PMC:7212965 / 37963-39110
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T82 | 299-304 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T83 | 399-404 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T84 | 543-548 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T85 | 765-770 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T86 | 873-878 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T63 | 299-304 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T64 | 399-404 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T65 | 543-548 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T66 | 765-770 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T67 | 873-878 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T183 | 140-148 | Disease | denotes | diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T184 | 305-311 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T185 | 405-411 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T186 | 430-458 | Disease | denotes | acute intermittent porphyria | http://purl.obolibrary.org/obo/MONDO_0008294 |
| T187 | 449-458 | Disease | denotes | porphyria | http://purl.obolibrary.org/obo/MONDO_0019142|http://purl.obolibrary.org/obo/MONDO_0037939 |
| T189 | 462-485 | Disease | denotes | porphyria cutanea tarda | http://purl.obolibrary.org/obo/MONDO_0008296|http://purl.obolibrary.org/obo/MONDO_0015104 |
| T191 | 462-471 | Disease | denotes | porphyria | http://purl.obolibrary.org/obo/MONDO_0019142|http://purl.obolibrary.org/obo/MONDO_0037939 |
| T193 | 504-520 | Disease | denotes | hypersensitivity | http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271 |
| T195 | 696-712 | Disease | denotes | hypersensitivity | http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271 |
| T197 | 771-777 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T198 | 899-908 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T199 | 918-934 | Disease | denotes | hepatic diseases | http://purl.obolibrary.org/obo/MONDO_0005154 |
| T200 | 1024-1050 | Disease | denotes | cardiac conduction defects | http://purl.obolibrary.org/obo/MONDO_0007264 |
| T201 | 1082-1093 | Disease | denotes | arrhythmias | http://purl.obolibrary.org/obo/MONDO_0007263 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T300 | 231-232 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T301 | 299-304 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T302 | 299-304 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T303 | 399-404 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T304 | 399-404 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T305 | 502-503 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T306 | 765-770 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T307 | 765-770 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T308 | 873-878 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T309 | 873-878 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T63 | 0-11 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T64 | 16-34 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T65 | 220-225 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T66 | 316-327 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T67 | 643-661 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T68 | 786-804 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T69 | 979-984 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T167 | 102-118 | Phenotype | denotes | nausea, vomiting | http://purl.obolibrary.org/obo/HP_0002017 |
| T168 | 120-134 | Phenotype | denotes | abdominal pain | http://purl.obolibrary.org/obo/HP_0002027 |
| T169 | 140-148 | Phenotype | denotes | diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
| T170 | 504-520 | Phenotype | denotes | hypersensitivity | http://purl.obolibrary.org/obo/HP_0041092 |
| T171 | 533-538 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
| T172 | 601-609 | Phenotype | denotes | jaundice | http://purl.obolibrary.org/obo/HP_0000952 |
| T173 | 696-712 | Phenotype | denotes | hypersensitivity | http://purl.obolibrary.org/obo/HP_0041092 |
| T174 | 899-908 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
| T175 | 1024-1050 | Phenotype | denotes | cardiac conduction defects | http://purl.obolibrary.org/obo/HP_0031546 |
| T176 | 1082-1093 | Phenotype | denotes | arrhythmias | http://purl.obolibrary.org/obo/HP_0011675 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T9 | 504-520 | http://purl.obolibrary.org/obo/GO_0002524 | denotes | hypersensitivity |
| T10 | 696-712 | http://purl.obolibrary.org/obo/GO_0002524 | denotes | hypersensitivity |
| T11 | 1024-1042 | http://purl.obolibrary.org/obo/GO_0061337 | denotes | cardiac conduction |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T236 | 0-34 | Sentence | denotes | Chloroquine and hydroxychloroquine |
| T237 | 35-412 | Sentence | denotes | Both chloroquines have reported infrequent Gl adverse effects (ie, nausea, vomiting, abdominal pain, and diarrhea).84 , 85 The National Institute of Health LiverTox resource rates both drugs with a likelihood score of D (possible rare cause of clinically apparent liver injury).86 Chloroquine is rarely linked to aminotransferase elevations or clinically apparent liver injury. |
| T238 | 413-610 | Sentence | denotes | In patients with acute intermittent porphyria or porphyria cutanea tarda, it can trigger a hypersensitivity attack with fever and serum aminotransferase elevations, sometimes resulting in jaundice. |
| T239 | 611-662 | Sentence | denotes | This is seen less commonly with hydroxychloroquine. |
| T240 | 663-822 | Sentence | denotes | Such reactions are thought to be hypersensitivity reactions and there is no known cross-reactivity in liver injury between hydroxychloroquine and choloroquine. |
| T241 | 823-1010 | Sentence | denotes | Hydroxychloroquine is known to concentrate in the liver, thus patients with hepatitis or other hepatic diseases, or patients taking other known hepatotoxic drugs, should exercise caution. |
| T242 | 1011-1147 | Sentence | denotes | In addition, cardiac conduction defects leading to clinically relevant arrhythmias are an important adverse effect of these medications. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 956 | 0-11 | Chemical | denotes | Chloroquine | MESH:D002738 |
| 957 | 16-34 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 984 | 416-424 | Species | denotes | patients | Tax:9606 |
| 985 | 885-893 | Species | denotes | patients | Tax:9606 |
| 986 | 939-947 | Species | denotes | patients | Tax:9606 |
| 987 | 40-52 | Chemical | denotes | chloroquines | MESH:D002738 |
| 988 | 316-327 | Chemical | denotes | Chloroquine | MESH:D002738 |
| 989 | 643-661 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 990 | 786-804 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 991 | 809-821 | Chemical | denotes | choloroquine | |
| 992 | 823-841 | Chemical | denotes | Hydroxychloroquine | MESH:D006886 |
| 993 | 102-108 | Disease | denotes | nausea | MESH:D009325 |
| 994 | 110-118 | Disease | denotes | vomiting | MESH:D014839 |
| 995 | 120-134 | Disease | denotes | abdominal pain | MESH:D015746 |
| 996 | 140-148 | Disease | denotes | diarrhea | MESH:D003967 |
| 997 | 299-311 | Disease | denotes | liver injury | MESH:D017093 |
| 998 | 399-411 | Disease | denotes | liver injury | MESH:D017093 |
| 999 | 462-485 | Disease | denotes | porphyria cutanea tarda | MESH:D017119 |
| 1000 | 504-520 | Disease | denotes | hypersensitivity | MESH:D004342 |
| 1001 | 533-538 | Disease | denotes | fever | MESH:D005334 |
| 1002 | 601-609 | Disease | denotes | jaundice | MESH:D007565 |
| 1003 | 696-712 | Disease | denotes | hypersensitivity | MESH:D004342 |
| 1004 | 765-777 | Disease | denotes | liver injury | MESH:D017093 |
| 1005 | 899-908 | Disease | denotes | hepatitis | MESH:D056486 |
| 1006 | 918-934 | Disease | denotes | hepatic diseases | MESH:D056486 |
| 1007 | 967-978 | Disease | denotes | hepatotoxic | MESH:D056486 |
| 1008 | 1024-1050 | Disease | denotes | cardiac conduction defects | OMIM:115080 |
| 1009 | 1082-1093 | Disease | denotes | arrhythmias | MESH:D001145 |