> top > docs > PMC:7216760 > spans > 1076-21515 > annotations

PMC:7216760 / 1076-21515 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 1120-1124 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T2 3737-3740 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T3 3774-3781 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T4 3792-3795 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T5 4051-4056 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T6 4102-4109 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T7 4219-4225 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T8 4288-4292 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T9 4386-4392 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T10 4422-4431 Body_part denotes cytoplasm http://purl.org/sig/ont/fma/fma66835
T11 4448-4452 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T12 4490-4494 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T13 4529-4550 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T14 4655-4661 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T15 4810-4816 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T16 4883-4887 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T17 4888-4895 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T18 4982-4990 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T19 5107-5128 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T20 5135-5146 Body_part denotes compartment http://purl.org/sig/ont/fma/fma76577
T21 5199-5211 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T22 5199-5203 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T23 5235-5240 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 5289-5294 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T25 5365-5381 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T26 5376-5381 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T27 5389-5401 Body_part denotes nasal cavity http://purl.org/sig/ont/fma/fma54378
T28 5715-5721 Body_part denotes sputum http://purl.org/sig/ont/fma/fma312401
T29 5961-5984 Body_part denotes lower respiratory tract http://purl.org/sig/ont/fma/fma45662
T30 6019-6023 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T31 6244-6248 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T32 6274-6280 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T33 6303-6307 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T34 6470-6478 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T35 6506-6514 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T36 6557-6570 Body_part denotes interleukin-6 http://purl.org/sig/ont/fma/fma264829
T37 6680-6685 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T38 6763-6770 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T39 6821-6829 Body_part denotes troponin http://purl.org/sig/ont/fma/fma62338
T40 6874-6880 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T41 6891-6896 Body_part denotes Chest http://purl.org/sig/ont/fma/fma9576
T42 7160-7164 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T43 7165-7170 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T44 7213-7218 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T45 7271-7276 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T46 7278-7284 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T47 7303-7307 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T48 7324-7329 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T49 7335-7339 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T50 7572-7576 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T51 7577-7583 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T52 8094-8112 Body_part denotes respiratory system http://purl.org/sig/ont/fma/fma7158
T53 8397-8404 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T54 8488-8493 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T55 8495-8502 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T56 8508-8516 Body_part denotes prostate http://purl.org/sig/ont/fma/fma9600
T57 8517-8523 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T58 8525-8529 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T59 8592-8597 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T60 8605-8624 Body_part denotes prostate epithelium http://purl.org/sig/ont/fma/fma66812
T61 8605-8613 Body_part denotes prostate http://purl.org/sig/ont/fma/fma9600
T62 8614-8624 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T63 8674-8683 Body_part denotes androgens http://purl.org/sig/ont/fma/fma83375
T64 8712-8721 Body_part denotes estrogens http://purl.org/sig/ont/fma/fma83376
T65 9252-9255 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T66 9272-9280 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T67 9371-9379 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T68 9456-9466 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T69 9483-9490 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T70 9574-9584 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T71 9587-9594 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T72 9663-9670 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T73 9693-9703 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T74 9706-9713 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T75 9774-9784 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T76 9798-9805 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T77 9825-9832 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T78 9893-9898 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T79 9938-9942 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T80 9951-9958 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T81 10001-10008 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T82 10042-10050 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T83 10147-10150 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T84 10161-10164 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T85 10317-10321 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T86 10384-10387 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T87 10437-10440 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T88 10457-10463 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T89 10770-10778 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T90 11122-11126 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T91 11154-11161 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T92 11577-11582 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T93 11667-11675 Body_part denotes Antibody http://purl.org/sig/ont/fma/fma62871
T94 11727-11734 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T95 11952-11955 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T96 11985-11993 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T97 12167-12175 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T98 12305-12309 Body_part denotes back http://purl.org/sig/ont/fma/fma25056
T99 12765-12768 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T100 12930-12939 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T101 13439-13442 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T102 13531-13538 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T103 14286-14299 Body_part denotes interleukin-6 http://purl.org/sig/ont/fma/fma264829
T104 14566-14577 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T105 15240-15248 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T106 15326-15334 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T107 15383-15388 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T108 16999-17008 Body_part denotes glutamine http://purl.org/sig/ont/fma/fma82752
T109 17324-17330 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T110 17388-17394 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T111 17809-17819 Body_part denotes microsomes http://purl.org/sig/ont/fma/fma67438
T112 17943-17947 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T113 18372-18374 Body_part denotes AG http://purl.org/sig/ont/fma/fma61898
T114 19418-19421 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T115 19724-19728 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T116 19729-19736 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 5389-5401 Body_part denotes nasal cavity http://purl.obolibrary.org/obo/UBERON_0001707
T2 5715-5721 Body_part denotes sputum http://purl.obolibrary.org/obo/UBERON_0007311
T3 5961-5984 Body_part denotes lower respiratory tract http://purl.obolibrary.org/obo/UBERON_0001558
T4 5967-5984 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T5 6019-6023 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T6 6244-6248 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 6274-6280 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T8 6680-6685 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T9 6874-6880 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T10 6891-6896 Body_part denotes Chest http://purl.obolibrary.org/obo/UBERON_0001443
T11 7160-7164 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T12 7271-7276 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T13 7278-7284 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T14 7324-7329 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T15 7572-7576 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T16 7577-7583 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T17 7663-7687 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T18 7689-7692 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T19 8094-8112 Body_part denotes respiratory system http://purl.obolibrary.org/obo/UBERON_0001004
T20 8517-8523 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T21 8605-8624 Body_part denotes prostate epithelium http://purl.obolibrary.org/obo/UBERON_0000428
T22 8614-8624 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T23 9833-9838 Body_part denotes shell http://purl.obolibrary.org/obo/UBERON_0006612
T24 11577-11582 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T25 11979-11984 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T26 17943-17947 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T27 19724-19728 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T10 57-104 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T11 57-90 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T12 106-114 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 150-159 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T14 262-286 Disease denotes coronavirus disease-2019 http://purl.obolibrary.org/obo/MONDO_0100096
T15 288-296 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T16 630-634 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T17 687-695 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 780-791 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T19 1069-1073 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T20 1085-1093 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T21 1363-1367 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T22 1401-1409 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T23 1771-1779 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T24 1904-1913 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T25 2077-2086 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T26 2113-2122 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T27 2124-2127 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T28 2240-2248 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T29 2876-2885 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T30 3019-3029 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T31 3322-3332 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T32 3478-3486 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 3552-3560 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T34 3620-3628 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 3664-3672 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 3863-3871 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T37 3876-3884 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 4033-4041 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T39 5329-5337 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T40 5338-5346 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T41 5468-5477 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T42 5608-5617 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T43 5671-5680 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T44 5967-5994 Disease denotes respiratory tract infection http://purl.obolibrary.org/obo/MONDO_0024355
T45 5985-5994 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T46 6072-6107 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T47 6078-6107 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T48 6109-6113 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T49 6179-6201 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T50 6203-6220 Disease denotes diabetes mellitus http://purl.obolibrary.org/obo/MONDO_0005015
T51 6222-6234 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T52 6244-6256 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T53 6258-6264 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T54 6266-6288 Disease denotes chronic kidney disease http://purl.obolibrary.org/obo/MONDO_0005300
T55 6274-6288 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T57 6294-6301 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T58 6328-6332 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T59 6404-6419 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T60 6410-6419 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T61 6497-6500 Disease denotes CRS http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361
T63 6649-6660 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T64 6868-6887 Disease denotes acute kidney injury http://purl.obolibrary.org/obo/MONDO_0002492
T65 6881-6887 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T66 6923-6931 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T67 6990-7005 Disease denotes viral pneumonia http://purl.obolibrary.org/obo/MONDO_0006012
T68 6996-7005 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T69 7119-7127 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T70 7501-7519 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T71 7510-7519 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T72 7950-7953 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T73 8157-8169 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T74 8325-8333 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 9054-9062 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T76 9235-9243 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T77 10446-10454 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T78 10751-10759 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T79 10790-10805 Disease denotes Viral Infection http://purl.obolibrary.org/obo/MONDO_0005108
T80 10796-10805 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T81 10828-10836 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T82 11079-11087 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T83 11244-11252 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T84 11328-11336 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T85 11546-11554 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T86 11902-11910 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T87 12125-12133 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T88 12372-12380 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T89 12556-12564 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T90 12639-12647 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T91 12836-12844 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T92 13101-13110 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T93 13177-13196 Disease denotes Ebola virus disease http://purl.obolibrary.org/obo/MONDO_0005737
