolibrary.org/obo/MONDO_0018959
T79 10841-10849 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T80 10852-10861 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T81 10941-10950 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T82 11564-11572 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T83 11757-11765 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T84 11901-11909 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T85 12248-12256 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T86 12399-12407 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T87 15046-15054 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T98 116-117 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T99 180-181 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T100 391-392 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T101 424-426 http://purl.obolibrary.org/obo/CLO_0001577 denotes Å3
T102 540-542 http://purl.obolibrary.org/obo/CLO_0001577 denotes Å3
T103 554-555 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T104 590-591 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T105 652-659 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T106 687-692 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T107 708-710 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T108 856-857 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T109 992-994 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T110 1130-1131 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T111 1239-1243 http://purl.obolibrary.org/obo/UBERON_0000025 denotes tube
T112 1337-1338 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T113 1453-1454 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T114 1507-1508 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T115 1662-1664 http://purl.obolibrary.org/obo/CLO_0001577 denotes Å3
T116 1761-1762 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T117 1803-1804 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T118 1823-1824 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T119 2087-2088 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T120 2171-2172 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T121 2412-2417 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T122 2609-2612 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T123 2613-2614 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T124 2819-2822 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T125 2823-2824 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T126 2854-2855 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T127 3107-3114 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T128 3213-3214 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T129 3314-3315 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T130 3363-3368 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T131 3531-3532 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T132 3700-3702 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T133 3700-3702 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T134 3879-3881 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T135 3879-3881 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T136 3979-3980 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T137 4051-4052 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T138 4060-4062 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T139 4077-4079 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T140 4157-4158 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T141 4222-4241 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residues
T142 4222-4241 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residues
T143 4417-4418 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T144 4545-4546 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T145 4709-4710 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T146 4791-4793 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T147 4813-4815 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T148 5015-5034 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residues
T149 5015-5034 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residues
T150 5102-5104 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T151 5197-5198 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T152 5276-5277 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T153 5389-5390 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T154 5536-5537 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T155 5650-5651 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T156 5653-5654 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T157 5762-5763 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T158 5826-5827 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T159 5922-5923 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T160 5952-5953 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T161 6098-6099 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T162 6384-6385 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T163 6424-6426 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T164 6477-6480 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T165 6502-6503 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T166 6835-6841 http://purl.obolibrary.org/obo/UBERON_0002553 denotes cavity
T167 6985-6986 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T168 7142-7160 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residue
T169 7142-7160 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residue
T170 7192-7194 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T171 7357-7358 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T172 7370-7376 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T173 7377-7385 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T174 7418-7419 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T175 7427-7445 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residue
T176 7427-7445 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residue
T177 7534-7536 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T178 7735-7736 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T179 7867-7869 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T180 8222-8223 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T181 8333-8352 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residues
T182 8333-8352 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residues
T183 8505-8507 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T184 8608-8609 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T185 8912-8915 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T186 8986-8989 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T187 9179-9182 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T188 9183-9184 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T189 9223-9229 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T190 9235-9240 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T191 9289-9290 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T192 9390-9395 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T193 9418-9420 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T194 9469-9470 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T195 9611-9613 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T196 9737-9738 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T197 10061-10064 http://purl.obolibrary.org/obo/CLO_0001002 denotes 162
T198 10146-10151 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T199 10156-10162 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T200 10163-10170 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T201 10461-10462 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T202 10463-10468 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T203 10578-10579 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T204 10892-10897 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T205 11266-11271 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T206 11319-11325 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T207 11326-11334 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T208 11407-11408 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T209 11544-11545 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T210 11598-11599 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T211 11664-11665 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T212 12049-12054 http://purl.obolibrary.org/obo/CLO_0050605 denotes (d) 4
T213 12081-12082 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T214 12730-12731 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T215 12749-12750 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T216 12948-12949 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T217 12975-12976 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T218 13124-13125 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T219 13448-13453 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T220 13545-13550 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T221 13559-13565 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T222 13566-13574 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T223 13583-13588 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T224 13708-13710 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T225 13733-13738 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T226 13871-13872 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T227 13924-13928 http://purl.obolibrary.org/obo/UBERON_0000033 denotes head
T228 13924-13928 http://www.ebi.ac.uk/efo/EFO_0000964 denotes head
T229 14044-14049 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T230 14106-14107 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T231 14126-14141 http://purl.obolibrary.org/obo/GO_0043234 denotes protein complex
T232 14381-14383 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T233 14825-14830 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T234 14906-14911 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T235 15080-15084 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T236 15085-15093 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T156 43-46 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T157 51-66 Chemical denotes ganglioside GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048
T159 51-62 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T160 63-66 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_73110
T161 93-96 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T162 123-131 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T163 182-207 Chemical denotes nitrogen-containing group http://purl.obolibrary.org/obo/CHEBI_51144
T164 182-190 Chemical denotes nitrogen http://purl.obolibrary.org/obo/CHEBI_25555
T165 202-207 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T166 235-247 Chemical denotes acetyl group http://purl.obolibrary.org/obo/CHEBI_40574
T167 235-241 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_46887
