PMC:7212965 / 40985-42728
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T91 | 380-385 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T92 | 1080-1085 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T93 | 1175-1180 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T94 | 1275-1280 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T69 | 380-385 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T70 | 1080-1085 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T71 | 1175-1180 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T72 | 1275-1280 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T211 | 73-81 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T212 | 275-283 | Disease | denotes | diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T213 | 386-392 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T214 | 464-480 | Disease | denotes | hypersensitivity | http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271 |
| T216 | 523-529 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T217 | 989-997 | Disease | denotes | Diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T218 | 1181-1187 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T219 | 1534-1542 | Disease | denotes | Diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T312 | 380-385 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T313 | 380-385 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T314 | 847-848 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T315 | 1175-1180 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T316 | 1175-1180 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T317 | 1275-1280 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T318 | 1275-1280 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T92 | 146-150 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T93 | 151-155 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T94 | 576-587 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T95 | 869-878 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T96 | 882-885 | Chemical | denotes | CYP | http://purl.obolibrary.org/obo/CHEBI_38559 |
| T97 | 894-903 | Chemical | denotes | Lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T98 | 904-913 | Chemical | denotes | ritonavir | http://purl.obolibrary.org/obo/CHEBI_45409 |
| T99 | 1675-1683 | Chemical | denotes | aldehyde | http://purl.obolibrary.org/obo/CHEBI_17478 |
| T100 | 1706-1714 | Chemical | denotes | xanthine | http://purl.obolibrary.org/obo/CHEBI_15318|http://purl.obolibrary.org/obo/CHEBI_17712 |
| T102 | 1727-1735 | Chemical | denotes | aldehyde | http://purl.obolibrary.org/obo/CHEBI_17478 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T189 | 237-253 | Phenotype | denotes | Nausea, vomiting | http://purl.obolibrary.org/obo/HP_0002017 |
| T190 | 255-269 | Phenotype | denotes | abdominal pain | http://purl.obolibrary.org/obo/HP_0002027 |
| T191 | 275-283 | Phenotype | denotes | diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
| T192 | 464-480 | Phenotype | denotes | hypersensitivity | http://purl.obolibrary.org/obo/HP_0041092 |
| T193 | 914-933 | Phenotype | denotes | Nausea and vomiting | http://purl.obolibrary.org/obo/HP_0002017 |
| T194 | 967-981 | Phenotype | denotes | Abdominal pain | http://purl.obolibrary.org/obo/HP_0002027 |
| T195 | 989-997 | Phenotype | denotes | Diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
| T196 | 1511-1526 | Phenotype | denotes | Nausea/vomiting | http://purl.obolibrary.org/obo/HP_0002017 |
| T197 | 1534-1542 | Phenotype | denotes | Diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T12 | 464-480 | http://purl.obolibrary.org/obo/GO_0002524 | denotes | hypersensitivity |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T257 | 0-91 | Sentence | denotes | Table 3 Gastrointestinal Treatment Adverse Effects of Currently Utilized COVID-19 Therapies |
| T258 | 92-168 | Sentence | denotes | Medication type Medication name Adverse effects Major drug–drug interactions |
| T259 | 169-193 | Sentence | denotes | Gastrointestinal Hepatic |
| T260 | 194-333 | Sentence | denotes | Antimalarial ChloroquineHydroxychloroquine Nausea, vomiting, abdominal pain, and diarrhea reported; frequency not defined Likelihood score: |
| T261 | 334-406 | Sentence | denotes | D (possible rare cause of clinically apparent liver injury).Description: |
| T262 | 407-444 | Sentence | denotes | Rare elevations in aminotransferases. |
| T263 | 445-530 | Sentence | denotes | Most reactions are hypersensitivity with no known cross reactivity to hepatic injury. |
| T264 | 531-598 | Sentence | denotes | If this occurs, reasonable to switch between chloroquine therapies. |