T94 13235-13243 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T95 13305-13313 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T96 13712-13724 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T97 14044-14052 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T98 14369-14377 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T99 14708-14716 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T100 16395-16403 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T101 17164-17172 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 17518-17526 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T103 17535-17543 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T104 17710-17718 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T105 18316-18324 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T106 18820-18828 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T107 18901-18909 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T108 19112-19116 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T109 19128-19136 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T110 19919-19927 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T111 20427-20435 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T8 36-37 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 182-185 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T10 241-246 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T11 247-250 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T12 311-313 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T13 333-334 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 371-383 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T15 425-430 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T16 669-674 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T17 821-826 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T18 831-837 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T19 877-884 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T20 900-901 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 932-937 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T22 1026-1031 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T23 1120-1124 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T24 1168-1172 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T25 1216-1223 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T26 1293-1294 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T27 1302-1303 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 1370-1371 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 1372-1377 http://purl.obolibrary.org/obo/NCBITaxon_9837 denotes camel
T30 1389-1390 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 1452-1456 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes Bats
T32 1703-1706 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T33 1866-1867 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T34 2235-2237 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T35 2692-2693 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 2724-2725 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 2821-2826 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T38 3273-3278 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T39 3633-3638 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T40 3741-3746 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T41 3751-3754 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T42 3796-3803 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T43 3844-3846 http://purl.obolibrary.org/obo/CLO_0007074 denotes kb
T44 3844-3846 http://purl.obolibrary.org/obo/CLO_0051988 denotes kb
T45 3996-4001 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T46 4051-4056 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T47 4288-4292 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T48 4321-4329 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T49 4448-4452 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T50 4490-4494 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T51 4500-4505 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T52 4575-4583 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T53 4722-4723 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54 4883-4887 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T55 5030-5032 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T56 5199-5203 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T57 5235-5240 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T58 5289-5294 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T59 5365-5375 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T60 5376-5381 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T61 5395-5401 http://purl.obolibrary.org/obo/UBERON_0002553 denotes cavity
T62 5530-5535 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T63 5545-5546 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T64 5638-5644 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T65 5883-5890 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airways
T66 5959-5960 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67 5961-5984 http://purl.obolibrary.org/obo/UBERON_0001558 denotes lower respiratory tract
T68 6019-6023 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T69 6019-6023 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T70 6244-6248 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T71 6244-6248 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T72 6274-6280 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T73 6274-6280 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T74 6274-6280 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T75 6557-6570 http://purl.obolibrary.org/obo/PR_000001393 denotes interleukin-6
T76 6680-6685 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T77 6680-6685 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T78 6798-6809 http://purl.obolibrary.org/obo/PR_000007299 denotes prothrombin
T79 6874-6880 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T80 6874-6880 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T81 6874-6880 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T82 6891-6896 http://www.ebi.ac.uk/efo/EFO_0000965 denotes Chest
T83 7058-7059 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T84 7160-7164 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T85 7160-7164 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T86 7165-7170 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T87 7213-7218 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T88 7271-7276 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T89 7271-7276 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T90 7271-7276 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T91 7271-7276 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T92 7278-7284 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T93 7278-7284 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T94 7278-7284 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T95 7295-7301 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testes
T96 7303-7307 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T97 7324-7329 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T98 7335-7339 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T99 7394-7395 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T100 7572-7576 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T101 7572-7576 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T102 7644-7645 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T103 7997-7998 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T104 8094-8112 http://purl.obolibrary.org/obo/UBERON_0001004 denotes respiratory system
T105 8113-8115 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T106 8367-8369 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T107 8488-8493 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T108 8495-8502 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T109 8495-8502 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T110 8495-8502 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T111 8525-8529 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T112 8592-8597 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T113 8614-8624 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T114 8758-8761 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T115 8935-8941 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T116 9076-9084 http://purl.obolibrary.org/obo/CLO_0001658 denotes actively
T117 9190-9191 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T118 9340-9342 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T119 9340-9342 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T120 9410-9418 http://purl.obolibrary.org/obo/UBERON_0000158 denotes Membrane
T121 9524-9525 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T122 9595-9598 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T123 9759-9764 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T124 9812-9813 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T125 9850-9855 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T126 9891-9892 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T127 9938-9942 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T128 9972-9980 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T129 10191-10192 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T130 10478-10479 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T131 10736-10738 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T132 10736-10738 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T133 10858-10859 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T134 10916-10918 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T135 11000-11004 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T136 11168-11173 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T137 11197-11198 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T138 11282-11285 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T139 11380-11381 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T140 11571-11582 http://purl.obolibrary.org/obo/UBERON_0000178 denotes whole blood
T141 11571-11582 http://www.ebi.ac.uk/efo/EFO_0000296 denotes whole blood
T142 11966-11971 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T143 11994-12001 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T144 12075-12080 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T145 12272-12277 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T146 12491-12492 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T147 12594-12596 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T148 12598-12600 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T149 12930-12939 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T150 13034-13040 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T151 13155-13161 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T152 13165-13171 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T153 13183-13188 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T154 13209-13215 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T155 13244-13246 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T156 13443-13448 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T157 13726-13729 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T158 13758-13766 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T159 13767-13769 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T160 13868-13869 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T161 14129-14136 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T162 14226-14232 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T163 14286-14299 http://purl.obolibrary.org/obo/PR_000001393 denotes interleukin-6
T164 14417-14419 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T165 14578-14587 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T166 14642-14652 http://purl.obolibrary.org/obo/UBERON_0000473 denotes is testing
T167 14753-14759 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T168 14879-14889 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T169 14914-14915 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T170 15339-15344 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T171 15383-15388 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T172 15494-15499 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T173 15632-15635 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T174 15729-15730 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T175 15875-15883 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T176 15922-15923 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T177 15942-15943 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T178 16056-16058 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T179 16151-16153 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T180 16174-16179 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T181 16195-16196 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T182 16435-16436 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T183 16600-16602 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T184 16600-16602 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T185 16897-16898 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T186 16941-16942 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T187 16972-16973 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T188 16987-16989 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T189 17244-17246 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T190 17263-17264 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T191 17324-17330 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T192 17388-17394 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T193 17418-17419 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T194 17466-17467 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T195 17618-17620 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T196 17793-17798 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T197 17803-17808 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T198 17943-17947 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T199 17943-17947 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T200 18266-18276 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing is
T201 18389-18391 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T202 18389-18391 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T203 18590-18592 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T204 18590-18592 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T205 18594-18596 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T206 18597-18598 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T207 19173-19174 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T208 19185-19188 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T209 19366-19369 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T210 19422-19429 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T211 19435-19436 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T212 19536-19537 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T213 19580-19585 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T214 19608-19617 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T215 19655-19656 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T216 19724-19728 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T217 19724-19728 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T218 19774-19779 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T219 19930-19933 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T220 19957-19958 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T221 20007-20010 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T222 20097-20102 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T223 20198-20205 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T224 20414-20415 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T4 481-486 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T5 492-496 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T6 516-521 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T7 580-584 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T8 704-709 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T9 3585-3595 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T10 4102-4109 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T11 4134-4145 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T12 4219-4225 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T13 4724-4737 Chemical denotes macromolecule http://purl.obolibrary.org/obo/CHEBI_33839