T168 242-247 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T169 249-251 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T171 284-292 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T172 499-509 Chemical denotes saccharide http://purl.obolibrary.org/obo/CHEBI_16646
T173 518-533 Chemical denotes ganglioside GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048
T175 518-529 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T176 530-533 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_73110
T177 556-561 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T178 567-578 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T179 754-764 Chemical denotes saccharide http://purl.obolibrary.org/obo/CHEBI_16646
T180 773-776 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T183 781-784 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T184 858-865 Chemical denotes solvent http://purl.obolibrary.org/obo/CHEBI_46787
T185 1001-1004 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T186 1028-1038 Chemical denotes saccharide http://purl.obolibrary.org/obo/CHEBI_16646
T187 1047-1050 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T190 1073-1085 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T191 1087-1090 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T192 1113-1120 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T193 1133-1136 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T194 1184-1186 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T196 1206-1215 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T197 1266-1272 Chemical denotes carbon http://purl.obolibrary.org/obo/CHEBI_27594|http://purl.obolibrary.org/obo/CHEBI_33415
T199 1283-1291 Chemical denotes nitrogen http://purl.obolibrary.org/obo/CHEBI_25555
T200 1301-1307 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T201 1316-1324 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T202 1379-1382 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T203 1391-1401 Chemical denotes saccharide http://purl.obolibrary.org/obo/CHEBI_16646
T204 1410-1425 Chemical denotes ganglioside GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048
T206 1410-1421 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T207 1422-1425 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_73110
T208 1590-1593 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T209 1602-1612 Chemical denotes saccharide http://purl.obolibrary.org/obo/CHEBI_16646
T210 1621-1624 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T213 1740-1747 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T214 1870-1881 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T215 1974-1985 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T216 2070-2077 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T217 2089-2100 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T218 2163-2166 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T219 2174-2185 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T220 2386-2394 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T221 2430-2436 Chemical denotes corona http://purl.obolibrary.org/obo/CHEBI_37409
T222 2451-2459 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T223 2642-2653 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T224 2856-2867 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T225 3013-3024 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T226 3047-3058 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T227 3160-3171 Chemical denotes neurotoxins http://purl.obolibrary.org/obo/CHEBI_50910
T228 3222-3229 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T229 3399-3402 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T230 3447-3454 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T231 3460-3463 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T232 3464-3473 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T233 3512-3519 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T234 3585-3592 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T235 3666-3673 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T236 3700-3702 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T237 3842-3845 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T238 3879-3881 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T239 3911-3918 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T240 4009-4013 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T241 4060-4062 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T242 4077-4079 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T243 4152-4154 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T244 4222-4232 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T245 4222-4227 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T246 4228-4232 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T247 4791-4793 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T248 4896-4903 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T249 5015-5025 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T250 5015-5020 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T251 5021-5025 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T252 5172-5179 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T253 5191-5194 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T254 5217-5220 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T255 5262-5269 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T256 5425-5428 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T257 5455-5462 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T258 5636-5643 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T259 5895-5898 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T260 5971-5974 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T261 6071-6074 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T262 6088-6095 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T263 6112-6115 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T264 6129-6136 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T265 6149-6152 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T266 6183-6190 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T267 6260-6263 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T268 6264-6272 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T269 6387-6390 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T270 6410-6417 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T271 6424-6426 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T272 6552-6555 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T273 6616-6626 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T274 6616-6621 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T275 6622-6626 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T276 6670-6673 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T277 6770-6773 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T278 6810-6817 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T279 6864-6872 Chemical denotes Hydrogen http://purl.obolibrary.org/obo/CHEBI_18276
T280 6942-6945 Chemical denotes Gln http://purl.obolibrary.org/obo/CHEBI_30011
T281 6962-6965 Chemical denotes Ser http://purl.obolibrary.org/obo/CHEBI_17115|http://purl.obolibrary.org/obo/CHEBI_29999
T283 6987-6995 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T284 7023-7026 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T285 7080-7087 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T286 7088-7091 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T287 7102-7105 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T290 7142-7160 Chemical denotes amino acid residue http://purl.obolibrary.org/obo/CHEBI_33708
T291 7142-7152 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T292 7142-7147 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T293 7148-7152 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T294 7171-7173 Chemical denotes SD http://purl.obolibrary.org/obo/CHEBI_74807
T295 7192-7194 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T296 7273-7276 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T299 7318-7331 Chemical denotes sphingomyelin http://purl.obolibrary.org/obo/CHEBI_17636|http://purl.obolibrary.org/obo/CHEBI_64583
T301 7336-7347 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T302 7359-7364 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T303 7427-7445 Chemical denotes amino acid residue http://purl.obolibrary.org/obo/CHEBI_33708
T304 7427-7437 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T305 7427-7432 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T306 7433-7437 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T307 7568-7576 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T308 7647-7650 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T309 7651-7659 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T310 7693-7700 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T311 7719-7731 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T312 7737-7742 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T313 7822-7833 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T314 7840-7847 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T315 7867-7869 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T316 7902-7905 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T319 7906-7918 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T320 7946-7952 Chemical denotes lipids http://purl.obolibrary.org/obo/CHEBI_18059
T321 7959-7972 Chemical denotes sphingomyelin http://purl.obolibrary.org/obo/CHEBI_17636|http://purl.obolibrary.org/obo/CHEBI_64583
T323 7977-7988 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T324 8089-8101 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T325 8116-8127 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T326 8132-8145 Chemical denotes sphingomyelin http://purl.obolibrary.org/obo/CHEBI_17636|http://purl.obolibrary.org/obo/CHEBI_64583
T328 8195-8198 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T331 8266-8273 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T332 8333-8343 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T333 8333-8338 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T334 8339-8343 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T335 8366-8373 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T336 8395-8398 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T337 8456-8459 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T340 8475-8480 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T341 8583-8595 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T342 8617-8628 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T343 8629-8632 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T344 9418-9420 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T345 9436-9439 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T348 9446-9453 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T349 9471-9476 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T350 9494-9497 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T353 9498-9510 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T354 9534-9545 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T355 9547-9551 Chemical denotes chol http://purl.obolibrary.org/obo/CHEBI_16113
