PMC:7216762 / 10912-13244
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7216762","sourcedb":"PMC","sourceid":"7216762","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7216762","text":"Development of More Rapid Diagnostic Tools\nIt is apparent that quick and reliable tests for positivity to SARS-CoV-2 are of paramount importance for identifying infected individuals and breaking the contagion propagation chain. Current analysis methods rely on the amplification of viral genetic material isolated from the patient sample (generally a nasopharyngeal swab) that takes altogether 6 to 7 h. This takes into account the lengthy careful preparation of dangerous samples in a P3 facility followed by a pushed PCR protocol.\nAn Italian multinational company, DiaSorin, has developed a much quicker analytical solution that will allow for obtaining a viral positivity answer in 60 min.9 The company completed, in collaboration with the above-mentioned Spallanzani Institute and the S. Matteo Hospital in Pavia, all the necessary tests and obtained EU and FDA–EUA (Emergency Use Authorization) approval.10 The test was developed taking into account 150 viral sequences deposited in worldwide databases, in order to detect all the currently known variants and minimize false negative results. Compatibly with the necessary production scale-up, this represents a strong asset for the quick analysis of samples directly at POC (point of care).\nThe escalation of this pandemic found the world utterly unprepared to face it as a united front, as the situation would require for maximum contagion containment efficacy. Italy found itself instead as the unfortunate Western pioneer of this fight. As a country, we are still days (?) away from the peak, and we have already paid a steep price as it is.\nTo conclude on a more auspicious note, the Innovative Medicines Initiative (IMI), a big private–public partnership in the life sciences, launched their 21st call putting on the Table 45 M € for collaborative projects of public and private institutions to fight against COVID-19.11 They are looking for proposals that will develop antivirals and therapeutics for the current or future outbreaks or rapid diagnostic tools for the detection of asymptomatic carriers and symptomatic infected individuals.\nDespite the many scientific efforts described here and the titanic efforts of our doctors and nurses, the only truly effective “vaccine” we have available at the moment is social distancing, so #staysafe, #stayhome, 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