T14 4888-4895 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T15 4982-4990 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T16 6572-6574 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T18 6695-6702 Chemical denotes lactate http://purl.obolibrary.org/obo/CHEBI_24996
T19 6763-6770 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T20 6816-6818 Chemical denotes PT http://purl.obolibrary.org/obo/CHEBI_141395
T21 6834-6842 Chemical denotes creatine http://purl.obolibrary.org/obo/CHEBI_16919|http://purl.obolibrary.org/obo/CHEBI_57947
T23 7308-7310 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T24 7669-7680 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T25 7689-7692 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T26 7721-7732 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T27 7740-7751 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T28 7760-7774 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T31 7760-7771 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T32 7772-7774 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T33 7784-7795 Chemical denotes vasodilator http://purl.obolibrary.org/obo/CHEBI_35620
T34 7796-7807 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T35 7835-7849 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T38 7835-7846 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T39 7847-7849 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T40 7854-7865 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T41 7890-7904 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T44 7890-7901 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T45 7902-7904 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T46 7938-7949 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T47 7972-7983 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T48 8254-8268 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T49 8258-8268 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T50 8270-8274 Chemical denotes ACEI http://purl.obolibrary.org/obo/CHEBI_35457
T51 8279-8290 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T52 8397-8404 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T53 8530-8532 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T54 8674-8683 Chemical denotes androgens http://purl.obolibrary.org/obo/CHEBI_50113
T55 8712-8721 Chemical denotes estrogens http://purl.obolibrary.org/obo/CHEBI_50114
T56 9021-9025 Chemical denotes ACEI http://purl.obolibrary.org/obo/CHEBI_35457
T57 9272-9280 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T58 9340-9342 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T59 9371-9379 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T60 9456-9466 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T61 9456-9461 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T62 9462-9466 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T63 9483-9490 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T64 9574-9584 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T65 9574-9579 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T66 9580-9584 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T67 9587-9594 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T68 9663-9670 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T69 9693-9703 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T70 9693-9698 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T71 9699-9703 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T72 9706-9713 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T73 9774-9784 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T74 9774-9779 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T75 9780-9784 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T76 9798-9805 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T77 9825-9832 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T78 9893-9898 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T79 9951-9958 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T80 10001-10008 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T81 10042-10050 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T82 10736-10738 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T83 10770-10778 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T84 11107-11109 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T85 11114-11116 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401
T86 11154-11161 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T87 11727-11734 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T88 12396-12401 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T89 12473-12478 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T90 12528-12533 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T91 12573-12575 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T92 12580-12582 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401
T93 12616-12621 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T94 12765-12788 Chemical denotes HIV protease inhibitors http://purl.obolibrary.org/obo/CHEBI_35660
T95 12769-12788 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T97 12778-12788 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T98 12789-12798 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T99 13007-13023 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T100 13058-13067 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T101 13068-13078 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T102 13111-13115 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T103 13291-13301 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T104 13332-13337 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T105 13389-13403 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T106 13389-13398 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T107 13399-13403 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T108 13404-13413 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T109 13531-13538 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T110 13621-13625 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T111 13930-13938 Chemical denotes thiazide http://purl.obolibrary.org/obo/CHEBI_50264
T112 13940-13948 Chemical denotes thiazide http://purl.obolibrary.org/obo/CHEBI_50264
T113 13954-13963 Chemical denotes diuretics http://purl.obolibrary.org/obo/CHEBI_35498
T114 13965-13989 Chemical denotes calcium channel blockers http://purl.obolibrary.org/obo/CHEBI_38215
T115 13965-13972 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T117 13991-14005 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T118 13995-14005 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T119 14011-14022 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T120 14301-14303 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T122 14462-14472 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T123 14497-14508 Chemical denotes ruxolitinib http://purl.obolibrary.org/obo/CHEBI_66919
T124 14653-14662 Chemical denotes quinolone http://purl.obolibrary.org/obo/CHEBI_23765
T125 14664-14673 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T126 14681-14687 Chemical denotes lactam http://purl.obolibrary.org/obo/CHEBI_24995
T127 14688-14699 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T128 14773-14778 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T129 14857-14862 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T130 15132-15137 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T131 15240-15248 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T132 15297-15309 Chemical denotes polypeptides http://purl.obolibrary.org/obo/CHEBI_15841
T133 15326-15334 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T134 15439-15443 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T135 15562-15570 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T136 15731-15734 Chemical denotes Cys http://purl.obolibrary.org/obo/CHEBI_15356|http://purl.obolibrary.org/obo/CHEBI_17561|http://purl.obolibrary.org/obo/CHEBI_29950
T139 15954-15957 Chemical denotes Cys http://purl.obolibrary.org/obo/CHEBI_15356|http://purl.obolibrary.org/obo/CHEBI_17561|http://purl.obolibrary.org/obo/CHEBI_29950
T142 15966-15969 Chemical denotes Glu http://purl.obolibrary.org/obo/CHEBI_16015|http://purl.obolibrary.org/obo/CHEBI_18237|http://purl.obolibrary.org/obo/CHEBI_29972
T145 15970-15973 Chemical denotes Asp http://purl.obolibrary.org/obo/CHEBI_17053|http://purl.obolibrary.org/obo/CHEBI_22660|http://purl.obolibrary.org/obo/CHEBI_29958
T148 16045-16048 Chemical denotes Gln http://purl.obolibrary.org/obo/CHEBI_30011
T149 16056-16058 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T150 16127-16130 Chemical denotes Gly http://purl.obolibrary.org/obo/CHEBI_15428
T151 16132-16135 Chemical denotes Ala http://purl.obolibrary.org/obo/CHEBI_16977|http://purl.obolibrary.org/obo/CHEBI_46217
T153 16140-16143 Chemical denotes Ser http://purl.obolibrary.org/obo/CHEBI_17115|http://purl.obolibrary.org/obo/CHEBI_29999
T155 16151-16153 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T156 16296-16306 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T157 16437-16451 Chemical denotes peptidomimetic http://purl.obolibrary.org/obo/CHEBI_63175
T158 16464-16473 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T159 16600-16602 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T160 16677-16685 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T161 16759-16768 Chemical denotes aldehydes http://purl.obolibrary.org/obo/CHEBI_17478
T162 16827-16832 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T163 16850-16853 Chemical denotes Cys http://purl.obolibrary.org/obo/CHEBI_15356|http://purl.obolibrary.org/obo/CHEBI_17561|http://purl.obolibrary.org/obo/CHEBI_29950
T166 16962-16968 Chemical denotes lactam http://purl.obolibrary.org/obo/CHEBI_24995
T167 16987-16989 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T168 16999-17008 Chemical denotes glutamine http://purl.obolibrary.org/obo/CHEBI_28300
T169 17244-17246 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T170 17247-17252 Chemical denotes amide http://purl.obolibrary.org/obo/CHEBI_29337|http://purl.obolibrary.org/obo/CHEBI_32988
T172 17265-17273 Chemical denotes pyridone http://purl.obolibrary.org/obo/CHEBI_38183
T173 17618-17620 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T174 17910-17912 Chemical denotes CD http://purl.obolibrary.org/obo/CHEBI_8673
T175 18217-18232 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T176 18222-18232 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T177 18316-18339 Chemical denotes SARS-CoV Mpro inhibitor http://purl.obolibrary.org/obo/CHEBI_147285
T178 18330-18339 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T179 18372-18374 Chemical denotes AG http://purl.obolibrary.org/obo/CHEBI_27569|http://purl.obolibrary.org/obo/CHEBI_40618|http://purl.obolibrary.org/obo/CHEBI_73757
T182 18389-18391 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T183 18467-18477 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T184 18490-18504 Chemical denotes peptidomimetic http://purl.obolibrary.org/obo/CHEBI_63175
T185 18513-18521 Chemical denotes acceptor http://purl.obolibrary.org/obo/CHEBI_15339
T186 18556-18565 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T187 18590-18592 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T188 18804-18806 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507
T189 19012-19022 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T190 19031-19041 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T191 19657-19661 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 150-159 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T2 5961-5994 Phenotype denotes lower respiratory tract infection http://purl.obolibrary.org/obo/HP_0002783
T3 6006-6013 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T4 6078-6098 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T5 6179-6201 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T6 6203-6220 Phenotype denotes diabetes mellitus http://purl.obolibrary.org/obo/HP_0000819
T7 6222-6234 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T8 6236-6256 Phenotype denotes chronic lung disease http://purl.obolibrary.org/obo/HP_0006528
T9 6258-6264 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T10 6266-6288 Phenotype denotes chronic kidney disease http://purl.obolibrary.org/obo/HP_0012622
T11 6294-6301 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T12 6470-6495 Phenotype denotes cytokine release syndrome http://purl.obolibrary.org/obo/HP_0033041
T13 6506-6520 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T14 6649-6660 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T15 6666-6693 Phenotype denotes elevations in liver enzymes http://purl.obolibrary.org/obo/HP_0002910
T16 6868-6887 Phenotype denotes acute kidney injury http://purl.obolibrary.org/obo/HP_0001919
T17 6996-7005 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T18 8157-8169 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T19 13701-13724 Phenotype denotes pancreatic inflammation http://purl.obolibrary.org/obo/HP_0001733

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3 2339-2348 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T4 2339-2348 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T5 4302-4313 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T6 4321-4336 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T7 4341-4352 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T8 4769-4782 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T9 4888-4907 http://purl.obolibrary.org/obo/GO_0006412 denotes protein translation
T10 5180-5191 http://purl.obolibrary.org/obo/GO_0006810 denotes transported
T11 5249-5259 http://purl.obolibrary.org/obo/GO_0006887 denotes exocytosis
T12 5555-5577 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T13 5562-5577 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T14 5754-5776 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T15 5761-5776 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T16 6404-6419 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T17 7408-7418 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T18 7625-7634 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T19 7625-7634 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T20 7913-7929 http://purl.obolibrary.org/obo/GO_0042310 denotes vasoconstriction
T21 8736-8746 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T22 9548-9564 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T23 10339-10348 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T24 10626-10643 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T25 10626-10643 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T26 10790-10805 http://purl.obolibrary.org/obo/GO_0016032 denotes Viral Infection
T27 13712-13724 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T28 14578-14596 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T29 14578-14587 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T30 16884-16893 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T31 17948-17955 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T9 0-511 Sentence denotes As first reported in December 2019, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused an outbreak of atypical pneumonia in Wuhan, China, that has since spread globally.1 The disease caused by this new virus has been named coronavirus disease-2019 (COVID-19) and on March 11, 2020 was declared a global pandemic by the World Health Organization (WHO).1 Currently, there are seven known human coronaviruses classified into two broad genera of alpha- and beta-coronaviruses.