T356 9561-9574 Chemical denotes sphingomyelin http://purl.obolibrary.org/obo/CHEBI_17636|http://purl.obolibrary.org/obo/CHEBI_64583
T358 9576-9578 Chemical denotes SM http://purl.obolibrary.org/obo/CHEBI_17076|http://purl.obolibrary.org/obo/CHEBI_74817|http://purl.obolibrary.org/obo/CHEBI_17636
T361 9580-9586 Chemical denotes lipids http://purl.obolibrary.org/obo/CHEBI_18059
T362 9611-9613 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T363 9697-9708 Chemical denotes Cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T364 9713-9726 Chemical denotes sphingomyelin http://purl.obolibrary.org/obo/CHEBI_17636|http://purl.obolibrary.org/obo/CHEBI_64583
T366 9748-9751 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T369 9784-9791 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T370 9800-9810 Chemical denotes Amino acid http://purl.obolibrary.org/obo/CHEBI_33704
T371 9806-9810 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T372 9838-9849 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T373 9850-9853 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T374 9893-9900 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T375 9912-9917 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T376 10118-10123 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T377 10233-10243 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T378 10233-10238 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T379 10239-10243 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T380 10557-10560 Chemical denotes PAM http://purl.obolibrary.org/obo/CHEBI_51135|http://purl.obolibrary.org/obo/CHEBI_60882
T382 10673-10676 Chemical denotes PAM http://purl.obolibrary.org/obo/CHEBI_51135|http://purl.obolibrary.org/obo/CHEBI_60882
T384 10708-10717 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T385 10729-10732 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T386 10823-10826 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T387 10981-10988 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T388 11019-11031 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T389 11141-11144 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T390 11149-11161 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T391 11197-11204 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T392 11257-11260 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T393 11294-11306 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T394 11456-11465 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T395 11476-11479 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T396 11495-11498 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T397 11547-11550 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T398 11581-11588 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T399 11601-11612 Chemical denotes Ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T400 11647-11650 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T403 11651-11660 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T404 11724-11729 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T405 11774-11781 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T406 11805-11808 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T407 11813-11825 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T408 11861-11864 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T409 11874-11885 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T410 11918-11925 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T411 11956-11968 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T412 12062-12071 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T413 12083-12094 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T414 12107-12110 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T417 12111-12119 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T418 12145-12154 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T419 12205-12215 Chemical denotes saccharide http://purl.obolibrary.org/obo/CHEBI_16646
T420 12265-12272 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T421 12290-12293 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T424 12309-12320 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T425 12416-12423 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T426 12441-12444 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T427 12567-12570 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T428 12575-12578 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T431 12703-12706 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T434 12773-12776 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T437 12792-12801 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T438 12871-12874 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T439 12912-12918 Chemical denotes lipids http://purl.obolibrary.org/obo/CHEBI_18059
T440 12977-12988 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T441 13042-13051 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T442 13150-13159 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T443 13222-13232 Chemical denotes saccharide http://purl.obolibrary.org/obo/CHEBI_16646
T444 13241-13244 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T447 13279-13290 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T448 13332-13343 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T449 13432-13435 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T450 13454-13465 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T451 13632-13641 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T452 13745-13752 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T453 13809-13820 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T454 14007-14010 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T455 14056-14063 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T456 14126-14133 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T457 14155-14158 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T460 14191-14194 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T461 14218-14225 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T462 14242-14245 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T463 14301-14304 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T466 14543-14550 Chemical denotes alanine http://purl.obolibrary.org/obo/CHEBI_16449
T467 14583-14586 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T468 14705-14708 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T469 14806-14811 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T470 14864-14867 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T473 14889-14892 Chemical denotes ATM http://purl.obolibrary.org/obo/CHEBI_2955
T474 14976-14987 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T475 15007-15012 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T476 15032-15042 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3 625-636 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T4 3347-3362 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into host

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T10 63-66 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T11 530-533 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T12 773-776 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T13 1047-1050 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T14 1422-1425 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T15 1621-1624 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T16 7102-7105 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T17 7273-7276 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T18 7902-7905 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T19 8195-8198 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T20 8456-8459 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T21 9436-9439 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T22 9494-9497 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T23 9748-9751 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T24 11647-11650 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T25 12107-12110 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T26 12290-12293 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T27 12575-12578 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T28 12703-12706 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T29 12773-12776 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T30 13241-13244 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T31 14155-14158 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T32 14301-14304 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T33 14864-14867 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T74 0-10 Sentence denotes 3 Results
T75 12-66 Sentence denotes 3.1 Molecular mimicry between ATM and ganglioside GM1
T76 67-118 Sentence denotes The chemical structure of ATM is shown in Fig. 1 a.
T77 119-257 Sentence denotes The molecule contains two sugar-like pyranyl rings, one with a nitrogen-containing group (N-pyr), the other with an acetyl group (Ac-pyr).
T78 258-437 Sentence denotes The remaining part of the molecule is cyclic, so that its overall conformational flexibility, although significant, is restricted to a limited spatial volume of 2082 Å3 (Fig. 1b).
T79 438-712 Sentence denotes Interestingly, this volume is almost the same as that of the saccharide part of ganglioside GM1 (2293 Å3, Fig. 1b), a lipid raft ganglioside that plays a critical role in the binding and endocytosis of respiratory viruses [26], including pathogenic human coronaviruses [27].
T80 713-932 Sentence denotes Beyond their similar spatial volume, the saccharide part of GM1 and ATM also share some analogous chemical features, including sugar rings and a solvent-accessible surface dotted with several CH and OH groups (Fig. 1b).
T81 933-1051 Sentence denotes This molecular similarity is further illustrated in Figure S1 where ATM is superimposed on the saccharide part of GM1.
T82 1052-1201 Sentence denotes Fig. 1 Structures of azithromycin (ATM) and SARS-CoV-2 spike protein trimer. (a) ATM, with both sugar-like pyranyl groups N-pyr and Ac-pyr indicated.
T83 1202-1426 Sentence denotes The molecules are shown in chemical, tube and sphere rendering (carbon in green, nitrogen in blue, oxygen in red, hydrogen in white). (b) Molecular structure similarity between ATM and the saccharide part of ganglioside GM1.
T84 1427-1566 Sentence denotes Both structures can adopt a globular shape the surface of which is covered with a patchwork of OH (arrows 1 and 2) and CH groups (arrow 3).
T85 1567-1846 Sentence denotes The volume occupied by ATM and the saccharide part of GM1 can be estimated to be 2082 and 2293 Å3, respectively. (c) front and above views of the trimeric spike, each spike protein subunit with a distinct surface colour (cyan for chain A, yellow for chain B, purple for chain C).
T86 1847-1969 Sentence denotes Atoms belonging to the ganglioside-binding domain of each subunit are visible underneath the slightly transparent surface.