| T265 | 599-691 | Sentence | denotes | Substrate for CYP2D6 and CYP3A4 substrateSame as above; also substrate for CYP3A5 and CYP2C8 |
| T266 | 692-768 | Sentence | denotes | Antiviral Remdesivir Not reported (limited data available) Likelihood score: |
| T267 | 769-792 | Sentence | denotes | Not scored.Description: |
| T268 | 793-842 | Sentence | denotes | Hepatotoxicity reported; frequency not yet known. |
| T269 | 843-893 | Sentence | denotes | Not a significant inducer/inhibitor of CYP enzymes |
| T270 | 894-934 | Sentence | denotes | Lopinavir/ritonavir Nausea and vomiting: |
| T271 | 935-962 | Sentence | denotes | 5%–10% (higher in children: |
| T272 | 963-982 | Sentence | denotes | 20%)Abdominal pain: |
| T273 | 983-998 | Sentence | denotes | 1%–10%Diarrhea: |
| T274 | 999-1064 | Sentence | denotes | 10%–30% + dose-dependentOther: dysguesia in adults <2%, children: |
| T275 | 1065-1102 | Sentence | denotes | 25%, increased serum amylase, lipase: |
| T276 | 1103-1109 | Sentence | denotes | 3%–8%. |
| T277 | 1110-1127 | Sentence | denotes | Likelihood score: |
| T278 | 1128-1201 | Sentence | denotes | D (possible, rare cause of clinically apparent liver injury).Description: |
| T279 | 1202-1383 | Sentence | denotes | Hepatotoxicity ranges from mild elevations in aminotransferases to acute liver failure.Recovery takes 1–2 mo.Re-challenging may lead to recurrence and should be avoided if possible. |
| T280 | 1384-1498 | Sentence | denotes | Substrate for: CYP3A4, CYP2D6P-gpInducer for: CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, UGT1A1Inhibitor for: CYP3A4 |
| T281 | 1499-1527 | Sentence | denotes | Favipiravir Nausea/vomiting: |
| T282 | 1528-1543 | Sentence | denotes | 5%–15%Diarrhea: |
| T283 | 1544-1586 | Sentence | denotes | 5%Limited data available Likelihood score: |
| T284 | 1587-1609 | Sentence | denotes | Not scoredDescription: |
| T285 | 1610-1648 | Sentence | denotes | 3% prevalence, but few data available. |
| T286 | 1649-1743 | Sentence | denotes | Inhibitor for: CYP2C8 and aldehyde oxidaseMetabolized by xanthine oxidase and aldehyde oxidase |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1072 | 613-619 | Gene | denotes | CYP2D6 | Gene:1565 |
| 1073 | 624-630 | Gene | denotes | CYP3A4 | Gene:1576 |
| 1074 | 674-680 | Gene | denotes | CYP3A5 | Gene:1577 |
| 1075 | 685-691 | Gene | denotes | CYP2C8 | Gene:1558 |
| 1076 | 1399-1405 | Gene | denotes | CYP3A4 | Gene:1576 |
| 1077 | 1407-1413 | Gene | denotes | CYP2D6 | Gene:1565 |
| 1078 | 1430-1436 | Gene | denotes | CYP1A2 | Gene:1544 |
| 1079 | 1438-1444 | Gene | denotes | CYP2B6 | Gene:1555 |
| 1080 | 1446-1452 | Gene | denotes | CYP2C8 | Gene:1558 |
| 1081 | 1454-1460 | Gene | denotes | CYP2C9 | Gene:1559 |
| 1082 | 1462-1469 | Gene | denotes | CYP2C19 | Gene:1557 |
| 1083 | 1471-1477 | Gene | denotes | UGT1A1 | Gene:54658 |
| 1084 | 1492-1498 | Gene | denotes | CYP3A4 | Gene:1576 |
| 1085 | 1664-1670 | Gene | denotes | CYP2C8 | Gene:1558 |
| 1086 | 169-185 | Gene | denotes | Gastrointestinal | Gene:2770 |
| 1087 | 953-961 | Species | denotes | children | Tax:9606 |
| 1088 | 1055-1063 | Species | denotes | children | Tax:9606 |
| 1089 | 207-236 | Chemical | denotes | ChloroquineHydroxychloroquine | |
| 1090 | 576-587 | Chemical | denotes | chloroquine | MESH:D002738 |
| 1091 | 702-712 | Chemical | denotes | Remdesivir | MESH:C000606551 |
| 1092 | 237-243 | Disease | denotes | Nausea | MESH:D009325 |
| 1093 | 245-253 | Disease | denotes | vomiting | MESH:D014839 |
| 1094 | 255-269 | Disease | denotes | abdominal pain | MESH:D015746 |
| 1095 | 275-283 | Disease | denotes | diarrhea | MESH:D003967 |
| 1096 | 380-392 | Disease | denotes | liver injury | MESH:D017093 |
| 1097 | 464-480 | Disease | denotes | hypersensitivity | MESH:D004342 |
| 1098 | 515-529 | Disease | denotes | hepatic injury | MESH:D056486 |
| 1099 | 793-807 | Disease | denotes | Hepatotoxicity | MESH:D056486 |
| 1100 | 904-920 | Disease | denotes | ritonavir Nausea | MESH:D009325 |
| 1101 | 925-933 | Disease | denotes | vomiting | MESH:D014839 |
| 1102 | 967-981 | Disease | denotes | Abdominal pain | MESH:D015746 |
| 1103 | 989-997 | Disease | denotes | Diarrhea | MESH:D003967 |
| 1104 | 1030-1039 | Disease | denotes | dysguesia | |
| 1105 | 1175-1187 | Disease | denotes | liver injury | MESH:D017093 |
| 1106 | 1202-1216 | Disease | denotes | Hepatotoxicity | MESH:D056486 |
| 1107 | 1269-1288 | Disease | denotes | acute liver failure | MESH:D017114 |
| 1108 | 1499-1526 | Disease | denotes | Favipiravir Nausea/vomiting | MESH:D020250 |
| 1109 | 1533-1542 | Disease | denotes | %Diarrhea | MESH:D003967 |
| 1112 | 8-24 | Gene | denotes | Gastrointestinal | Gene:2770 |
| 1113 | 73-81 | Disease | denotes | COVID-19 | MESH:C000657245 |