T10 512-1718 Sentence denotes The alpha-coronaviruses comprise HCoV-NL63 and HCoV-229E, while the beta-coronaviruses comprise HCoV-OC43, HCoV-HKU1, SARS, Middle East Respiratory Syndrome virus (MERS), and SARS-CoV-2.2 The alpha-coronaviruses and HCoV-OC43 and HCoV-HKU1 are among the causes of the common cold and have been circulating in human and animal populations for many years.2 All these viruses originate from a common ancestor and enter the human population through zoonotic transfer or species jumping.3 Although the first four known human coronaviruses originated from birds, SARS, MERS, and SARS-CoV-2 appear, on the basis of gene sequence analysis, to have originated from bats.4 However, in each case, these more recent viruses appear to have been transmitted through an intermediate host such as a civet, a small nocturnal mammal native to tropical Asia and Africa (SARS), a camel (MERS), or a pangolin (SARS-CoV-2) after acquiring additional mutations.2 Bats harbor more strains of coronavirus than other mammals, estimated to range from 5000 to 10,000 distinct subtypes.5 Therefore, additional epidemics are highly likely to occur in the future due to the abundant number of coronaviruses present in the bat population.
T11 1719-1893 Sentence denotes As of May 6th, 2020, more than 3.7 million cases of SARS-CoV-2 positive patients have been reported worldwide with over 260,000 deaths, reflecting a ∼6.8% case fatality rate.
T12 1894-2408 Sentence denotes While the infection fatality rate is currently unknown, and likely to be lower than the current case fatality rate, estimates suggest it is close to 1%, or approximately 10 times the infection fatality rate of seasonal influenza (flu), which is fatal in only ∼0.1% of infected patients.6 In contrast to previous coronavirus epidemics (Table S1), COVID-19 is indiscriminately wreaking havoc globally with no apparent end in sight due to its high virulence and the absence of resistance among the general population.
T13 2409-2487 Sentence denotes In general, all pandemics pass through three phases until they become endemic.
T14 2488-2657 Sentence denotes The first phase of “seeding” or slow spread is often not noticed early enough, leading to dissemination of the disease before effective countermeasures can be initiated.
T15 2658-2851 Sentence denotes During the second phase, there is a rapid increase in cases until a peak occurs in the number of infected individuals; parallel efforts to control and contain the virus can mitigate this phase.
T16 2852-2965 Sentence denotes In the third phase, the infection rate curve will start to decrease until the disease becomes extinct or endemic.
T17 2966-3162 Sentence denotes The kinetics of increase and decrease in the rate of infections can vary significantly between populations depending on the use of preventive measures and the availability of effective treatments.
T18 3163-3389 Sentence denotes Previous coronavirus outbreaks and the current pandemic highlight the urgent unmet medical need to expand and focus our research tools on these long neglected infectious diseases and to prepare for future inevitable pandemics.
T19 3390-3631 Sentence denotes Herein, we briefly recap the current and potential future therapeutic interventions for SARS-CoV-2 and highlight the recently published crystal structures of the SARS-CoV-2 main protease and its inhibitors as novel agents against SARS-CoV-2.
T20 3633-3663 Sentence denotes Virus Structure and Life Cycle
T21 3664-3747 Sentence denotes SARS-CoV-2 is an enveloped, nonsegmented single stranded, positive sense RNA virus.
T22 3748-3862 Sentence denotes It has one of the largest genomes among all RNA viruses, comprising approximately 30 kilobases (kb) (NC_045512.2).
T23 3863-4453 Sentence denotes SARS-CoV and SARS-CoV-2 belong to the same Coronaviridae family that also includes the highly fatal Middle East Respiratory Syndrome virus (MERS) that appeared in 2012.7 SARS-CoV-2 enters cells through the interaction of its surface Spike protein with the host receptor, angiotensin-converting enzyme 2 (ACE2).8 Subsequent proteolytic cleavage by the host serine protease TMPRSS2 or perhaps other proteases allows subsequent cell entry by endocytosis.8 Upon membrane fusion and endocytosis, the viral nucleocapsid with its genome payload is released into the cytoplasm of the infected cell.
T24 4454-5295 Sentence denotes Following its release into the host cell, the virus usurps portions of the endoplasmic reticulum to form numerous double membrane vesicles.9 These vesicles are perfect sanctuaries to protect the viral genome and allow an efficient replication process to occur through a macromolecule complex called the replication–transcription complex (RTC).10 The viral genome is subsequently translated into viral polyproteins using the host cell protein translation machinery, which are then cleaved into structural and nonstructural viral proteins by two viral proteases, Mpro and PLpro.11 This step is followed by the assembly of viral particles (virions) in the endoplasmic reticulum/golgi compartment.12 The packaged virions are then transported to the cell surface, are released from the cells through exocytosis, and proceed to infect other cells.
T25 5297-5337 Sentence denotes Clinical Course and Outcomes of COVID-19
T26 5338-5578 Sentence denotes SARS-CoV-2 likely binds to epithelial cells in the nasal cavity during the asymptomatic state of the disease (initial 1–2 days of infection) where there might be some local propagation of the virus but with a limited innate immune response.
T27 5579-5777 Sentence denotes Within the next few days the infection starts in the upper airway and during this stage the infection can be detected by nasal swabs or sputum as well as early markers of the innate immune response.
T28 5778-6031 Sentence denotes About 80% of infected patients show mild symptoms that are mostly restricted to the upper and conducting airways.13 However, about 20% of infected patients will progress to develop a lower respiratory tract infection leading to hypoxia, and lung damage.
T29 6032-6142 Sentence denotes These patients are liable to succumb to acute respiratory distress syndrome (ARDS), which is frequently fatal.
T30 6143-7311 Sentence denotes Patients with comorbidities such as cardiovascular disease, diabetes mellitus, hypertension, chronic lung disease, cancer, chronic kidney disease, and obesity (body mass index ≥30) and ARDS are at increased risk of death.14 The available data indicate that the viral infection can produce an excessive immune reaction known as cytokine release syndrome (CRS) or “cytokine storm” associated with elevated levels of interleukin-6 (IL-6).15 Laboratory findings associated with worse clinical outcomes include lymphopenia, and elevations in liver enzymes, lactate dehydrogenase (LDH), inflammatory markers (e.g., C-reactive protein [CRP], ferritin), d-dimer, prothrombin time (PT), troponin and creatine phosphokinase (CPK), and acute kidney injury.15 Chest CT scans in patients with COVID-19 commonly show ground-glass opacification, consistent with viral pneumonia with abnormalities more likely to be bilateral with a peripheral distribution involving the lower lobes.16 While SARS-CoV-2 entry is dependent on ACE2 in lung cells,8 ACE2 expression is not exclusive to the lungs, and higher relative ACE2 expression is observed in heart, kidney, GIT, and testes (Gene ID:
T31 7312-7319 Sentence denotes 59272).
T32 7320-7477 Sentence denotes The organ- and cell-specific expression of ACE2 suggests that it may play a role in the regulation of cardiovascular and renal function as well as fertility.
T33 7478-8533 Sentence denotes Surprisingly, the 2003 SARS-CoV infection was shown to downregulate the expression of ACE2 in lung tissue reducing transmissibility but increasing virulence.17 ACE2, a component of the renin-angiotensin system (RAS), catalyzes the cleavage of angiotensin I into angiotensin 1–9 and angiotensin II into the vasodilator angiotensin 1–7.18 The balance between angiotensin II and angiotensin (1–7) is critical since angiotensin II elicits vasoconstriction via the angiotensin AT1 receptor, whereas angiotensin (1–7) exerts a vasodilatory effect mediated by AT2 with multiple beneficial effects on the cardiovascular and respiratory system.18 While ACE2 appears to be involved in the hypertension and respiratory manifestations of severely ill patients, the benefits and merits of ACE inhibitors (ACEI) or angiotensin receptor 1 blockers (ARBs) in the SARS-CoV-2 patient is still controversial.18 The priming of the S viral protein by TMPRSS2 is crucial for viral entry where TMPRSS2 expression is very high in the lungs, kidneys, and prostate tissue (Gene ID:
T34 8534-8722 Sentence denotes 7113).8 TMPRSS2 is predominantly expressed in the luminal cells of the prostate epithelium, where its expression is regulated positively by androgens and negatively regulated by estrogens.