T87 1970-2037 Sentence denotes The ganglioside-binding domains, the NTD and the RBD are indicated.
T88 2038-2238 Sentence denotes Given that the SARS-CoV-2 spike protein displays a ganglioside-binding site at the tip of its NTD [10], the possibility that ATM, as a “ganglioside mimic”, could also bind to this site was considered.
T89 2239-2343 Sentence denotes The structural features of the SARS-CoV-2 spike in the prefusion conformation [20] are shown in Fig. 1c.
T90 2344-2478 Sentence denotes It consists of three interdigitated spike proteins that provide the virus its typical corona-like shape in electron microscopy images.
T91 2479-2600 Sentence denotes In each subunit, the most distant part from the viral envelope is divided into two separate domains, the NTD and the RBD.
T92 2601-2780 Sentence denotes The NTD has a flat surface available for ganglioside binding [10], and this process is independent from the ACE-2 receptor recognition, which occurs at the tip of the RBD [11,20].
T93 2781-2896 Sentence denotes When seen from above, the viral spike has a typical triangle shape, with a ganglioside-binding domain at each apex.
T94 2897-3036 Sentence denotes Thus, the spike central area is devoted to ACE-2 binding, leaving three peripheric flat surface areas available for ganglioside attachment.
T95 3037-3177 Sentence denotes Such dual ganglioside/receptor binding is commonly used by pathogenic viruses such as HIV-1 [28], [29], [30] and bacterial neurotoxins [16].
T96 3178-3369 Sentence denotes By combining the high affinity for a single protein receptor with multiple low affinity attachment sites, these pathogens have selected a very efficient pathway to gain entry into host cells.
T97 3371-3454 Sentence denotes 3.2 Characterization of an ATM binding site at the tip of SARS-CoV-2 spike protein
T98 3455-3603 Sentence denotes When ATM molecules were merged with the SARS-CoV-2 spike protein, there was a very good fit for one particular pose at the tip of protein (Fig. 2 ).
T99 3604-3755 Sentence denotes All other docking attempts on the NTD or the RBD of the spike protein were unsuccessful (Figure S2) as they did not satisfy the minimum cut-off values.
T100 3756-3828 Sentence denotes Not surprisingly, their trajectories started destabilizing before 10 ns.
T101 3829-3963 Sentence denotes In contrast, ATM #1 (coloured in yellow in Figure S2) remained bound to the spike protein throughout the simulation process (Fig. 3 ).
T102 3964-4156 Sentence denotes Interestingly, a significant movement of the drug was observed from its docked pose to a stable MD pose (dock-to-MD transition), particularly during the first 10-ns of simulations (Figure S3).
T103 4157-4215 Sentence denotes A stable complex association was then reached after 10 ns.
T104 4216-4386 Sentence denotes Three amino acid residues, referred to as the “QFN triad”, exhibited significant conformational rearrangement during the binding process: Q-134, F-135 and N-137 (Fig. 3).
T105 4387-4594 Sentence denotes The principal moves comprised a significant reorientation of the aromatic ring of F-135, from suboptimal stacking to stabilized T-shape CH-π interaction, and a concomitant retraction of the Q-134 side chain.
T106 4595-4817 Sentence denotes Fluctuations during the 10 to 50 ns period did not affect the overall geometry of the complex, which converged to a mean energy of interaction of 92.4 ± 5.8 kJ.mol−1 as determined from triplicate MD simulations (Table S1).
T107 4818-5002 Sentence denotes Schematically, the binding site is formed by two discontinuous regions of the protein, including the QFN triad with additional C-136, D-138, R-158 and S-161 residues (Fig. 4, Fig. 5 ).
T108 5003-5117 Sentence denotes These seven amino acid residues accounted for almost 90% of the whole energy of interaction (Table S1 and Fig. 5).
T109 5118-5357 Sentence denotes Fig. 2 Molecular complex between the SARS-CoV-2 spike protein trimer and ATM. (a) Detailed view of ATM bound to the NTD tip of SARS-CoV-2 spike protein chain A, shown at two distinct magnifications and orientations (left and right panels).
T110 5358-5450 Sentence denotes Note that the NTD tip displays a complementary landing surface for ATM (highlighted in red).
T111 5451-5703 Sentence denotes The protein stretch 134-138, which contains the QFN triad, is highlighted in green. (b) The trimeric structure of the SARS-CoV-2 spike is represented in surface rendition with subunit (protein chain A, B and C) in cyan, yellow and purple, respectively.
T112 5704-5785 Sentence denotes AMT (in red) is bound to the tip of the NTD domain of the A subunit (left panel).
T113 5786-5907 Sentence denotes The ribbon structure of the cyan (chain A) subunit is shown in the right panel. (c) Above views of the spike-ATM complex.
T114 5908-6003 Sentence denotes Note that the B and C subunits also display a fully accessible ATM binding site (red asterisk).
T115 6004-6148 Sentence denotes Fig. 3 Induced-fit conformational rearrangements during binding of ATM on the spike protein. (a) Docking of ATM on the spike protein (time = 0).
T116 6149-6240 Sentence denotes ATM is in yellow spheres, and the protein segment 134-137 is in balls and sticks rendition.
T117 6241-6299 Sentence denotes Three parts of the ATM molecule are marked with asterisks.
T118 6300-6454 Sentence denotes The orientation of the side chains of residues 134-137 is shown under the complex. (b) ATM bound to the spike protein after MD simulations (time = 50 ns).
T119 6455-6534 Sentence denotes Note that the complex has evolved according to a typical induced-fit mechanism.
T120 6535-6598 Sentence denotes The asterisks on ATM help visualize its conformational changes.
T121 6599-6749 Sentence denotes Reorientation of amino acid side chains is also clearly visible in the ATM-spike complex and in the isolated 134-137 fragment shown under the complex.
T122 6750-6818 Sentence denotes Fig. 4 Schematic of ATM interaction at the tip of the spike protein.
T123 6819-6863 Sentence denotes Residues lining cavity under 3.5Å are shown.
