PMC:7212965 / 96092-98142 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7212965","sourcedb":"PMC","sourceid":"7212965","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7212965","text":"Medication class Medication Sourcea Indirect GI adverse events Other\nNausea/vomiting Abdominal pain Diarrhea Jaundice Hepatotoxicity\nAntiviral Lopinavir/ritonavir FDA/ manufacturer's label110 HIV Nausea (5%–16%); vomiting (children 21%; adults 2%–7%) Reported 1%–11% 7%–28%; greater with once-daily dosing — Increased serum ALT: 1%–11%; hepatitis including AST/ALT/GGT elevations: 4%; hyperbilirubinemia (children 3%; adults 1%) Dysgeusia (children 22%; adults \u003c2%); hyperamylasemia (3%–8%), dyspepsia (\u003c6%), increased lipase (3%–5%), flatulence (1-4%), gastroenteritis (3%)\nNIH Liver Tox111 HIV Range from mild to ALF. Recovery takes 1–2 mo. Do not re-challenge with medication. Monitor for exacerbation of HBV/HCV\nMomattin,105 2019 MERS Prevalence of GI AEs not reported in this SR\nYao,106 2020 SARS/MERS AEs not reported in this SR (can check primary studies) SARS: 2 retrospective cohort studies (combined with steroids); MERS: 1 RCT combined with IFN, 1 retrospective cohort combined with IFN/ribavirin, and 2 case reports also combined with IFN/ribavirin\nRemdesivir Al-Tawfiq,107 2020 MERS\nSheahan,108 2020 MERS\nAntimalarial Chloroquine FDA/ manufacturer's label/NIH Liver Tox111,112 Malaria Reported; frequency not defined Abdominal cramps reported; frequency not defined Reported; frequency not defined Rarely linked to aminotransferase elevations or clinically apparent liver injury. In patients with AIP or PCT, it can trigger an attack with fever and serum aminotransferase elevations, sometimes resulting in jaundice Minor metabolism by liver (∼30%); mostly excreted in urine Likelihood score: D (possible rare cause of clinically apparent liver injury)\nHydroxychloroquine113 FDA / Manufacturer's label Malaria / SLE Reported; frequency not defined Reported; frequency not defined Reported; frequency not defined Same as chloroquine above; can be exchanged with chloroquine as most reactions are hypersensitivity and no known cross reactivity to hepatic injury Likelihood score: D (possible rare cause of clinically apparent liver 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