T35 8723-8921 Sentence denotes The hormonal regulation of TMPRSS2 has been suggested to be linked to the fact that men are at higher risk than women to become seriously ill with COVID-19.19 TMPRSS2 knockout in mice is not lethal.
T36 8922-9210 Sentence denotes In contrast, humans are intolerant to the loss of function of ACE2.19 Concerns about the effect of ACEI and AT receptor blockers in COVID-19 patients are actively being investigated in the clinic, with the most recent reports offering encouragement that they may have a beneficial effect.
T37 9212-9234 Sentence denotes Potential Drug Targets
T38 9235-9565 Sentence denotes SARS-CoV-2 viral RNA encodes several proteins that are potentially druggable targets (Figure 1 and Table S2), including four structural proteins: the Spike (S), Envelope (E), Membrane (M), and Nucleocapsid (N).1 The 1273 amino acid, 141 kDa, Spike protein is heavily N-glycosylated and is a major inducer of host immune responses.
T39 9566-9685 Sentence denotes The 222 amino acid M protein has three transmembrane domains and is the most abundant structural protein in the virion.
T40 9686-9765 Sentence denotes The 75 amino acid E protein is important for assembly and release of the virus.
T41 9766-9943 Sentence denotes The 419 amino acid nucleocapsid protein forms a protective protein shell around the virus genetic material and is encased in a lipid envelope that is usurped from the host cell.
T42 9944-10009 Sentence denotes Matrix protein connects the membrane to the nucleocapsid protein.
T43 10010-10323 Sentence denotes There are also 16 nonstructural proteins (nsp1–16)1 including several for which there are X-ray crystallography-derived structural data: RNA dependent RNA polymerase (nsp12, RdRp), a papain-like protease (nsp3, PLpro), the main protease (nsp5, 3CLpro, or Mpro), and exonuclease/N7-methyltransferase (nsp14, ExoN).
T44 10324-10441 Sentence denotes RdRp catalyzes synthesis of the full length negative-strand RNA template used by RdRp to make more viral genomic RNA.
T45 10442-10740 Sentence denotes The SARS-CoV-2 genome also contains a number of open reading frames (ORFs): namely, ORF 1a proposed to encode nsp1 to nsp11; ORF1b, is proposed to encode nsp12 to nsp16, essential for viral replication, and ORFs 3a, 3b, 6, 7a, 7b, 8, 9a, 9b, and 10, which encode for accessory proteins1 (Table S2).
T46 10741-10779 Sentence denotes Figure 1 SARS-CoV-2 encoded proteins.
T47 10781-10805 Sentence denotes Treating Viral Infection
T48 10807-10838 Sentence denotes Immunization against SARS-CoV-2
T49 10839-10926 Sentence denotes The development of a manufacturable, safe, and effective vaccine may take 12–18 months.
T50 10927-11118 Sentence denotes Several phase I clinical trials are currently recruiting participants to test the safety, reactogenicity, and immunogenicity of several investigational SARS-CoV-2 vaccines (Tables S3 and S4).
T51 11119-11278 Sentence denotes An mRNA vaccine based on the Spike protein began human clinical trials within a record 63 days from first publication of the SARS-CoV-2 sequence (NCT04283461).
T52 11279-11666 Sentence denotes It has been suggested that the mutation rate for SARS-CoV-2 is expected to be low, raising hope that a successful vaccine will provide life-long immunity.20 Hyperimmune globulin isolated from the sera of convalescent patients having high titers of antibodies against SARS-CoV-2 or even their whole blood may provide instant “passive” short-lived immunity mainly via viral neutralization.
T53 11667-11861 Sentence denotes Antibody dependent therapy, for example targeting the Spike protein might represent the most efficient, near-term therapeutic intervention if regulatory and safety requirements can be addressed.
T54 11862-12134 Sentence denotes With over 1.3 million positive cases of COVID-19 in the US based solely on the results of RNA molecular tests, large-scale antibody testing should be expedited to identify individuals who have been exposed to the virus but were never officially confirmed to have COVID-19.
T55 12135-12325 Sentence denotes An understanding what levels of antibody confer immunity postinfection could be used to determine who may be less likely to transmit the virus and thus may be able to go back safely to work.
T56 12327-12343 Sentence denotes Drug Repurposing
T57 12344-12423 Sentence denotes Developing highly selective SARS-CoV-2 specific new drugs will take many years.
T58 12424-12745 Sentence denotes Alternatively, repurposing of existing, approved drugs can present a more rapid strategy to identifying drugs effective in treating COVID-19 (Tables S3 and S4 and Figure S1).11 Repurposing of drugs that would block SARS-CoV-2 entry and/or replication are urgently needed to mitigate the symptomatic burden of the disease.
T59 12746-12998 Sentence denotes Unfortunately, the HIV protease inhibitors ritonavir/liponavir failed to show efficacy in SARS-CoV-2 infected patients.21 Hydroxychloroquine, which may act by increasing the pH within lysosomes, was granted FDA authorization for use in emergency cases.
T60 12999-13325 Sentence denotes Several antiviral agents are being tested such as the RdRp inhibitor remdesivir and the approved anti-influenza drug faviprivir.8 Remdesivir was previously tested in humans with Ebola virus disease and also in animal models of MERS and SARS-CoV.11 At least six clinical trials are evaluating remdesivir in SARS-CoV-2 patients.
T61 13326-13414 Sentence denotes Other drugs that might inhibit RdRp include the broad-spectrum antiviral drug ribavirin.
T62 13415-13520 Sentence denotes RdRp conservation among RNA virus families makes it an exciting target for the discovery of newer agents.
T63 13521-13646 Sentence denotes The Spike protein, ACE2, and TMPRSS2 may also represent interesting therapeutic targets for current drug repurposing efforts.
T64 13647-14067 Sentence denotes Camostat mesylate, approved in Japan for treatment of pancreatic inflammation, has been shown to block TMPRSS2 activity.22 Arbidol, which is hypothesized to block Spike/ACE2 binding, is being investigated clinically, and a clinical trial was recently launched to study the effect of thiazide, thiazide-like diuretics, calcium channel blockers, ACE inhibitors, and angiotensin receptor blockers in COVID-19 (NCT04330300).
T65 14068-14247 Sentence denotes The availability of soluble recombinant hACE2 encouraged its testing in two clinical trials; although one was terminated (NCT04287686) the other is currently active (NCT04335136).
T66 14248-14597 Sentence denotes Monoclonal antibodies, especially for interleukin-6 (IL-6) or its receptor, are also being considered for the control of SARS-CoV-2 associated respiratory exacerbations.11 Interestingly, several Janus Kinase (JAK) inhibitors such as baricitinib and ruxolitinib are currently being evaluated given their involvement in interleukin signaling pathways.
T67 14598-14731 Sentence denotes Another currently recruiting clinical trial is testing quinolone, macrolide, and β-lactam antibiotics against COVID-19 (NCT02735707).
T68 14732-14842 Sentence denotes Multiple groups have tested FDA approved drugs in various in vitro assays as well as in computational screens.
T69 14843-15206 Sentence denotes Many of these drugs show inhibitory activities, although not always at a concentration that may be safely achieved in patients.23 Controlled clinical trials of these agents are mandatory to assess their efficacy and safety without creating false positive hope or depleting the supplies of drugs needed to treat the diseases for which they were initially approved.
T70 15208-15220 Sentence denotes Novel Agents
T71 15221-16164 Sentence denotes Mpro and PLpro are cysteine proteases responsible for the cleavage of viral polypeptides into functional proteins for virus replication and packaging within host cells.24 These enzymes represent the best characterized drug targets among coronaviruses and are currently the focus of attention among scientists seeking novel coronavirus small molecule therapeutics.25 Mpro is shared by all coronavirus genera and has similarity to the 3Cpro of the Enterovirus genus in the picornavirus family.24 Mpro contains a Cys···His catalytic dyad with an additional α-helical domain involved in the dimerization of the protease, which is essential for its catalytic activity.25 The enteroviral 3Cpro functions as a monomer featuring a classical Cys···His···Glu/Asp catalytic triad.24 Yet, they share the almost absolute requirement for Gln in the P1 position of the substrate and space for only small residues such as Gly, Ala, or Ser in the P1′ position.
T72 16165-16913 Sentence denotes Since no human proteases with a similar cleavage specificity are known, it may be possible to identify highly selective Mpro/3Cpro inhibitors, which display minimal inhibition of host proteases.26 The 3-D structures of unliganded SARS-CoV-2 Mpro and of its complex with a peptidomimetic α-ketoamide inhibitor (11r) have been solved26 and were used to support the design of an optimized derivative (13b) through docking studies (Figure S2). α-Ketoamides can interact with the catalytic center of Mpro through two hydrogen bonding interactions rather than only one as with other warheads such as aldehydes or Michael acceptors.24 Nucleophilic attack of the α-keto group by the catalytic Cys residue results in reversible formation of a thiohemiketal.