T124 6864-6924 Sentence denotes Hydrogen bonds and CH-π stacking interactions are indicated.
T125 6925-7041 Sentence denotes Note that Q-134 (Gln-134) and S-161 (Ser-161) are linked by a hydrogen bond, which stabilizes the ATM-spike complex.
T126 7042-7116 Sentence denotes Fig. 5 Energy of interaction of spike protein-ATM and spike-GM1 complexes.
T127 7117-7257 Sentence denotes Results are expressed by amino acid residue as mean ± SD of three distinct MD simulations (50 ns) with the same starting docking conditions.
T128 7258-7393 Sentence denotes In the case of GM1, the simulations are done in presence of sphingomyelin and cholesterol to mimic a lipid raft plasma membrane domain.
T129 7394-7483 Sentence denotes Each bar corresponds to a single amino acid residue, as indicated in the horizontal axis.
T130 7484-7537 Sentence denotes Detailed values and statistics are shown in Table S1.
T131 7538-7669 Sentence denotes The complex was stabilized by hydrogen bonds, CH-π and van der Waals interactions distributed over the whole ATM molecule (Fig. 4).
T132 7671-7754 Sentence denotes 3.3 SARS-CoV-2 spike protein interactions with gangliosides in a lipid raft domain
T133 7755-7995 Sentence denotes Based on recent in-silico data that led to the characterization of ganglioside-spike protein interactions [10], MD simulations were performed with GM1 gangliosides surrounded by typical raft lipids, i.e. sphingomyelin and cholesterol (Figs.
T134 7996-8006 Sentence denotes 5 and 6 ).
T135 8007-8107 Sentence denotes These new data confirmed and extended our previous results obtained with isolated gangliosides [10].
T136 8108-8283 Sentence denotes Indeed, cholesterol and sphingomyelin appeared to stabilize the typical chalice-shaped GM1 dimer, which serves as a landing platform for the SARS-CoV-2 spike protein (Fig. 6).
T137 8284-8520 Sentence denotes Moreover, the histograms of Fig. 5 show that all amino acid residues of the spike protein that are involved in ATM binding, including the QFN triad, are also essential for GM1 binding in the lipid raft environment (Table S1 and Fig. 5).
T138 8521-8688 Sentence denotes Taken together, these data indicate that the NTD of the viral glycoprotein may display a common ganglioside/ATM binding site, in agreement with our working hypothesis.
T139 8689-8887 Sentence denotes Sequence alignments revealed that this common binding site, including the QFN triad, is totally conserved among clinical isolates of SARS-CoV-2 from various geographical origins worldwide (Fig. 7 ).
T140 8888-9070 Sentence denotes It is also conserved in bat RaTG13, which further illustrates the close relationship between this bat coronavirus and the SARS-CoV-2 strains that are currently circulating the world.
T141 9071-9159 Sentence denotes This region of the NTD should therefore be considered for SARS-CoV-2 vaccine strategies.
T142 9160-9410 Sentence denotes However, the motif has a different sequence signature in other animal- and human-related SARS coronaviruses (Fig. 7), indicating a recent evolution that may be linked to the higher contagiousness of SARS-CoV-2 compared with other human coronaviruses.
T143 9411-9489 Sentence denotes Fig. 6 MD simulations of GM1-spike protein interaction in a lipid raft domain.
T144 9490-9587 Sentence denotes Two GM1 gangliosides were merged with eight cholesterol (chol) and two sphingomyelin (SM) lipids.
T145 9588-9651 Sentence denotes After initial docking, MD simulations were performed for 50 ns.
T146 9652-9696 Sentence denotes Two distinct views of the complex are shown.
T147 9697-9792 Sentence denotes Cholesterol and sphingomyelin stabilize a dimer of GM1 clamped by the NTD of the spike protein.
T148 9793-9901 Sentence denotes Fig. 7 Amino acid sequence alignments of the ganglioside/ATM binding domain of the SARS-CoV-2 spike protein.
T149 9902-10066 Sentence denotes The first group of sequences includes clinical SARS-CoV-2 isolates from various geographical origins aligned with the reference sequence (6VSB_A, fragment 111-162).
T150 10067-10106 Sentence denotes The QFN triad is highlighted in yellow.
T151 10107-10196 Sentence denotes The second group of sequences includes human and animal viruses compared with SARS-CoV-2.
T152 10197-10339 Sentence denotes Deletions are highlighted in green, amino acid changes are highlighted in blue, conserved residues of the QFN triad are highlighted in yellow.
T153 10340-10689 Sentence denotes The degree of conservation observed in each column is symbolized by an asterisk (*) when the residue is fully conserved, a colon (:) for distinct residues with strongly similar properties (scoring > 0.5 in the Gonnet PAM 250 matrix), and a period (.) for distinct residues with weakly similar properties (scoring ≤ 0.5 in the Gonnet PAM 250 matrix).
T154 10691-10743 Sentence denotes 3.4 Synergistic antiviral effects of ATM and CLQ-OH
T155 10744-11032 Sentence denotes Overall, these molecular modelling studies are consistent with the notion that ATM might inhibit SARS-CoV-2 infection through direct binding to the virus spike and subsequent neutralization of the infection process, which requires spike protein recognition and attachment to gangliosides.
T156 11033-11084 Sentence denotes This mechanism of action is illustrated in Fig. 8 .
T157 11085-11114 Sentence denotes Comparing the models in Figs.
T158 11115-11231 Sentence denotes 8a and 8b shows that both ATM and gangliosides bind to the same site of the spike protein, centred on the QFN triad.
T159 11232-11345 Sentence denotes Thus, in the presence of ATM, the virus spike would not reach gangliosides on the host plasma membrane (Fig. 8c).
T160 11346-11480 Sentence denotes To the best of our knowledge, it is the first time that such a mechanism of action is proposed to explain the antiviral effect of ATM.
T161 11481-11789 Sentence denotes Fig. 8 CLQ-OH/ATM combination therapy at the molecular level. (a) ATM bound to the SARS-CoV-2 spike protein trimer. (b) Ganglioside dimer (two symmetrically arranged GM1 molecules in a typical chalice-like shape, just like the one observed in lipid raft simulations) bound to SARS-CoV-2 spike protein trimer.
T162 11790-11933 Sentence denotes Note that both ATM and gangliosides share the same binding region. (c) ATM prevents ganglioside binding to the SARS-CoV-2 spike protein trimer.
T163 11934-12101 Sentence denotes CLQ-OH, once bound to gangliosides (blue and orange surfaces), also prevents any interaction with the viral spike. (d) 4 CLQ-OH molecules bound to a ganglioside dimer.
T164 12102-12294 Sentence denotes Each GM1 molecule is blocked by two CLQ-OH molecules (blue and orange surfaces), which wrap around the saccharide part. (e) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to GM1.
T165 12295-12445 Sentence denotes Note that the ganglioside interacts with Q-134 and F-135, but not with D-138. (f) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to ATM.
T166 12446-12523 Sentence denotes In this case, the binding site includes D-138 in addition to Q-134 and F-135.
T167 12524-12644 Sentence denotes Note that N-137, which interacts with both ATM and GM1, is not visible in these representations as it is located behind.
T168 12645-12707 Sentence denotes This study also looked at CLQ-OH and its interaction with GM1.
T169 12708-12807 Sentence denotes We recently published a model describing a complex formed by one GM1 and two CLQ-OH molecules [10].
T170 12808-12947 Sentence denotes For comparison, the same molecular modelling approaches as for ATM (in the presence of surrounding raft lipids) were applied to this model.
T171 12948-13076 Sentence denotes A stable complex formed by a ganglioside dimer, each monomer being associated with two CLQ-OH molecules, was obtained (Fig. 8d).
T172 13077-13245 Sentence denotes The stability of this complex is reinforced by a rearrangement of CLQ-OH molecules that interact with each other as well as interacting with the saccharide part of GM1.
T173 13246-13407 Sentence denotes Consequently, the surface of the ganglioside is almost completely masked, so that the ganglioside dimer can no longer be recognized by the viral spike (Fig. 8c).
T174 13408-13589 Sentence denotes In the presence of both ATM and CLQ-OH, virus-ganglioside interactions are efficiently blocked, preventing any close contact between the virus and the plasma membrane of host cells.
T175 13590-13670 Sentence denotes The molecular details of this synergistic antiviral effect are worth mentioning.
T176 13671-13688 Sentence denotes As shown in Figs.
T177 13689-13827 Sentence denotes 5 and 8e and Table S1, the QFN triad of the virus spike protein is predicted to interact with the central region of the ganglioside dimer.
T178 13828-13947 Sentence denotes If the dimer is compared metaphorically to a butterfly, this region corresponds to the insect's head between the wings.
T179 13948-14074 Sentence denotes For its part, CLQ-OH binds to the wings (Fig. 8d), whereas ATM neutralizes the QFN triad of the virus spike protein (Fig. 8f).
T180 14075-14226 Sentence denotes Indeed, all attempts to obtain a stable raft-spike protein complex aborted when GM1 was covered by CLMQ-OH and when ATM was bound to the spike protein.
T181 14227-14483 Sentence denotes In the case of ATM, these data confirm that the QFN triad is critical for GM1 recognition and that although other residues are involved (Fig. 5 and Table S1), the whole binding process is fully controlled by the primary interaction driven by the QFN triad.
T182 14484-14629 Sentence denotes In agreement with this notion, mutating the QFN triad with alanine residues resulted in an aborted ATM binding process at the post-docking steps.
T183 14630-14994 Sentence denotes Taken together, these molecular modelling studies indicate that CLQ-OH and ATM, when bound to their respective targets, totally mask the complementary surfaces provided by the lipid raft and the virus spike (Fig. 8c): CLQ-OH binds to GM1 and covers the wing, ATM binds to the virus spike and prevents any interaction with the central area of the ganglioside dimer.
T184 14995-15094 Sentence denotes Hence, both drugs act as competitive inhibitors of SARS-CoV-2 attachment to the host-cell membrane.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
275 51-66 Chemical denotes ganglioside GM1 MESH:D005677
294 1526-1540 Gene denotes arrows 1 and 2
295 1734-1739 Gene denotes spike Gene:43740568
296 1722-1727 Gene denotes spike Gene:43740568
297 1107-1112 Gene denotes spike Gene:43740568
298 1096-1106 Species denotes SARS-CoV-2 Tax:2697049
299 1073-1085 Chemical denotes azithromycin MESH:D017963
300 1174-1179 Chemical denotes N-pyr MESH:D009242
301 1184-1190 Chemical denotes Ac-pyr
302 1266-1272 Chemical denotes carbon MESH:D002244
303 1283-1291 Chemical denotes nitrogen MESH:D009584
304 1301-1307 Chemical denotes oxygen MESH:D010100