T73 16914-17289 Sentence denotes These α-ketoamides feature a 5-membered rigid γ-lactam as a mimic of the P1 residue, glutamine, required for Mpro specificity, with the advantage of reducing the loss of entropy upon binding.24 Follow up optimization efforts guided by docking to the SARS-CoV-2 Mpro co-crystal structure with 11r, included incorporation of the P3-P2 amide bond into a pyridone ring as in 13a.
T74 17290-17482 Sentence denotes The resulting half-life of 13a in plasma was enhanced by 3 fold relative to 11r, in vitro kinetic plasma solubility improved by a factor of ∼19 and thermodynamic solubility by a factor of ∼13.
T75 17483-17731 Sentence denotes 13a inhibited purified recombinant SARS-CoV-2 Mpro, SARS-CoV Mpro, and MERS-CoV Mpro in the submicromolar range.26 Modification of the P1′ and P3 moieties of 13a afforded an optimized derivative 13b which was crystallized with SARS-CoV-2 Mpro (PDB:
T76 17732-17747 Sentence denotes 6Y2G and 6Y2F).
T77 17748-17820 Sentence denotes Both 13a and 13b displayed good stability in mouse and human microsomes.
T78 17821-17920 Sentence denotes 13b (3 mg/kg) showed longer t1/2, tmax, and residence time compared to 13a (20 mg/kg) in CD-1 mice.
T79 17921-17990 Sentence denotes Both compounds showed lung tropism which is thought to be beneficial.
T80 17991-18233 Sentence denotes While the development of these ketoamides into clinical candidates requires additional safety studies, the availability of their crystal structures is of great importance in facilitating the discovery and development of other Mpro inhibitors.
T81 18234-18393 Sentence denotes One of the suggested agents for testing is the previously reported Rhinovirus and SARS-CoV Mpro inhibitor clinical candidate rupintrivir (AG-7088) (Figure S2).
T82 18394-18530 Sentence denotes In addition, other groups recently reported Mpro crystal structures with inhibitors such as the peptidomimetic Michael acceptor N3 (PDB:
T83 18531-18575 Sentence denotes 6LU7) and the reversible inhibitor X77 (PDB:
T84 18576-18794 Sentence denotes 6W63) (Figure S2).27 A large array of Mpro crystal structures with multiple covalent and noncovalent fragments were solved through an exceptionally large screen with vast opportunities for fragment growing and merging.
T85 18795-19056 Sentence denotes The cryo EM structure of SARS-CoV-2 RdRp was recently solved, showing nearly an identical sequence to its SARS-CoV homologue.28 RdRp should be another high priority target for therapeutic intervention given that lead inhibitors such as remdesivir already exist.
T86 19058-19069 Sentence denotes Conclusions
T87 19070-19232 Sentence denotes Since 2003, the three pandemics caused by SARS, MERS, and SARS-CoV-2 are believed to have initiated as a result of bat coronaviruses crossing the species barrier.
T88 19233-19381 Sentence denotes Therefore, other epidemics are likely to occur in the future due to the effectively unlimited supply of coronaviruses present in the bat population.
T89 19382-19641 Sentence denotes Equally concerning is the fact that RNA viruses lack a genomic proof-reading mechanism and therefore are prone to mutation, raising the specter that once a new coronavirus begins circulating in the human population it will be extremely difficult to eliminate.
T90 19642-19780 Sentence denotes Finally, for a drug to be most effective, it must reach its site of action (e.g., lung tissues) in sufficient quantity to clear the virus.
T91 19781-19984 Sentence denotes With nearly three million reported cases, >260,000 deaths, millions out of work, and billions of dollars in lost revenue, it appears that SARS-CoV-2 has altered daily life for a sustained period of time.
T92 19985-20103 Sentence denotes This cascading effect has generated unprecedented momentum and scientific effort around the globe to fight this virus.
T93 20104-20344 Sentence denotes Success will require creative thinking, new technologies, innovative approaches, particularly focused on speed to market, and combinations of different modalities to effectively combat not just the current foe but also future coronaviruses.
T94 20345-20439 Sentence denotes We remain hopeful that we will be more prepared for the emergence of a potential “SARS-CoV-3”.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
54 38-55 Species denotes novel coronavirus Tax:2697049
55 57-104 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
56 106-116 Species denotes SARS-CoV-2 Tax:2697049
57 425-430 Species denotes human Tax:9606
58 431-444 Species denotes coronaviruses Tax:11118
59 492-510 Species denotes beta-coronaviruses Tax:694002
60 522-535 Species denotes coronaviruses Tax:11118
61 545-554 Species denotes HCoV-NL63 Tax:277944
62 559-568 Species denotes HCoV-229E Tax:11137
63 580-598 Species denotes beta-coronaviruses Tax:694002
64 608-617 Species denotes HCoV-OC43 Tax:31631
65 619-628 Species denotes HCoV-HKU1 Tax:290028
66 687-697 Species denotes SARS-CoV-2 Tax:2697049
67 710-723 Species denotes coronaviruses Tax:11118
68 728-737 Species denotes HCoV-OC43 Tax:31631
69 742-751 Species denotes HCoV-HKU1 Tax:290028
70 821-826 Species denotes human Tax:9606
71 932-937 Species denotes human Tax:9606
72 1026-1031 Species denotes human Tax:9606
73 1032-1045 Species denotes coronaviruses Tax:11118
74 1085-1095 Species denotes SARS-CoV-2 Tax:2697049
75 1320-1326 Species denotes mammal Tax:9606
76 1372-1377 Species denotes camel Tax:9837
77 1401-1411 Species denotes SARS-CoV-2 Tax:2697049
78 1480-1491 Species denotes coronavirus Tax:11118
79 1674-1687 Species denotes coronaviruses Tax:11118
80 150-159 Disease denotes pneumonia MESH:D011014
81 262-286 Disease denotes coronavirus disease-2019 MESH:C000657245
82 288-296 Disease denotes COVID-19 MESH:C000657245
83 676-680 Disease denotes MERS MESH:D018352
84 787-791 Disease denotes cold MESH:D000067390
85 957-974 Disease denotes zoonotic transfer MESH:D015047
86 1075-1079 Disease denotes MERS MESH:D018352
87 1379-1383 Disease denotes MERS MESH:D018352
97 1771-1781 Species denotes SARS-CoV-2 Tax:2697049
98 1791-1799 Species denotes patients Tax:9606
99 2171-2179 Species denotes patients Tax:9606
100 2206-2217 Species denotes coronavirus Tax:11118
101 1847-1853 Disease denotes deaths MESH:D003643
102 1904-1913 Disease denotes infection MESH:D007239
103 2077-2086 Disease denotes infection MESH:D007239
104 2162-2170 Disease denotes infected MESH:D007239
105 2240-2248 Disease denotes COVID-19 MESH:C000657245
114 3172-3183 Species denotes coronavirus Tax:11118
115 3478-3488 Species denotes SARS-CoV-2 Tax:2697049
116 3552-3562 Species denotes SARS-CoV-2 Tax:2697049
117 3620-3630 Species denotes SARS-CoV-2 Tax:2697049
118 2755-2763 Disease denotes infected MESH:D007239
119 2876-2885 Disease denotes infection MESH:D007239
120 3019-3029 Disease denotes infections MESH:D007239
121 3322-3341 Disease denotes infectious diseases MESH:D003141
138 4134-4165 Gene denotes angiotensin-converting enzyme 2 Gene:59272
139 4167-4171 Gene denotes ACE2 Gene:59272
140 4235-4242 Gene denotes TMPRSS2 Gene:7113
141 5015-5019 Gene denotes Mpro Gene:8673700