305 1316-1324 Chemical denotes hydrogen MESH:D006859
306 1391-1401 Chemical denotes saccharide MESH:D002241
307 1410-1421 Chemical denotes ganglioside MESH:D005732
308 1422-1425 Chemical denotes GM1 MESH:D005677
309 1621-1624 Chemical denotes GM1 MESH:D005677
310 1870-1881 Chemical denotes ganglioside MESH:D005732
311 1974-1985 Chemical denotes ganglioside MESH:D005732
323 687-692 Species denotes human Tax:9606
324 693-706 Species denotes coronaviruses Tax:11118
325 182-190 Chemical denotes nitrogen MESH:D009584
326 209-214 Chemical denotes N-pyr MESH:D009242
327 249-255 Chemical denotes Ac-pyr
328 499-509 Chemical denotes saccharide MESH:D002241
329 518-533 Chemical denotes ganglioside GM1 MESH:D005677
330 556-561 Chemical denotes lipid MESH:D008055
331 567-578 Chemical denotes ganglioside MESH:D005732
332 773-776 Chemical denotes GM1 MESH:D005677
333 1047-1050 Chemical denotes GM1 MESH:D005677
350 2064-2069 Gene denotes spike Gene:43740568
351 2709-2714 Gene denotes ACE-2 Gene:59272
352 2940-2945 Gene denotes ACE-2 Gene:59272
353 2907-2912 Gene denotes spike Gene:43740568
354 2813-2818 Gene denotes spike Gene:43740568
355 2380-2385 Gene denotes spike Gene:43740568
356 2281-2286 Gene denotes spike Gene:43740568
357 2053-2063 Species denotes SARS-CoV-2 Tax:2697049
358 2270-2280 Species denotes SARS-CoV-2 Tax:2697049
359 2089-2100 Chemical denotes ganglioside MESH:D005732
360 2174-2185 Chemical denotes ganglioside MESH:D005732
361 2642-2653 Chemical denotes ganglioside MESH:D005732
362 2856-2867 Chemical denotes ganglioside MESH:D005732
363 3047-3058 Chemical denotes ganglioside MESH:D005732
364 3013-3035 Disease denotes ganglioside attachment MESH:D005733
365 3123-3171 Disease denotes HIV-1 [28], [29], [30] and bacterial neurotoxins MESH:D016920
368 3441-3446 Gene denotes spike Gene:43740568
369 3430-3440 Species denotes SARS-CoV-2 Tax:2697049
379 5256-5261 Gene denotes spike Gene:43740568
380 5889-5894 Gene denotes spike Gene:43740568
381 5166-5171 Gene denotes spike Gene:43740568
382 5922-5929 Gene denotes B and C
383 5580-5585 Gene denotes spike Gene:43740568
384 5653-5660 Gene denotes B and C
385 5155-5165 Species denotes SARS-CoV-2 Tax:2697049
386 5245-5255 Species denotes SARS-CoV-2 Tax:2697049
387 5569-5579 Species denotes SARS-CoV-2 Tax:2697049
392 6082-6087 Gene denotes spike Gene:43740568
393 6123-6128 Gene denotes spike Gene:43740568
394 6404-6409 Gene denotes spike Gene:43740568
395 6674-6679 Gene denotes spike Gene:43740568
402 6804-6809 Gene denotes spike Gene:43740568
403 7027-7032 Gene denotes spike Gene:43740568
404 6864-6872 Chemical denotes Hydrogen MESH:D006859
405 6942-6945 Chemical denotes Gln MESH:D005973
406 6962-6965 Chemical denotes Ser MESH:D012694
407 6987-6995 Chemical denotes hydrogen MESH:D006859
414 7074-7079 Gene denotes spike Gene:43740568
415 7096-7101 Gene denotes spike Gene:43740568
416 7273-7276 Chemical denotes GM1 MESH:D005677
417 7318-7331 Chemical denotes sphingomyelin MESH:D013109
418 7336-7347 Chemical denotes cholesterol MESH:D002784
419 7359-7364 Chemical denotes lipid MESH:D008055
427 3506-3511 Gene denotes spike Gene:43740568
428 3660-3665 Gene denotes spike Gene:43740568
429 3905-3910 Gene denotes spike Gene:43740568
430 3495-3505 Species denotes SARS-CoV-2 Tax:2697049
431 4263-4266 Chemical denotes QFN
432 4371-4372 Chemical denotes N MESH:D009584
433 4945-4946 Chemical denotes C MESH:D002244
435 7568-7576 Chemical denotes hydrogen MESH:D006859
440 7687-7692 Gene denotes spike Gene:43740568
441 7676-7686 Species denotes SARS-CoV-2 Tax:2697049
442 7719-7731 Chemical denotes gangliosides MESH:D005732
443 7737-7742 Chemical denotes lipid MESH:D008055
457 9778-9783 Gene denotes spike Gene:43740568
458 9436-9439 Chemical denotes GM1 MESH:D005677
459 9471-9476 Chemical denotes lipid MESH:D008055
460 9494-9497 Chemical denotes GM1 MESH:D005677
461 9498-9510 Chemical denotes gangliosides MESH:D005732
462 9534-9545 Chemical denotes cholesterol MESH:D002784
463 9547-9551 Chemical denotes chol MESH:D002784
464 9561-9574 Chemical denotes sphingomyelin MESH:D013109
465 9576-9578 Chemical denotes SM MESH:D013109
466 9580-9586 Chemical denotes lipids MESH:D008055
467 9697-9708 Chemical denotes Cholesterol MESH:D002784
468 9713-9726 Chemical denotes sphingomyelin MESH:D013109
469 9748-9751 Chemical denotes GM1 MESH:D005677
477 9887-9892 Gene denotes spike Gene:43740568
478 9876-9886 Species denotes SARS-CoV-2 Tax:2697049
479 9949-9959 Species denotes SARS-CoV-2 Tax:2697049
480 10146-10151 Species denotes human Tax:9606
481 10185-10195 Species denotes SARS-CoV-2 Tax:2697049
482 9838-9849 Chemical denotes ganglioside MESH:D005732
483 10303-10306 Chemical denotes QFN
510 8260-8265 Gene denotes spike Gene:43740568
511 8360-8365 Gene denotes spike Gene:43740568
512 7834-7839 Gene denotes spike Gene:43740568
513 8249-8259 Species denotes SARS-CoV-2 Tax:2697049
514 8822-8832 Species denotes SARS-CoV-2 Tax:2697049
515 8986-9001 Species denotes bat coronavirus Tax:1508220
516 9010-9020 Species denotes SARS-CoV-2 Tax:2697049
517 9129-9139 Species denotes SARS-CoV-2 Tax:2697049