142 4575-4583 Gene denotes membrane Gene:43740571
143 4321-4329 Gene denotes membrane Gene:43740571
144 4096-4101 Gene denotes Spike Gene:43740568
145 4364-4376 Gene denotes nucleocapsid Gene:43740575
146 3664-3674 Species denotes SARS-CoV-2 Tax:2697049
147 3863-3871 Species denotes SARS-CoV Tax:694009
148 3876-3886 Species denotes SARS-CoV-2 Tax:2697049
149 3906-3919 Species denotes Coronaviridae Tax:11118
150 4033-4043 Species denotes SARS-CoV-2 Tax:2697049
151 4219-4225 Chemical denotes serine MESH:D012694
152 4003-4007 Disease denotes MERS MESH:D018352
153 4439-4447 Disease denotes infected MESH:D007239
155 5329-5337 Disease denotes COVID-19 MESH:C000657245
227 6557-6570 Gene denotes interleukin-6 Gene:3569
228 6572-6576 Gene denotes IL-6 Gene:3569
229 6752-6770 Gene denotes C-reactive protein Gene:1401
230 6772-6775 Gene denotes CRP Gene:1401
231 7152-7156 Gene denotes ACE2 Gene:59272
232 7173-7177 Gene denotes ACE2 Gene:59272
233 7240-7244 Gene denotes ACE2 Gene:59272
234 7363-7367 Gene denotes ACE2 Gene:59272
235 7564-7568 Gene denotes ACE2 Gene:59272
236 7638-7642 Gene denotes ACE2 Gene:59272
237 7721-7755 Gene denotes angiotensin I into angiotensin 1–9
238 7760-7774 Gene denotes angiotensin II Gene:183
239 7796-7811 Gene denotes angiotensin 1–7
240 7835-7849 Gene denotes angiotensin II Gene:183
241 8122-8126 Gene denotes ACE2 Gene:59272
242 8254-8257 Gene denotes ACE Gene:1636
243 8408-8415 Gene denotes TMPRSS2 Gene:7113
244 8449-8456 Gene denotes TMPRSS2 Gene:7113
245 8542-8549 Gene denotes TMPRSS2 Gene:7113
246 8750-8757 Gene denotes TMPRSS2 Gene:7113
247 8882-8889 Gene denotes TMPRSS2 Gene:50528
248 8984-8988 Gene denotes ACE2 Gene:59272
249 7890-7904 Gene denotes angiotensin II Gene:183
250 8389-8390 Gene denotes S Gene:43740568
251 5338-5348 Species denotes SARS-CoV-2 Tax:2697049
252 5800-5808 Species denotes patients Tax:9606
253 5925-5933 Species denotes patients Tax:9606
254 6038-6046 Species denotes patients Tax:9606
255 6143-6151 Species denotes Patients Tax:9606
256 6909-6917 Species denotes patients Tax:9606
257 7119-7129 Species denotes SARS-CoV-2 Tax:2697049
258 8217-8225 Species denotes patients Tax:9606
259 8325-8335 Species denotes SARS-CoV-2 Tax:2697049
260 8336-8343 Species denotes patient Tax:9606
261 8807-8810 Species denotes men Tax:9606
262 8835-8840 Species denotes women Tax:9606
263 8902-8906 Species denotes mice Tax:10090
264 8935-8941 Species denotes humans Tax:9606
265 9063-9071 Species denotes patients Tax:9606
266 6834-6842 Chemical denotes creatine MESH:D003401
267 8279-8310 Chemical denotes angiotensin receptor 1 blockers
268 8312-8316 Chemical denotes ARBs
269 8584-8591 Chemical denotes luminal MESH:D010634
270 5468-5477 Disease denotes infection MESH:D007239
271 5608-5617 Disease denotes infection MESH:D007239
272 5671-5680 Disease denotes infection MESH:D007239
273 5791-5799 Disease denotes infected MESH:D007239
274 5916-5924 Disease denotes infected MESH:D007239
275 5967-5994 Disease denotes respiratory tract infection MESH:D012141
276 6006-6013 Disease denotes hypoxia MESH:D000860
277 6019-6030 Disease denotes lung damage MESH:D008171
278 6072-6107 Disease denotes acute respiratory distress syndrome MESH:D012128
279 6109-6113 Disease denotes ARDS MESH:D012128
280 6179-6201 Disease denotes cardiovascular disease MESH:D002318
281 6203-6220 Disease denotes diabetes mellitus MESH:D003920
282 6222-6234 Disease denotes hypertension MESH:D006973
283 6244-6256 Disease denotes lung disease MESH:D008171
284 6258-6264 Disease denotes cancer MESH:D009369
285 6266-6288 Disease denotes chronic kidney disease MESH:D051436
286 6294-6301 Disease denotes obesity MESH:D009765
287 6328-6332 Disease denotes ARDS MESH:D012128
288 6358-6363 Disease denotes death MESH:D003643
289 6404-6419 Disease denotes viral infection MESH:D001102
290 6649-6660 Disease denotes lymphopenia MESH:D008231
291 6868-6887 Disease denotes acute kidney injury MESH:D058186
292 6923-6931 Disease denotes COVID-19 MESH:C000657245
293 6990-7005 Disease denotes viral pneumonia
294 7501-7519 Disease denotes SARS-CoV infection MESH:C000657245
295 8157-8169 Disease denotes hypertension MESH:D006973
296 8870-8878 Disease denotes COVID-19 MESH:C000657245
297 9054-9062 Disease denotes COVID-19 MESH:C000657245
325 9392-9393 Gene denotes S Gene:43740568
326 9396-9404 Gene denotes Envelope Gene:43740570
327 9406-9407 Gene denotes E Gene:43740570
328 9410-9418 Gene denotes Membrane Gene:43740571
329 9420-9421 Gene denotes M Gene:43740571
330 9428-9440 Gene denotes Nucleocapsid Gene:43740575
331 9442-9443 Gene denotes N Gene:43740575
332 10052-10056 Gene denotes nsp1 Gene:10045
333 10184-10188 Gene denotes RdRp Gene:43740578
334 10215-10219 Gene denotes nsp3 Gene:10044
335 10248-10252 Gene denotes nsp5 Gene:92521
336 10265-10269 Gene denotes Mpro Gene:8673700
337 10324-10328 Gene denotes RdRp Gene:43740578
338 10552-10556 Gene denotes nsp1 Gene:10045
339 9972-9980 Gene denotes membrane Gene:43740571
340 9477-9482 Gene denotes Spike Gene:43740568
341 9385-9390 Gene denotes Spike Gene:43740568
342 9988-10000 Gene denotes nucleocapsid Gene:43740575
343 9785-9797 Gene denotes nucleocapsid Gene:43740575
344 9899-9907 Gene denotes envelope Gene:43740570
345 10405-10409 Gene denotes RdRp Gene:43740578
346 9704-9705 Gene denotes E Gene:43740570
347 9585-9586 Gene denotes M Gene:43740571
348 9502-9503 Gene denotes N Gene:43740575
349 9235-9245 Species denotes SARS-CoV-2 Tax:2697049
350 10446-10456 Species denotes SARS-CoV-2 Tax:2697049
351 9893-9898 Chemical denotes lipid MESH:D008055
353 10751-10761 Species denotes SARS-CoV-2 Tax:2697049
355 10790-10805 Disease denotes Viral Infection MESH:D001102
367 11148-11153 Gene denotes Spike Gene:43740568
368 11721-11726 Gene denotes Spike Gene:43740568
369 10984-10996 Species denotes participants Tax:9606
370 11079-11089 Species denotes SARS-CoV-2 Tax:2697049
371 11168-11173 Species denotes human Tax:9606
372 11244-11254 Species denotes SARS-CoV-2 Tax:2697049
373 11328-11338 Species denotes SARS-CoV-2 Tax:2697049
374 11496-11504 Species denotes patients Tax:9606
375 11546-11556 Species denotes SARS-CoV-2 Tax:2697049
376 11902-11910 Disease denotes COVID-19 MESH:C000657245
377 12125-12133 Disease denotes COVID-19 MESH:C000657245
425 13053-13057 Gene denotes RdRp Gene:43740578
426 13357-13361 Gene denotes RdRp Gene:43740578
427 13540-13544 Gene denotes ACE2 Gene:59272
428 13550-13557 Gene denotes TMPRSS2 Gene:7113
429 13750-13757 Gene denotes TMPRSS2 Gene:7113
430 13816-13820 Gene denotes ACE2 Gene:59272
431 13991-13994 Gene denotes ACE Gene:1636
432 14108-14113 Gene denotes hACE2 Gene:59272
433 14286-14299 Gene denotes interleukin-6 Gene:3569
434 14301-14305 Gene denotes IL-6 Gene:3569
435 13415-13419 Gene denotes RdRp Gene:43740578
436 13810-13815 Gene denotes Spike Gene:43740568
437 13525-13530 Gene denotes Spike Gene:43740568
438 12372-12382 Species denotes SARS-CoV-2 Tax:2697049
439 12639-12649 Species denotes SARS-CoV-2 Tax:2697049
440 12856-12864 Species denotes patients Tax:9606
441 13165-13171 Species denotes humans Tax:9606
442 13235-13243 Species denotes SARS-CoV Tax:694009