518 9235-9240 Species denotes human Tax:9606
519 9249-9267 Species denotes SARS coronaviruses Tax:694009
520 9359-9369 Species denotes SARS-CoV-2 Tax:2697049
521 9390-9395 Species denotes human Tax:9606
522 9396-9409 Species denotes coronaviruses Tax:11118
523 7822-7833 Chemical denotes ganglioside MESH:D005732
524 7902-7918 Chemical denotes GM1 gangliosides MESH:D005677
525 7946-7952 Chemical denotes lipids MESH:D008055
526 7959-7972 Chemical denotes sphingomyelin MESH:D013109
527 7977-7988 Chemical denotes cholesterol MESH:D002784
528 8089-8101 Chemical denotes gangliosides MESH:D005732
529 8116-8127 Chemical denotes cholesterol MESH:D002784
530 8132-8145 Chemical denotes sphingomyelin MESH:D013109
531 8195-8198 Chemical denotes GM1 MESH:D005677
532 8456-8459 Chemical denotes GM1 MESH:D005677
533 8475-8480 Chemical denotes lipid MESH:D008055
534 8617-8628 Chemical denotes ganglioside MESH:D005732
535 8629-8632 Chemical denotes ATM MESH:D017963
537 10737-10743 Chemical denotes CLQ-OH
567 12410-12415 Gene denotes spike Gene:43740568
568 12259-12264 Gene denotes spike Gene:43740568
569 12042-12047 Gene denotes spike Gene:43740568
570 11912-11917 Gene denotes spike Gene:43740568
571 11768-11773 Gene denotes spike Gene:43740568
572 11575-11580 Gene denotes spike Gene:43740568
573 11564-11574 Species denotes SARS-CoV-2 Tax:2697049
574 11757-11767 Species denotes SARS-CoV-2 Tax:2697049
575 11901-11911 Species denotes SARS-CoV-2 Tax:2697049
576 12248-12258 Species denotes SARS-CoV-2 Tax:2697049
577 12399-12409 Species denotes SARS-CoV-2 Tax:2697049
578 11488-11494 Chemical denotes CLQ-OH
579 11601-11612 Chemical denotes Ganglioside MESH:D005732
580 11647-11650 Chemical denotes GM1 MESH:D005677
581 11724-11729 Chemical denotes lipid MESH:D008055
582 11813-11825 Chemical denotes gangliosides MESH:D005732
583 11874-11885 Chemical denotes ganglioside MESH:D005732
584 11934-11940 Chemical denotes CLQ-OH
585 11956-11968 Chemical denotes gangliosides MESH:D005732
586 12055-12061 Chemical denotes CLQ-OH
587 12083-12094 Chemical denotes ganglioside MESH:D005732
588 12107-12110 Chemical denotes GM1 MESH:D005677
589 12138-12144 Chemical denotes CLQ-OH
590 12290-12293 Chemical denotes GM1 MESH:D005677
591 12309-12320 Chemical denotes ganglioside MESH:D005732
592 12486-12491 Chemical denotes D-138
593 12507-12512 Chemical denotes Q-134
594 12534-12539 Chemical denotes N-137 MESH:C022084
595 12575-12578 Chemical denotes GM1 MESH:D005677
605 11191-11196 Gene denotes spike Gene:43740568
606 11272-11277 Gene denotes spike Gene:43740568
607 10898-10903 Gene denotes spike Gene:43740568
608 10975-10980 Gene denotes spike Gene:43740568
609 11019-11031 Chemical denotes gangliosides MESH:D005732
610 11149-11161 Chemical denotes gangliosides MESH:D005732
611 11294-11306 Chemical denotes gangliosides MESH:D005732
612 10841-10861 Disease denotes SARS-CoV-2 infection MESH:C000657245
613 10941-10950 Disease denotes infection MESH:D007239
647 13739-13744 Gene denotes spike Gene:43740568
648 14050-14055 Gene denotes spike Gene:43740568
649 14212-14217 Gene denotes spike Gene:43740568
650 14912-14917 Gene denotes spike Gene:43740568
651 14831-14836 Gene denotes spike Gene:43740568
652 14120-14125 Gene denotes spike Gene:43740568
653 13391-13396 Gene denotes spike Gene:43740568
654 15046-15056 Species denotes SARS-CoV-2 Tax:2697049
655 12671-12677 Chemical denotes CLQ-OH
656 12703-12706 Chemical denotes GM1 MESH:D005677
657 12773-12776 Chemical denotes GM1 MESH:D005677
658 12785-12791 Chemical denotes CLQ-OH
659 12912-12918 Chemical denotes lipids MESH:D008055
660 12977-12988 Chemical denotes ganglioside MESH:D005732
661 13035-13041 Chemical denotes CLQ-OH
662 13143-13149 Chemical denotes CLQ-OH
663 13241-13244 Chemical denotes GM1 MESH:D005677
664 13279-13290 Chemical denotes ganglioside MESH:D005732
665 13332-13343 Chemical denotes ganglioside MESH:D005732
666 13440-13446 Chemical denotes CLQ-OH
667 13454-13465 Chemical denotes ganglioside MESH:D005732
668 13809-13820 Chemical denotes ganglioside MESH:D005732
669 13962-13968 Chemical denotes CLQ-OH
670 14155-14158 Chemical denotes GM1 MESH:D005677
671 14174-14181 Chemical denotes CLMQ-OH
672 14275-14278 Chemical denotes QFN
673 14301-14304 Chemical denotes GM1 MESH:D005677
674 14543-14550 Chemical denotes alanine MESH:D000409
675 14694-14700 Chemical denotes CLQ-OH
676 14806-14811 Chemical denotes lipid MESH:D008055
677 14848-14854 Chemical denotes CLQ-OH
678 14864-14867 Chemical denotes GM1 MESH:D005677
679 14976-14987 Chemical denotes ganglioside MESH:D005732

2_test

Id Subject Object Predicate Lexical cue
32405156-18279660-48151022 708-710 18279660 denotes 27
32405156-32075877-48151023 2318-2320 32075877 denotes 20
32405156-32132184-48151024 2773-2775 32132184 denotes 11
32405156-32075877-48151025 2776-2778 32075877 denotes 20
32405156-31431523-48151026 3173-3175 31431523 denotes 16
T61528 708-710 18279660 denotes 27
T54896 2318-2320 32075877 denotes 20
T86066 2773-2775 32132184 denotes 11
T70176 2776-2778 32075877 denotes 20
T42537 3173-3175 31431523 denotes 16