443 13305-13315 Species denotes SARS-CoV-2 Tax:2697049
444 13316-13324 Species denotes patients Tax:9606
445 14369-14379 Species denotes SARS-CoV-2 Tax:2697049
446 14961-14969 Species denotes patients Tax:9606
447 12789-12798 Chemical denotes ritonavir MESH:D019438
448 12799-12808 Chemical denotes liponavir
449 12868-12886 Chemical denotes Hydroxychloroquine MESH:D006886
450 13068-13078 Chemical denotes remdesivir MESH:C000606551
451 13116-13126 Chemical denotes faviprivir
452 13129-13139 Chemical denotes Remdesivir MESH:C000606551
453 13291-13301 Chemical denotes remdesivir MESH:C000606551
454 13404-13413 Chemical denotes ribavirin MESH:D012254
455 13647-13664 Chemical denotes Camostat mesylate MESH:C034532
456 13770-13777 Chemical denotes Arbidol MESH:C086979
457 13930-13938 Chemical denotes thiazide MESH:D049971
458 13940-13948 Chemical denotes thiazide MESH:D049971
459 13965-13972 Chemical denotes calcium MESH:D002118
460 14481-14492 Chemical denotes baricitinib MESH:C000596027
461 14497-14508 Chemical denotes ruxolitinib MESH:C540383
462 14653-14662 Chemical denotes quinolone MESH:D015363
463 14664-14673 Chemical denotes macrolide MESH:D018942
464 14679-14687 Chemical denotes β-lactam MESH:D047090
465 12556-12564 Disease denotes COVID-19 MESH:C000657245
466 12836-12855 Disease denotes SARS-CoV-2 infected MESH:C000657245
467 13183-13196 Disease denotes virus disease MESH:D001102
468 13226-13230 Disease denotes MERS MESH:D018352
469 13701-13724 Disease denotes pancreatic inflammation MESH:D007249
470 14044-14052 Disease denotes COVID-19 MESH:C000657245
471 14708-14716 Disease denotes COVID-19 MESH:C000657245
541 17721-17725 Gene denotes Mpro Gene:8673700
542 18217-18221 Gene denotes Mpro Gene:8673700
543 18438-18442 Gene denotes Mpro Gene:8673700
544 18831-18835 Gene denotes RdRp Gene:43740578
545 18923-18927 Gene denotes RdRp Gene:43740578
546 18614-18618 Gene denotes Mpro Gene:8673700
547 18325-18329 Gene denotes Mpro Gene:8673700
548 17563-17567 Gene denotes Mpro Gene:8673700
549 17544-17548 Gene denotes Mpro Gene:8673700
550 17529-17533 Gene denotes Mpro Gene:8673700
551 17175-17179 Gene denotes Mpro Gene:8673700
552 17023-17027 Gene denotes Mpro Gene:8673700
553 16660-16664 Gene denotes Mpro Gene:8673700
554 16406-16410 Gene denotes Mpro Gene:8673700
555 15715-15719 Gene denotes Mpro Gene:8673700
556 15587-15591 Gene denotes Mpro Gene:8673700
557 15221-15225 Gene denotes Mpro Gene:8673700
558 15458-15471 Species denotes coronaviruses Tax:11118
559 15538-15555 Species denotes novel coronavirus Tax:2697049
560 15609-15620 Species denotes coronavirus Tax:11118
561 16174-16179 Species denotes human Tax:9606
562 16395-16405 Species denotes SARS-CoV-2 Tax:2697049
563 17164-17174 Species denotes SARS-CoV-2 Tax:2697049
564 17518-17528 Species denotes SARS-CoV-2 Tax:2697049
565 17535-17543 Species denotes SARS-CoV Tax:694009
566 17554-17562 Species denotes MERS-CoV Tax:1335626
567 17710-17720 Species denotes SARS-CoV-2 Tax:2697049
568 17793-17798 Species denotes mouse Tax:10090
569 17803-17808 Species denotes human Tax:9606
570 17915-17919 Species denotes mice Tax:10090
571 18301-18311 Species denotes Rhinovirus Tax:12059
572 18316-18324 Species denotes SARS-CoV Tax:694009
573 18820-18830 Species denotes SARS-CoV-2 Tax:2697049
574 18901-18909 Species denotes SARS-CoV Tax:694009
575 16285-16289 Gene denotes Mpro Gene:8673700
576 15731-15734 Chemical denotes Cys MESH:D003545
577 15954-15957 Chemical denotes Cys MESH:D003545
578 15960-15963 Chemical denotes His MESH:D006639
579 15966-15969 Chemical denotes Glu MESH:D018698
580 15970-15973 Chemical denotes Asp MESH:D001224
581 16045-16048 Chemical denotes Gln MESH:D005973
582 16127-16130 Chemical denotes Gly MESH:D005998
583 16132-16135 Chemical denotes Ala MESH:D000409
584 16140-16143 Chemical denotes Ser MESH:D012694
585 16452-16463 Chemical denotes α-ketoamide
586 16605-16617 Chemical denotes α-Ketoamides
587 16677-16685 Chemical denotes hydrogen MESH:D006859
588 16759-16768 Chemical denotes aldehydes MESH:D000447
589 16850-16853 Chemical denotes Cys MESH:D003545
590 16899-16912 Chemical denotes thiohemiketal
591 16920-16932 Chemical denotes α-ketoamides
592 16960-16968 Chemical denotes γ-lactam
593 16999-17008 Chemical denotes glutamine MESH:D005973
594 17206-17209 Chemical denotes 11r
595 17241-17243 Chemical denotes P3
596 17244-17246 Chemical denotes P2 MESH:C020845
597 17247-17252 Chemical denotes amide MESH:D000577
598 17265-17273 Chemical denotes pyridone MESH:D011728
599 17317-17320 Chemical denotes 13a
600 17641-17644 Chemical denotes 13a
601 17678-17681 Chemical denotes 13b
602 17753-17756 Chemical denotes 13a
603 17761-17764 Chemical denotes 13b
604 17821-17824 Chemical denotes 13b
605 17892-17895 Chemical denotes 13a
606 18022-18032 Chemical denotes ketoamides
607 18359-18370 Chemical denotes rupintrivir MESH:C118874
608 18372-18379 Chemical denotes AG-7088 MESH:C118874
609 19031-19041 Chemical denotes remdesivir MESH:C000606551
620 19128-19138 Species denotes SARS-CoV-2 Tax:2697049
621 19189-19202 Species denotes coronaviruses Tax:11118
622 19337-19350 Species denotes coronaviruses Tax:11118
623 19538-19553 Species denotes new coronavirus Tax:2697049
624 19580-19585 Species denotes human Tax:9606
625 19919-19929 Species denotes SARS-CoV-2 Tax:2697049
626 20330-20343 Species denotes coronaviruses Tax:11118
627 20427-20435 Species denotes SARS-CoV Tax:694009
628 19118-19122 Disease denotes MERS MESH:D018352
629 19832-19838 Disease denotes deaths MESH:D003643

2_test

Id Subject Object Predicate Lexical cue
32388976-32123347-144031 4031-4032 32123347 denotes 7
32388976-32142651-144032 4173-4174 32142651 denotes 8
32388976-32142651-144033 4314-4315 32142651 denotes 8
32388976-18798692-144034 4593-4594 18798692 denotes 9
32388976-20007278-144035 4797-4799 20007278 denotes 10
32388976-32226821-144036 5030-5032 32226821 denotes 11
32388976-9658133-144037 5147-5149 9658133 denotes 12
32388976-32171076-144038 6578-6580 32171076 denotes 15
32388976-32171076-144039 6888-6890 32171076 denotes 15
32388976-32133578-144040 7110-7112 32133578 denotes 16
32388976-32142651-144041 7171-7172 32142651 denotes 8
32388976-16007097-144042 7635-7637 16007097 denotes 17
32388976-32125455-144043 7812-7814 32125455 denotes 18
32388976-32125455-144044 8113-8115 32125455 denotes 18
32388976-32125455-144045 8367-8369 32125455 denotes 18
32388976-32142651-144046 8540-8541 32142651 denotes 8
32388976-32015508-144047 9445-9446 32015508 denotes 1
32388976-32015508-144048 10060-10061 32015508 denotes 1
32388976-32015508-144049 10727-10728 32015508 denotes 1
32388976-32284615-144050 11433-11435 32284615 denotes 20
32388976-32226821-144051 12598-12600 32226821 denotes 11
32388976-32142651-144052 13127-13128 32142651 denotes 8
32388976-32226821-144053 13244-13246 32226821 denotes 11
32388976-22496216-144054 13767-13769 22496216 denotes 22
32388976-32226821-144055 14417-14419 32226821 denotes 11
32388976-25039866-144056 15584-15586 25039866 denotes 25
32388976-25039866-144057 15884-15886 25039866 denotes 25
32388976-32277040-144058 18920-18922 32277040 denotes 28